Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

Journal of Neuroscience Research

Volumn 93, Issue 12, 2015, Pages 1778-1794

  Daulatzai, Mak Adam ^a  

^a The University of Melbourne   (Australia)

Author keywords

Abeta; Alzheimer's disease; Cognitive dysfunction; Hypoperfusion; Neuroinflammation; Obstructive sleep apnea; Tau hyperphosphorylation

Indexed keywords

GLUCOSE; TAU PROTEIN; AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; BRAIN ATROPHY; BRAIN HYPOXIA; BRAIN MITOCHONDRION; BRAIN PERFUSION; CLINICAL TRIAL (TOPIC); COGNITIVE DEFECT; ENDOTHELIAL DYSFUNCTION; GLUCOSE HOMEOSTASIS; GRAY MATTER; GRAY MATTER ATROPHY; HUMAN; HYPERTENSION; INFLAMMATION; NERVE DEGENERATION; NONHUMAN; OBESITY; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SLEEP DISORDERED BREATHING; UPREGULATION; WHITE MATTER; AGING; AMYLOID PLAQUE; COGNITION DISORDERS; COMPLICATION; METABOLISM; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLE; PATHOLOGY;

AGING; AMYLOID BETA-PEPTIDES; COGNITION DISORDERS; HUMANS; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; PLAQUE, AMYLOID; SLEEP APNEA, OBSTRUCTIVE;

EID: 84945493528     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23634     Document Type: Review

References (269)

