Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

European Journal of Pharmacology

Volumn 592, Issue 1-3, 2008, Pages 33-40

  Norez, Caroline ^a   Vandebrouck, Clarisse ^a   Antigny, Fabrice ^a   Dannhoffer, Luc ^a   Blondel, Marc ^b,c   Becq, Frédéric ^a  

^a UNIVERSITÉ DE POITIERS   (France)

^b STATION BIOLOGIQUE   (France)

^c BREST UNIVERSITY HOSPITAL   (France)

Author keywords

Ca2+ influx; CaCC; Chloride channels; Cystic fibrosis; Guanabenz; Human airway epithelial cells; Pharmacology

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; AMILORIDE; CALCIUM; CALIXARENE; CHLORIDE CHANNEL; GLIBENCLAMIDE; GUANABENZ; GUANABENZ ACETATE; HISTAMINE; IODIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CASPASE 3;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHLORIDE CONDUCTANCE; CHLORIDE CURRENT; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; ELECTROPHYSIOLOGY; EXTRACELLULAR CALCIUM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; APOPTOSIS; CELL LINE; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; EPITHELIUM CELL; METABOLISM; PATCH CLAMP; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ADRENERGIC ALPHA-AGONISTS; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE; CELL SURVIVAL; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; GUANABENZ; HUMANS; IODIDES; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RECEPTORS, ADRENERGIC, ALPHA-2; RESPIRATORY MUCOSA;

EID: 49749141982     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.103     Document Type: Article

References (56)

