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Volumn 60, Issue 3, 2016, Pages 218-234

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained

Author keywords

Calcium; ER; Mitochondria; Mitochondrial dynamics; Mitochondrial transport; Neurodegeneration; UPR

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ASCORBIC ACID; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CURCUMIN; CYCLOSPORIN A; DEXPRAMIPEXOLE; DIMEBON; IONOTROPIC RECEPTOR; MANGANESE SUPEROXIDE DISMUTASE; MELATONIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NORPHENAZONE; PRAMIPEXOLE; THIOCTIC ACID; UBIQUINONE; CALCIUM; REACTIVE OXYGEN METABOLITE;

EID: 84975466642     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2016.04.010     Document Type: Review
Times cited : (42)

References (231)
  • 1
    • 84939562716 scopus 로고    scopus 로고
    • The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
    • (PubMed PMID: 26210990 PubMed Central PMCID: PMC4541706)
    • [1] Scheper, W., Hoozemans, J.J., The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol. (Berl.) 130:3 (2015), 315–331, 10.1007/s00401-015-1462-8 (PubMed PMID: 26210990 PubMed Central PMCID: PMC4541706).
    • (2015) Acta Neuropathol. (Berl.) , vol.130 , Issue.3 , pp. 315-331
    • Scheper, W.1    Hoozemans, J.J.2
  • 2
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • (PubMed PMID: 15603751)
    • [2] Schroder, M., Kaufman, R.J., ER stress and the unfolded protein response. Mutat. Res. 569:1-2 (2005), 29–63, 10.1016/j.mrfmmm.2004.06.056 (PubMed PMID: 15603751).
    • (2005) Mutat. Res. , vol.569 , Issue.1-2 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 3
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: controlling cell fate decisions under ER stress and beyond
    • (PubMed PMID: 22251901)
    • [3] Hetz, C., The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 13:2 (2012), 89–102, 10.1038/nrm3270 (PubMed PMID: 22251901).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , Issue.2 , pp. 89-102
    • Hetz, C.1
  • 4
    • 0034644111 scopus 로고    scopus 로고
    • ER stress response: getting the UPR hand on misfolded proteins
    • (PubMed PMID: 10898996)
    • [4] Hampton, R.Y., ER stress response: getting the UPR hand on misfolded proteins. Curr. Biol. 10:14 (2000), R518–R521 (PubMed PMID: 10898996).
    • (2000) Curr. Biol. , vol.10 , Issue.14 , pp. R518-R521
    • Hampton, R.Y.1
  • 5
    • 13644256191 scopus 로고    scopus 로고
    • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    • (PubMed PMID: 15705855)
    • [5] Boyce, M., Bryant, K.F., Jousse, C., Long, K., Harding, H.P., Scheuner, D., Kaufman, R.J., Ma, D., Coen, D.M., Ron, D., Yuan, J., A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:5711 (2005), 935–939, 10.1126/science.1101902 (PubMed PMID: 15705855).
    • (2005) Science , vol.307 , Issue.5711 , pp. 935-939
    • Boyce, M.1    Bryant, K.F.2    Jousse, C.3    Long, K.4    Harding, H.P.5    Scheuner, D.6    Kaufman, R.J.7    Ma, D.8    Coen, D.M.9    Ron, D.10    Yuan, J.11
  • 6
    • 0034515724 scopus 로고    scopus 로고
    • ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
    • (PubMed PMID: 11163209)
    • [6] Ye, J., Rawson, R.B., Komuro, R., Chen, X., Dave, U.P., Prywes, R., Brown, M.S., Goldstein, J.L., ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6:6 (2000), 1355–1364 (PubMed PMID: 11163209).
    • (2000) Mol. Cell , vol.6 , Issue.6 , pp. 1355-1364
    • Ye, J.1    Rawson, R.B.2    Komuro, R.3    Chen, X.4    Dave, U.P.5    Prywes, R.6    Brown, M.S.7    Goldstein, J.L.8
  • 7
    • 23144451257 scopus 로고    scopus 로고
    • ERAD: the long road to destruction
    • (PubMed PMID: 16056268)
    • [7] Meusser, B., Hirsch, C., Jarosch, E., Sommer, T., ERAD: the long road to destruction. Nat. Cell Biol. 7:8 (2005), 766–772, 10.1038/ncb0805-766 (PubMed PMID: 16056268).
    • (2005) Nat. Cell Biol. , vol.7 , Issue.8 , pp. 766-772
    • Meusser, B.1    Hirsch, C.2    Jarosch, E.3    Sommer, T.4
  • 8
    • 84886749523 scopus 로고    scopus 로고
    • IRE1: ER stress sensor and cell fate executor
    • (PubMed PMID: 23880584 PubMed Central PMCID: PMC3818365)
    • [8] Chen, Y., Brandizzi, F., IRE1: ER stress sensor and cell fate executor. Trends Cell Biol. 23:11 (2013), 547–555, 10.1016/j.tcb.2013.06.005 (PubMed PMID: 23880584 PubMed Central PMCID: PMC3818365).
    • (2013) Trends Cell Biol. , vol.23 , Issue.11 , pp. 547-555
    • Chen, Y.1    Brandizzi, F.2
  • 9
    • 84883780939 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells
    • (PubMed PMID: 23994613)
    • [9] Fonseca, A.C., Ferreiro, E., Oliveira, C.R., Cardoso, S.M., Pereira, C.F., Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells. Biochim. Biophys. Acta 1832:12 (2013), 2191–2203, 10.1016/j.bbadis.2013.08.007 (PubMed PMID: 23994613).
    • (2013) Biochim. Biophys. Acta , vol.1832 , Issue.12 , pp. 2191-2203
    • Fonseca, A.C.1    Ferreiro, E.2    Oliveira, C.R.3    Cardoso, S.M.4    Pereira, C.F.5
  • 10
    • 79954425809 scopus 로고    scopus 로고
    • Protein folding stress in neurodegenerative diseases: a glimpse into the ER
    • (PubMed PMID: 21288706)
    • [10] Matus, S., Glimcher, L.H., Hetz, C., Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr. Opin. Cell Biol. 23:2 (2011), 239–252, 10.1016/j.ceb.2011.01.003 (PubMed PMID: 21288706).
    • (2011) Curr. Opin. Cell Biol. , vol.23 , Issue.2 , pp. 239-252
    • Matus, S.1    Glimcher, L.H.2    Hetz, C.3
  • 11
    • 33645141853 scopus 로고    scopus 로고
    • ER stress and neurodegenerative diseases
    • (PubMed PMID: 16397584)
    • [11] Lindholm, D., Wootz, H., Korhonen, L., ER stress and neurodegenerative diseases. Cell Death Differ. 13:3 (2006), 385–392, 10.1038/sj.cdd.4401778 (PubMed PMID: 16397584).
    • (2006) Cell Death Differ. , vol.13 , Issue.3 , pp. 385-392
    • Lindholm, D.1    Wootz, H.2    Korhonen, L.3
  • 12
    • 84890096545 scopus 로고    scopus 로고
    • Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
    • (PubMed PMID: 24231356 PubMed Central PMCID: PMC3859413)
    • [12] Guo, X., Disatnik, M.H., Monbureau, M., Shamloo, M., Mochly-Rosen, D., Qi, X., Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J. Clin. Invest. 123:12 (2013), 5371–5388, 10.1172/JCI70911 (PubMed PMID: 24231356 PubMed Central PMCID: PMC3859413).
    • (2013) J. Clin. Invest. , vol.123 , Issue.12 , pp. 5371-5388
    • Guo, X.1    Disatnik, M.H.2    Monbureau, M.3    Shamloo, M.4    Mochly-Rosen, D.5    Qi, X.6
  • 13
    • 28644433087 scopus 로고    scopus 로고
    • Normal huntingtin function: an alternative approach to Huntington's disease
    • (PubMed PMID: 16288298)
    • [13] Cattaneo, E., Zuccato, C., Tartari, M., Normal huntingtin function: an alternative approach to Huntington's disease. Nat. Rev. Neurosci. 6:12 (2005), 919–930, 10.1038/nrn1806 (PubMed PMID: 16288298).
    • (2005) Nat. Rev. Neurosci. , vol.6 , Issue.12 , pp. 919-930
    • Cattaneo, E.1    Zuccato, C.2    Tartari, M.3
  • 14
    • 78650827764 scopus 로고    scopus 로고
    • Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease
    • (PubMed PMID: 21189122)
    • [14] Vidal, R., Caballero, B., Couve, A., Hetz, C., Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease. Curr. Mol. Med. 11:1 (2011), 1–12 (PubMed PMID: 21189122).
    • (2011) Curr. Mol. Med. , vol.11 , Issue.1 , pp. 1-12
    • Vidal, R.1    Caballero, B.2    Couve, A.3    Hetz, C.4
  • 15
    • 67650566385 scopus 로고    scopus 로고
    • Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease
    • (PubMed PMID: 19433866 PubMed Central PMCID: PMC2709382)
    • [15] Carnemolla, A., Fossale, E., Agostoni, E., Michelazzi, S., Calligaris, R., De Maso, L., Del Sal, G., MacDonald, M.E., Persichetti, F., Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease. J. Biol. Chem. 284:27 (2009), 18167–18173, 10.1074/jbc.M109.018325 (PubMed PMID: 19433866 PubMed Central PMCID: PMC2709382).
    • (2009) J. Biol. Chem. , vol.284 , Issue.27 , pp. 18167-18173
    • Carnemolla, A.1    Fossale, E.2    Agostoni, E.3    Michelazzi, S.4    Calligaris, R.5    De Maso, L.6    Del Sal, G.7    MacDonald, M.E.8    Persichetti, F.9
  • 16
    • 76249091683 scopus 로고    scopus 로고
    • Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease
    • (PubMed PMID: 19646509)
    • [16] Cho, K.J., Lee, B.I., Cheon, S.Y., Kim, H.W., Kim, H.J., Kim, G.W., Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease. Neuroscience 163:4 (2009), 1128–1134, 10.1016/j.neuroscience.2009.07.048 (PubMed PMID: 19646509).
    • (2009) Neuroscience , vol.163 , Issue.4 , pp. 1128-1134
    • Cho, K.J.1    Lee, B.I.2    Cheon, S.Y.3    Kim, H.W.4    Kim, H.J.5    Kim, G.W.6
  • 17
    • 57749116408 scopus 로고    scopus 로고
    • Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
    • (PubMed PMID: 19015277 PubMed Central PMCID: PMC2600758)
    • [17] Duennwald, M.L., Lindquist, S., Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev. 22:23 (2008), 3308–3319, 10.1101/gad.1673408 (PubMed PMID: 19015277 PubMed Central PMCID: PMC2600758).
    • (2008) Genes Dev. , vol.22 , Issue.23 , pp. 3308-3319
    • Duennwald, M.L.1    Lindquist, S.2
  • 18
    • 84859577308 scopus 로고    scopus 로고
    • AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease
    • (PubMed PMID: 22445760)
    • [18] Zuleta, A., Vidal, R.L., Armentano, D., Parsons, G., Hetz, C., AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease. Biochem. Biophys. Res. Commun. 420:3 (2012), 558–563, 10.1016/j.bbrc.2012.03.033 (PubMed PMID: 22445760).
    • (2012) Biochem. Biophys. Res. Commun. , vol.420 , Issue.3 , pp. 558-563
    • Zuleta, A.1    Vidal, R.L.2    Armentano, D.3    Parsons, G.4    Hetz, C.5
  • 19
    • 84860471873 scopus 로고    scopus 로고
    • Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
    • (PubMed PMID: 22337954 PubMed Central PMCID: PMC3335312)
    • [19] Vidal, R.L., Figueroa, A., Court, F.A., Thielen, P., Molina, C., Wirth, C., Caballero, B., Kiffin, R., Segura-Aguilar, J., Cuervo, A.M., Glimcher, L.H., Hetz, C., Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum. Mol. Genet. 21:10 (2012), 2245–2262, 10.1093/hmg/dds040 (PubMed PMID: 22337954 PubMed Central PMCID: PMC3335312).
    • (2012) Hum. Mol. Genet. , vol.21 , Issue.10 , pp. 2245-2262
    • Vidal, R.L.1    Figueroa, A.2    Court, F.A.3    Thielen, P.4    Molina, C.5    Wirth, C.6    Caballero, B.7    Kiffin, R.8    Segura-Aguilar, J.9    Cuervo, A.M.10    Glimcher, L.H.11    Hetz, C.12
  • 20
    • 80054037000 scopus 로고    scopus 로고
    • Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin
    • (PubMed PMID: 21896647; PubMed Central PMCID: PMC3178454)
    • [20] Lajoie, P., Snapp, E.L., Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin. J. Cell Sci. 124:Pt. 19 (2011), 3332–3343, 10.1242/jcs.087510 (PubMed PMID: 21896647; PubMed Central PMCID: PMC3178454).
    • (2011) J. Cell Sci. , vol.124 , pp. 3332-3343
    • Lajoie, P.1    Snapp, E.L.2
  • 21
    • 84860443709 scopus 로고    scopus 로고
    • GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins
    • (PubMed PMID: 22490889)
    • [21] Jiang, Y., Lv, H., Liao, M., Xu, X., Huang, S., Tan, H., Peng, T., Zhang, Y., Li, H., GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins. Neurosci. Lett. 516:2 (2012), 182–187, 10.1016/j.neulet.2012.03.074 (PubMed PMID: 22490889).
    • (2012) Neurosci. Lett. , vol.516 , Issue.2 , pp. 182-187
    • Jiang, Y.1    Lv, H.2    Liao, M.3    Xu, X.4    Huang, S.5    Tan, H.6    Peng, T.7    Zhang, Y.8    Li, H.9
  • 22
    • 66449112462 scopus 로고    scopus 로고
    • SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition
    • (PubMed PMID: 19240033 PubMed Central PMCID: PMC2670137)
    • [22] Noh, J.Y., Lee, H., Song, S., Kim, N.S., Im, W., Kim, M., Seo, H., Chung, C.W., Chang, J.W., Ferrante, R.J., Yoo, Y.J., Ryu, H., Jung, Y.K., SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. J. Biol. Chem. 284:17 (2009), 11318–11325, 10.1074/jbc.M807620200 (PubMed PMID: 19240033 PubMed Central PMCID: PMC2670137).
    • (2009) J. Biol. Chem. , vol.284 , Issue.17 , pp. 11318-11325
    • Noh, J.Y.1    Lee, H.2    Song, S.3    Kim, N.S.4    Im, W.5    Kim, M.6    Seo, H.7    Chung, C.W.8    Chang, J.W.9    Ferrante, R.J.10    Yoo, Y.J.11    Ryu, H.12    Jung, Y.K.13
  • 23
    • 4444298732 scopus 로고    scopus 로고
    • Induction of neuronal death by ER stress in Alzheimer's disease
    • (PubMed PMID: 15363492)
    • [23] Katayama, T., Imaizumi, K., Manabe, T., Hitomi, J., Kudo, T., Tohyama, M., Induction of neuronal death by ER stress in Alzheimer's disease. J. Chem. Neuroanat. 28:1–2 (2004), 67–78, 10.1016/j.jchemneu.2003.12.004 (PubMed PMID: 15363492).
    • (2004) J. Chem. Neuroanat. , vol.28 , Issue.1-2 , pp. 67-78
    • Katayama, T.1    Imaizumi, K.2    Manabe, T.3    Hitomi, J.4    Kudo, T.5    Tohyama, M.6
  • 24
    • 74549169836 scopus 로고    scopus 로고
    • ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
    • (PubMedPMID:20035627;PubMedCentralPMCID:PMC2806266)
    • [24] Salminen, A., Kauppinen, A., Suuronen, T., Kaarniranta, K., Ojala, J., ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J. Neuroinflammation, 6, 2009, 41, 10.1186/1742-2094-6-41 (PubMedPMID:20035627;PubMedCentralPMCID:PMC2806266).
    • (2009) J. Neuroinflammation , vol.6 , pp. 41
    • Salminen, A.1    Kauppinen, A.2    Suuronen, T.3    Kaarniranta, K.4    Ojala, J.5
  • 25
    • 79955804227 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    • (PubMed PMID: 21252911 PubMed Central PMCID: PMC3131935)
    • [25] Nijholt, D.A., de Graaf, T.R., van Haastert, E.S., Oliveira, A.O., Berkers, C.R., Zwart, R., Ovaa, H., Baas, F., Hoozemans, J.J., Scheper, W., Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. Cell Death Differ. 18:6 (2011), 1071–1081, 10.1038/cdd.2010.176 (PubMed PMID: 21252911 PubMed Central PMCID: PMC3131935).
