Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

Neuroscience

Volumn 277, Issue , 2014, Pages 132-138

  Jiang, H Q ^a   Ren, M ^b   Jiang, H Z ^a   Wang, J ^a   Zhang, J ^c   Yin, X ^a   Wang, S Y ^a   Qi, Y ^a   Wang, X D ^a   Feng, H L ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

ALS; ER stress; Guanabenz; Neurodegeneration; P eIF2

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALANINE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; G110; GLUCOSE REGULATED PROTEIN 78; GLYCINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANABENZ; INITIATION FACTOR 2ALPHA; INOSITOL OXYGENASE; INOSITOL REQUIRING ENZYME 1; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6ALPHA; PROTEIN IRE1; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FEMALE; IMMUNOHISTOCHEMISTRY; LIFESPAN; MITOCHONDRION; MOTOR DYSFUNCTION; MOTOR NERVE; MOTOR PERFORMANCE; MOUSE; MSOD1 MOUSE; NERVE DEGENERATION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ROTAROD TEST; SURVIVAL TIME; SYMPTOMATOLOGY; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; CELL DEATH; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; MOTONEURON; MOTOR ACTIVITY; ONSET AGE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SURVIVAL; TRANSGENIC MOUSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; DRUG EFFECT; LIFE EXTENSION; MALE; WEIGHT REDUCTION;

AGE OF ONSET; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; GUANABENZ; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR ACTIVITY; MOTOR NEURONS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS;

EID: 84904860146     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.03.047     Document Type: Article

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