Evidence for and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease

Journal of Alzheimer's Disease

Volumn 52, Issue 3, 2016, Pages 781-799

  Jayne, Tanya ^a   Newman, Morgan ^a   Verdile, Giuseppe ^b,c,d   Sutherland, Greg ^e   Münch, Gerald ^f   Musgrave, Ian ^a   Moussavi Nik, Seyyed Hani ^a   Lardelli, Michael ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CURTIN UNIVERSITY   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d HOLLYWOOD PRIVATE HOSPITAL   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Amyloid precursor protein secretases; familial Alzheimer's disease; gamma secretase; human APP protein; human PSEN1 protein; human PSEN2 protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN; PSEN1 PROTEIN, HUMAN; SECRETASE;

ALLELE; ALZHEIMER DISEASE; AUTOPHAGY; AUTOSOMAL DOMINANT INHERITANCE; BRAIN REGION; CELL POPULATION; ENZYME ACTIVITY; FAMILIAL ALZHEIMER DISEASE; FAMILIAL DISEASE; FRAMESHIFT MUTATION; GENE LOCUS; GENE MUTATION; HUMAN; HYDROPHOBICITY; MISSENSE MUTATION; NONHUMAN; OPEN READING FRAME; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; UNFOLDED PROTEIN RESPONSE; ANIMAL; GENETICS; METABOLISM; MUTATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; MUTATION; PRESENILIN-1;

EID: 84971574703     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-151186     Document Type: Review

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