1. Adams N, Strauss M, Schluchter M, Redline S. 2001. Relation of measures of sleep-disordered breathing to neuropsychological functioning. Am J Respir Crit Care Med 163:1626-1631.
2. Al Suwaidi J, Higano ST, Holmes DR Jr, Lennon R, Lerman A. 2001. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol 37:1523-1528.
3. Almendros I, Farré R, Planas AM, Torres M, Bonsignore MR, Navajas D, Montserrat JM. 2011. Tissue oxygenation in brain, muscle, and fat in a rat model of sleep apnea: differential effect of obstructive apneas and intermittent hypoxia. Sleep 34:1127-1133.
4. Ancoli-Israel S, Klauber MR, Butters N, Parker L, Kripke DF. 1991a. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 39:258-263.
5. Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. 1991b. Sleep-disordered breathing in community-dwelling elderly. Sleep 14:486-495.
6. Ancoli-Israel S, Kripke DF, Klauber MR, Parker L, Stepnowsky C, Kullen A, Fell R. 1993. Natural history of sleep-disordered breathing in community-dwelling elderly. Sleep 16:S25-S29.
7. Ancoli-Israel S, Klauber MR, Stepnowsky C, Estline E, Chinn A, Fell R. 1995. Sleep-disordered breathing in African-American elderly. Am J Respir Crit Care Med 152:1946-1949.
8. Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Liu L, Ayalon L, He F, Loredo JS. 2008. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc 56:2076-2081.
9. Anglade P, Vyas S, Hirsch EC, Agid Y. 1997. Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. Histol Histopathol 12:603-610.
10. Arnaud L, Robakis NK, Figueiredo-Pereira ME. 2006. It may take inflammation, phosphorylation, and ubiquitination to 'tangle' in Alzheimer's disease. Neurodegener Dis 3:313-319.
11. Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. 2005. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 172:1447-1451.
12. Atkeson A, Jelic S. 2008. Mechanisms of endothelial dysfunction in obstructive sleep apnea. Vasc Health Risk Manag 4:1327-1335.
13. Atkeson A, Yeh SY, Malhotra A, Jelic S. 2009. Endothelial function in obstructive sleep apnea. Prog Cardiovasc Dis 51:351-362.
14. Austin BP, Nair VA, Meier TB, Xu G, Rowley HA, Carlsson CM, Johnson SC, Prabhakaran V. 2011. Effects of hypoperfusion in Alzheimer's disease. J Alzheimers Dis 26:123-133.
15. Aviles-Reyes RX, Angelo MF, Villarreal A, Rios H, Lazarowski A, Ramos AJ. 2010. Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. J Neurochem 112:854-869.
16. Ayalon L, Ancoli-Israel S, Aka AA, McKenna BS, Drummond SP. 2009. Relationship between obstructive sleep apnea severity and brain activation during a sustained attention task. Sleep 32:373-381.
17. Badran M, Golbidi S, Devlin A, Ayas N, Laher I. 2014. Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity. Sleep Med 15:596-602.
18. BaHammam AS, Obeidat A, Barataman K, Bahammam SA, Olaish AH, Sharif MM. 2014. A comparison between the AASM 2012 and 2007 definitions for detecting hypopnea. Sleep Breath 18:767-773.
19. Bålfors EM1, Franklin KA. 1994. Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med 150:1587-1591.
20. Bayer J, Rune G, Schultz H, Tobia MJ, Mebes I, Katzler O, Sommer T. 2015. The effect of estrogen synthesis inhibition on hippocampal memory. Psychoneuroendocrinology 56:213-225.
21. Bazan NG, Palacios-Pelaez R, Lukiw WJ. 2002. Hypoxia signaling to genes: significance in Alzheimer's disease. Mol Neurobiol 26:283-298.
22. Beebe DW, Gozal D. 2002. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res 11:1-16.
23. Beebe D, Groesz L, Wells C, Nichols A, McGee K. 2003. The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep 26:298-307.
24. Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG. 2004. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 165:1643-1652.
25. Bouzid MA, Filaire E, McCall A, Fabre C. 2015. Radical oxygen species, exercise and aging: an update. Sports Med (E-pub ahead of print).
26. Breteler MM. 2000. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 21:153-160.
27. Briançon-Marjollet A, Weiszenstein M, Henri M, Thomas A, Godin-Ribuot D, Polak J. 2015. The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms. Diabetol Metab Syndr 7:25.
28. Büchner NJ, Quack I, Woznowski M, Stähle C, Wenzel U, Rump LC. 2011. Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration 82:409-417.
29. Caine D, Watson JD. 2000. Neuropsychological and neuropathological sequelae of cerebral anoxia: a critical review. J Int Neuropsychol Soc 6:86-99.
30. Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Alemanno F, Ferini-Strambi L. 2011. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 183:1419-1426.
31. Capone C, Faraco G, Peterson JR, Coleman C, Anrather J, Milner TA, Pickel VM, Davisson RL, Iadecola C. 2012. Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. J Neurosci 32:4878-4886.
32. Carlson JT, Rangemark C, Hedner JA. 1996. Attenuated endothelium-dependent vascular relaxation in patients with sleep apnoea. J Hypertens 14:577-584.
33. Carpagnano GE, Kharitonov SA, Resta O, Foschino-Barbaro MP, Gramiccioni E, Barnes PJ. 2002. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 122:1162-1167.
34. Carrillo MC, Blackwell A, Hampel H, Lindborg J, Sperling R, Schenk D, Sevigny JJ, Ferris S, Bennett DA, Craft S, Hsu T, Klunk W. 2009. Early risk assessment for Alzheimer's disease. Alzheimers Dement 5:182-196.
