메뉴 건너뛰기




Volumn 36, Issue 4, 2013, Pages 103-106

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Author keywords

Glutathione; Magnetic resonance spectroscopy; N acetylcysteine; Redox ratio

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE;

EID: 84880828603     PISSN: 03625664     EISSN: 1537162X     Source Type: Journal    
DOI: 10.1097/WNF.0b013e31829ae713     Document Type: Article
Times cited : (162)

References (30)
  • 1
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, et al. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 1994;36: 348-355.
    • (1994) Ann Neurol , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3
  • 2
    • 34249864552 scopus 로고    scopus 로고
    • Altered intracellular redox status in gaucher disease fibroblasts and impairment of adaptive response against oxidative stress
    • DeGanuto M, Pittis MG, Pines A, et al. Altered Intracellular Redox Status in Gaucher Disease Fibroblasts and Impairment of Adaptive Response Against Oxidative Stress. J Cell Physiol 2007;21: 223-235.
    • (2007) J Cell Physiol , vol.21 , pp. 223-235
    • Deganuto, M.1    Pittis, M.G.2    Pines, A.3
  • 3
    • 31044436427 scopus 로고    scopus 로고
    • Blood oxidative stress markers in gaucher disease patients
    • Roversi FM, Galdieri LC, Grego BHC, et al. Blood oxidative stress markers in Gaucher disease patients. Clinica Chimica Acta 2006;364: 316-320.
    • (2006) Clinica Chimica Acta , vol.364 , pp. 316-320
    • Roversi, F.M.1    Galdieri, L.C.2    Grego, B.H.C.3
  • 4
    • 0036570159 scopus 로고    scopus 로고
    • Oxidatively modified proteins in aging and disease
    • Beal MF. Oxidatively modified proteins in aging and disease. Free Radic Biol Med 2002;32(9): 797.
    • (2002) Free Radic Biol Med , vol.32 , Issue.9 , pp. 797
    • Beal, M.F.1
  • 5
    • 53149087460 scopus 로고    scopus 로고
    • Mitochondrial alterations in parkinson's disease: New clues
    • Vila M, Ramonet D, Perier C. Mitochondrial alterations in Parkinson's disease: new clues. J Neurochem 2008;107: 317-328.
    • (2008) J Neurochem , vol.107 , pp. 317-328
    • Vila, M.1    Ramonet, D.2    Perier, C.3
  • 6
    • 33744984830 scopus 로고    scopus 로고
    • Proteasomal dysfunction in sporadic parkinson's disease
    • McNaught KS, Jackson T, JnoBaptiste R, et al. Proteasomal dysfunction in sporadic Parkinson's disease. Neurology 2006;66(100): S37.
    • (2006) Neurology , vol.66 , Issue.100
    • McNaught, K.S.1    Jackson, T.2    Jnobaptiste, R.3
  • 7
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in parkinson's disease
    • Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol 2003;53(Suppl 3): S26-S36.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Jenner, P.1
  • 8
    • 70350319531 scopus 로고    scopus 로고
    • Multicenter analysis of glucocerebrosidase mutations in parkinson's disease
    • Sidranski E, Nalls MA, Aasly JO, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 2009;361: 1651-1661.
    • (2009) N Engl J Med , vol.361 , pp. 1651-1661
    • Sidranski, E.1    Nalls, M.A.2    Aasly, J.O.3
  • 9
    • 80052028927 scopus 로고    scopus 로고
    • Exploring the link between glucocereborsidase mutations and parkinsonism
    • Westbroek W, Gustafson AM, Sidransky E. Exploring the link between glucocereborsidase mutations and parkinsonism. Trends Mol Med 2011;17(9): 485-493.
    • (2011) Trends Mol Med , vol.17 , Issue.9 , pp. 485-493
    • Westbroek, W.1    Gustafson, A.M.2    Sidransky, E.3
  • 10
    • 67651148277 scopus 로고    scopus 로고
    • Randomized. double-blind, pilot evaluation of intravenous glutathione in parkinson's disease
    • Hauser RA, Lyons KE, McClain T, et al. Randomized. double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease. Movement Disorders 2009;24(7): 979-983.
    • (2009) Movement Disorders , vol.24 , Issue.7 , pp. 979-983
    • Hauser, R.A.1    Lyons, K.E.2    McClain, T.3
  • 11
    • 0034672943 scopus 로고    scopus 로고
    • Metabolism and functions of glutathione in brain
    • Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol 2000;62(6): 649-671.
    • (2000) Prog Neurobiol , vol.62 , Issue.6 , pp. 649-671
    • Dringen, R.1
  • 12
    • 56649105351 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Aoyama K, Watabe M, Nakaki T. Regulation of glutathione synthesis. J Pharmacol Sci 2008;108: 227-238.
    • (2008) J Pharmacol Sci , vol.108 , pp. 227-238
    • Aoyama, K.1    Watabe, M.2    Nakaki, T.3
  • 13
    • 29444459269 scopus 로고    scopus 로고
    • Neuronal glutathione deficiency and age-dependent neurodegeneration in the eaac1 deficient mouse
    • Aoyama K, et al. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci 2006;9(1): 119-126.
    • (2006) Nat Neurosci , vol.9 , Issue.1 , pp. 119-126
    • Aoyama, K.1
  • 14
    • 68949129086 scopus 로고    scopus 로고
    • Role of n-acetylcysteine in glutathione synthesis in human erythrocytes
    • Whillier S, Raftos JE, Chapman B, et al. Role of N-acetylcysteine in glutathione synthesis in human erythrocytes. Redox Report 2009;14(3): 115-124.
    • (2009) Redox Report , vol.14 , Issue.3 , pp. 115-124
    • Whillier, S.1    Raftos, J.E.2    Chapman, B.3
  • 15
    • 79953277595 scopus 로고    scopus 로고
    • N-acetylcysteine prevents loss of dopaminergic neurons in the eaac1-1- mouse
