ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

Nature Communications

Volumn 5, Issue , 2014, Pages

  Stoica, Radu ^a   De Vos, Kurt J ^a,c   Paillusson, Sébastien ^a   Mueller, Sarah ^a   Sancho, Rosa M ^a,d   Lau, Kwok Fai ^a,e   Vizcay Barrena, Gema ^a   Lin, Wen Lang ^b   Xu, Ya Fei ^b   Lewis, Jada ^b   Dickson, Dennis W ^b   Petrucelli, Leonard ^b   Mitchell, Jacqueline C ^a   Shaw, Christopher E ^a   Miller, Christopher C J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d Alzheimer's Research UK   (United Kingdom)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLYCOGEN SYNTHASE KINASE 3BETA; MITOCHONDRIAL PROTEIN; PROTEIN TYROSINE PHOSPHATASE INTERACTING PROTEIN 51; SYNAPTOBREVIN; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG; VESICLE ASSOCIATED MEMBRANE PROTEIN ASSOCIATED PROTEIN B; CALCIUM; DNA BINDING PROTEIN; FAM82A2 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MEMBRANE PROTEIN; PROTEIN TDP-43; PROTEIN TYROSINE PHOSPHATASE; PTPIP51 PROTEIN, MOUSE; TDP-43 PROTEIN, HUMAN; TDP-43 PROTEIN, MOUSE; VAPB PROTEIN, HUMAN; VAPB PROTEIN, MOUSE; VESICULAR TRANSPORT PROTEIN;

CALCIUM; CELL ORGANELLE; DISEASE PREVALENCE; ENZYME ACTIVITY; HOMEOSTASIS; MITOCHONDRION; PATHOGEN; PHYSIOLOGY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; ENDOPLASMIC RETICULUM; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; OUTER MEMBRANE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL LINE; HEK293 CELL LINE; METABOLISM;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CALCIUM; CELL LINE; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FRONTOTEMPORAL DEMENTIA; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTEIN TYROSINE PHOSPHATASES; VESICULAR TRANSPORT PROTEINS;

EID: 84901925681     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4996     Document Type: Article

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