Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

Neurobiology of Disease

Volumn 62, Issue , 2014, Pages 218-232

  Peviani, Marco ^a   Salvaneschi, Eleonora ^a   Bontempi, Leonardo ^a   Petese, Alessandro ^a   Manzo, Antonio ^b   Rossi, Daniela ^a   Salmona, Mario ^c   Collina, Simona ^a   Bigini, Paolo ^c   Curti, Daniela ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

BDNF; Motor neurons; Neurodegeneration; Reactive gliosis; Sigma 1 receptor; Wobbler

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; BRAIN DERIVED NEUROTROPHIC FACTOR; CD206 ANTIGEN; CD68 ANTIGEN; COPPER ZINC SUPEROXIDE DISMUTASE; INTERLEUKIN 1BETA; LYMPHOCYTE ANTIGEN; MESSENGER RNA; SIGMA 1 OPIATE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFICACY; FEMALE; GENE MUTATION; GRAY MATTER; GRIP STRENGTH; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOTOR NEURON DISEASE; MOUSE; NERVE DEGENERATION; NERVE REGENERATION; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OCULOMOTOR NERVE DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOD1 GENE; TREATMENT OUTCOME;

ALS; AMYLOID PRECURSOR PROTEIN; AMYOTROPHIC LATERAL SCLEROSIS; APP; BDNF; BRAIN DERIVED NEUROTROPHIC FACTOR; CENTRAL NERVOUS SYSTEM; CNS; ENDOPLASMIC RETICULUM; ER; FRONTO-TEMPORAL LOBAR DEGENERATION WITH CO-OCCURRENCE OF MOTOR NEURON DISEASE; FTLD-MND; FUS; FUSED IN SARCOMA; GFAP; GLIAL FIBRILLARY ACIDIC PROTEIN; IL-1Β; IL-6; INOSITOL 1 4, 5-TRIPHOSPHATE RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; IP3R; MAM; MITOCHONDRION-ASSOCIATED ER MEMBRANE; MND; MOTOR NEURON DISEASE; MOTOR NEURONS; N-METHYL DI-ASPARTATE; NEURODEGENERATION; NEUROTRACE; NMDA; NT; PKC; PROTEIN KINASE C; REACTIVE GLIOSIS; S1R; SIGMA-1 RECEPTOR; SOD1; SUPEROXIDE DISMUTASE 1; TDP-43; TGN; TNF-Α; TRANS-GOLGI NETWORK; TRANSACTIVE RESPONSE-DNA BINDING PROTEIN 43; TUMOR NECROSIS FACTOR ALPHA; VACUOLAR/VESICULAR PROTEIN SORTING 54; VAPB; VESICULAR ASSOCIATED PROTEIN B; VPS54; WOBBLER; WR;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; FEMALE; LOCOMOTION; MALE; MICE; MICE, TRANSGENIC; MORPHOLINES; MOTOR NEURON DISEASE; MOTOR NEURONS; MUTATION; NEUROGLIA; NEUROPROTECTIVE AGENTS; RECEPTORS, SIGMA; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84886816838     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.10.010     Document Type: Article

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