Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Journal of Cell Biology

Volumn 198, Issue 1, 2012, Pages 23-35

  Coen, Katrijn ^a   Flannagan, Ronald S ^c   Baron, Szilvia ^b   Carraro Lacroix, Luciene R ^c   Wang, Dong ^d   Vermeire, Wendy ^a   Michiels, Christine ^a   Munck, Sebastian ^a   Baert, Veerle ^a   Sugita, Shuzo ^e   Wuytack, Frank ^b   Hiesinger, Peter Robin ^d   Grinstein, Sergio ^c   Annaert, Wim ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; PRESENILIN; PROTON PUMP; UNCLASSIFIED DRUG; VACUOLAR ATPASE;

ACIDIFICATION; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CALCIUM HOMEOSTASIS; CELL DESTRUCTION; CELL FRACTIONATION; CELL MIGRATION; DROSOPHILA MELANOGASTER; ELECTRORETINOGRAM; ENDOLYSOSOMAL DYSFUNCTION; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GLYCOSYLATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INBORN ERROR OF METABOLISM; LYSOSOME MEMBRANE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FIBROBLASTS; GLYCOSYLATION; HIPPOCAMPUS; HOMEOSTASIS; HUMANS; LYSOSOMES; MICE; MICE, KNOCKOUT; NEURONS; PRESENILIN-1; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84865086929     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201201076     Document Type: Article

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