    • (2011) Cell Death Differ. , vol.18 , Issue.6 , pp. 1071-1081
    • Nijholt, D.A.1    de Graaf, T.R.2    van Haastert, E.S.3    Oliveira, A.O.4    Berkers, C.R.5    Zwart, R.6    Ovaa, H.7    Baas, F.8    Hoozemans, J.J.9    Scheper, W.10
  • 27
    • 80054680024 scopus 로고    scopus 로고
    • Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus
    • (PubMed PMID: 22046282 PubMed Central PMCID: PMC3194795)
    • [27] Prasanthi, J.R., Larson, T., Schommer, J., Ghribi, O., Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PLoS One, 6(10), 2011, e26420, 10.1371/journal.pone.0026420 (PubMed PMID: 22046282 PubMed Central PMCID: PMC3194795).
    • (2011) PLoS One , vol.6 , Issue.10 , pp. e26420
    • Prasanthi, J.R.1    Larson, T.2    Schommer, J.3    Ghribi, O.4
  • 30
    • 84903197320 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress mediates amyloid beta neurotoxicity via mitochondrial cholesterol trafficking
    • (PubMed PMID: 24815354 PubMed Central PMCID: PMC4076561)
    • [30] Barbero-Camps, E., Fernandez, A., Baulies, A., Martinez, L., Fernandez-Checa, J.C., Colell, A., Endoplasmic reticulum stress mediates amyloid beta neurotoxicity via mitochondrial cholesterol trafficking. Am. J. Pathol. 184:7 (2014), 2066–2081, 10.1016/j.ajpath.2014.03.014 (PubMed PMID: 24815354 PubMed Central PMCID: PMC4076561).
    • (2014) Am. J. Pathol. , vol.184 , Issue.7 , pp. 2066-2081
    • Barbero-Camps, E.1    Fernandez, A.2    Baulies, A.3    Martinez, L.4    Fernandez-Checa, J.C.5    Colell, A.6
  • 32
    • 79751509762 scopus 로고    scopus 로고
    • Parkinson's disease: genetics and pathogenesis
    • (PubMed PMID: 21034221)
    • [32] Shulman, J.M., De Jager, P.L., Feany, M.B., Parkinson's disease: genetics and pathogenesis. Annu. Rev. Pathol. 6 (2011), 193–222, 10.1146/annurev-pathol-011110-130242 (PubMed PMID: 21034221).
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 193-222
    • Shulman, J.M.1    De Jager, P.L.2    Feany, M.B.3
  • 33
    • 85046912310 scopus 로고    scopus 로고
    • Recent advances in the genetics and pathogenesis of Parkinson's disease
    • (author reply PubMed PMID: 12370484)
    • [33] Burke, W.J., Recent advances in the genetics and pathogenesis of Parkinson's disease. Neurology, 59(7), 2002, 1118 (author reply PubMed PMID: 12370484).
    • (2002) Neurology , vol.59 , Issue.7 , pp. 1118
    • Burke, W.J.1
  • 34
    • 84877302055 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease
    • [34] Omura, T., Kaneko, M., Okuma, Y., Matsubara, K., Nomura, Y., Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease. Oxid. Med. Cell. Longev., 2013, 2013, 239854, 10.1155/2013/239854.PubMedPMID:23710284;PubMedCentralPMCID:PMC3654363.
    • (2013) Oxid. Med. Cell. Longev. , vol.2013 , pp. 239854
    • Omura, T.1    Kaneko, M.2    Okuma, Y.3    Matsubara, K.4    Nomura, Y.5
  • 35
    • 84875259777 scopus 로고    scopus 로고
    • An ERcentric view of parkinson's disease
    • (PubMed PMID: 23352769)
    • [35] Mercado, G., Valdes, P., Hetz, C., An ERcentric view of parkinson's disease. Trends Mol. Med. 19:3 (2013), 165–175, 10.1016/j.molmed.2012.12.005 (PubMed PMID: 23352769).
    • (2013) Trends Mol. Med. , vol.19 , Issue.3 , pp. 165-175
    • Mercado, G.1    Valdes, P.2    Hetz, C.3
  • 37
    • 84856954609 scopus 로고    scopus 로고
    • The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant alpha-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins
    • (PubMed PMID: 22045699 PubMed Central PMCID: PMC3277305)
    • [37] Belal, C., Ameli, N.J., El Kommos, A., Bezalel, S., Al'Khafaji, A.M., Mughal, M.R., Mattson, M.P., Kyriazis, G.A., Tyrberg, B., Chan, S.L., The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant alpha-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Hum. Mol. Genet. 21:5 (2012), 963–977, 10.1093/hmg/ddr502 (PubMed PMID: 22045699 PubMed Central PMCID: PMC3277305).
    • (2012) Hum. Mol. Genet. , vol.21 , Issue.5 , pp. 963-977
    • Belal, C.1    Ameli, N.J.2    El Kommos, A.3    Bezalel, S.4    Al'Khafaji, A.M.5    Mughal, M.R.6    Mattson, M.P.7    Kyriazis, G.A.8    Tyrberg, B.9    Chan, S.L.10
  • 38
    • 79551647443 scopus 로고    scopus 로고
    • Induction of the unfolded protein response by alpha-synuclein in experimental models of Parkinson's disease
    • (PubMed PMID: 21166675)
    • [38] Bellucci, A., Navarria, L., Zaltieri, M., Falarti, E., Bodei, S., Sigala, S., Battistin, L., Spillantini, M., Missale, C., Spano, P., Induction of the unfolded protein response by alpha-synuclein in experimental models of Parkinson's disease. J. Neurochem. 116:4 (2011), 588–605, 10.1111/j.1471-4159.2010.07143.x (PubMed PMID: 21166675).
    • (2011) J. Neurochem. , vol.116 , Issue.4 , pp. 588-605
    • Bellucci, A.1    Navarria, L.2    Zaltieri, M.3    Falarti, E.4    Bodei, S.5    Sigala, S.6    Battistin, L.7    Spillantini, M.8    Missale, C.9    Spano, P.10
  • 39
    • 84942313644 scopus 로고    scopus 로고
    • LRRK2 and ubiquitination: implications for kinase inhibitor therapy
    • (PubMed PMID: 26341487 PubMed Central PMCID: PMC4613699)
    • [39] Melrose, H.L., LRRK2 and ubiquitination: implications for kinase inhibitor therapy. Biochem. J. 470:3 (2015), e21–e24, 10.1042/BJ20150785 (PubMed PMID: 26341487 PubMed Central PMCID: PMC4613699).
    • (2015) Biochem. J. , vol.470 , Issue.3 , pp. e21-e24
    • Melrose, H.L.1
  • 40
    • 79961078072 scopus 로고    scopus 로고
    • Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans
    • (PubMed PMID: 21857923 PubMed Central PMCID: PMC3153934)
    • [40] Yuan, Y., Cao, P., Smith, M.A., Kramp, K., Huang, Y., Hisamoto, N., Matsumoto, K., Hatzoglou, M., Jin, H., Feng, Z., Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. PLoS One, 6(8), 2011, e22354, 10.1371/journal.pone.0022354 (PubMed PMID: 21857923 PubMed Central PMCID: PMC3153934).
    • (2011) PLoS One , vol.6 , Issue.8 , pp. e22354
    • Yuan, Y.1    Cao, P.2    Smith, M.A.3    Kramp, K.4    Huang, Y.5    Hisamoto, N.6    Matsumoto, K.7    Hatzoglou, M.8    Jin, H.9    Feng, Z.10
  • 41
    • 85011423442 scopus 로고    scopus 로고
    • LRRK2 at the crossroad between autophagy and microtubule trafficking: insights into parkinson's disease
    • (PubMed PMID: 26740081)
    • [41] Esteves, A.R., Cardoso, S.M., LRRK2 at the crossroad between autophagy and microtubule trafficking: insights into parkinson's disease. Neuroscientist, 2016, 10.1177/1073858415616558 (PubMed PMID: 26740081).
    • (2016) Neuroscientist
    • Esteves, A.R.1    Cardoso, S.M.2
  • 42
    • 84862907943 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
    • (PubMed PMID: 22012985 PubMed Central PMCID: PMC3259011)
    • [42] Gomez-Suaga, P., Luzon-Toro, B., Churamani, D., Zhang, L., Bloor-Young, D., Patel, S., Woodman, P.G., Churchill, G.C., Hilfiker, S., Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum. Mol. Genet. 21:3 (2012), 511–525, 10.1093/hmg/ddr481 (PubMed PMID: 22012985 PubMed Central PMCID: PMC3259011).
    • (2012) Hum. Mol. Genet. , vol.21 , Issue.3 , pp. 511-525
    • Gomez-Suaga, P.1    Luzon-Toro, B.2    Churamani, D.3    Zhang, L.4    Bloor-Young, D.5    Patel, S.6    Woodman, P.G.7    Churchill, G.C.8    Hilfiker, S.9
  • 43
    • 84872691988 scopus 로고    scopus 로고
    • Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons
    • (PubMed PMID: 23231918; PubMed Central PMCID: PMC3562730)
    • [43] Cherra, S.J. 3rd, Steer, E., Gusdon, A.M., Kiselyov, K., Chu, C.T., Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am. J. Pathol. 182:2 (2013), 474–484, 10.1016/j.ajpath.2012.10.027 (PubMed PMID: 23231918; PubMed Central PMCID: PMC3562730).
    • (2013) Am. J. Pathol. , vol.182 , Issue.2 , pp. 474-484
    • Cherra, S.J.1    Steer, E.2    Gusdon, A.M.3    Kiselyov, K.4    Chu, C.T.5
  • 44
    • 84914173185 scopus 로고    scopus 로고
    • ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase
    • (PubMedPMID:25520620;PubMedCentralPMCID:PMC4251436)
    • [44] Jaronen, M., Goldsteins, G., Koistinaho, J., ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase. Front. Cell. Neurosci., 8, 2014, 402, 10.3389/fncel.2014.00402 (PubMedPMID:25520620;PubMedCentralPMCID:PMC4251436).
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 402
    • Jaronen, M.1    Goldsteins, G.2    Koistinaho, J.3
  • 45
    • 44849124411 scopus 로고    scopus 로고
    • ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
    • (PubMed PMID: 18519638 PubMed Central PMCID: PMC2418582)
    • [45] Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo, H., ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev. 22:11 (2008), 1451–1464, 10.1101/gad.1640108 (PubMed PMID: 18519638 PubMed Central PMCID: PMC2418582).
    • (2008) Genes Dev. , vol.22 , Issue.11 , pp. 1451-1464
    • Nishitoh, H.1    Kadowaki, H.2    Nagai, A.3    Maruyama, T.4    Yokota, T.5    Fukutomi, H.6    Noguchi, T.7    Matsuzawa, A.8    Takeda, K.9    Ichijo, H.10
  • 46
    • 84896710448 scopus 로고    scopus 로고
    • ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
    • (PubMed PMID: 24312274 PubMed Central PMCID: PMC3843686)
    • [46] Walker, A.K., Soo, K.Y., Sundaramoorthy, V., Parakh, S., Ma, Y., Farg, M.A., Wallace, R.H., Crouch, P.J., Turner, B.J., Horne, M.K., Atkin, J.D., ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation. PLoS One, 8(11), 2013, e81170, 10.1371/journal.pone.0081170 (PubMed PMID: 24312274 PubMed Central PMCID: PMC3843686).
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e81170
    • Walker, A.K.1    Soo, K.Y.2    Sundaramoorthy, V.3    Parakh, S.4    Ma, Y.5    Farg, M.A.6    Wallace, R.H.7    Crouch, P.J.8    Turner, B.J.9    Horne, M.K.10    Atkin, J.D.11
  • 47
    • 79551584057 scopus 로고    scopus 로고
    • The unfolded protein response in familial amyotrophic lateral sclerosis
    • (PubMed PMID: 21159797 PubMed Central PMCID: PMC3033190)
    • [47] Wang, L., Popko, B., Roos, R.P., The unfolded protein response in familial amyotrophic lateral sclerosis. Hum. Mol. Genet. 20:5 (2011), 1008–1015, 10.1093/hmg/ddq546 (PubMed PMID: 21159797 PubMed Central PMCID: PMC3033190).
    • (2011) Hum. Mol. Genet. , vol.20 , Issue.5 , pp. 1008-1015
    • Wang, L.1    Popko, B.2    Roos, R.P.3
  • 48
    • 33749563294 scopus 로고    scopus 로고
    • Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    • (PubMed PMID: 16847061)
    • [48] Atkin, J.D., Farg, M.A., Turner, B.J., Tomas, D., Lysaght, J.A., Nunan, J., Rembach, A., Nagley, P., Beart, P.M., Cheema, S.S., Horne, M.K., Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J. Biol. Chem. 281:40 (2006), 30152–30165, 10.1074/jbc.M603393200 (PubMed PMID: 16847061).
    • (2006) J. Biol. Chem. , vol.281 , Issue.40 , pp. 30152-30165
    • Atkin, J.D.1    Farg, M.A.2    Turner, B.J.3    Tomas, D.4    Lysaght, J.A.5    Nunan, J.6    Rembach, A.7    Nagley, P.8    Beart, P.M.9    Cheema, S.S.10    Horne, M.K.11
  • 49
    • 70349627027 scopus 로고    scopus 로고
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    • (PubMed PMID: 19762508 PubMed Central PMCID: PMC2758741)
    • [49] Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A.M., Brown, R.H., Glimcher, L.H., XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23:19 (2009), 2294–2306, 10.1101/gad.1830709 (PubMed PMID: 19762508 PubMed Central PMCID: PMC2758741).
    • (2009) Genes Dev. , vol.23 , Issue.19 , pp. 2294-2306
    • Hetz, C.1    Thielen, P.2    Matus, S.3    Nassif, M.4    Court, F.5    Kiffin, R.6    Martinez, G.7    Cuervo, A.M.8    Brown, R.H.9    Glimcher, L.H.10
  • 50
    • 84866748196 scopus 로고    scopus 로고
    • Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase
    • (PubMed PMID: 22459602)
    • [50] Farg, M.A., Soo, K.Y., Walker, A.K., Pham, H., Orian, J., Horne, M.K., Warraich, S.T., Williams, K.L., Blair, I.P., Atkin, J.D., Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase. Neurobiol. Aging 33:12 (2012), 2855–2868, 10.1016/j.neurobiolaging.2012.02.009 (PubMed PMID: 22459602).
    • (2012) Neurobiol. Aging , vol.33 , Issue.12 , pp. 2855-2868
    • Farg, M.A.1    Soo, K.Y.2    Walker, A.K.3    Pham, H.4    Orian, J.5    Horne, M.K.6    Warraich, S.T.7    Williams, K.L.8    Blair, I.P.9    Atkin, J.D.10
  • 53
    • 84898817967 scopus 로고    scopus 로고
    • An enhanced integrated stress response ameliorates mutant SOD1-induced ALS
    • (PubMed PMID: 24368417 PubMed Central PMCID: PMC3990163)
    • [53] Wang, L., Popko, B., Roos, R.P., An enhanced integrated stress response ameliorates mutant SOD1-induced ALS. Hum. Mol. Genet. 23:10 (2014), 2629–2638, 10.1093/hmg/ddt658 (PubMed PMID: 24368417 PubMed Central PMCID: PMC3990163).
    • (2014) Hum. Mol. Genet. , vol.23 , Issue.10 , pp. 2629-2638
    • Wang, L.1    Popko, B.2    Roos, R.P.3
  • 54
    • 79151483641 scopus 로고    scopus 로고
    • Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients
    • (PubMed PMID: 21168498)
    • [54] Vijayalakshmi, K., Alladi, P.A., Ghosh, S., Prasanna, V.K., Sagar, B.C., Nalini, A., Sathyaprabha, T.N., Raju, T.R., Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients. Neurobiol. Dis. 41:3 (2011), 695–705, 10.1016/j.nbd.2010.12.005 (PubMed PMID: 21168498).