35. Cassar A, Morgenthaler TI, Rihal CS, Prasad A, Lennon RJ, Lerman LO, Lerman A. 2014. Coronary endothelial function in patients with obstructive sleep apnea. Coron Artery Dis 25:16-22.
36. Celle S, Annweiler C, Pichot V, Bartha R, Barthélémy JC, Roche F, Beauchet O. 2012. Association between ambulatory 24-hour blood pressure levels and brain volume reduction: a cross-sectional elderly population-based study. Hypertension 60:1324-1331.
37. Chan PH. 2005. Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Ann N Y Acad Sci 1042:203-209.
38. Chen HL, Lu CH, Lin HC, Chen PC, Chou KH, Lin WM, Tsai NW, Su YJ, Friedman M, Lin CP, Lin WC. 2015. White matter damage and systemic inflammation in obstructive sleep apnea. Sleep 38:361-370.
39. Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, Simon RP. 1998. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
40. Cheng B, Mattson MP. 1991. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron 7:1031-1041.
41. Cheng B, Mattson MP. 1992. Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF. Exp Neurol 117:114-123.
42. Chong MS, Ayalon L, Marler M, Loredo JS, Corey-Bloom J, Palmer BW, Liu L, Ancoli-Israel S. 2006. Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer's disease with sleep-disordered breathing. J Am Geriatr Soc 54:777-781.
43. Chouliaras L, Sierksma AS, Kenis G, Prickaerts J, Lemmens MA, Brasnjevic I, van Donkelaar EL, Martinez-Martinez P, Losen M, De Baets MH, Kholod N, van Leeuwen FW, Hof PR, van Os J, Steinbusch HW, van den Hove DL, Rutten BP. 2010. Gene-environment interaction research and transgenic mouse models of Alzheimer's disease. Int J Alzheimers Dis 2010. pii:859101.
44. Cohen-Zion M, Stepnowsky C, Marler p, Shochat T, Kripke DF, Ancoli-Israel S. 2001. Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc 49:1622-1627.
45. Cooke JR, Ayalon L, Palmer BW, Loredo JS, Corey-Bloom J, Natarajan L, Liu L, Ancoli-Israel S. 2009. Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary study. J Clin Sleep Med 5:305-309.
46. Copinschi G, Leproult R, Spiegel K. 2014. The important role of sleep in metabolism. Front Horm Res 42:59-72.
47. Corfield DR, Meadows GE. 2006. Control of cerebral blood flow during sleep and the effects of hypoxia. Adv Exp Med Biol 588:65-73.
48. Craft S. 2007. Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4:147-152.
49. Daffertshofer M, Hennerici M. 1995. Cerebrovascular regulation and vasoneuronal coupling. J Clin Ultrasound 23:125-138.
50. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K, Mowinckel P. 1994. Simultaneous assessment of vasoreactivity using transcranial Doppler ultrasound and cerebral blood flow in healthy subjects. J Cereb Blood Flow Metab 14:974-981.
51. Daulatzai MA. 2010. Early stages of pathogenesis in memory impairment during normal senescence and Alzheimer's disease. J Alzheimers Dis 20:355-367.
52. Daulatzai MA. 2012a. Neuroinflammation and dysfunctional nucleus tractus solitarius: their role in neuropathogenesis of Alzheimer's dementia. Neurochem Res 37:846-868.
53. Daulatzai MA. 2012b. Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease. Neurochem Res 37:2627-2658.
54. Daulatzai MA. 2013a. Death by a thousand cuts in Alzheimer's disease: hypoxia-the prodrome. Neurotox Res 24:216-243.
55. Daulatzai MA. 2013b. Neurotoxic saboteurs: straws that break the hippo's (hippocampus) back drive cognitive impairment and Alzheimer's disease. Neurotox Res 24:407-459.
56. Daulatzai MA. 2014. Obesity and gut's dysbiosis promote neuroinflammation, cognitive impairment, and vulnerability to Alzheimer's disease: new directions and therapeutic implications. J Mol Genet Med 2014:1-10.
57. Daulatzai MA 2015a. Nonceliac gluten sensitivity triggers gut dysbiosis, neuroinflammation, gut-brain axis dysfunction, and dementia. CNS Neurol Disord Drug Targets 14:110-131.
58. Daulatzai MA. 2015b. "Boomerang neuropathology" of late-onset Alzheimer's disease is shrouded in harmful "BDDS": breathing, diet, drinking, and sleep during aging. Neurotox Res 28:55-93.
59. Daulatzai MA. 2015c. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. J Neural Transm (E-pub ahead of print).
60. 2 after menopause in healthy women: effects of age and fitness. Respir Physiol Neurobiol 184:1-8.
61. De Caro R, Parenti A, Montisci M, Guidolin D, Macchi V. 2003. Symmetrical selective neuronal necrosis in solitary tract nuclei. Int J Legal Med 117:253-254.
62. De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL. 2007. Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282:11590-11601.
63. de la Monte SM, Neely TR, Cannon J, Wands JR. 2000. Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons. Cell Mol Life Sci 57:1471-1481.
64. Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS. 2010. Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol 298:C1594-C1602.
65. Drager LF, Jun JC, Vsevolod Y, Polotsky VY. 2010. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best Pract Res Clin Endocrinol Metab 24:843-851.
66. Drummond SP, Brown GG, Stricker JL, Buxton RB, Wong EC, Gillin JC. 1999. Sleep deprivation-induced reduction in cortical functional response to serial subtraction. Neuroreport 10:3745-3748.
67. Duranteau J, Chandel NS, Kulisz A, Shao Z, Schumacker PT. 1998. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J Biol Chem 273:11619-11624.
