A randomized clinical trial of high-dosage coenzyme Q10 in early parkinson disease no evidence of benefit

JAMA Neurology

Volumn 75, Issue 1, 2014, Pages 543-552

  Flint Beal, M ^a   Oakes, David ^b   Shoulson, Ira ^c   Henchcliffe, Claire ^a   Galpern, Wendy R ^d   Haas, Richard ^e   Juncos, Jorge L ^f   Nutt, John G ^g   Voss, Tiffini Smith ^h   Ravina, Bernard ⁱ   Shults, Clifford M ^e,j   Helles, Karen ^b   Snively, Victoria ^b   Lew, Mark F ^k   Griebner, Brian ^b   Watts, Arthur ^b   Gao, Shan ^b   Pourcher, Emmanuelle ^l   Bond, Louisette ^l   Kompoliti, Katie ^m   Agarwal, Pinky ⁿ   Sia, Cherissa ⁿ   Jog, Mandar ^o   Cole, Linda ^o   Sultana, Munira ^o   Kurlan, Roger ^p   Richard, Irene ^b   Deeley, Cheryl ^b   Waters, Cheryl H ^q   Figueroa, Angel ^q   Arkun, Ani ^a   Brodsky, Matthew ^g   Ondo, William G ^r   Hunter, Christine B ^s   Jimenez Shahed, Joohi ^s   Palao, Alicia ^s   Miyasaki, Janis M ^t   So, Julie ^t   Tetrud, James ^u   Reys, Liza ^u   Smith, Katharine ^u   Singer, Carlos ^v   Blenke, Anita ^v   Russell, David S ^w   Cotto, Candace ^w   Friedman, Joseph H ^x,y   Lannon, Margaret ^x,z   Zhang, Lin ^aa   Drasby, Edward ^z   Kumar, Rajeev ^ab   Subramanian, Thyagarajan ^ac   Ford, Donna Stuppy ^ad   Grimes, David A ^ad   Cote, Diane ^ad   Conway, Jennifer ^ad   Siderowf, Andrew D ^ae   Leslie Evatt, Marian ^f,af   Sommerfeld, Barbara ^f   Lieberman, Abraham N ^ag   Okun, Michael S ^ah   Rodriguez, Ramon L ^ah   Merritt, Stacy ^ah   Louise Swartz, Camille ^ah   Wayne Martin, W R ^ai   King, Pamela ^ai   Stover, Natividad ^aj   Guthrie, Stephanie ^aj   Watts, Ray L ^aj   Ahmed, Anwar ^ak   Fernandez, Hubert H ^ak   Winters, Adrienna ^ak   Mari, Zoltan ^al   Dawson, Ted M ^al   Dunlop, Becky ^al   Feigin, Andrew S ^am   Shannon, Barbara ^am   Nirenberg, Melissa Jill ^an   Ogg, Mattson ^a   Ellias, Samuel A ^ao   Thomas, Cathi Ann ^ao   Frei, Karen ^ap   Bodis Wollner, Ivan ^aq   Glazman, Sofya ^aq   Mayer, Thomas ^aq   Hauser, Robert A ^ar   Pahwa, Rajesh ^as   Langhammer, April ^as   Ranawaya, Ranjit ^at   Derwent, Lorelei ^at   Sethi, Kapil D ^au   Farrow, Buff ^au   Prakash, Rajan ^au   