    • (2011) Neurobiol. Dis. , vol.41 , Issue.3 , pp. 695-705
    • Vijayalakshmi, K.1    Alladi, P.A.2    Ghosh, S.3    Prasanna, V.K.4    Sagar, B.C.5    Nalini, A.6    Sathyaprabha, T.N.7    Raju, T.R.8
  • 55
    • 84867885631 scopus 로고    scopus 로고
    • Endoplasmic reticulum (ER) stress inhibitor salubrinal protects against ceramide-induced SH-SY5Y cell death
    • (PubMed PMID: 22935424)
    • [55] Gong, T., Wang, Q., Lin, Z., Chen, M.L., Sun, G.Z., Endoplasmic reticulum (ER) stress inhibitor salubrinal protects against ceramide-induced SH-SY5Y cell death. Biochem. Biophys. Res. Commun. 427:3 (2012), 461–465, 10.1016/j.bbrc.2012.08.068 (PubMed PMID: 22935424).
    • (2012) Biochem. Biophys. Res. Commun. , vol.427 , Issue.3 , pp. 461-465
    • Gong, T.1    Wang, Q.2    Lin, Z.3    Chen, M.L.4    Sun, G.Z.5
  • 56
    • 84953328544 scopus 로고    scopus 로고
    • All roads go to Salubrinal: endoplasmic reticulum stress, neuroprotection and glial scar formation
    • (PubMed PMID: 26889171 PubMed Central PMCID: PMC4730807)
    • [56] Romero-Ramirez, L., Nieto-Sampedro, M., Barreda-Manso, M.A., All roads go to Salubrinal: endoplasmic reticulum stress, neuroprotection and glial scar formation. Neural Regener. Res. 10:12 (2015), 1926–1927, 10.4103/1673-5374.169619 (PubMed PMID: 26889171 PubMed Central PMCID: PMC4730807).
    • (2015) Neural Regener. Res. , vol.10 , Issue.12 , pp. 1926-1927
    • Romero-Ramirez, L.1    Nieto-Sampedro, M.2    Barreda-Manso, M.A.3
  • 57
    • 84930755676 scopus 로고    scopus 로고
    • Salubrinal inhibits the expression of proteoglycans and favors neurite outgrowth from cortical neurons in vitro
    • (PubMed PMID: 25882497)
    • [57] Barreda-Manso, M.A., Yanguas-Casas, N., Nieto-Sampedro, M., Romero-Ramirez, L., Salubrinal inhibits the expression of proteoglycans and favors neurite outgrowth from cortical neurons in vitro. Exp. Cell Res. 335:1 (2015), 82–90, 10.1016/j.yexcr.2015.04.002 (PubMed PMID: 25882497).
    • (2015) Exp. Cell Res. , vol.335 , Issue.1 , pp. 82-90
    • Barreda-Manso, M.A.1    Yanguas-Casas, N.2    Nieto-Sampedro, M.3    Romero-Ramirez, L.4
  • 58
    • 33846577831 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
    • (PubMed PMID: 17251432)
    • [58] Sokka, A.L., Putkonen, N., Mudo, G., Pryazhnikov, E., Reijonen, S., Khiroug, L., Belluardo, N., Lindholm, D., Korhonen, L., Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J. Nneurosci. 27:4 (2007), 901–908, 10.1523/JNEUROSCI.4289-06.2007 (PubMed PMID: 17251432).
    • (2007) J. Nneurosci. , vol.27 , Issue.4 , pp. 901-908
    • Sokka, A.L.1    Putkonen, N.2    Mudo, G.3    Pryazhnikov, E.4    Reijonen, S.5    Khiroug, L.6    Belluardo, N.7    Lindholm, D.8    Korhonen, L.9
  • 59
    • 67349164383 scopus 로고    scopus 로고
    • A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
    • (PubMed PMID: 19330001)
    • [59] Saxena, S., Cabuy, E., Caroni, P., A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci. 12:5 (2009), 627–636, 10.1038/nn.2297 (PubMed PMID: 19330001).
    • (2009) Nat. Neurosci. , vol.12 , Issue.5 , pp. 627-636
    • Saxena, S.1    Cabuy, E.2    Caroni, P.3
  • 61
    • 84885463900 scopus 로고    scopus 로고
    • Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
    • (PubMed PMID: 24107777)
    • [61] Moreno, J.A., Halliday, M., Molloy, C., Radford, H., Verity, N., Axten, J.M., Ortori, C.A., Willis, A.E., Fischer, P.M., Barrett, D.A., Mallucci, G.R., Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci. Transl. Med., 5(206), 2013, 206ra138, 10.1126/scitranslmed.3006767 (PubMed PMID: 24107777).
    • (2013) Sci. Transl. Med. , vol.5 , Issue.206 , pp. 206ra138
    • Moreno, J.A.1    Halliday, M.2    Molloy, C.3    Radford, H.4    Verity, N.5    Axten, J.M.6    Ortori, C.A.7    Willis, A.E.8    Fischer, P.M.9    Barrett, D.A.10    Mallucci, G.R.11
  • 63
    • 84898009679 scopus 로고    scopus 로고
    • Evidence for eIF2alpha phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
    • (PubMed PMID: 24401334 PubMed Central PMCID: PMC3979916)
    • [63] Krishnamoorthy, J., Rajesh, K., Mirzajani, F., Kesoglidou, P., Papadakis, A.I., Koromilas, A.E., Evidence for eIF2alpha phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle 13:5 (2014), 801–806, 10.4161/cc.27726 (PubMed PMID: 24401334 PubMed Central PMCID: PMC3979916).
    • (2014) Cell Cycle , vol.13 , Issue.5 , pp. 801-806
    • Krishnamoorthy, J.1    Rajesh, K.2    Mirzajani, F.3    Kesoglidou, P.4    Papadakis, A.I.5    Koromilas, A.E.6
  • 65
    • 84964694840 scopus 로고    scopus 로고
    • The small molecule ISRIB reverses the effects of eIF2alpha phosphorylation on translation and stress granule assembly
    • (PubMed PMID: 25719440 PubMed Central PMCID: PMC4341466)
    • [65] Sidrauski, C., McGeachy, A.M., Ingolia, N.T., Walter, P., The small molecule ISRIB reverses the effects of eIF2alpha phosphorylation on translation and stress granule assembly. eLife, 4, 2015, 10.7554/eLife.05033 (PubMed PMID: 25719440 PubMed Central PMCID: PMC4341466).
    • (2015) eLife , vol.4
    • Sidrauski, C.1    McGeachy, A.M.2    Ingolia, N.T.3    Walter, P.4
  • 67
    • 49749141982 scopus 로고    scopus 로고
    • Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells
    • (PubMed PMID: 18640110)
    • [67] Norez, C., Vandebrouck, C., Antigny, F., Dannhoffer, L., Blondel, M., Becq, F., Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells. Eur. J. Pharmacol. 592:1–3 (2008), 33–40, 10.1016/j.ejphar.2008.06.103 (PubMed PMID: 18640110).
    • (2008) Eur. J. Pharmacol. , vol.592 , Issue.1-3 , pp. 33-40
    • Norez, C.1    Vandebrouck, C.2    Antigny, F.3    Dannhoffer, L.4    Blondel, M.5    Becq, F.6
  • 68
    • 44349185449 scopus 로고    scopus 로고
    • Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions
    • (PubMed PMID: 18431471 PubMed Central PMCID: PMC2291559)
    • [68] Tribouillard-Tanvier, D., Beringue, V., Desban, N., Gug, F., Bach, S., Voisset, C., Galons, H., Laude, H., Vilette, D., Blondel, M., Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One, 3(4), 2008, e1981, 10.1371/journal.pone.0001981 (PubMed PMID: 18431471 PubMed Central PMCID: PMC2291559).
    • (2008) PLoS One , vol.3 , Issue.4 , pp. e1981
    • Tribouillard-Tanvier, D.1    Beringue, V.2    Desban, N.3    Gug, F.4    Bach, S.5    Voisset, C.6    Galons, H.7    Laude, H.8    Vilette, D.9    Blondel, M.10
  • 69
    • 84908344184 scopus 로고    scopus 로고
    • Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis
    • (PubMed PMID: 25134731 PubMed Central PMCID: PMC4179984)
    • [69] Wang, L., Popko, B., Tixier, E., Roos, R.P., Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol. Dis. 71 (2014), 317–324, 10.1016/j.nbd.2014.08.010 (PubMed PMID: 25134731 PubMed Central PMCID: PMC4179984).
    • (2014) Neurobiol. Dis. , vol.71 , pp. 317-324
    • Wang, L.1    Popko, B.2    Tixier, E.3    Roos, R.P.4
  • 70
    • 84904860146 scopus 로고    scopus 로고
    • Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
    • (PubMed PMID: 24699224)
    • [70] Jiang, H.Q., Ren, M., Jiang, H.Z., Wang, J., Zhang, J., Yin, X., Wang, S.Y., Qi, Y., Wang, X.D., Feng, H.L., Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neuroscience 277 (2014), 132–138, 10.1016/j.neuroscience.2014.03.047 (PubMed PMID: 24699224).
    • (2014) Neuroscience , vol.277 , pp. 132-138
    • Jiang, H.Q.1    Ren, M.2    Jiang, H.Z.3    Wang, J.4    Zhang, J.5    Yin, X.6    Wang, S.Y.7    Qi, Y.8    Wang, X.D.9    Feng, H.L.10
  • 71
    • 84927619395 scopus 로고    scopus 로고
    • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
    • (PubMed PMID: 25859045 PubMed Central PMCID: PMC4490275)
    • [71] Das, I., Krzyzosiak, A., Schneider, K., Wrabetz, L., D'Antonio, M., Barry, N., Sigurdardottir, A., Bertolotti, A., Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348:6231 (2015), 239–242, 10.1126/science.aaa4484 (PubMed PMID: 25859045 PubMed Central PMCID: PMC4490275).
    • (2015) Science , vol.348 , Issue.6231 , pp. 239-242
    • Das, I.1    Krzyzosiak, A.2    Schneider, K.3    Wrabetz, L.4    D'Antonio, M.5    Barry, N.6    Sigurdardottir, A.7    Bertolotti, A.8
  • 72
    • 84859587957 scopus 로고    scopus 로고
    • The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
    • (PubMed PMID: 22315414 PubMed Central PMCID: PMC3326519)
    • [72] Cross, B.C., Bond, P.J., Sadowski, P.G., Jha, B.K., Zak, J., Goodman, J.M., Silverman, R.H., Neubert, T.A., Baxendale, I.R., Ron, D., Harding, H.P., The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc. Natl. Acad. Sci. U. S. A. 109:15 (2012), E869–E878, 10.1073/pnas.1115623109 (PubMed PMID: 22315414 PubMed Central PMCID: PMC3326519).
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , Issue.15 , pp. E869-E878
    • Cross, B.C.1    Bond, P.J.2    Sadowski, P.G.3    Jha, B.K.4    Zak, J.5    Goodman, J.M.6    Silverman, R.H.7    Neubert, T.A.8    Baxendale, I.R.9    Ron, D.10    Harding, H.P.11
  • 73
    • 79251589342 scopus 로고    scopus 로고
    • Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
    • (PubMed PMID: 21081713 PubMed Central PMCID: PMC3056474)
    • [73] Papandreou, I., Denko, N.C., Olson, M., Van Melckebeke, H., Lust, S., Tam, A., Solow-Cordero, D.E., Bouley, D.M., Offner, F., Niwa, M., Koong, A.C., Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117:4 (2011), 1311–1314, 10.1182/blood-2010-08-303099 (PubMed PMID: 21081713 PubMed Central PMCID: PMC3056474).
    • (2011) Blood , vol.117 , Issue.4 , pp. 1311-1314
    • Papandreou, I.1    Denko, N.C.2    Olson, M.3    Van Melckebeke, H.4    Lust, S.5    Tam, A.6    Solow-Cordero, D.E.7    Bouley, D.M.8    Offner, F.9    Niwa, M.10    Koong, A.C.11
  • 75
    • 80051512571 scopus 로고    scopus 로고
    • Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1, 2, 3 6-tetrahydropyridine-induced mouse model of Parkinson's disease
    • (PubMed PMID: 21804220)
    • [75] Li, S., Pu, X.P., Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1, 2, 3 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Biol. Pharm. Bull. 34:8 (2011), 1291–1296 (PubMed PMID: 21804220).
    • (2011) Biol. Pharm. Bull. , vol.34 , Issue.8 , pp. 1291-1296
    • Li, S.1    Pu, X.P.2
  • 76
    • 67349270928 scopus 로고    scopus 로고
    • Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro
    • (PubMed PMID: 19327378)
    • [76] Mu, X., He, G., Cheng, Y., Li, X., Xu, B., Du, G., Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol. Biochem. Behav. 92:4 (2009), 642–648, 10.1016/j.pbb.2009.03.008 (PubMed PMID: 19327378).
    • (2009) Pharmacol. Biochem. Behav. , vol.92 , Issue.4 , pp. 642-648
    • Mu, X.1    He, G.2    Cheng, Y.3    Li, X.4    Xu, B.5    Du, G.6
  • 77
    • 84907311915 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice
    • (PubMed PMID: 25087727)
    • [77] Patil, S.P., Jain, P.D., Sancheti, J.S., Ghumatkar, P.J., Tambe, R., Sathaye, S., Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice. Neuropharmacology 86 (2014), 192–202, 10.1016/j.neuropharm.2014.07.012 (PubMed PMID: 25087727).
    • (2014) Neuropharmacology , vol.86 , pp. 192-202
    • Patil, S.P.1    Jain, P.D.2    Sancheti, J.S.3    Ghumatkar, P.J.4    Tambe, R.5    Sathaye, S.6
  • 78
    • 84885106405 scopus 로고    scopus 로고
    • Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues
    • (PubMed PMID: 23869584 PubMed Central PMCID: PMC3799596)
    • [78] Zhang, H., Nakajima, S., Kato, H., Gu, L., Yoshitomi, T., Nagai, K., Shinmori, H., Kokubo, S., Kitamura, M., Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues. Br. J. Pharmacol. 170:4 (2013), 822–834, 10.1111/bph.12306 (PubMed PMID: 23869584 PubMed Central PMCID: PMC3799596).
    • (2013) Br. J. Pharmacol. , vol.170 , Issue.4 , pp. 822-834
    • Zhang, H.1    Nakajima, S.2    Kato, H.3    Gu, L.4    Yoshitomi, T.5    Nagai, K.6    Shinmori, H.7    Kokubo, S.8    Kitamura, M.9
  • 79
    • 84855708250 scopus 로고    scopus 로고
    • Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress
    • (PubMed PMID: 22223342)
    • [79] Mimori, S., Okuma, Y., Kaneko, M., Kawada, K., Hosoi, T., Ozawa, K., Nomura, Y., Hamana, H., Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress. Biol. Pharm. Bull. 35:1 (2012), 84–90 (PubMed PMID: 22223342).
    • (2012) Biol. Pharm. Bull. , vol.35 , Issue.1 , pp. 84-90
    • Mimori, S.1    Okuma, Y.2    Kaneko, M.3    Kawada, K.4    Hosoi, T.5    Ozawa, K.6    Nomura, Y.7    Hamana, H.8
  • 80
    • 84905172448 scopus 로고    scopus 로고
    • The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases
    • (PubMed PMID: 24891994 PubMed Central PMCID: PMC4030606)
    • [80] Vang, S., Longley, K., Steer, C.J., Low, W.C., The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Glob. Adv. Health Med. 3:3 (2014), 58–69, 10.7453/gahmj.2014.017 (PubMed PMID: 24891994 PubMed Central PMCID: PMC4030606).
    • (2014) Glob. Adv. Health Med. , vol.3 , Issue.3 , pp. 58-69
    • Vang, S.1    Longley, K.2    Steer, C.J.3    Low, W.C.4
  • 82
    • 84886816838 scopus 로고    scopus 로고
    • Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
    • (PubMed PMID: 24141020)
    • [82] Peviani, M., Salvaneschi, E., Bontempi, L., Petese, A., Manzo, A., Rossi, D., Salmona, M., Collina, S., Bigini, P., Curti, D., Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol. Dis. 62 (2014), 218–232, 10.1016/j.nbd.2013.10.010 (PubMed PMID: 24141020).