1. Al-Bazzaz F., and Jayaram T. Ion transport by canine tracheal mucosa: effect of elevation of cellular calcium. Exp. Lung Res. 2 (1981) 121-130
2. Alexander S.P.H., Mathie A., and Peters J.A. Guide to receptors and channels (GRAC). Br. J. Pharmacol. 150 (2007) S1-S168
3. Anderson M.P., Berger H.A., Rich D.P., Gregory R.J., Smith A.E., and Welsh M.J. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67 (1991) 775-784
4. Antigny F., Norez C., Becq F., and Vandebrouck C. Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR. Cell Calcium 43 (2008) 175-183
5. Barthelson R.A., Jacoby D.B., and Widdicombe J.H. Regulation of chloride secretion in dog tracheal epithelium by protein kinase C. Am. J. Physiol. 253 (1987) C802-C808
6. Begenisch T., and Melvin J.E. Regulation of chloride channels in secretory epithelia. J. Membr. Biol. 163 (1998) 77-85
7. Boucher R.C., Cheng E.H., Paradiso A.M., Stutts M.J., Knowles M.R., and Earp H.S. Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms. J. Clin. Invest. 84 (1989) 424-1431
8. Brown H.A., Lazarowski R.C., Boucher R.C., and Harden T.K. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells. Mol. Pharmacol. 40 (1991) 648-655
9. Choi S.H., Choi D.H., Lee J.J., Park M.S., and Chun B.G. Imidazoline drugs stabilize lysosomes and inhibit oxydative cytotoxicity in astrocytes. Free Radic. Biol. Med. 32 (2001) 94-405
10. Clarke L.L., Grubb B.R., Yankaskas J.R., Cotton C.U., McKenzie A., and Boucher R.C. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 479-483
11. Cloutier M.M., Guernsey L., Mattes P., and Koeppen B. Duramycin enhances chloride secretion in airway epithelium. Am. J. Physiol. 259 (1990) C450-C454
12. Cloutier M.M., Guernsey L., and Sha'afi R.I. Duramycin increases intracellular calcium in airway epithelium. Membr. Biochem. 10 (1993) 107-118
13. Eggermont J. Calcium-activated chloride channels: (un)known, (un)loved?. Proc. Am. Thorac. Soc. 1 (2004) 22-27
14. Frings S., Reuter D., and Kleene S.J. Neuronal Ca2+-activated Cl- channels: homing in on an elusive channel species. Prog. Neurobiol. 60 (2000) 247-289
15. Gerasimenko J.V., Sherwood M., Tepikin A.V., Petersen O.H., and Gerasimenko O.V. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J. Cell Sci. 119 (2006) 226-238
16. Grasemann H., Stehling F., Brunar H., Widmann R., Laliberte T.W., Molina L., Döring G., and Ratjen F. Inhalation of Moli1901 in patients with cystic fibrosis. Chest 131 (2007) 1461-1466
17. Greenwood I.A., and Leblanc N. Overlapping pharmacology of Ca2+-activated Cl- and K+ channels. Trends Pharmacol Sci. 128 (2007) 1-5
18. Grygorczyk R., and Bridges R.J. Whole-cell chloride conductances in cultured brushed human nasal epitelial cells. Can. J. Physiol. Pharmacol. 70 (1992) 1134-1141
19. Hartzell C., Putzier I., and Arreola J. Calcium-activated chloride channels. Annu. Rev. Physiol. 67 (2005) 718-758
20. Holmes B., Brogden R.N., Hell R.C., Speight T.M., and Avery G.S. Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26 (1983) 212-229
21. Hwang T.H., Schwiebert E.M., and Guggino W.B. Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors. Am. J. Physiol. 270 (1996) C1611-C1623
22. Jefferson D.M., Valentich J.D., Marini F.C., Grubman S.A., Iannuzzi M.C., Dorkin H.L., Li M., Klinger K.W., and Welsh M.J. Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines. Am. J. Physiol. 259 (1990) 496-505
23. Jentsch T.J., Stein V., Weinreich F., and Zdebik A.A. Molecular structure and physiological function of chloride channels. Physiol. Rev. 82 (2002) 503-568
24. Knowles M.R., and Boucher R.C. Mucus clearance as a primary innate defense mechanism for mamalian airways. J. Clin. Invest. 109 (2002) 571-577
25. Knowles M.R., Buntin W.H., Bromberg P.A., Gatzy J.T., and Boucher R.C. Measurements of transepithelial electric potential differences in the trachea and bronchi of human subjects in vivo. Am. Rev. Respir. Dis. 126 (1982) 108-112
26. Knowles M.R., Clarke L.L., and Boucher R.C. Extracellular ATP and UTP induce chloride secretion in nasal epithelia of cystic fibrosis patients and normal subjects in vivo. Chest 101 (1992) 60S-63S
27. Kunzelmann K., Milenkovic V.M., Spitzner M., Soria R.B., and Schreiber R. Calcium-dependent chloride conductance in epithelia: is there a contribution by bestrophin?. Pflugers Arch. 454 (2007) 879-889
28. Large W.A., and Wang Q. Characteristics and physiological role of the Ca2+-activated chloride conductance in smooth muscle. Am. J. Physiol., Cell Physiol. 40 (1996) C435-C454
29. Loewen M.E., and Forsyth G.W. Structure and function of CLCA proteins. Physiol. Rev. 85 (2005) 1061-1092