Litvan, Irene ^e   Robinson, Annette ^av   Sahay, Alok ^aw   Gartner, Maureen ^aw   Hinson, Vanessa K ^ax   Markind, Samuel ^ay   Pelikan, Melisa ^ay   Perlmutter, Joel S ^az   Hartlein, Johanna ^az   Molho, Eric ^ba   Evans, Sharon ^ba   Adler, Charles H ^bb   Duffy, Amy ^bb   Lind, Marlene ^bb   Elmer, Lawrence ^bc   Davis, Kathy ^bd   Spears, Julia ^bd   Wilson, Stephanie ^bd   Leehey, Maureen A ^be   Hermanowicz, Neal ^bf   Niswonger, Shari ^bf   Shill, Holly A ^bg   Obradov, Sanja ^bg   Rajput, Alex ^bh   Cowper, Marilyn ^bh   Lessig, Stephanie ^bi   Song, David ^bi   Fontaine, Deborah ^bi   Zadikoff, Cindy ^bj   Williams, Karen ^bj   Blindauer, Karen A ^bk   Bergholte, Jo ^bk   Propsom, Clara Schindler ^bk   Stacy, Mark A ^bl   Field, Joanne ^bl   Mihaila, Dragos ^bm   Chilton, Mark ^bm   Uc, Ergun Y ^bn   Sieren, Jeri ^bn   Simon, David K ^bo   Kraics, Lauren ^bo   Silver, Althea ^bo   Boyd, James T ^bp   Hamill, Robert W ^bp   Ingvoldstad, Christopher ^bp   Young, Jennifer ^bp   Thomas, Karen ^bq   Kostyk, Sandra K ^bq   Wojcieszek, Joanne ^br   Pfeiffer, Ronald F ^bs   Panisset, Michel ^bt   Beland, Monica ^bt   Reich, Stephen G ^bu   Cines, Michelle ^bu   Zappala, Nancy ^bu   Rivest, Jean ^bv   Zweig, Richard ^bw   Pepper Lumina, L ^bw   Lynn Hilliard, Colette ^bx   Grill, Stephen ^al   Kellermann, Marye ^by   Tuite, Paul ^bz   Rolandelli, Susan ^bz   Kang, Un Jung ^ca   Young, Joan ^ca   Rao, Jayaraman ^cb   Cook, Maureen M ^cb   Severt, Lawrence ^cc   Boyar, Karyn ^cc   McCoy, Arita ^cd   Dorward, Bari J ^ce   Tran, Michelle ^ap   Sombai, Jassie ^ap   Quesada, Monica ^cf   Hupcey, Roxana ^cg   Miracle, Dawn ^ab   Altin, Lisa ^ch   Weeks, Mary Louise ^ci   Simpson, Edith ^ag   Suelter, Michele ^ah   Scott, Ingrid ^ai   McMurray, Rebecca ^aj   Velcheva, Malinka ^a   McClain, Theresa ^cj   Khavarian, Leyla ^cj   Zimmerman, Jennifer ^ck   Zomok, Marci ^cl   Scott, Mary E ^cm   Olalde, Heena ^cn   Miller, Jared ^co   Oesterle, Colette ^bp   Pancake, Paige ^bq   Belden, Joann ^cp   Soucy, Daniel ^bv   Johnson, Labrillia ^cq   Kashouty, Rabih ^cc   Roth, Lauren ^cc   Niles, Lisa ^x   Nickels, Breanna ^ab   more..

