Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

EMBO Journal

Volumn 31, Issue 21, 2012, Pages 4106-4123

  Area Gomez, Estela ^a   Del Carmen Lara Castillo, Maria ^a   Tambini, Marc D ^a   Guardia Laguarta, Cristina ^a   De Groof, Ad J C ^a,b,e   Madra, Moneek ^a   Ikenouchi, Junichi ^c   Umeda, Masato ^c   Bird, Thomas D ^d   Sturley, Stephen L ^a   Schon, Eric A ^a  

^a NewYork Presbyterian Hospital   (United States)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF WASHINGTON   (United States)

^e INTERVET INTERNATIONAL BV   (Netherlands)

Author keywords

APP; cholesterol; MAM; phospholipids; presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHOLESTEROL ESTER; GAMMA SECRETASE; PHOSPHOLIPID; PRESENILIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CALCIUM HOMEOSTASIS; CELL MUTANT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FAMILIAL DISEASE; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID RAFT; MITOCHONDRIA ASSOCIATED ENDOPLASMIC RETICULUM MEMBRANE; MOLECULAR INTERACTION; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; UPREGULATION;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM; FIBROBLASTS; HUMANS; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PRESENILIN-1; PRESENILIN-2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS;

EID: 84868524156     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.202     Document Type: Article

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