30. Ma T., Thiagarajah J.R., Yang H., Sonawane N.D., Folli C., Galietta L.J., and Verkman A.S. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J. Clin. Invest. 110 (2002) 1651-1658
31. Marcet B., and Boeynaems J.M. Relationships between cystic fibrosis transmembrane conductance regulator, extracellular nucleotides and cystic fibrosis. Pharmacol. Ther. 112 (2006) 719-732
32. Marivingt-Mounir C., Norez C., Derand R., Bulteau-Pignoux L., Nguyen-Huy D., Viossat B., Morgant G., Becq F., Vierfond J.M., and Mettey Y. Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels. J. Med. Chem. 47 (2004) 962-972
33. Mason S.J., Paradiso A.M., and Boucher R.C. Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium. Br. J. Pharmacol. 103 (1991) 1649-1656
34. Molina y Vedia, L., Stutts, M.J., Boucher, R.C., Henke, D.C., 1996. Method of treating retained pulmonary secretion. US Patent 5512269.
35. Nilius B., and Droogmans G. Amazing chloride channels: an overview. Acta Physiol. Scand. 177 (2003) 119-147
36. Nilius B., Prenen J., Voets T., Van den Bremt K., Eggermont J., and Droogmans G. Kinetic and pharmacological properties of the calcium-activated chloride-current in macrovascular endothelial cells. Cell Calcium 22 (1997) 53-63
37. Noel S., Wilke M., Bot A., De Jonge H.R., and Becq F. Parallel improvement of sodium and chloride transport defects by miglustat in cystic fibrosis epithelial cells. J. Pharmacol. Exp. Ther. 325 (2008) 1016-1023
38. Norez C., Heda G.D., Jensen T., Kogan I., Hughes L.K., Auzanneau C., Dérand R., Bulteau-Pignoux L., Li C., Ramjeesingh M., Li H., Sheppard D.N., Bear C.E., Riordan J.R., and Becq F. Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods. J. Cyst. Fibros. 3 (2004) 119-121
39. Norez C., Antigny F., Becq F., and Vandebrouck C. Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells. Traffic 7 (2006) 562-573
40. Norez C., Noel S., Wilke M., Bijvelds M., Jorna H., Melin P., DeJonge H., and Becq F. Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat. FEBS Lett. 580 (2006) 2081-2086
41. O'Reilly C.M., O'Farrel A.M., and Ryan P. Purinoceptor activation of chloride transport in cystic fibrosis and CFTR-transfected pancreatic cell lines. Br. J. Pharmacol. 124 (1998) 1597-1606
42. Ozog M.A., Wilson J.X., Dixon S.J., and Cechetto D.F. Rilmenidine elevates cytosolic free calcium concentration in suspended cerebral astrocytes. J. Neurochem. 71 (1998) 1429-1435
43. Paradiso A.M., Ribeiro C., and Boucher R.C. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia. J. Gen. Physiol. 117 (2001) 53-66
44. Reis D.J., Regunathan S., Golanov E.V., and Feinstein D.L. Protection of focal ischemic infarction by rilmenidine in the animal: evidence that interactions with central imidazoline receptors may be protective. Am. J. Cardiol. 74 (1994) 25A-30A
45. Ritzka M., Stanke F., Jansen S., Gruber A.D., Pusch L., Woelfl S., Veeze H.J., Halley D.J., and Tümmler B. The CLCA gene locus as a modulator of thengastrointestinal basic defect in cystic fibrosis. Hum. Genet. 115 (2004) 483-491
46. Schultz B.D., DeRoos A.D., Venglarik C.J., Singh A.K., Frizzell R.A., and Bridges R.J. Glibenclamide blockade of CFTR chloride channels. Am. J. Physiol. 271 (1996) L192-L200
47. Schultz B.D., Singh A.K., Devor D.C., and Bridges R.J. Pharmacology of CFTR chloride channel activity. Physiol. Rev. 79 (1999) 109-144
48. Sheppard D.N., and Welsh M.J. Inhibition of the cystic fibrosis transmembrane conductance regulator by ATP-sensitive K+ channel regulators. Ann. N. Y. Acad. Sci. 707 (1993) 275-284
49. Strauss O. The retinal pigment epithelium in visual function. Physiol. Rev. 85 (2005) 293-300
50. Stutts M.J., Chinet T.C., Mason S.J., Fullton J.M., Clarke L.L., and Boucher R.C. Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 1621-1625
51. Thelin W.R., and Boucher R.C. The epithelium as a target for therapy in cystic fibrosis. Curr. Opin. Pharmacol. 7 (2007) 290-295
52. Welsh M.J. Effect of phorbol ester and calcium ionophore on chloride secretion in canine tracheal epithelium. Am. J. Physiol. 253 (1987) C828-C834
53. Willumsen N.J., and Boucher R.C. Activation of an apical Cl- conductance by Ca2+ ionophore in cystic fibrosis airway epithelia. Am. J. Physiol. 256 (1989) C226-C233
54. Wine J.J. The genesis of cystic fibrosis lung disease. J. Clin. Invest. 103 (1999) 309-312
55. Worrell R.T., and Frizzell R.A. CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. Am. J. Physiol. 260 (1991) C877-C882
56. Zeitlin P.L., Boyle M.P., Guggino W.B., and Molina L. A phase I trial of intranasal Moli1901 for cystic fibrosis. Chest 125 (2004) 143-149