Dysregulated IP3 Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation in Presenilin1 Results in Exaggerated Ca2+ Signals and Altered Membrane Excitability

Journal of Neuroscience

Volumn 24, Issue 2, 2004, Pages 508-513

  Stutzmann, Grace E ^a   Caccamo, Antonella ^a   LaFerla, Frank M ^a   Parker, Ian ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer; Calcium Ca ; Cortex; Imaging; Inositol triphosphate; Patch clamp; Pyramidal

Indexed keywords

CALCIUM; INOSITOL TRISPHOSPHATE; PRESENILIN 1; CALCIUM CHANNEL; CELL RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE; MEMBRANE PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; BRAIN SLICE; CALCIUM SIGNALING; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; FLUORESCENCE; GENE MUTATION; HYPERPOLARIZATION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PATCH CLAMP; PATHOPHYSIOLOGY; PHOTOLYSIS; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; SECOND MESSENGER; TRANSGENIC MOUSE; ACTION POTENTIAL; ANIMAL; BRAIN CORTEX; CELL MEMBRANE; CYTOLOGY; ELECTRIC CONDUCTIVITY; GENE EXPRESSION; GENETICS; METABOLISM; MUTATION; NERVE CELL; PHYSIOLOGY;

ACTION POTENTIALS; ALZHEIMER DISEASE; ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MEMBRANE; CEREBRAL CORTEX; ELECTRIC CONDUCTIVITY; GENE EXPRESSION; INOSITOL 1,4,5-TRISPHOSPHATE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; PATCH-CLAMP TECHNIQUES; PRESENILIN-1; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 1342288871     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4386-03.2004     Document Type: Article

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