    • (2014) Neurobiol. Dis. , vol.62 , pp. 218-232
    • Peviani, M.1    Salvaneschi, E.2    Bontempi, L.3    Petese, A.4    Manzo, A.5    Rossi, D.6    Salmona, M.7    Collina, S.8    Bigini, P.9    Curti, D.10
  • 83
    • 84890560755 scopus 로고    scopus 로고
    • The role of heat shock proteins in Amyotrophic Lateral Sclerosis: the therapeutic potential of Arimoclomol
    • (PubMed PMID: 23978556)
    • [83] Kalmar, B., Lu, C.H., Greensmith, L., The role of heat shock proteins in Amyotrophic Lateral Sclerosis: the therapeutic potential of Arimoclomol. Pharmacol. Ther. 141:1 (2014), 40–54, 10.1016/j.pharmthera.2013.08.003 (PubMed PMID: 23978556).
    • (2014) Pharmacol. Ther. , vol.141 , Issue.1 , pp. 40-54
    • Kalmar, B.1    Lu, C.H.2    Greensmith, L.3
  • 84
    • 77950377674 scopus 로고    scopus 로고
    • Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    • (PubMedPMID:20211007;PubMedCentralPMCID:PMC2841120)
    • [84] Paris, D., Ganey, N.J., Laporte, V., Patel, N.S., Beaulieu-Abdelahad, D., Bachmeier, C., March, A., Ait-Ghezala, G., Mullan, M.J., Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. J. Neuroinflammation, 7, 2010, 17, 10.1186/1742-2094-7-17 (PubMedPMID:20211007;PubMedCentralPMCID:PMC2841120).
    • (2010) J. Neuroinflammation , vol.7 , pp. 17
    • Paris, D.1    Ganey, N.J.2    Laporte, V.3    Patel, N.S.4    Beaulieu-Abdelahad, D.5    Bachmeier, C.6    March, A.7    Ait-Ghezala, G.8    Mullan, M.J.9
  • 85
    • 33744486642 scopus 로고    scopus 로고
    • Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
    • (PubMed PMID: 16909005)
    • [85] Kiaei, M., Kipiani, K., Petri, S., Chen, J., Calingasan, N.Y., Beal, M.F., Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2:5 (2005), 246–254, 10.1159/000090364 (PubMed PMID: 16909005).
    • (2005) Neurodegener. Dis. , vol.2 , Issue.5 , pp. 246-254
    • Kiaei, M.1    Kipiani, K.2    Petri, S.3    Chen, J.4    Calingasan, N.Y.5    Beal, M.F.6
  • 86
    • 84890613378 scopus 로고    scopus 로고
    • Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease
    • (PubMed PMID: 24344631 PubMed Central PMCID: PMC3878847)
    • [86] Ho, S.W., Tsui, Y.T., Wong, T.T., Cheung, S.K., Goggins, W.B., Yi, L.M., Cheng, K.K., Baum, L., Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease. Transl. Neurodegener., 2(1), 2013, 24, 10.1186/2047-9158-2-24 (PubMed PMID: 24344631 PubMed Central PMCID: PMC3878847).
    • (2013) Transl. Neurodegener. , vol.2 , Issue.1 , pp. 24
    • Ho, S.W.1    Tsui, Y.T.2    Wong, T.T.3    Cheung, S.K.4    Goggins, W.B.5    Yi, L.M.6    Cheng, K.K.7    Baum, L.8
  • 87
    • 84861050854 scopus 로고    scopus 로고
    • ER-Mitochondria crosstalk during cerebral ischemia: molecular chaperones and ER-Mitochondrial calcium transfer
    • (PubMedPMID:22577383;PubMedCentralPMCID:PMC3335182)
    • [87] Ouyang, Y.B., Giffard, R.G., ER-Mitochondria crosstalk during cerebral ischemia: molecular chaperones and ER-Mitochondrial calcium transfer. Int. J. Cell Biol., 2012, 2012, 493934, 10.1155/2012/493934 (PubMedPMID:22577383;PubMedCentralPMCID:PMC3335182).
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 493934
    • Ouyang, Y.B.1    Giffard, R.G.2
  • 88
    • 0025516235 scopus 로고
    • The endoplasmic reticulum and calcium storage
    • (PubMed PMID: 2085319)
    • [88] Koch, G.L., The endoplasmic reticulum and calcium storage. BioEssays 12:11 (1990), 527–531, 10.1002/bies.950121105 (PubMed PMID: 2085319).
    • (1990) BioEssays , vol.12 , Issue.11 , pp. 527-531
    • Koch, G.L.1
  • 89
    • 80054776671 scopus 로고    scopus 로고
    • Endoplasmic-reticulum calcium depletion and disease
    • (PMID: 21441595 PubMed; PubMed Central PMCID: PMC3098671)
    • [89] Mekahli, D., Bultynck, G., Parys, J.B., De Smedt, H., Missiaen, L., Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harb. Perspect. Biol., 3(6), 2011, 10.1101/cshperspect.a004317 (PMID: 21441595 PubMed; PubMed Central PMCID: PMC3098671).
    • (2011) Cold Spring Harb. Perspect. Biol. , vol.3 , Issue.6
    • Mekahli, D.1    Bultynck, G.2    Parys, J.B.3    De Smedt, H.4    Missiaen, L.5
  • 90
    • 0034953943 scopus 로고    scopus 로고
    • Ion channel diseases of the central nervous system
    • (PubMed PMID: 11474425)
    • [90] Li, M., Lester, H.A., Ion channel diseases of the central nervous system. CNS Drug Rev. 7:2 (2001), 214–240 (PubMed PMID: 11474425).
    • (2001) CNS Drug Rev. , vol.7 , Issue.2 , pp. 214-240
    • Li, M.1    Lester, H.A.2
  • 91
    • 36049008767 scopus 로고    scopus 로고
    • The amyloid beta ion channel hypothesis of Alzheimer's disease
    • (PubMed PMID: 19300589; PubMed Central PMCID: PMC2656296)
    • [91] Shirwany, N.A., Payette, D., Xie, J., Guo, Q., The amyloid beta ion channel hypothesis of Alzheimer's disease. Neuropsychiatr. Dis. Treat. 3:5 (2007), 597–612 (PubMed PMID: 19300589; PubMed Central PMCID: PMC2656296).
    • (2007) Neuropsychiatr. Dis. Treat. , vol.3 , Issue.5 , pp. 597-612
    • Shirwany, N.A.1    Payette, D.2    Xie, J.3    Guo, Q.4
  • 92
    • 84878667542 scopus 로고    scopus 로고
    • The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases
    • (PubMed PMID: 24179464 PubMed Central PMCID: PMC3648780)
    • [92] Cataldi, M., The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases. Curr. Neuropharmacol. 11:3 (2013), 276–297, 10.2174/1570159X11311030004 (PubMed PMID: 24179464 PubMed Central PMCID: PMC3648780).
    • (2013) Curr. Neuropharmacol. , vol.11 , Issue.3 , pp. 276-297
    • Cataldi, M.1
  • 93
    • 0028194834 scopus 로고
    • Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line
    • (PubMed PMID: 8159758 PubMed Central PMCID: PMC43583)
    • [93] Smith, R.G., Alexianu, M.E., Crawford, G., Nyormoi, O., Stefani, E., Appel, S.H., Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line. Proc. Natl. Acad. Sci. U. S. A. 91:8 (1994), 3393–3397 (PubMed PMID: 8159758 PubMed Central PMCID: PMC43583).
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , Issue.8 , pp. 3393-3397
    • Smith, R.G.1    Alexianu, M.E.2    Crawford, G.3    Nyormoi, O.4    Stefani, E.5    Appel, S.H.6
  • 94
    • 45249117227 scopus 로고    scopus 로고
    • Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating
    • (PubMed PMID: 18579078 PubMed Central PMCID: PMC2495086)
    • [94] Cheung, K.H., Shineman, D., Muller, M., Cardenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V.M., Foskett, J.K., Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58:6 (2008), 871–883, 10.1016/j.neuron.2008.04.015 (PubMed PMID: 18579078 PubMed Central PMCID: PMC2495086).
    • (2008) Neuron , vol.58 , Issue.6 , pp. 871-883
    • Cheung, K.H.1    Shineman, D.2    Muller, M.3    Cardenas, C.4    Mei, L.5    Yang, J.6    Tomita, T.7    Iwatsubo, T.8    Lee, V.M.9    Foskett, J.K.10
  • 95
    • 0023823738 scopus 로고
    • Decreased brain [3H]inositol 1, 4 5-trisphosphate binding in alzheimer's disease
    • (PubMed PMID: 2853852)
    • [95] Young, L.T., Kish, S.J., Li, P.P., Warsh, J.J., Decreased brain [3H]inositol 1, 4 5-trisphosphate binding in alzheimer's disease. Neurosci. Lett. 94:1–2 (1988), 198–202 (PubMed PMID: 2853852).
    • (1988) Neurosci. Lett. , vol.94 , Issue.1-2 , pp. 198-202
    • Young, L.T.1    Kish, S.J.2    Li, P.P.3    Warsh, J.J.4
  • 96
    • 77950362173 scopus 로고    scopus 로고
    • Control of intracellular calcium signaling as a neuroprotective strategy
    • (PubMed PMID: 20335972 PubMed Central PMCID: PMC2847496)
    • [96] Duncan, R.S., Goad, D.L., Grillo, M.A., Kaja, S., Payne, A.J., Koulen, P., Control of intracellular calcium signaling as a neuroprotective strategy. Molecules 15:3 (2010), 1168–1195, 10.3390/molecules15031168 (PubMed PMID: 20335972 PubMed Central PMCID: PMC2847496).
    • (2010) Molecules , vol.15 , Issue.3 , pp. 1168-1195
    • Duncan, R.S.1    Goad, D.L.2    Grillo, M.A.3    Kaja, S.4    Payne, A.J.5    Koulen, P.6
  • 97
    • 1342288871 scopus 로고    scopus 로고
    • Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability
    • (PubMed PMID: 14724250)
    • [97] Stutzmann, G.E., Caccamo, A., LaFerla, F.M., Parker, I., Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J. Neurosci. 24:2 (2004), 508–513, 10.1523/JNEUROSCI.4386-03.2004 (PubMed PMID: 14724250).
    • (2004) J. Neurosci. , vol.24 , Issue.2 , pp. 508-513
    • Stutzmann, G.E.1    Caccamo, A.2    LaFerla, F.M.3    Parker, I.4
  • 98
    • 33747195017 scopus 로고    scopus 로고
    • An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
    • (PubMed PMID: 16844381)
    • [98] Ferreiro, E., Resende, R., Costa, R., Oliveira, C.R., Pereira, C.M., An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol. Dis. 23:3 (2006), 669–678, 10.1016/j.nbd.2006.05.011 (PubMed PMID: 16844381).
    • (2006) Neurobiol. Dis. , vol.23 , Issue.3 , pp. 669-678
    • Ferreiro, E.1    Resende, R.2    Costa, R.3    Oliveira, C.R.4    Pereira, C.M.5
  • 99
    • 33646886822 scopus 로고    scopus 로고
    • Up-regulation of inositol 1, 4 5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells
    • (PubMed PMID: 16675011)
    • [99] Kasri, N.N., Kocks, S.L., Verbert, L., Hebert, S.S., Callewaert, G., Parys, J.B., Missiaen, L., De Smedt, H., Up-regulation of inositol 1, 4 5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells. Cell Calcium 40:1 (2006), 41–51, 10.1016/j.ceca.2006.03.005 (PubMed PMID: 16675011).
    • (2006) Cell Calcium , vol.40 , Issue.1 , pp. 41-51
    • Kasri, N.N.1    Kocks, S.L.2    Verbert, L.3    Hebert, S.S.4    Callewaert, G.5    Parys, J.B.6    Missiaen, L.7    De Smedt, H.8
  • 100
    • 68049134265 scopus 로고    scopus 로고
    • Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice
    • (PubMed PMID: 19641109)
    • [100] Chakroborty, S., Goussakov, I., Miller, M.B., Stutzmann, G.E., Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. J. Neurosci. 29:30 (2009), 9458–9470, 10.1523/JNEUROSCI.2047–09.2009 (PubMed PMID: 19641109).
    • (2009) J. Neurosci. , vol.29 , Issue.30 , pp. 9458-9470
    • Chakroborty, S.1    Goussakov, I.2    Miller, M.B.3    Stutzmann, G.E.4
  • 101
    • 33646945317 scopus 로고    scopus 로고
    • Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice
    • (PubMed PMID: 16687509)
    • [101] Stutzmann, G.E., Smith, I., Caccamo, A., Oddo, S., Laferla, F.M., Parker, I., Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 26:19 (2006), 5180–5189, 10.1523/JNEUROSCI (PubMed PMID: 16687509).
    • (2006) J. Neurosci. , vol.26 , Issue.19 , pp. 5180-5189
    • Stutzmann, G.E.1    Smith, I.2    Caccamo, A.3    Oddo, S.4    Laferla, F.M.5    Parker, I.6
  • 102
    • 0033059445 scopus 로고    scopus 로고
    • Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies
    • (PubMed PMID: 10408600)
    • [102] Kelliher, M., Fastbom, J., Cowburn, R.F., Bonkale, W., Ohm, T.G., Ravid, R., Sorrentino, V., O'Neill, C., Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies. Neuroscience 92:2 (1999), 499–513 (PubMed PMID: 10408600).
    • (1999) Neuroscience , vol.92 , Issue.2 , pp. 499-513
    • Kelliher, M.1    Fastbom, J.2    Cowburn, R.F.3    Bonkale, W.4    Ohm, T.G.5    Ravid, R.6    Sorrentino, V.7    O'Neill, C.8
  • 103
    • 0041963057 scopus 로고    scopus 로고
    • Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
    • (PubMed PMID: 12873381; PubMed Central PMCID: PMC3220623)
    • [103] Tang, T.S., Tu, H., Chan, E.Y., Maximov, A., Wang, Z., Wellington, C.L., Hayden, M.R., Bezprozvanny, I., Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:2 (2003), 227–239 (PubMed PMID: 12873381; PubMed Central PMCID: PMC3220623).
    • (2003) Neuron , vol.39 , Issue.2 , pp. 227-239
    • Tang, T.S.1    Tu, H.2    Chan, E.Y.3    Maximov, A.4    Wang, Z.5    Wellington, C.L.6    Hayden, M.R.7    Bezprozvanny, I.8
  • 104
    • 59649118434 scopus 로고    scopus 로고
    • Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model
    • (PubMed PMID: 19193873; PubMed Central PMCID: PMC2768402)
    • [104] Tang, T.S., Guo, C., Wang, H., Chen, X., Bezprozvanny, I., Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J. Neurosci. 29:5 (2009), 1257–1266, 10.1523/JNEUROSCI.4411-08.2009 (PubMed PMID: 19193873; PubMed Central PMCID: PMC2768402).
    • (2009) J. Neurosci. , vol.29 , Issue.5 , pp. 1257-1266
    • Tang, T.S.1    Guo, C.2    Wang, H.3    Chen, X.4    Bezprozvanny, I.5
  • 105
    • 82055164052 scopus 로고    scopus 로고
    • Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
    • (PubMedPMID:22118545;PubMedCentralPMCID:PMC3235068)
    • [105] Chen, X., Wu, J., Lvovskaya, S., Herndon, E., Supnet, C., Bezprozvanny, I., Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Mol. Neurodegener., 6, 2011, 81, 10.1186/1750-1326-6-81 (PubMedPMID:22118545;PubMedCentralPMCID:PMC3235068).
    • (2011) Mol. Neurodegener. , vol.6 , pp. 81
    • Chen, X.1    Wu, J.2    Lvovskaya, S.3    Herndon, E.4    Supnet, C.5    Bezprozvanny, I.6
  • 106
    • 84871355082 scopus 로고    scopus 로고
    • Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease
    • (PubMed PMID: 23284867 PubMed Central PMCID: PMC3528716)
    • [106] Chakroborty, S., Briggs, C., Miller, M.B., Goussakov, I., Schneider, C., Kim, J., Wicks, J., Richardson, J.C., Conklin, V., Cameransi, B.G., Stutzmann, G.E., Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease. PLoS One, 7(12), 2012, e52056, 10.1371/journal.pone.0052056 (PubMed PMID: 23284867 PubMed Central PMCID: PMC3528716).
