Rab1-dependent ER–Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

Acta Neuropathologica

Volumn 130, Issue 5, 2015, Pages 679-697

  Soo, Kai Y ^a   Halloran, Mark ^a,b   Sundaramoorthy, Vinod ^a,b   Parakh, Sonam ^a,b   Toth, Reka P ^b   Southam, Katherine A ^c   McLean, Catriona A ^d,e   Lock, Peter ^a   King, Anna ^f   Farg, Manal A ^a   Atkin, Julie D ^a,b  

^a LA TROBE UNIVERSITY   (Australia)

^b MACQUARIE UNIVERSITY   (Australia)

^c UNIVERSITY OF TASMANIA   (Australia)

^d ALFRED HOSPITAL   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Amyotrophic lateral sclerosis; ER Golgi transport; FUS; SOD1; TDP 43

Indexed keywords

COAT PROTEIN COMPLEX II; COPPER ZINC SUPEROXIDE DISMUTASE; CREATINE KINASE; ENDOPLASMIC RETICULUM GOLGI INTERMEDIATE COMPARTMENT PROTEIN 53; EPOTHILONE D; FUSED IN SARCOMA PROTEIN; MUTANT PROTEIN; PACLITAXEL; PROTEIN DISULFIDE ISOMERASE; PROTEINASE K; RAB PROTEIN; SECRETORY PROTEIN; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; FUS PROTEIN, HUMAN; RNA BINDING PROTEIN; SUPEROXIDE DISMUTASE; TDP-43 PROTEIN, HUMAN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; ENZYME MECHANISM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; IN VITRO STUDY; MICROTUBULE; MOTONEURON; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SECRETORY PATHWAY; SPINAL CORD; VESICULOVIRUS; AGED; ANIMAL; COP-COATED VESICLE; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; COP-COATED VESICLES; CYTOPLASM; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FEMALE; GOLGI APPARATUS; HUMANS; MALE; MICE; MIDDLE AGED; MUTATION; NEURONS; RAB1 GTP-BINDING PROTEINS; RNA-BINDING PROTEIN FUS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84945492093     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1468-2     Document Type: Article

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