Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

British Journal of Pharmacology

Volumn 170, Issue 4, 2013, Pages 822-834

  Zhang, Hui ^a   Nakajima, Shotaro ^a   Kato, Hironori ^a   Gu, Liubao ^a,b   Yoshitomi, Tatsuya ^a   Nagai, Kaoru ^a   Shinmori, Hideyuki ^a   Kokubo, Susumu ^a   Kitamura, Masanori ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b BEIJING HOSPITAL   (China)

Author keywords

4 phenylbutyric acid; ATF6; chemical chaperone; endoplasmic reticulum (ER) stress; IRE1; PERK eIF2 ; unfolded protein response (UPR)

Indexed keywords

2 (2 NAPHATHYLOXY)ACETIC ACID; 2 (4 METHOXYPHENOXY)ACETIC ACID; 2 (4 NITROPHENOXY)ACETIC ACID; 4 PHENYLBUTYRIC ACID; 4 PHENYLBUTYRIC ACID DERIVATIVE; ACTIVATING TRANSCRIPTION FACTOR 6; BUTYRIC ACID DERIVATIVE; ERSE PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; PERK PROTEIN; PROTEIN IRE1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG; UPRE PROTEIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; RAT; RNA SPLICING; UNFOLDED PROTEIN RESPONSE;

4-PHENYLBUTYRIC ACID; ATF6; CHEMICAL CHAPERONE; ENDOPLASMIC RETICULUM (ER) STRESS; IRE1; PERK-EIF2Α; UNFOLDED PROTEIN RESPONSE (UPR);

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIM DOMAIN PROTEINS; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; NF-KAPPA B; PHENYLBUTYRATES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 84885106405     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12306     Document Type: Article

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