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e52056
    • Chakroborty, S.1    Briggs, C.2    Miller, M.B.3    Goussakov, I.4    Schneider, C.5    Kim, J.6    Wicks, J.7    Richardson, J.C.8    Conklin, V.9    Cameransi, B.G.10    Stutzmann, G.E.11
  • 107
    • 84864403738 scopus 로고    scopus 로고
    • Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G(9)(3)A) mice
    • (PubMed PMID: 22750242)
    • [107] Staats, K.A., Van Rillaer, M., Scheveneels, W., Verbesselt, R., Van Damme, P., Robberecht, W., Van Den Bosch, L., Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G(9)(3)A) mice. Neuroscience 220 (2012), 26–31, 10.1016/j.neuroscience.2012.06.050 (PubMed PMID: 22750242).
    • (2012) Neuroscience , vol.220 , pp. 26-31
    • Staats, K.A.1    Van Rillaer, M.2    Scheveneels, W.3    Verbesselt, R.4    Van Damme, P.5    Robberecht, W.6    Van Den Bosch, L.7
  • 108
    • 34447103855 scopus 로고    scopus 로고
    • Biochemical properties and cellular localisation of STIM proteins
    • (PubMed PMID: 17382385)
    • [108] Dziadek, M.A., Johnstone, L.S., Biochemical properties and cellular localisation of STIM proteins. Cell Calcium 42:2 (2007), 123–132, 10.1016/j.ceca.2007.02.006 (PubMed PMID: 17382385).
    • (2007) Cell Calcium , vol.42 , Issue.2 , pp. 123-132
    • Dziadek, M.A.1    Johnstone, L.S.2
  • 109
    • 84888353917 scopus 로고    scopus 로고
    • Calcium signaling and neurodegeneration
    • (PubMed PMID: 22649630; PubMed Central PMCID: PMC3347543)
    • [109] Bezprozvanny, I.B., Calcium signaling and neurodegeneration. Acta Nat. 2:1 (2010), 72–82 (PubMed PMID: 22649630; PubMed Central PMCID: PMC3347543).
    • (2010) Acta Nat. , vol.2 , Issue.1 , pp. 72-82
    • Bezprozvanny, I.B.1
  • 110
    • 0034657414 scopus 로고    scopus 로고
    • Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
    • (PubMed PMID: 10811821; PubMed Central PMCID: PMC2174559)
    • [110] Leissring, M.A., Akbari, Y., Fanger, C.M., Cahalan, M.D., Mattson, M.P., LaFerla, F.M., Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149:4 (2000), 793–798 (PubMed PMID: 10811821; PubMed Central PMCID: PMC2174559).
    • (2000) J. Cell Biol. , vol.149 , Issue.4 , pp. 793-798
    • Leissring, M.A.1    Akbari, Y.2    Fanger, C.M.3    Cahalan, M.D.4    Mattson, M.P.5    LaFerla, F.M.6
  • 112
    • 84893469844 scopus 로고    scopus 로고
    • Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis
    • (PubMed PMID: 24501372 PubMed Central PMCID: PMC3913875)
    • [112] Kawamata, H., Ng, S.K., Diaz, N., Burstein, S., Morel, L., Osgood, A., Sider, B., Higashimori, H., Haydon, P.G., Manfredi, G., Yang, Y., Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J. Neurosci. 34:6 (2014), 2331–2348, 10.1523/JNEUROSCI (PubMed PMID: 24501372 PubMed Central PMCID: PMC3913875).
    • (2014) J. Neurosci. , vol.34 , Issue.6 , pp. 2331-2348
    • Kawamata, H.1    Ng, S.K.2    Diaz, N.3    Burstein, S.4    Morel, L.5    Osgood, A.6    Sider, B.7    Higashimori, H.8    Haydon, P.G.9    Manfredi, G.10    Yang, Y.11
  • 114
    • 84888331632 scopus 로고    scopus 로고
    • Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease
    • (PubMedPMID:24324398;PubMedCentralPMCID:PMC3838962)
    • [114] Czeredys, M., Gruszczynska-Biegala, J., Schacht, T., Methner, A., Kuznicki, J., Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Front. Mol. Neurosci., 6, 2013, 42, 10.3389/fnmol.2013.00042 (PubMedPMID:24324398;PubMedCentralPMCID:PMC3838962).
    • (2013) Front. Mol. Neurosci. , vol.6 , pp. 42
    • Czeredys, M.1    Gruszczynska-Biegala, J.2    Schacht, T.3    Methner, A.4    Kuznicki, J.5
  • 115
    • 84866728707 scopus 로고    scopus 로고
    • Endoplasmic reticulum-mitochondria contacts: function of the junction
    • (PubMed PMID: 22992592)
    • [115] Rowland, A.A., Voeltz, G.K., Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat. Rev. Mol. Cell Biol. 13:10 (2012), 607–625, 10.1038/nrm3440 (PubMed PMID: 22992592).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , Issue.10 , pp. 607-625
    • Rowland, A.A.1    Voeltz, G.K.2
  • 117
    • 84870984470 scopus 로고    scopus 로고
    • PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
    • (PubMed PMID: 22705852 PubMed Central PMCID: PMC3469056)
    • [117] Verfaillie, T., Rubio, N., Garg, A.D., Bultynck, G., Rizzuto, R., Decuypere, J.P., Piette, J., Linehan, C., Gupta, S., Samali, A., Agostinis, P., PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 19:11 (2012), 1880–1891, 10.1038/cdd.2012.74 (PubMed PMID: 22705852 PubMed Central PMCID: PMC3469056).
    • (2012) Cell Death Differ. , vol.19 , Issue.11 , pp. 1880-1891
    • Verfaillie, T.1    Rubio, N.2    Garg, A.D.3    Bultynck, G.4    Rizzuto, R.5    Decuypere, J.P.6    Piette, J.7    Linehan, C.8    Gupta, S.9    Samali, A.10    Agostinis, P.11
  • 118
    • 84855883812 scopus 로고    scopus 로고
    • Proteomic analysis of lipid raft-enriched membranes isolated from internal organelles
    • (PubMed PMID: 22037461 PubMed Central PMCID: PMC3253365)
    • [118] Poston, C.N., Duong, E., Cao, Y., Bazemore-Walker, C.R., Proteomic analysis of lipid raft-enriched membranes isolated from internal organelles. Biochem. Biophys. Res. Commun. 415:2 (2011), 355–360, 10.1016/j.bbrc.2011.10.072 (PubMed PMID: 22037461 PubMed Central PMCID: PMC3253365).
    • (2011) Biochem. Biophys. Res. Commun. , vol.415 , Issue.2 , pp. 355-360
    • Poston, C.N.1    Duong, E.2    Cao, Y.3    Bazemore-Walker, C.R.4
  • 119
    • 35549006797 scopus 로고    scopus 로고
    • Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2 +) signaling and cell survival
    • (PubMed PMID: 17981125)
    • [119] Hayashi, T., Su, T.P., Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2 +) signaling and cell survival. Cell 131:3 (2007), 596–610, 10.1016/j.cell.2007.08.036 (PubMed PMID: 17981125).
    • (2007) Cell , vol.131 , Issue.3 , pp. 596-610
    • Hayashi, T.1    Su, T.P.2
  • 121
    • 38049155818 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
    • (PubMed PMID: 17700538)
    • [121] Deniaud, A., Sharaf el dein, O., Maillier, E., Poncet, D., Kroemer, G., Lemaire, C., Brenner, C., Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27:3 (2008), 285–299, 10.1038/sj.onc.1210638 (PubMed PMID: 17700538).
    • (2008) Oncogene , vol.27 , Issue.3 , pp. 285-299
    • Deniaud, A.1    Sharaf el dein, O.2    Maillier, E.3    Poncet, D.4    Kroemer, G.5    Lemaire, C.6    Brenner, C.7
  • 122
    • 54949110895 scopus 로고    scopus 로고
    • Calcium and apoptosis ER-mitochondria Ca2+ transfer in the control of apoptosis
    • (PubMed PMID: 18955969; PubMed Central PMCID: PMC2844952)
    • [122] Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., Rizzuto, R., Calcium and apoptosis ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene 27:50 (2008), 6407–6418, 10.1038/onc.2008.308 (PubMed PMID: 18955969; PubMed Central PMCID: PMC2844952).
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6407-6418
    • Pinton, P.1    Giorgi, C.2    Siviero, R.3    Zecchini, E.4    Rizzuto, R.5
  • 123
    • 84871726622 scopus 로고    scopus 로고
    • Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM)
    • (PubMed PMID: 22575682)
    • [123] Raturi, A., Simmen, T., Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochim. Biophys. Acta 1833:1 (2013), 213–224, 10.1016/j.bbamcr.2012.04.013 (PubMed PMID: 22575682).
    • (2013) Biochim. Biophys. Acta , vol.1833 , Issue.1 , pp. 213-224
    • Raturi, A.1    Simmen, T.2
  • 126
    • 84911899819 scopus 로고    scopus 로고
    • Amyloid-beta peptides are generated in mitochondria-associated endoplasmic reticulum membranes
    • (PubMed PMID: 25096627)
    • [126] Schreiner, B., Hedskog, L., Wiehager, B., Ankarcrona, M., Amyloid-beta peptides are generated in mitochondria-associated endoplasmic reticulum membranes. J. Alzheimer's Dis. 43:2 (2015), 369–374, 10.3233/JAD-132543 (PubMed PMID: 25096627).
    • (2015) J. Alzheimer's Dis. , vol.43 , Issue.2 , pp. 369-374
    • Schreiner, B.1    Hedskog, L.2    Wiehager, B.3    Ankarcrona, M.4
  • 128
    • 84876098997 scopus 로고    scopus 로고
    • The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering
    • (PubMed PMID: 23418303)
    • [128] Ottolini, D., Cali, T., Negro, A., Brini, M., The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering. Hum. Mol. Genet. 22:11 (2013), 2152–2168, 10.1093/hmg/ddt068 (PubMed PMID: 23418303).
    • (2013) Hum. Mol. Genet. , vol.22 , Issue.11 , pp. 2152-2168
    • Ottolini, D.1    Cali, T.2    Negro, A.3    Brini, M.4
  • 129
    • 84942777656 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases
    • (PubMed PMID: 25999419)
    • [129] Kornfeld, O.S., Hwang, S., Disatnik, M.-H., Chen, C.-H., Qvit, N., Mochly-Rosen, D., Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases. Circ. Res. 116:11 (2015), 1783–1799, 10.1161/circresaha.116.305432 (PubMed PMID: 25999419).
    • (2015) Circ. Res. , vol.116 , Issue.11 , pp. 1783-1799
    • Kornfeld, O.S.1    Hwang, S.2    Disatnik, M.-H.3    Chen, C.-H.4    Qvit, N.5    Mochly-Rosen, D.6
  • 130
    • 4544235673 scopus 로고    scopus 로고
    • Calcium, ATP, and ROS: a mitochondrial love-hate triangle
    • (PubMed PMID: 15355853)
    • [130] Brookes, P.S., Yoon, Y., Robotham, J.L., Anders, M.W., Sheu, S.S., Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. Cell Physiol. 287:4 (2004), C817–C833, 10.1152/ajpcell.00139.2004 (PubMed PMID: 15355853).
    • (2004) Am. J. Physiol. Cell Physiol. , vol.287 , Issue.4 , pp. C817-C833
    • Brookes, P.S.1    Yoon, Y.2    Robotham, J.L.3    Anders, M.W.4    Sheu, S.S.5
  • 131
    • 0019614894 scopus 로고
    • Ratio of central nervous-system to body metabolism in vertebrates – its constancy and functional basis
    • (R203-R12. PubMed PMID: WOS:A1981MG81500084)
    • [131] Mink, J.W., Blumenschine, R.J., Adams, D.B., Ratio of central nervous-system to body metabolism in vertebrates – its constancy and functional basis. Am. J. Physiol., 241(3), 1981 (R203-R12. PubMed PMID: WOS:A1981MG81500084).
    • (1981) Am. J. Physiol. , vol.241 , Issue.3
    • Mink, J.W.1    Blumenschine, R.J.2    Adams, D.B.3
  • 132
    • 84938920704 scopus 로고    scopus 로고
    • The regulation of neuronal mitochondrial metabolism by calcium
    • (PubMed PMID: WOS: 000359733900006)
    • [132] Llorente-Folch, I., Rueda, C.B., Pardo, B., Szabadkai, G., Duchen, M.R., Satrustegui, J., The regulation of neuronal mitochondrial metabolism by calcium. J. Physiol. (London) 593:16 (2015), 3447–3462, 10.1113/Jp270254 (PubMed PMID: WOS: 000359733900006).
    • (2015) J. Physiol. (London) , vol.593 , Issue.16 , pp. 3447-3462
    • Llorente-Folch, I.1    Rueda, C.B.2    Pardo, B.3    Szabadkai, G.4    Duchen, M.R.5    Satrustegui, J.6
  • 133
    • 0035909948 scopus 로고    scopus 로고
    • Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection
    • (PubMed PMID: WOS: 000172848800099)
    • [133] Almeida, A., Almeida, J., Bolanos, J.P., Moncada, S., Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proc. Natl. Acad. Sci. U. S. A. 98:26 (2001), 15294–15299, 10.1073/pnas.261560998 (PubMed PMID: WOS: 000172848800099).
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , Issue.26 , pp. 15294-15299
    • Almeida, A.1    Almeida, J.2    Bolanos, J.P.3    Moncada, S.4
  • 134
    • 67349249403 scopus 로고    scopus 로고
    • The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
    • 747–U105, PubMed PMID: WOS: 000266503700020
    • [134] Herrero-Mendez, A., Almeida, A., Fernandez, E., Maestre, C., Moncada, S., Bolanos, J.P., The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat. Cell Biol., 11(6), 2009, 10.1038/ncb1881 747–U105, PubMed PMID: WOS: 000266503700020.
    • (2009) Nat. Cell Biol. , vol.11 , Issue.6
    • Herrero-Mendez, A.1    Almeida, A.2    Fernandez, E.3    Maestre, C.4    Moncada, S.5    Bolanos, J.P.6
  • 135
    • 77049184121 scopus 로고
    • Latent adenosinetriphosphatase activity in resting rat liver mitochondria
    • (PubMed PMID: 13129268)
    • [135] Potter, V.R., Siekevitz, P., Simonson, H.C., Latent adenosinetriphosphatase activity in resting rat liver mitochondria. J. Biol. Chem. 205:2 (1953), 893–908 (PubMed PMID: 13129268).
    • (1953) J. Biol. Chem. , vol.205 , Issue.2 , pp. 893-908
    • Potter, V.R.1    Siekevitz, P.2    Simonson, H.C.3
  • 136
    • 0001699841 scopus 로고
    • The energy-Linked reaction of calcium with mitochondria
    • (PubMed PMID: 14304892)
    • [136] Chance, B., The energy-Linked reaction of calcium with mitochondria. J. Biol. Chem. 240 (1965), 2729–2748 (PubMed PMID: 14304892).
    • (1965) J. Biol. Chem. , vol.240 , pp. 2729-2748
    • Chance, B.1
  • 137
    • 0016246085 scopus 로고
    • Inhibition of mitochondrial calcium-Transport by lanthanides and ruthenium red
    • (PubMed PMID: WOS:A1974T267800003)
    • [137] Reed, K.C., Bygrave, F.L., Inhibition of mitochondrial calcium-Transport by lanthanides and ruthenium red. Biochem. J. 140:2 (1974), 143–155 (PubMed PMID: WOS:A1974T267800003).
    • (1974) Biochem. J. , vol.140 , Issue.2 , pp. 143-155
    • Reed, K.C.1    Bygrave, F.L.2
  • 138
    • 84876712709 scopus 로고    scopus 로고
    • Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria
    • (PubMed PMID: WOS: 000318143700009)
    • [138] Glancy, B., Willis, W.T., Chess, D.J., Balaban, R.S., Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria. Biochemistry 52:16 (2013), 2793–2809, 10.1021/bi3015983 (PubMed PMID: WOS: 000318143700009).
    • (2013) Biochemistry , vol.52 , Issue.16 , pp. 2793-2809
    • Glancy, B.1    Willis, W.T.2    Chess, D.J.3    Balaban, R.S.4
  • 139
    • 0028909355 scopus 로고
    • Influence of calcium on nadh and succinate oxidation by rat-heart submitochondrial particles
    • (PubMed PMID: WOS:A1995QH02900022)
    • [139] Panov, A.V., Scaduto, R.C., Influence of calcium on nadh and succinate oxidation by rat-heart submitochondrial particles. Arch. Biochem. Biophys. 316:2 (1995), 815–820, 10.1006/abbi.1995.1109 (PubMed PMID: WOS:A1995QH02900022).