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f EMORY UNIVERSITY   (United States)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^h MERCK RESEARCH LABORATORIES   (United States)

ⁱ BIOGEN   (United States)

^j VETERANS AFFAIRS MEDICAL CENTER   (United States)

^k UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^l Quebec Memory and Motor Skills Disorders Research Center   (Canada)

^m RUSH UNIVERSITY MEDICAL CENTER   (United States)

ⁿ Booth Gardner Parkinson's Care Center   (United States)

^o LONDON HEALTH SCIENCES CENTRE   (Canada)

^p Atlantic Neuroscience Institute   (United States)

^q NEUROLOGICAL INSTITUTE   (United States)

^r UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^s BAYLOR COLLEGE OF MEDICINE   (United States)

^t UNIVERSITY OF TORONTO   (Canada)

^u PARKINSON S INSTITUTE   (United States)

^v UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^w INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

^x BUTLER HOSPITAL   (United States)

^y BROWN UNIVERSITY   (United States)

^z Port City Neurology   (United States)

^aa UNIVERSITY OF CALIFORNIA   (United States)

^ab School of Medicine and Sacramento VA Medical Center ^*  (United States)

^ac PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^ad UNIVERSITY OF OTTAWA   (Canada)

^ae AVID RADIOPHARMACEUTICALS   (United States)

^af ATLANTA VA MEDICAL CENTER   (United States)

^ag BARROW NEUROLOGICAL INSTITUTE   (United States)

^ah UNIVERSITY OF FLORIDA   (United States)

^ai UNIVERSITY OF ALBERTA   (Canada)

^aj UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^ak LERNER RESEARCH INSTITUTE   (United States)

^al JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^am FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^an NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^ao BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ap The Parkinson and Movement Disorders Institute   (United States)

^aq SUNY DOWNSTATE MEDICAL CENTER   (United States)

^ar UNIVERSITY OF SOUTH FLORIDA   (United States)

^as UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^at UNIVERSITY OF CALGARY   (Canada)

^au MEDICAL COLLEGE OF GEORGIA   (United States)

^av University of Louisville School of Medicine   (United States)

^aw UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^ax MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^ay Associated Neurologists   (United States)

^az WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ba ALBANY MEDICAL CENTER   (United States)

^bb MAYO CLINIC   (United States)

^bc UNIVERSITY OF TOLEDO   (United States)

^bd MEDICAL COLLEGE OF OHIO   (United States)

^be UNIVERSITY OF COLORADO   (United States)

^bf UNIVERSITY OF CALIFORNIA   (United States)

^bg SUN HEALTH RESEARCH INSTITUTE   (United States)

^bh UNIVERSITY OF SASKATCHEWAN   (Canada)

^bi UNIVERSITY OF CALIFORNIA   (United States)

^bj NORTHWESTERN UNIVERSITY   (United States)

^bk MEDICAL COLLEGE OF WISCONSIN   (United States)

^bl DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bm SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^bn UNIVERSITY OF IOWA   (United States)

^bo HARVARD MEDICAL SCHOOL   (United States)

^bp UNIVERSITY OF VERMONT   (United States)

^bq OHIO STATE UNIVERSITY   (United States)

^br INDIANA UNIVERSITY   (United States)

^bs UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^bt NOTRE DAME HOSPITAL   (Canada)

^bu UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^bv UNIVERSITÉ DE SHERBROOKE   (Canada)

^bw LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^bx University of Chicago ^*  (United States)

^by Parkinson's and Movement Disorders Center of Maryland   (United States)

^bz UNIVERSITY OF MINNESOTA   (United States)

^ca UNIVERSITY OF CHICAGO   (United States)

^cb OCHSNER CLINIC FOUNDATION   (United States)

^cc BETH ISRAEL MEDICAL CENTER   (United States)

^cd JOHNS HOPKINS UNIVERSITY   (United States)

^ce Booth Gardner Parkinson's Care Center   (United States)

^cf UNIVERSITY OF MIAMI   (United States)

^cg UNIVERSITY OF CALIFORNIA   (United States)

^ch UNIVERSITY OF PENNSYLVANIA   (United States)

^ci EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cj UNIVERSITY OF SOUTH FLORIDA   (United States)

^ck MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^cl MAYO CLINIC   (United States)

^cm Medical University of Ohio   (United States)

^cn UNIVERSITY OF IOWA   (United States)

^co BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^cp INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cq Louisiana State University Health Science Center Shreveport   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; PLACEBO; UBIDECARENONE;

ADULT; ANGIODYSPLASIA; ANXIETY; ARTICLE; BACKACHE; CANCER RECURRENCE; CONSTIPATION; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FALLING; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEADACHE; HUMAN; HYPERTENSION; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE MYELOMA; NAUSEA; PARKINSON DISEASE; PATIENT COMPLIANCE; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; TREATMENT OUTCOME; TREMOR; UNIFIED PARKINSON DISEASE RATING SCALE; URINARY TRACT INFECTION;

AGED; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EARLY DIAGNOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; UBIQUINONE;

EID: 84900479240     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2014.131     Document Type: Article

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