Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

Science

Volumn 342, Issue 6161, 2013, Pages 983-987

  Chung, Chee Yeun ^a   Khurana, Vikram ^a,b   Auluck, Pavan K ^a,b   Tardiff, Daniel F ^a   Mazzulli, Joseph R ^b   Soldner, Frank ^a   Baru, Valeriya ^a,c   Lou, Yali ^a,c   Freyzon, Yelena ^a   Cho, Sukhee ^c   Mungenast, Alison E ^c   Muffat, Julien ^a   Mitalipova, Maisam ^a   Pluth, Michael D ^c   Jui, Nathan T ^c   Schul̈e, Birgitt ^d   Lippard, Stephen J ^c   Tsai, Li Huei ^c   Krainc, Dimitri ^b   Buchwald, Stephen L ^c   Jaenisch, Rudolf ^a,c   Lindquist, Susan ^a,c   more..

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d PARKINSON S INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CARRIER PROTEIN; GLUCOSYLCERAMIDASE; NEUROSERPIN; NICASTRIN; PROTEIN NAB2; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE;

CYTOLOGY; MOLECULAR ANALYSIS; NEUROLOGY; PHENOTYPE; TOXICITY; YEAST;

ARTICLE; BRAIN NERVE CELL; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; NERVE CELL; NERVE DEGENERATION; NITRATION; NITROSATIVE STRESS; NONHUMAN; OXIDATION REDUCTION REACTION; PARKINSON DISEASE; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; MUTATION; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; RAT;

IPS;

ALPHA-SYNUCLEIN; ANIMALS; BENZIMIDAZOLES; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MUTATION; NEUROGENESIS; NEURONS; PARKINSON DISEASE; RATS;

EID: 84888070126     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1245296     Document Type: Article

References (28)

1. D. J. Irwin et al., Ann. Neurol. 72, 587-598 (2012).
2. P. J. Spira, D. M. Sharpe, G. Halliday, J. Cavanagh, G. A. Nicholson, Ann. Neurol. 49, 313-319 (2001).
3. K. Markopoulou et al., Acta Neuropathol. 116, 25-35 (2008).
4. F. Soldner et al., Cell 146, 318-331 (2011).
5. T. Saito et al., Cereb. Cortex 21, 588-596 (2011).
6. H. N. Nguyen et al., Cell Stem Cell 8, 267-280 (2011).
7. B. Byers et al., PLOS ONE 6, e26159 (2011).
8. O. Cooper et al., Sci. Transl. Med. 4, 141ra90 (2012).
9. A. D. Gitler et al., Nat. Genet. 41, 308-315 (2009).
10. T. F. Outeiro, S. Lindquist, Science 302, 1772-1775 (2003).
11. V. Khurana, S. Lindquist, Nat. Rev. Neurosci. 11, 436-449 (2010).
12. A. A. Cooper et al., Science 313, 324-328 (2006).
13. A. Sarver, J. DeRisi, Mol. Biol. Cell 16, 4781-4791 (2005).
14. B. I. Giasson et al., Science 290, 985-989 (2000).
15. E. Gómez-Tortosa et al., Acta Neuropathol. 103, 495-500 (2002).
16. P. R. Castello et al., Proc. Natl. Acad. Sci. U.S.A. 105, 8203-8208 (2008).
17. M. D. Pluth, E. Tomat, S. J. Lippard, Annu. Rev. Biochem. 80, 333-355 (2011).
18. P. T. Kotzbauer et al., Exp. Neurol. 187, 279-288 (2004).
19. E. Colla et al., J. Neurosci. 32, 3306-3320 (2012).
20. K. Tabuchi, G. Chen, T. C. Südhof, J. Shen, J. Neurosci. 29, 7290-7301 (2009).
21. R. N. Alcalay et al., Neurology 78, 1434-1440 (2012).
22. J. R. Mazzulli et al., Cell 146, 37-52 (2011).
23. M. Mitalipova et al., Stem Cells 21, 521-526 (2003).
24. D. F. Tardiff et al., Science 342, 979-983 (2013).
25. C. M. Haynes, S. Caldwell, A. A. Cooper, J. Cell Biol. 158, 91-102 (2002).
26. P. Donovan, P. Poronnik, Int. J. Biochem. Cell Biol. 45, 706-710 (2013).
27. A. C. Elden et al., Nature 466, 1069-1075 (2010).
28. S. Treusch et al., Science 334, 1241-1245 (2011).