    • (1995) Arch. Biochem. Biophys. , vol.316 , Issue.2 , pp. 815-820
    • Panov, A.V.1    Scaduto, R.C.2
  • 140
    • 0033965893 scopus 로고    scopus 로고
    • The allosteric ATP-inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP-dependent phosphorylation
    • (PubMed PMID: WOS:000085022000027)
    • [140] Bender, E., Kadenbach, B., The allosteric ATP-inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP-dependent phosphorylation. FEBS Lett. 466:1 (2000), 130–134, 10.1016/S0014-5793(99)01773-1 (PubMed PMID: WOS:000085022000027).
    • (2000) FEBS Lett. , vol.466 , Issue.1 , pp. 130-134
    • Bender, E.1    Kadenbach, B.2
  • 141
    • 63349087445 scopus 로고    scopus 로고
    • Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation
    • Eub 2009/02/28. S0891-5849(09)00081-1 [ii]. PubMed PMID: 19245829
    • [141] Tahara, E.B., Navarete, F.D., Kowaltowski, A.J., Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Free Radic. Biol. Med. 46:9 (2009), 1283–1297, 10.1016/j.freeradbiomed.2009.02.008 Eub 2009/02/28. S0891-5849(09)00081-1 [ii]. PubMed PMID: 19245829.
    • (2009) Free Radic. Biol. Med. , vol.46 , Issue.9 , pp. 1283-1297
    • Tahara, E.B.1    Navarete, F.D.2    Kowaltowski, A.J.3
  • 142
    • 0021780726 scopus 로고
    • Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory
    • (PubMed PMID: MEDLINE:4062824)
    • [142] Sohal, R.S., Allen, R.G., Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory. Basic Life Sci. 35 (1985), 75–104 (PubMed PMID: MEDLINE:4062824).
    • (1985) Basic Life Sci. , vol.35 , pp. 75-104
    • Sohal, R.S.1    Allen, R.G.2
  • 143
    • 63849184477 scopus 로고    scopus 로고
    • Crosstalk signaling between mitochondrial Ca2+ and ROS
    • (PubMed PMID: WOS: 000262352400076)
    • [143] Feissner, R.F., Skalska, J., Gaum, W.E., Sheu, S.S., Crosstalk signaling between mitochondrial Ca2+ and ROS. Front. Biosci. (Landmark) 14 (2009), 1197–1218, 10.2741/3303 (PubMed PMID: WOS: 000262352400076).
    • (2009) Front. Biosci. (Landmark) , vol.14 , pp. 1197-1218
    • Feissner, R.F.1    Skalska, J.2    Gaum, W.E.3    Sheu, S.S.4
  • 144
    • 0037716926 scopus 로고    scopus 로고
    • Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone
    • (PubMed PMID: WOS:000183121500036)
    • [144] Sousa, S.C., Maciel, E.N., Vercesi, A.E., Castilho, R.F., Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone. FEBS Lett. 543:1–3 (2003), 179–183, 10.1016/s0014-5793(03)00421-6 (PubMed PMID: WOS:000183121500036).
    • (2003) FEBS Lett. , vol.543 , Issue.1-3 , pp. 179-183
    • Sousa, S.C.1    Maciel, E.N.2    Vercesi, A.E.3    Castilho, R.F.4
  • 145
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • [145] Harman, D., Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956), 298–300.
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 146
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • (PubMed PMID: 17051205)
    • [146] Lin, M.T., Beal, M.F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:7113 (2006), 787–795, 10.1038/nature05292 (PubMed PMID: 17051205).
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 147
    • 1642308134 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • (PubMed PMID: 15031734)
    • [147] Barnham, K.J., Masters, C.L., Bush, A.I., Neurodegenerative diseases and oxidative stress. Nat. Rev. Drug Discov. 3:3 (2004), 205–214, 10.1038/nrd1330 (PubMed PMID: 15031734).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.3 , pp. 205-214
    • Barnham, K.J.1    Masters, C.L.2    Bush, A.I.3
  • 148
    • 1642483509 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • (PubMed PMID: 14739060)
    • [148] Emerit, J., Edeas, M., Bricaire, F., Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 58:1 (2004), 39–46 (PubMed PMID: 14739060).
    • (2004) Biomed. Pharmacother. , vol.58 , Issue.1 , pp. 39-46
    • Emerit, J.1    Edeas, M.2    Bricaire, F.3
  • 149
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • (PubMed PMID: 15190254)
    • [149] Lu, T., Pan, Y., Kao, S.Y., Li, C., Kohane, I., Chan, J., Yankner, B.A., Gene regulation and DNA damage in the ageing human brain. Nature 429:6994 (2004), 883–891, 10.1038/nature02661 (PubMed PMID: 15190254).
    • (2004) Nature , vol.429 , Issue.6994 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.Y.3    Li, C.4    Kohane, I.5    Chan, J.6    Yankner, B.A.7
  • 150
    • 0029838063 scopus 로고    scopus 로고
    • Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice
    • (PubMed PMID: 8790408 PubMed Central PMCID: PMCPMC38506)
    • [150] Lebovitz, R.M., Zhang, H., Vogel, H., Cartwright, J. Jr., Dionne, L., Lu, N., Huang, S., Matzuk, M.M., Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 93:18 (1996), 9782–9787 (PubMed PMID: 8790408 PubMed Central PMCID: PMCPMC38506).
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , Issue.18 , pp. 9782-9787
    • Lebovitz, R.M.1    Zhang, H.2    Vogel, H.3    Cartwright, J.4    Dionne, L.5    Lu, N.6    Huang, S.7    Matzuk, M.M.8
  • 153
    • 84914677322 scopus 로고    scopus 로고
    • Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
    • (PubMed PMID: 25286015; PubMed Central PMCID: PMCPMC4266079)
    • [153] Abe, K., Itoyama, Y., Sobue, G., Tsuji, S., Aoki, M., Doyu, M., Hamada, C., Kondo, K., Yoneoka, T., Akimoto, M., Yoshino, H., Edaravone, A.L.S.S.G., Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler. Frontotemporal Degener. 15:7-8 (2014), 610–617, 10.3109/21678421.2014.959024 (PubMed PMID: 25286015; PubMed Central PMCID: PMCPMC4266079).
    • (2014) Amyotroph Lateral Scler. Frontotemporal Degener. , vol.15 , Issue.7-8 , pp. 610-617
    • Abe, K.1    Itoyama, Y.2    Sobue, G.3    Tsuji, S.4    Aoki, M.5    Doyu, M.6    Hamada, C.7    Kondo, K.8    Yoneoka, T.9    Akimoto, M.10    Yoshino, H.11    Edaravone, A.L.S.S.G.12
  • 154
    • 84908222221 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is sufficient for the induction of IL-1 beta production via activation of the NF-kappa B and inflammasome pathways
    • (PubMed PMID: WOS:000343807400002)
    • [154] Kim, S., Joe, Y., Jeong, S.O., Zheng, M., Back, S.H., Park, S.W., Ryter, S.W., Chung, H.T., Endoplasmic reticulum stress is sufficient for the induction of IL-1 beta production via activation of the NF-kappa B and inflammasome pathways. Innate Immun. 20:8 (2014), 799–815, 10.1177/1753425913508593 (PubMed PMID: WOS:000343807400002).
    • (2014) Innate Immun. , vol.20 , Issue.8 , pp. 799-815
    • Kim, S.1    Joe, Y.2    Jeong, S.O.3    Zheng, M.4    Back, S.H.5    Park, S.W.6    Ryter, S.W.7    Chung, H.T.8
  • 155
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • (PubMed PMID: 23102266 PubMed Central PMCID: PMCPMC3484374)
    • [155] Sena, L.A., Chandel, N.S., Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48:2 (2012), 158–167, 10.1016/j.molcel.2012.09.025 (PubMed PMID: 23102266 PubMed Central PMCID: PMCPMC3484374).
    • (2012) Mol. Cell , vol.48 , Issue.2 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 156
    • 84872512504 scopus 로고    scopus 로고
    • European Huntington's Disease N. A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease
    • (PubMed PMID: 23108692)
    • [156] Group HIotHS, European Huntington's Disease N. A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease. JAMA Neurol. 70:1 (2013), 25–33, 10.1001/2013.jamaneurol.382 (PubMed PMID: 23108692).
    • (2013) JAMA Neurol. , vol.70 , Issue.1 , pp. 25-33
    • Group HIotHS1
  • 157
    • 47149108940 scopus 로고    scopus 로고
    • Hung D, dimebon i. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
    • (PubMed PMID: 18640457)
    • [157] Doody, R.S., Gavrilova, S.I., Sano, M., Thomas, R.G., Aisen, P.S., Bachurin, S.O., Seely, L., Hung D, dimebon i. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 372:9634 (2008), 207–215, 10.1016/S0140-6736(08)61074-0 (PubMed PMID: 18640457).
    • (2008) Lancet , vol.372 , Issue.9634 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7
  • 158
    • 77956666900 scopus 로고    scopus 로고
    • Dimebon disappointment
    • (PubMed PMID: 20836898 PubMed Central PMCID: PMCPMC2983434)
    • [158] Jones, R.W., Dimebon disappointment. Alzheimers Res. Ther., 2(5), 2010, 25, 10.1186/alzrt49 (PubMed PMID: 20836898 PubMed Central PMCID: PMCPMC2983434).
    • (2010) Alzheimers Res. Ther. , vol.2 , Issue.5 , pp. 25
    • Jones, R.W.1
  • 159
    • 33748201552 scopus 로고    scopus 로고
    • Mitochondria-targeted peptide antioxidants: novel neuroprotective agents
    • (PubMed PMID: 17025271)
    • [159] Szeto, H.H., Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J. 8 (2006), E521–E531, 10.1208/aapsj080362 (PubMed PMID: 17025271).
    • (2006) AAPS J. , vol.8 , pp. E521-E531
    • Szeto, H.H.1
  • 160
    • 84897388046 scopus 로고    scopus 로고
    • Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis
    • (PubMed PMID: 24134698)
    • [160] Birk, A.V., Chao, W.M., Bracken, C., Warren, J.D., Szeto, H.H., Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis. Br. J. Pharmacol. 171 (2014), 2017–2028, 10.1111/bph.12468 (PubMed PMID: 24134698).
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 2017-2028
    • Birk, A.V.1    Chao, W.M.2    Bracken, C.3    Warren, J.D.4    Szeto, H.H.5
  • 161
    • 33746397617 scopus 로고    scopus 로고
    • Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis
    • (PubMed PMID: 16895581)
    • [161] Petri, S., Kiaei, M., Damiano, M., Hiller, A., Wille, E., Manfredi, G., Calingasan, N.Y., Szeto, H.H., Beal, M.F., Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. J. Neurochem. 98:4 (2006), 1141–1148, 10.1111/j.1471-4159.2006.04018.x (PubMed PMID: 16895581).
    • (2006) J. Neurochem. , vol.98 , Issue.4 , pp. 1141-1148
    • Petri, S.1    Kiaei, M.2    Damiano, M.3    Hiller, A.4    Wille, E.5    Manfredi, G.6    Calingasan, N.Y.7    Szeto, H.H.8    Beal, M.F.9
  • 162
    • 68949213947 scopus 로고    scopus 로고
    • Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1, 2, 3 6-tetrahydropyridine neurotoxicity
    • (PubMed PMID: 19203217 PubMed Central PMCID: PMCPMC2819801)
    • [162] Yang, L., Zhao, K., Calingasan, N.Y., Luo, G., Szeto, H.H., Beal, M.F., Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1, 2, 3 6-tetrahydropyridine neurotoxicity. Antioxid. Redox Signal. 11:9 (2009), 2095–2104, 10.1089/ARS.2009.2445 (PubMed PMID: 19203217 PubMed Central PMCID: PMCPMC2819801).
    • (2009) Antioxid. Redox Signal. , vol.11 , Issue.9 , pp. 2095-2104
    • Yang, L.1    Zhao, K.2    Calingasan, N.Y.3    Luo, G.4    Szeto, H.H.5    Beal, M.F.6
  • 163
    • 84903301367 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes
    • (PubMed PMID: 24060637 PubMed Central PMCID: PMCPMC3961561)
    • [163] Jin, H., Kanthasamy, A., Ghosh, A., Anantharam, V., Kalyanaraman, B., Kanthasamy, A.G., Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim. Biophys. Acta 1842:8 (2014), 1282–1294, 10.1016/j.bbadis.2013.09.007 (PubMed PMID: 24060637 PubMed Central PMCID: PMCPMC3961561).
    • (2014) Biochim. Biophys. Acta , vol.1842 , Issue.8 , pp. 1282-1294
    • Jin, H.1    Kanthasamy, A.2    Ghosh, A.3    Anantharam, V.4    Kalyanaraman, B.5    Kanthasamy, A.G.6
  • 164
    • 77955792985 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
    • (PubMed PMID: 20568096)
    • [164] Snow, B.J., Rolfe, F.L., Lockhart, M.M., Frampton, C.M., O'Sullivan, J.D., Fung, V., Smith, R.A., Murphy, M.P., Taylor, K.M., A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov. Disord. 25:11 (2010), 1670–1674, 10.1002/mds.23148 (PubMed PMID: 20568096).
    • (2010) Mov. Disord. , vol.25 , Issue.11 , pp. 1670-1674
    • Snow, B.J.1    Rolfe, F.L.2    Lockhart, M.M.3    Frampton, C.M.4    O'Sullivan, J.D.5    Fung, V.6    Smith, R.A.7    Murphy, M.P.8    Taylor, K.M.9
  • 165
    • 84856056846 scopus 로고    scopus 로고
    • Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
    • (PubMed PMID: 22218207)
    • [165] Sheng, Z.H., Cai, Q., Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13:2 (2012), 77–93, 10.1038/nrn3156 (PubMed PMID: 22218207).
    • (2012) Nat. Rev. Neurosci. , vol.13 , Issue.2 , pp. 77-93
    • Sheng, Z.H.1    Cai, Q.2
  • 166
    • 0037101606 scopus 로고    scopus 로고
    • Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses
    • (doi: 20026597. PubMed PMID: 12122046)
    • [166] Billups, B., Forsythe, I.D., Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses. J. Neurosc. 22:14 (2002), 5840–5847 (doi: 20026597. PubMed PMID: 12122046).
    • (2002) J. Neurosc. , vol.22 , Issue.14 , pp. 5840-5847
    • Billups, B.1    Forsythe, I.D.2
  • 167
    • 0019978703 scopus 로고
    • Replication of animal mitochondrial DNA
    • (Epub 1982/04/01. PubMed PMID: 6178513)
    • [167] Clayton, D.A., Replication of animal mitochondrial DNA. Cell 28:4 (1982), 693–705 (Epub 1982/04/01. PubMed PMID: 6178513).
    • (1982) Cell , vol.28 , Issue.4 , pp. 693-705
    • Clayton, D.A.1
  • 168
    • 84865544952 scopus 로고    scopus 로고
    • Mitochondrial fission, fusion, and stress
    • [168] Youle, R.J., Van Der Bliek, A.M., Mitochondrial fission, fusion, and stress. Science 337:6098 (2012), 1062–1065.
    • (2012) Science , vol.337 , Issue.6098 , pp. 1062-1065
    • Youle, R.J.1    Van Der Bliek, A.M.2
  • 169
    • 0032547797 scopus 로고    scopus 로고
    • The dynamin-related GTPase, dnm1p, controls mitochondrial morphology in yeast
    • (PubMed PMID: 9786946)
    • [169] Otsuga, D., Keegan, B.R., Brisch, E., Thatcher, J.W., Hermann, G.J., Bleazard, W., Shaw, J.M., The dynamin-related GTPase, dnm1p, controls mitochondrial morphology in yeast. J. Cell Biol. 143:2 (1998), 333–349, 10.1083/jcb.143.2.333 (PubMed PMID: 9786946).
    • (1998) J. Cell Biol. , vol.143 , Issue.2 , pp. 333-349
    • Otsuga, D.1    Keegan, B.R.2    Brisch, E.3    Thatcher, J.W.4    Hermann, G.J.5    Bleazard, W.6    Shaw, J.M.7
  • 170
    • 0032547754 scopus 로고    scopus 로고
    • Human dynamin-related protein controls the distribution of mitochondria
    • (PubMed PMID: 9786947)
    • [170] Smirnova, E., Shurland, D.-L., Ryazantsev, S.N., van der Bliek, A.M.A., Human dynamin-related protein controls the distribution of mitochondria. J. Cell Biol. 143:2 (1998), 351–358, 10.1083/jcb.143.2.351 (PubMed PMID: 9786947).