    • Berman AE, Chan WY, Brennan AM, et al. N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-1- mouse. Ann Neurol 2011;69: 509-520.
    • (2011) Ann Neurol , vol.69 , pp. 509-520
    • Berman, A.E.1    Chan, W.Y.2    Brennan, A.M.3
  • 16
    • 84858998255 scopus 로고    scopus 로고
    • N-acetylcysteiene reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitroproprionic ace-induced huntington's disease
    • Sandhir R, Sood A, Mehrotra A, et al. N-acetylcysteiene reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitroproprionic ace-induced Huntington's disease. Neurodegenerative Dis 2012;9: 145-157
    • (2012) Neurodegenerative Dis , vol.9 , pp. 145-215
    • Sandhir, R.1    Sood, A.2    Mehrotra, A.3
  • 17
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of n-acetylcysteine for patients with probable alzheimer's disease
    • Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology 2001;57: 1515-1517.
    • (2001) Neurology , vol.57 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 18
    • 70349613203 scopus 로고    scopus 로고
    • In vivo 1h nmr spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4t vs. 7t
    • Tkáč I, Öz G, Adriany G, et al. In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T. Magn Reson Med 2009;62(4): 868-879.
    • (2009) Magn Reson Med , vol.62 , Issue.4 , pp. 868-879
    • Tkáč, I.1    Öz, G.2    Adriany, G.3
  • 19
    • 0342948677 scopus 로고    scopus 로고
    • Field mapping without reference scan using asymmetric echo-planar techniques
    • Gruetter R, Tkáč I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000;43(2): 319-323.
    • (2000) Magn Reson Med , vol.43 , Issue.2 , pp. 319-323
    • Gruetter, R.1    Tkáč, I.2
  • 20
    • 79952802465 scopus 로고    scopus 로고
    • Short-echo single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 t: Validation in the cerebellum and brainstem
    • Öz G, Tkáč I. Short-echo, single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: validation in the cerebellum and brainstem. Magn Reson Med 2011;65(4): 901-910.
    • (2011) Magn Reson Med , vol.65 , Issue.4 , pp. 901-910
    • Öz, G.1    Tkáč, I.2
  • 21
    • 0034959727 scopus 로고    scopus 로고
    • Automatic quantitation of localized in vivo 1h spectra with lcmodel
    • Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001;14(4): 260-264.
    • (2001) NMR Biomed , vol.14 , Issue.4 , pp. 260-264
    • Provencher, S.W.1
  • 22
    • 0034099574 scopus 로고    scopus 로고
    • Proton nmr chemical shifts and coupling constants for brain metabolites
    • Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 2000; 13(3): 129-153.
    • (2000) NMR Biomed , vol.13 , Issue.3 , pp. 129-153
    • Govindaraju, V.1    Young, K.2    Maudsley, A.A.3
  • 24
    • 0027936437 scopus 로고
    • Analysis of macromolecule resonances in 1h nmr spectra of human brain
    • Behar KL, Rothman DL, Spencer DD, et al. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med 1994;32(3): 294-302.
    • (1994) Magn Reson Med , vol.32 , Issue.3 , pp. 294-302
    • Behar, K.L.1    Rothman, D.L.2    Spencer, D.D.3
  • 26
    • 0025975953 scopus 로고
    • Quantitative assessment of cerebral blood volume by single-photon emission computed tomography
    • Sabatini U, Celsis P, Viallard G, et al. Quantitative assessment of cerebral blood volume by single-photon emission computed tomography. Stroke 1991;22(3): 324-330.
    • (1991) Stroke , vol.22 , Issue.3 , pp. 324-330
    • Sabatini, U.1    Celsis, P.2    Viallard, G.3
  • 27
    • 84856258883 scopus 로고    scopus 로고
    • Elevated pontine and putamenal gaba levels in mild-moderate parkinson disease detected by 7 tesla proton mrs
    • Emir UE, Tuite PJ, Öz G. Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 Tesla proton MRS. Plos One 2012;7(1): 1-8.
    • (2012) Plos One , vol.7 , Issue.1 , pp. 1-8
    • Emir, U.E.1    Tuite, P.J.2    Öz, G.3
  • 28
    • 32544449312 scopus 로고    scopus 로고
    • Proton mrs of the unilateral substantia nigra in the human brain at 4 tesla: Detection of high gaba concentrations
    • Öz G, Terpstra M, Tkáč I, et al. Proton MRS of the unilateral substantia nigra in the human brain at 4 Tesla: detection of high GABA concentrations. Magn Reson Med 2006;55(2): 296-301.
    • (2006) Magn Reson Med , vol.55 , Issue.2 , pp. 296-301
    • Öz, G.1    Terpstra, M.2    Tkáč, I.3
  • 29
    • 67650483697 scopus 로고    scopus 로고
    • N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebo-controlled study
    • Grant JE, Odlaug BL, Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry 2009;66(7): 756-763.
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.7 , pp. 756-763
    • Grant, J.E.1    Odlaug, B.L.2    Kim, S.W.3
  • 30
    • 0029903551 scopus 로고    scopus 로고
    • Treatment of four siblings with progressive myoclonus epilepsy of the unverricht-lundborg type with n-acetylcysteine
    • Hurd RW, Wilder BJ, Helveston WR, et al. Treatment of four siblings with progressive myoclonus epilepsy of the Unverricht-Lundborg type with N-acetylcysteine. Neurology 1996;47: 1264-1268.
    • (1996) Neurology , vol.47 , pp. 1264-1268
    • Hurd, R.W.1    Wilder, B.J.2    Helveston, W.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.