Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

Cell Stem Cell

Volumn 12, Issue 4, 2013, Pages 487-496

  Kondo, Takayuki ^a,b,c   Asai, Masashi ^c,d,e   Tsukita, Kayoko ^a,c   Kutoku, Yumiko ^f   Ohsawa, Yutaka ^f   Sunada, Yoshihide ^f   Imamura, Keiko ^a   Egawa, Naohiro ^a   Yahata, Naoki ^a,c   Okita, Keisuke ^a   Takahashi, Kazutoshi ^a   Asaka, Isao ^a   Aoi, Takashi ^a   Watanabe, Akira ^a   Watanabe, Kaori ^c,e   Kadoya, Chie ^c,e   Nakano, Rie ^c,e   Watanabe, Dai ^b   Maruyama, Kei ^d   Hori, Osamu ^g   Hibino, Satoshi ^h   Choshi, Tominari ^h   Nakahata, Tatsutoshi ^a   Hioki, Hiroyuki ^b   Kaneko, Takeshi ^b   Naitoh, Motoko ^b   Yoshikawa, Katsuhiro ^b   Yamawaki, Satoko ^b   Suzuki, Shigehiko ^b   Hata, Ryuji ⁱ   Ueno, Shu Ichi ⁱ   Seki, Tsuneyoshi ^j   Kobayashi, Kazuhiro ^j   Toda, Tatsushi ^j   Murakami, Kazuma ^b   Irie, Kazuhiro ^b   Klein, William L ^k   Mori, Hiroshi ^l   Asada, Takashi ^m   Takahashi, Ryosuke ^b   Iwata, Nobuhisa ^c,e   Yamanaka, Shinya ^a,c   Inoue, Haruhisa ^a,c   more..

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e NAGASAKI UNIVERSITY   (Japan)

^f KAWASAKI MEDICAL SCHOOL   (Japan)

^g KANAZAWA UNIVERSITY   (Japan)

^h FUKUYAMA UNIVERSITY   (Japan)

ⁱ EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^j KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^k NORTHWESTERN UNIVERSITY   (United States)

^l OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^m UNIVERSITY OF TSUKUBA   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CASPASE 4; DOCOSAHEXAENOIC ACID; PEROXIREDOXIN 4;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CELL DIFFERENTIATION; CEREBRAL CORTEX; DOCOSAHEXAENOIC ACIDS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTRACELLULAR SPACE; MODELS, BIOLOGICAL; MUTANT PROTEINS; NEURONS; OXIDATIVE STRESS; PHENOTYPE; PROTEIN STRUCTURE, QUATERNARY;

EID: 84875916922     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2013.01.009     Document Type: Article

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