    • (1998) J. Cell Biol. , vol.143 , Issue.2 , pp. 351-358
    • Smirnova, E.1    Shurland, D.-L.2    Ryazantsev, S.N.3    van der Bliek, A.M.A.4
  • 171
    • 34547601410 scopus 로고    scopus 로고
    • Mitochondrial fusion protects against neurodegeneration in the cerebellum
    • (PubMed PMID: 17693261)
    • [171] Chen, H., McCaffery, J.M., Chan, D.C., Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130:3 (2007), 548–562 (PubMed PMID: 17693261).
    • (2007) Cell , vol.130 , Issue.3 , pp. 548-562
    • Chen, H.1    McCaffery, J.M.2    Chan, D.C.3
  • 172
    • 77955287381 scopus 로고    scopus 로고
    • Physiological functions of mitochondrial fusion
    • (Epub 2010/07/24. PubMed PMID: 20649534)
    • [172] Chen, H., Chan, D.C., Physiological functions of mitochondrial fusion. Ann. N. Y. Acad. Sci. 1201 (2010), 21–25, 10.1111/j.1749-6632.2010.05615.x (Epub 2010/07/24. PubMed PMID: 20649534).
    • (2010) Ann. N. Y. Acad. Sci. , vol.1201 , pp. 21-25
    • Chen, H.1    Chan, D.C.2
  • 173
    • 70350543964 scopus 로고    scopus 로고
    • SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle
    • (PubMed PMID: 19638400)
    • [173] Figueroa-Romero, C., Iñiguez-Lluhí, J.A., Stadler, J., Chang, C.-R., Arnoult, D., Keller, P.J., Hong, Y., Blackstone, C., Feldman, E.L., SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J. 23:11 (2009), 3917–3927 (PubMed PMID: 19638400).
    • (2009) FASEB J. , vol.23 , Issue.11 , pp. 3917-3927
    • Figueroa-Romero, C.1    Iñiguez-Lluhí, J.A.2    Stadler, J.3    Chang, C.-R.4    Arnoult, D.5    Keller, P.J.6    Hong, Y.7    Blackstone, C.8    Feldman, E.L.9
  • 174
    • 67650076601 scopus 로고    scopus 로고
    • MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
    • (PubMed PMID: WOS: 000267599700018)
    • [174] Braschi, E., Zunino, R., McBride, H.M., MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 10:7 (2009), 748–754, 10.1038/embor.2009.86 (PubMed PMID: WOS: 000267599700018).
    • (2009) EMBO Rep. , vol.10 , Issue.7 , pp. 748-754
    • Braschi, E.1    Zunino, R.2    McBride, H.M.3
  • 175
    • 84941799317 scopus 로고    scopus 로고
    • MAPL SUMOylation of drp1 stabilizes an ER/Mitochondrial platform required for cell death
    • (PubMed PMID: WOS:000365166500008)
    • [175] Prudent, J., Zunino, R., Sugiura, A., Mattie, S., Shore, G.C., McBride, H.M., MAPL SUMOylation of drp1 stabilizes an ER/Mitochondrial platform required for cell death. Mol. Cell 59:6 (2015), 941–955, 10.1016/j.molcel.2015.08.001 (PubMed PMID: WOS:000365166500008).
    • (2015) Mol. Cell , vol.59 , Issue.6 , pp. 941-955
    • Prudent, J.1    Zunino, R.2    Sugiura, A.3    Mattie, S.4    Shore, G.C.5    McBride, H.M.6
  • 176
    • 34347398050 scopus 로고    scopus 로고
    • The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division
    • (PubMed PMID: 17606867)
    • [176] Karbowski, M., Neutzner, A., Youle, R.J., The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J. Cell Biol. 178:1 (2007), 71–84 (PubMed PMID: 17606867).
    • (2007) J. Cell Biol. , vol.178 , Issue.1 , pp. 71-84
    • Karbowski, M.1    Neutzner, A.2    Youle, R.J.3
  • 177
    • 34848848492 scopus 로고    scopus 로고
    • The phosphorylation state of Drp1 determines cell fate
    • (PubMed PMID: 17906671 PubMed Central PMCID: PMCPMC2002565)
    • [177] Jahani-Asl, A., Slack, R.S., The phosphorylation state of Drp1 determines cell fate. EMBO Rep. 8:10 (2007), 912–913, 10.1038/sj.embor.7401077 (PubMed PMID: 17906671 PubMed Central PMCID: PMCPMC2002565).
    • (2007) EMBO Rep. , vol.8 , Issue.10 , pp. 912-913
    • Jahani-Asl, A.1    Slack, R.S.2
  • 178
    • 34848840991 scopus 로고    scopus 로고
    • Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
    • (PubMed PMID: 17721437)
    • [178] Cribbs, J.T., Strack, S., Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep. 8 (2007), 939–944, 10.1038/sj.embor.7401062 (PubMed PMID: 17721437).
    • (2007) EMBO Rep. , vol.8 , pp. 939-944
    • Cribbs, J.T.1    Strack, S.2
  • 179
    • 34547611925 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology
    • (PubMed PMID: WOS:000248196800003)
    • [179] Chang, C.R., Blackstone, C., Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J. Biol. Chem. 282:30 (2007), 21583–21587, 10.1074/jbc.C700083200 (PubMed PMID: WOS:000248196800003).
    • (2007) J. Biol. Chem. , vol.282 , Issue.30 , pp. 21583-21587
    • Chang, C.R.1    Blackstone, C.2
  • 180
    • 57349160257 scopus 로고    scopus 로고
    • Martins de brito O, chang CR, blackstone C, bernardi P, scorrano L. dephosphorylation by calcineurin regulates translocation of drp1 to mitochondria
    • (PubMed PMID: 18838687)
    • [180] Cereghetti, G.M., Stangherlin, A., Martins de brito O, chang CR, blackstone C, bernardi P, scorrano L. dephosphorylation by calcineurin regulates translocation of drp1 to mitochondria. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 15803–15808, 10.1073/pnas.0808249105 (PubMed PMID: 18838687).
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15803-15808
    • Cereghetti, G.M.1    Stangherlin, A.2
  • 182
    • 70349944660 scopus 로고    scopus 로고
    • The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
    • (PubMed PMID: WOS 000269960800006)
    • [182] Wakabayashi, J., Zhang, Z.Y., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T.W., Iijima, M., Sesaki, H., The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J. Cell Biol. 186:6 (2009), 805–816, 10.1083/jcb.200903065 (PubMed PMID: WOS 000269960800006).
    • (2009) J. Cell Biol. , vol.186 , Issue.6 , pp. 805-816
    • Wakabayashi, J.1    Zhang, Z.Y.2    Wakabayashi, N.3    Tamura, Y.4    Fukaya, M.5    Kensler, T.W.6    Iijima, M.7    Sesaki, H.8
  • 183
    • 68749083545 scopus 로고    scopus 로고
    • Calcium regulation of mitochondria motility and morphology
    • [183] Jeyaraju, D.V., Cisbani, G., Pellegrini, L., Calcium regulation of mitochondria motility and morphology. Biochim. Biophys. Acta 1787 (2009), 1363–1373.
    • (2009) Biochim. Biophys. Acta , vol.1787 , pp. 1363-1373
    • Jeyaraju, D.V.1    Cisbani, G.2    Pellegrini, L.3
  • 184
    • 33144473786 scopus 로고    scopus 로고
    • A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    • (PubMed PMID: 16484498)
    • [184] Shalizi, A., Gaudilliere, B., Yuan, Z., Stegmuller, J., Shirogane, T., Ge, Q., Tan, Y., Schulman, B., Harper, J.W., Bonni, A., A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311:5763 (2006), 1012–1017, 10.1126/science.1122513 (PubMed PMID: 16484498).
    • (2006) Science , vol.311 , Issue.5763 , pp. 1012-1017
    • Shalizi, A.1    Gaudilliere, B.2    Yuan, Z.3    Stegmuller, J.4    Shirogane, T.5    Ge, Q.6    Tan, Y.7    Schulman, B.8    Harper, J.W.9    Bonni, A.10
  • 185
    • 84950133238 scopus 로고    scopus 로고
    • Martin S: mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines
    • (PubMedPMID:25311713)
    • [185] Loriol, C., Casse, F., Khayachi, A., Poupon, G., Chafai, M., Deval, E., Gwizdek, C., Martin S: mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines. Nat. Commun., 5, 2014, 5113, 10.1038/ncomms6113 (PubMedPMID:25311713).
    • (2014) Nat. Commun. , vol.5 , pp. 5113
    • Loriol, C.1    Casse, F.2    Khayachi, A.3    Poupon, G.4    Chafai, M.5    Deval, E.6    Gwizdek, C.7
  • 186
    • 34248182897 scopus 로고    scopus 로고
    • Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
    • (PubMed PMID: 17470634 PubMed Central PMCID: PMCPMC2064824)
    • [186] Wasiak, S., Zunino, R., McBride, H.M., Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J. Cell Biol. 177:3 (2007), 439–450, 10.1083/jcb.200610042 (PubMed PMID: 17470634 PubMed Central PMCID: PMCPMC2064824).
    • (2007) J. Cell Biol. , vol.177 , Issue.3 , pp. 439-450
    • Wasiak, S.1    Zunino, R.2    McBride, H.M.3
  • 187
    • 79952037569 scopus 로고    scopus 로고
    • Elevated intracellular calcium causes distinct mitochondrial remodelling and calcineurin-dependent fission in astrocytes
    • (PubMed PMID: 21216007)
    • [187] Tan, A.R., Cai, A.Y., Deheshi, S., Rintoul, G.L., Elevated intracellular calcium causes distinct mitochondrial remodelling and calcineurin-dependent fission in astrocytes. Cell Calcium 49:2 (2011), 108–114, 10.1016/j.ceca.2010.12.002 (PubMed PMID: 21216007).
    • (2011) Cell Calcium , vol.49 , Issue.2 , pp. 108-114
    • Tan, A.R.1    Cai, A.Y.2    Deheshi, S.3    Rintoul, G.L.4
  • 188
    • 84928017503 scopus 로고    scopus 로고
    • Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling
    • (PubMed PMID: WOS 000353570500007)
    • [188] Deheshi, S., Dabiri, B., Fan, S., Tsang, M., Rintoul, G.L., Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling. J. Neurochem. 133:5 (2015), 684–699, 10.1111/jnc.13090 (PubMed PMID: WOS 000353570500007).
    • (2015) J. Neurochem. , vol.133 , Issue.5 , pp. 684-699
    • Deheshi, S.1    Dabiri, B.2    Fan, S.3    Tsang, M.4    Rintoul, G.L.5
  • 189
    • 84901752701 scopus 로고    scopus 로고
    • Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease
    • (Epub 2014/06/06PubMed. PMID:24900954;PubMedCentralPMCID:PMCPmc4036420)
    • [189] Hroudova, J., Singh, N., Fisar, Z., Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease. BioMed Res. Int., 2014, 2014, 175062, 10.1155/2014/175062 (Epub 2014/06/06PubMed. PMID:24900954;PubMedCentralPMCID:PMCPmc4036420).
    • (2014) BioMed Res. Int. , vol.2014 , pp. 175062
    • Hroudova, J.1    Singh, N.2    Fisar, Z.3
  • 190
    • 84865187620 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • (PubMed PMID: 22700435 PubMed Central PMCID: PMC3422529)
    • [190] Johri, A., Beal, M.F., Mitochondrial dysfunction in neurodegenerative diseases. J. Pharmacol. Exp. Ther. 342:3 (2012), 619–630, 10.1124/jpet.112.192138 (PubMed PMID: 22700435 PubMed Central PMCID: PMC3422529).
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , Issue.3 , pp. 619-630
    • Johri, A.1    Beal, M.F.2
  • 191
    • 84872833228 scopus 로고    scopus 로고
    • Mitochondrial dynamics in neurodegeneration
    • (Epub 2012/11/20. PubMed PMID: 23159640 PubMed Central PMCID: PMC3558617)
    • [191] Itoh, K., Nakamura, K., Iijima, M., Sesaki, H., Mitochondrial dynamics in neurodegeneration. Trends Cell Biol. 23:2 (2013), 64–71, 10.1016/j.tcb.2012.10.006 (Epub 2012/11/20. PubMed PMID: 23159640 PubMed Central PMCID: PMC3558617).
    • (2013) Trends Cell Biol. , vol.23 , Issue.2 , pp. 64-71
    • Itoh, K.1    Nakamura, K.2    Iijima, M.3    Sesaki, H.4
  • 192
    • 84872790484 scopus 로고    scopus 로고
    • Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression
    • (PubMedPMID:23351342; PubMedCentralPMCID:PMCPMC3577453)
    • [192] Cronin-Furman, E.N., Borland, M.K., Bergquist, K.E., Bennett, J.P. Jr., Trimmer, P.A., Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression. Mol. Neurodegener., 8, 2013, 6, 10.1186/1750-1326-8-6 (PubMedPMID:23351342; PubMedCentralPMCID:PMCPMC3577453).
    • (2013) Mol. Neurodegener. , vol.8 , pp. 6
    • Cronin-Furman, E.N.1    Borland, M.K.2    Bergquist, K.E.3    Bennett, J.P.4    Trimmer, P.A.5
  • 193
    • 84903779388 scopus 로고    scopus 로고
    • Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission
    • (PubMed PMID: 24681059 PubMed Central PMCID: PMCPMC4191657)
    • [193] Reddy, P.H., Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission. Drug Discov. Today 19:7 (2014), 951–955, 10.1016/j.drudis.2014.03.020 (PubMed PMID: 24681059 PubMed Central PMCID: PMCPMC4191657).
    • (2014) Drug Discov. Today , vol.19 , Issue.7 , pp. 951-955
    • Reddy, P.H.1
  • 194
    • 79952585486 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
    • (PubMed PMID: 21257639 PubMed Central PMCID: PMCPMC3049363)
    • [194] Shirendeb, U., Reddy, A.P., Manczak, M., Calkins, M.J., Mao, P., Tagle, D.A., Reddy, P.H., Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. Hum. Mol. Genet. 20:7 (2011), 1438–1455, 10.1093/hmg/ddr024 (PubMed PMID: 21257639 PubMed Central PMCID: PMCPMC3049363).
    • (2011) Hum. Mol. Genet. , vol.20 , Issue.7 , pp. 1438-1455
    • Shirendeb, U.1    Reddy, A.P.2    Manczak, M.3    Calkins, M.J.4    Mao, P.5    Tagle, D.A.6    Reddy, P.H.7
  • 195
    • 84928748470 scopus 로고    scopus 로고
    • Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling
    • (PubMed PMID 25941077)
    • [195] Brustovetsky, N., Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling. Mol. Neurobiol., 2015, 10.1007/s12035-015-9188-0 (PubMed PMID 25941077).
    • (2015) Mol. Neurobiol.
    • Brustovetsky, N.1
  • 196
    • 38849099158 scopus 로고    scopus 로고
    • Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
    • (PubMed PMID: 18267088)
    • [196] Cassidy-Stone, A., Chipuk, J.E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M.J., Shaw, J.T., Hinshaw, J.E., Green, D.R., Nunnari, J., Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell 14 (2008), 193–204, 10.1016/j.devcel.2007.11.019 (PubMed PMID: 18267088).
    • (2008) Dev. Cell , vol.14 , pp. 193-204
    • Cassidy-Stone, A.1    Chipuk, J.E.2    Ingerman, E.3    Song, C.4    Yoo, C.5    Kuwana, T.6    Kurth, M.J.7    Shaw, J.T.8    Hinshaw, J.E.9    Green, D.R.10    Nunnari, J.11
  • 197
    • 77951235489 scopus 로고    scopus 로고
    • Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1
    • (PubMed PMID: 20164189 PubMed Central PMCID: PMCPMC2857048)
    • [197] Cui, M., Tang, X., Christian, W.V., Yoon, Y., Tieu, K., Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. The Journal of biological chemistry. 285:15 (2010), 11740–11752, 10.1074/jbc.M109.066662 (PubMed PMID: 20164189 PubMed Central PMCID: PMCPMC2857048).
