A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation

Science

Volumn 311, Issue 5763, 2006, Pages 1012-1017

  Shalizi, Aryaman ^a   Gaudillière, Brice ^a   Yuan, Zengqiang ^a   Stegmüller, Judith ^a   Shirogane, Takahiro ^a   Ge, Qingyuan ^b   Tan, Yi ^b   Schulman, Brenda ^c   Harper, J Wade ^a   Bonni, Azad ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CALCIUM; ENZYME INHIBITION; NEUROLOGY;

MEF2; POSTSYNAPTIC DIFFERENTIATION; SWITCH CONTROLS; SYNAPSE FORMATION;

ACETYLATION;

CALCINEURIN; LYSINE; MYOCYTE ENHANCER FACTOR 2; SERINE; SUMO PROTEIN;

BIOLOGY;

ACETYLATION; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CEREBELLUM CORTEX; CONTROLLED STUDY; DENDRITE; DEPHOSPHORYLATION; GRANULE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; SUMOYLATION; SYNAPTOGENESIS;

ACETYLATION; ANIMALS; CALCINEURIN; CALCIUM; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL LINE; CEREBELLAR CORTEX; DENDRITES; ELECTROPORATION; HUMANS; MORPHOGENESIS; MYOGENIC REGULATORY FACTORS; NEURONS; PHOSPHORYLATION; RATS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SYNAPSES; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 33144473786     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1122513     Document Type: Article

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25. We thank G. Gill and members of the Bonni laboratory for critical reading of the manuscript, C. Li for statistical advice, and S. DiBacco for technical assistance. Supported by NIH grants NS41021 (A.B.) and AG1108S (J.W.H.), and fellowships from the Albert J. Ryan Foundation (A.S. and B.C.), Lefler Foundation (Z.Y.), and Deutsche Forschungsgemeinschaft (J.S.). A.B. is the recipient of a fellowship from the Alfred P. Sloan Foundation, a Robert H. Ebert Clinical Scholar award from the Esther A. and Joseph Klingenstein Fund, an EJLB Foundation award, and a Sidney Kimmel Foundation award.