Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients

Neurobiology of Disease

Volumn 41, Issue 3, 2011, Pages 695-705

  Vijayalakshmi, K ^a   Alladi, Phalguni Anand ^a   Ghosh, Shampa ^a   Prasanna, V K ^a   Sagar, B C ^a   Nalini, A ^a   Sathyaprabha, T N ^a   Raju, T R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Electron microscopy; GRP 78 and caspase 12; Immunocyto histochemistry; NSC 34 motor neuron cell line; Sporadic Amyotrophic Lateral Sclerosis; Western blotting

Indexed keywords

CASPASE 12; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE REGULATED PROTEIN 78;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; NEWBORN; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SPINAL CORD MOTONEURON;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELLS, CULTURED; CEREBROSPINAL FLUID; ENDOPLASMIC RETICULUM; HUMANS; MOTOR NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; SPINAL CORD;

EID: 79151483641     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.12.005     Document Type: Article

References (49)

1. Alladi P.A., et al. Effect of prenatal auditory enrichment on developmental expression of synaptophysin and syntaxin 1 in chick brainstem auditory nuclei. Neuroscience 2002, 114:577-590.
2. Alladi P.A., et al. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lower incidence of Parkinson's disease. Neuroscience 2009, 159:236-245.
3. Atkin J.D., et al. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J. Biol. Chem. 2006, 281:30152-30165.
4. Atkin J.D., et al. Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis. Neurobiol. Dis. 2008, 30:400-407.
5. Bence N.F., et al. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
6. Bonifacino J.S., Weissman A.M. Ubiquitin and the control of protein fate in the secretory and endocytic pathways. Annu. Rev. Cell Dev. Biol. 1998, 14:19-57.
7. Brooks B.R., et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 2000, 1:293-299.
8. Ciechanover A., Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 2003, 40:427-446.
9. Cruz-Sanchez F.F., et al. Amyotrophic lateral sclerosis brain banking: a proposal to standardize protocols and neuropathological diagnostic criteria. J. Neural Transm. Suppl. 1993, 39:215-222.
10. Forman M.S., et al. 'Unfolding' pathways in neurodegenerative disease. Trends Neurosci. 2003, 26:407-410.
11. Fujita E., et al. Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells. Cell Death Differ. 2002, 9:1108-1114.
12. Ghayur T., et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997, 386:619-623.
13. Ilieva E.V., et al. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 2007, 130:3111-3123.
14. Ito Y., Yamada M., Tanaka H., Aida K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T., Takahashi H., Hara H. Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice. Neurobiol. Dis. 2009, 36(3):470-476.
15. Kanekura K., et al. ER stress and unfolded protein response in amyotrophic lateral sclerosis. Mol. Neurobiol. 2009, 39:81-89.
16. Katayama T., et al. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. J. Biol. Chem. 2001, 276:43446-43454.
17. Kaufman R.J. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 2002, 110:1389-1398.
18. Kikuchi H., et al. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc. Natl Acad. Sci. USA 2006, 103:6025-6030.
19. Kleizen B., Braakman I. Protein folding and quality control in the endoplasmic reticulum. Curr. Opin. Cell Biol. 2004, 16:343-349.
20. Lamkanfi M., et al. Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 2007, 14:44-55.
21. Lindholm D., et al. ER stress and neurodegenerative diseases. Cell Death Differ. 2006, 13:385-392.
22. Matus S., et al. The stress rheostat: an interplay between the unfolded protein response UPR. and autophagy in neurodegeneration. Curr. Mol. Med. 2008, 8:157-172.
23. Mendonca D.M., et al. Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis. Braz. J. Med. Biol. Res. 2005, 38:925-933.
24. Mendonca D.M., Chimelli L., Martinez A.M. Expression of ubiquitin and proteasome in motorneurons and astrocytes of spinal cords from patients with amyotrophic lateral sclerosis. Neurosci. Lett. 2006, 404:315-319.
25. Momoi T. Caspases involved in ER stress-mediated cell death. J. Chem. Neuroanat. 2004, 28:101-105.
26. Nakagawa T., Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150:887-894.
27. Nakagawa T., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
28. Nalini A., et al. Clinical characteristics and survival pattern of 1,153 patients with amyotrophic lateral sclerosis: experience over 30years from India. J. Neurol. Sci. 2008, 272:60-70.
29. Oda Y., et al. Immunohistochemical study on choline acetyltransferase in the spinal cord of patients with amyotrophic lateral sclerosis. Pathol. Int. 1995, 45:933-939.
30. Oyanagi K., et al. Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum. Neuropathol. Appl. Neurobiol. 2008, 34:650-658.
31. Ramamohan P.Y., et al. Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord. Amyotroph. Lateral Scler. 2007, 8:79-82.
32. Rao M.S. Neurofilament phosphorylation is increased in ventral horn neurons of neonatal rat spinal cord exposed to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Neurodegeneration 1995, 4:397-401.
33. Rao R.V., et al. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 11:372-380.
34. Rao R.V., et al. Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J. Biol. Chem. 2004, 279:177-187.
35. Reddy R.K., et al. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J. Biol. Chem. 2003, 278:20915-20924.
36. Sasaki S. Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 2010, 69(4):346-355.
37. Shahani N., et al. Reactive astrogliosis in neonatal rat spinal cord after exposure to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Exp. Neurol. 1998, 149:295-298.
38. Shibata N., Kobayashi M. The role for oxidative stress in neurodegenerative diseases. Brain Nerve 2008, 60:157-170.
39. Shobha K. Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients. J. Neurol. Sci. 2007, 254:9-16.
40. Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci. 2003, 4:49-60.
41. Takahashi R., Imai Y. Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. J. Neurol. 2003, 250:III25-III29.
42. Tortarolo M., et al. Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. J. Neurochem. 2004, 88:481-493.
43. Travers K.J., et al. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 2000, 101:249-258.
44. Urano F., et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
45. Vijayalakshmi K., et al. Cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients induces degeneration of a cultured motor neuron cell line. Brain Res. 2009, 1263:122-133.
46. Wate R., et al. Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Acta Neuropathol. 2005, 110:557-562.
47. Woo M. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat. Immunol. 2003, 4:1016-1022.
48. Wootz H. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem. Biophys. Res. Commun. 2004, 322:281-286.
49. Yamagishi S. An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation. PLoS ONE 2007, 2:e1030.