    • (2010) The Journal of biological chemistry. , vol.285 , Issue.15 , pp. 11740-11752
    • Cui, M.1    Tang, X.2    Christian, W.V.3    Yoon, Y.4    Tieu, K.5
  • 198
    • 84944348457 scopus 로고    scopus 로고
    • Altered mitochondrial dynamics contributes to propofol-induced cell death in human stem cell-derived neurons
    • (PubMed PMID: 26352374 PubMed Central PMCID: PMCPMC4632973)
    • [198] Twaroski, D.M., Yan, Y., Zaja, I., Clark, E., Bosnjak, Z.J., Bai, X., Altered mitochondrial dynamics contributes to propofol-induced cell death in human stem cell-derived neurons. Anesthesiology 123:5 (2015), 1067–1083, 10.1097/ALN.0000000000000857 (PubMed PMID: 26352374 PubMed Central PMCID: PMCPMC4632973).
    • (2015) Anesthesiology , vol.123 , Issue.5 , pp. 1067-1083
    • Twaroski, D.M.1    Yan, Y.2    Zaja, I.3    Clark, E.4    Bosnjak, Z.J.5    Bai, X.6
  • 199
  • 200
    • 84919638437 scopus 로고    scopus 로고
    • Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells
    • [200] Wang, J., Hansen, K., Edwards, R., Van Houten, B., Qian, W., Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells. Biochem. Biophys. Res. Commun. 456:1 (2015), 7–12.
    • (2015) Biochem. Biophys. Res. Commun. , vol.456 , Issue.1 , pp. 7-12
    • Wang, J.1    Hansen, K.2    Edwards, R.3    Van Houten, B.4    Qian, W.5
  • 201
    • 84893307629 scopus 로고    scopus 로고
    • Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation
    • [201] Salabei, J.K., Hill, B.G., Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation. Redox Biol. 1:1 (2013), 542–551.
    • (2013) Redox Biol. , vol.1 , Issue.1 , pp. 542-551
    • Salabei, J.K.1    Hill, B.G.2
  • 202
    • 84885675007 scopus 로고    scopus 로고
    • Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation
    • [202] Kim, B., Kim, J.-S., Yoon, Y., Santiago, M.C., Brown, M.D., Park, J.-Y., Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation. Am. J. Physiol. 305:8 (2013), R927–R938.
    • (2013) Am. J. Physiol. , vol.305 , Issue.8 , pp. R927-R938
    • Kim, B.1    Kim, J.-S.2    Yoon, Y.3    Santiago, M.C.4    Brown, M.D.5    Park, J.-Y.6
  • 204
    • 84876312885 scopus 로고    scopus 로고
    • A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
    • (PubMed PMID: 23239023)
    • [204] Qi, X., Qvit, N., Su, Y.-C., Mochly-Rosen, D., A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J. Cell Sci. 126 (2013), 789–802 (PubMed PMID: 23239023).
    • (2013) J. Cell Sci. , vol.126 , pp. 789-802
    • Qi, X.1    Qvit, N.2    Su, Y.-C.3    Mochly-Rosen, D.4
  • 205
    • 84890096545 scopus 로고    scopus 로고
    • Inhibition of mitochondrial fragmentation diminishes Huntington disease—associated neurodegeneration
    • (PubMed PMID: 24231356)
    • [205] Guo, X., Disatnik, M.-H., Monbureau, M., Shamloo, M., Mochly-Rosen, D., Qi, X., Inhibition of mitochondrial fragmentation diminishes Huntington disease—associated neurodegeneration. J Clin. Invest., 2013, 123, 10.1172/JCI70911DS1 (PubMed PMID: 24231356).
    • (2013) J Clin. Invest. , pp. 123
    • Guo, X.1    Disatnik, M.-H.2    Monbureau, M.3    Shamloo, M.4    Mochly-Rosen, D.5    Qi, X.6
  • 206
    • 84921442644 scopus 로고    scopus 로고
    • Peptide therapeutics: current status and future directions
    • (PubMed PMID: 25450771)
    • [206] Fosgerau, K., Hoffmann, T., Peptide therapeutics: current status and future directions. Drug Discov. Today 20:1 (2015), 122–128, 10.1016/j.drudis.2014.10.003 (PubMed PMID: 25450771).
    • (2015) Drug Discov. Today , vol.20 , Issue.1 , pp. 122-128
    • Fosgerau, K.1    Hoffmann, T.2
  • 207
    • 0345687964 scopus 로고    scopus 로고
    • Pharmacologically active spider peptide toxins
    • (PubMed PMID: 14625686)
    • [207] Corzo, G., Escoubas, P., Pharmacologically active spider peptide toxins. Cell. Mol. Life Sci. 60:11 (2003), 2409–2426, 10.1007/s00018-003-3108-6 (PubMed PMID: 14625686).
    • (2003) Cell. Mol. Life Sci. , vol.60 , Issue.11 , pp. 2409-2426
    • Corzo, G.1    Escoubas, P.2
  • 208
    • 85000716806 scopus 로고    scopus 로고
    • Development of a backbone cyclic peptide library as potential antiparasitic therapeutics using microwave irradiation
    • [208] Qvit, N., Kornfeld, O.S., Development of a backbone cyclic peptide library as potential antiparasitic therapeutics using microwave irradiation. J. Vis. Exp., 107, 2016, 10.3791/53589.
    • (2016) J. Vis. Exp. , vol.107
    • Qvit, N.1    Kornfeld, O.S.2
  • 209
    • 60449096779 scopus 로고    scopus 로고
    • Moving or stopping mitochondria: miro as a traffic cop by sensing calcium
    • (PubMed PMID: 19249268)
    • [209] Cai, Q., Sheng, Z.H., Moving or stopping mitochondria: miro as a traffic cop by sensing calcium. Neuron 61:4 (2009), 493–496, 10.1016/j.neuron.2009.02.003 (PubMed PMID: 19249268).
    • (2009) Neuron , vol.61 , Issue.4 , pp. 493-496
    • Cai, Q.1    Sheng, Z.H.2
  • 211
    • 60449108890 scopus 로고    scopus 로고
    • Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses
    • (PubMed PMID: 19249275 PubMed Central PMCID: PMCPMC2670979)
    • [211] Macaskill, A.F., Rinholm, J.E., Twelvetrees, A.E., Arancibia-Carcamo, I.L., Muir, J., Fransson, A., Aspenstrom, P., Attwell, D., Kittler, J.T., Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 61:4 (2009), 541–555, 10.1016/j.neuron.2009.01.030 (PubMed PMID: 19249275 PubMed Central PMCID: PMCPMC2670979).
    • (2009) Neuron , vol.61 , Issue.4 , pp. 541-555
    • Macaskill, A.F.1    Rinholm, J.E.2    Twelvetrees, A.E.3    Arancibia-Carcamo, I.L.4    Muir, J.5    Fransson, A.6    Aspenstrom, P.7    Attwell, D.8    Kittler, J.T.9
  • 212
    • 58149091896 scopus 로고    scopus 로고
    • The mechanism of Ca2+ −dependent regulation of kinesin-mediated mitochondrial motility
    • (PubMed PMID: 19135897 PubMed Central PMCID: PMCPMC2768392)
    • [212] Wang, X., Schwarz, T.L., The mechanism of Ca2+ −dependent regulation of kinesin-mediated mitochondrial motility. Cell 136:1 (2009), 163–174, 10.1016/j.cell.2008.11.046 (PubMed PMID: 19135897 PubMed Central PMCID: PMCPMC2768392).
    • (2009) Cell , vol.136 , Issue.1 , pp. 163-174
    • Wang, X.1    Schwarz, T.L.2
  • 213
    • 58549119743 scopus 로고    scopus 로고
    • Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase
    • (PubMed PMID: 19098100; PubMed Central PMCID: PMCPMC2634948.)
    • [213] Saotome, M., Safiulina, D., Szabadkai, G., Das, S., Fransson, A., Aspenstrom, P., Rizzuto, R., Hajnoczky, G., Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc. Natl. Acad. Sci. U.S.A. 105:52 (2008), 20728–20733, 10.1073/pnas.0808953105 (PubMed PMID: 19098100; PubMed Central PMCID: PMCPMC2634948.).
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.52 , pp. 20728-20733
    • Saotome, M.1    Safiulina, D.2    Szabadkai, G.3    Das, S.4    Fransson, A.5    Aspenstrom, P.6    Rizzuto, R.7    Hajnoczky, G.8
  • 214
    • 84922329529 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its adaptive responses in tumor cells
    • (PubMed PMID: 25454774 PubMed Central PMCID: PMCPMC4274314)
    • [214] Rasola, A., Bernardi, P., The mitochondrial permeability transition pore and its adaptive responses in tumor cells. Cell Calcium 56:6 (2014), 437–445, 10.1016/j.ceca.2014.10.003 (PubMed PMID: 25454774 PubMed Central PMCID: PMCPMC4274314).
    • (2014) Cell Calcium , vol.56 , Issue.6 , pp. 437-445
    • Rasola, A.1    Bernardi, P.2
  • 215
    • 84883776628 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore: a mystery solved?
    • (PubMed PMID: 23675351)
    • [215] Bernardi, P., The mitochondrial permeability transition pore: a mystery solved?. Front. Physiol. 4 (2013), 1–12, 10.3389/fphys.2013.00095 (PubMed PMID: 23675351).
    • (2013) Front. Physiol. , vol.4 , pp. 1-12
    • Bernardi, P.1
  • 216
    • 80052627393 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis
    • (PubMed PMID: WOS:000295744800003)
    • [216] Rasola, A., Bernardi, P., Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis. Cell Calcium 50:3 (2011), 222–233, 10.1016/j.ceca.2011.04.007 (PubMed PMID: WOS:000295744800003).
    • (2011) Cell Calcium , vol.50 , Issue.3 , pp. 222-233
    • Rasola, A.1    Bernardi, P.2
  • 217
    • 84916613828 scopus 로고    scopus 로고
    • Cyclophilin D and myocardial ischemia?reperfusion injury: a fresh perspective
    • [217] Alam, M.R., Baetz, D., Ovize, M., Cyclophilin D and myocardial ischemia?reperfusion injury: a fresh perspective. J. Mol. Cell. Cardiol. 78 (2015), 80–89, 10.1016/j.yjmcc.2014.09.026.
    • (2015) J. Mol. Cell. Cardiol. , vol.78 , pp. 80-89
    • Alam, M.R.1    Baetz, D.2    Ovize, M.3
  • 218
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • (PubMed PMID: 1715244)
    • [218] Liu, J., Farmer, J.D., Lane, W.S., Friedman, J., Weissman, I., Schreiber, S.L., Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66 (1991), 807–815, 10.1016/0092-8674(91)90124-H (PubMed PMID: 1715244).
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 219
    • 84907164366 scopus 로고    scopus 로고
    • From chemical tools to clinical medicines: non-immunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds
    • (PubMed PMID: 24831536)
    • [219] Sweeney, Z.K., Fu, J., Wiedmann, B., From chemical tools to clinical medicines: non-immunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds. J. Med. Chem. 57 (2014), 7145–7159, 10.1021/jm500223x (PubMed PMID: 24831536).
    • (2014) J. Med. Chem. , vol.57 , pp. 7145-7159
    • Sweeney, Z.K.1    Fu, J.2    Wiedmann, B.3
  • 220
    • 79551567024 scopus 로고    scopus 로고
    • Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore
    • (PubMed PMID: 21297983 PubMed Central PMCID: PMCPMC3030572)
    • [220] Azzolin, L., Antolini, N., Calderan, A., Ruzza, P., Sciacovelli, M., Marin, O., Mammi, S., Bernardi, P., Rasola, A., Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore. PLoS One, 6(1), 2011, e16280, 10.1371/journal.pone.0016280 (PubMed PMID: 21297983 PubMed Central PMCID: PMCPMC3030572).
    • (2011) PLoS One , vol.6 , Issue.1 , pp. e16280
    • Azzolin, L.1    Antolini, N.2    Calderan, A.3    Ruzza, P.4    Sciacovelli, M.5    Marin, O.6    Mammi, S.7    Bernardi, P.8    Rasola, A.9
  • 221
    • 77249130723 scopus 로고    scopus 로고
    • Protective effects of kaempferol (3,4’,5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice
    • (PubMed PMID: 20139605)
    • [221] Kim, J.K., Choi, S.J., Cho, H.Y., Hwang, H.J., Kim, Y.J., Lim, S.T., Kim, C.J., Kim, H.K., Peterson, S., Shin, D.H., Protective effects of kaempferol (3,4’,5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice. Biosci. Biotechnol. Biochem. 74:2 (2010), 397–401, 10.1271/bbb.90585 (PubMed PMID: 20139605).
    • (2010) Biosci. Biotechnol. Biochem. , vol.74 , Issue.2 , pp. 397-401
    • Kim, J.K.1    Choi, S.J.2    Cho, H.Y.3    Hwang, H.J.4    Kim, Y.J.5    Lim, S.T.6    Kim, C.J.7    Kim, H.K.8    Peterson, S.9    Shin, D.H.10
  • 224
    • 33846115045 scopus 로고    scopus 로고
    • A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease
    • (PubMed PMID: 17200487)
    • [224] Investigators NN-P, A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 68:1 (2007), 20–28, 10.1212/01.wnl.0000250355.28474.8e (PubMed PMID: 17200487).
    • (2007) Neurology , vol.68 , Issue.1 , pp. 20-28
    • Investigators NN-P1
  • 225
    • 0345451597 scopus 로고    scopus 로고
    • Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients
    • (PubMed PMID: 9521279)
    • [225] Shults, C.W., Beal, M.F., Fontaine, D., Nakano, K., Haas, R.H., Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 50:3 (1998), 793–795 (PubMed PMID: 9521279).
    • (1998) Neurology , vol.50 , Issue.3 , pp. 793-795
    • Shults, C.W.1    Beal, M.F.2    Fontaine, D.3    Nakano, K.4    Haas, R.H.5
  • 228
    • 0346490300 scopus 로고    scopus 로고
    • Alzheimer's Disease Cooperative S. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
    • (PubMed PMID: 14655926; PubMed Central PMCID)
    • [228] Singer, C., Tractenberg, R.E., Kaye, J., Schafer, K., Gamst, A., Grundman, M., Thomas, R., Thal, L.J., Alzheimer's Disease Cooperative S. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep 26:7 (2003), 893–901 (PubMed PMID: 14655926; PubMed Central PMCID).
    • (2003) Sleep , vol.26 , Issue.7 , pp. 893-901
    • Singer, C.1    Tractenberg, R.E.2    Kaye, J.3    Schafer, K.4    Gamst, A.5    Grundman, M.6    Thomas, R.7    Thal, L.J.8
  • 229
    • 84880329276 scopus 로고    scopus 로고
    • Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial
    • (PubMed PMID: 23726851 PubMed Central PMCID: PMCPMC3714436)
    • [229] Schapira, A.H., McDermott, M.P., Barone, P., Comella, C.L., Albrecht, S., Hsu, H.H., Massey, D.H., Mizuno, Y., Poewe, W., Rascol, O., Marek, K., Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial. Lancet Neurol. 12:8 (2013), 747–755, 10.1016/S1474-4422(13)70117-0 (PubMed PMID: 23726851 PubMed Central PMCID: PMCPMC3714436).
    • (2013) Lancet Neurol. , vol.12 , Issue.8 , pp. 747-755
    • Schapira, A.H.1    McDermott, M.P.2    Barone, P.3    Comella, C.L.4    Albrecht, S.5    Hsu, H.H.6    Massey, D.H.7    Mizuno, Y.8    Poewe, W.9    Rascol, O.10    Marek, K.11
  • 230
    • 84880828603 scopus 로고    scopus 로고
    • N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases
    • (PubMed PMID: 23860343 PubMed Central PMCID: PMCPMC3934795)
    • [230] Holmay, M.J., Terpstra, M., Coles, L.D., Mishra, U., Ahlskog, M., Oz, G., Cloyd, J.C., Tuite, P.J., N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. Clin. Neuropharmacol. 36:4 (2013), 103–106, 10.1097/WNF.0b013e31829ae713 (PubMed PMID: 23860343 PubMed Central PMCID: PMCPMC3934795).
    • (2013) Clin. Neuropharmacol. , vol.36 , Issue.4 , pp. 103-106
    • Holmay, M.J.1    Terpstra, M.2    Coles, L.D.3    Mishra, U.4    Ahlskog, M.5    Oz, G.6    Cloyd, J.C.7    Tuite, P.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.