68. Durgan DJ, Crossland RF, Lloyd EE, Phillips SC, Bryan RM. 2015. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab 35:402-411.
69. Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. 2013. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med 188:996-1004.
70. Edwards BA, Wellman A, Sands SA, Owens RL, Eckert DJ, White DP, Malhotra A. 2014. Obstructive sleep apnea in older adults is a distinctly different physiological phenotype. Sleep 37:1227-1236.
71. Egashira N, Iwasaki K, Ishibashi M, Hatip-Al-Khatib I, Wolozin B, Mishima K, Irie K, Fujiwara M. 2002. Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neurons. Jpn J Pharmacol 90:321-327.
72. Ellen R, Marshall S, Palayew M, Molnar FJ, Wilson KG, Man-Son-Hing M. 2006. Systematic review of motor vehicle crash risk in persons with sleep apnea. J Clin Sleep Med 2:193-193.
73. Emerit J, Edeas M, Bricaire F. 2004. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58:39-46.
74. Fandakova Y, Lindenberger U, Shing YL. 2014. Deficits in process-specific prefrontal and hippocampal activations contribute to adult age differences in episodic memory interference. Cereb Cortex 24:1832-1844.
75. Fang H, Zhang LF, Meng FT, Du X, Zhou JN. 2010. Acute hypoxia promote the phosphorylation of tau via ERK pathway. Neurosci Lett 474:173-177.
76. Federal Interagency Forum on Aging Related Statistics. 2010. Older Americans 2012: key indicators of well-being. http://www.agingstats.gov
77. Feldstein CA. 2012. Association between chronic blood pressure changes and development of Alzheimer's disease. J Alzheimers Dis 32:753-763.
78. Ferini-Strambi L, Baietto C, Di Gioia M, Castaldi P, Castronovo C, Zucconi M, Cappa SF. 2003. Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Res Bull 61:87-92.
79. Fleminger S, Oliver D, Lovestone S, Rabe-Hesketh S, Giora A. 2003. Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74:857-862.
80. Fletcher EC. 2001. Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90:1600-1605.
81. Fletcher EC. 2003. Sympathetic over activity in the etiology of hypertension of obstructive sleep apnea. Sleep 26:15-19.
82. Floyd RA, Hensley K. 2002. Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23:795-807.
83. Folli F, Corradi D, Fanti P, Davalli A, Paez A, Giaccari A, Perego C, Muscogiuri G. 2011. The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 7:313-324.
84. Foster GE, Hanly PJ, Ostrowski M, Poulin MJ. 2007. Effects of continuous positive airway pressure on cerebral vascular response to hypoxia in patients with obstructive sleep apnea. Am J Respir Crit Care Med 175:720-725.
85. Foster GE, Brugniaux JV, Pialoux V, Duggan CT, Hanly PJ, Ahmed SB, Poulin MJ. 2009. Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans. J Physiol 587:3287-3299.
86. Foster GE, Hanly PJ, Ahmed SB, Beaudin AE, Pialoux V, Poulin MJ. 2010. Intermittent hypoxia increases arterial blood pressure in humans through a rennin-angiotensin system-dependent mechanism. Hypertension 56:369-377.
87. Friedman JE, Chow EJ, Haddad GG. 1998. State of actin filaments is changed by anoxia in cultured rat neocortical neurons. Neuroscience 82:421-427.
88. Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K. 2013. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice. Diabetologia 56:1403-1412.
89. Fung SJ, Xi M, Zhang J, Sampogna S, Chase MH. 2012. Apnea produces excitotoxic hippocampal synapses and neuronal apoptosis. Exp Neurol 238:107-113.
90. Furtner M, Staudacher M, Frauscher B, Brandauer E, Esnaola y Rojas MM, Gschliesser V, Poewe W, Schmidauer C, Ritsch-Marte M, Högl B. 2009. Cerebral vasoreactivity decreases overnight in severe obstructive sleep apnea syndrome: a study of cerebral hemodynamics. Sleep Med 10:875-881.
91. Gaig C, Iranzo A. 2012. Sleep-disordered breathing in neurodegenerative diseases. Curr Neurol Neurosci Rep 12:205-217.
92. Garvey JF, Pengo MF, Drakatos P, Kent BD. 2015. Epidemiological aspects of obstructive sleep apnea. J Thorac Dis 7:920-929.
93. Goedert M. 1993. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 16:460-465.
94. Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P, Caltagirone C, Cerroni G, Concari L, Cosentino FI, Ferrara S, Fermi S, Ferri R, Gelosa G, Lombardi G, Mazzei D, Mearelli S, Morrone E, Murri L, Nobili FM, Passero S, Perri R, Rocchi R, Sucapane P, Tognoni G, Zabberoni S, Sorbi S. 2012. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord 33:50-58.
95. Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M. 2009a. The upregulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. J Neurochem 108:1045-1056.
96. Guglielmotto M, Tamagno E, Danni O. 2009b. Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin. Sci World J 9:781-791.
97. Guilleminault C, Tilkian A, Dement WC. 1976. The sleep apnea syndromes. Annu Rev Med 27:465-484.
98. Halterman MW, Miller CC, Federoff HJ. 1999. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci 19:6818-6824.
99. Harper RM, Kumar R, Ogren JA, Macey PM. 2013. Sleep-disordered breathing: effects on brain structure and function. Respir Physiol Neurobiol 188:383-391.
100. Harsch IA, Hahn EG, Konturek PC. 2005. Insulin resistance and other metabolic aspects of the obstructive sleep apnea syndrome. Med Sci Monit 11:RA70-RA75.
101. Heinrich J, Spießhöfer J, Bitter T, Horstkotte D, Oldenburg O. 2015. Implications of revised AASM rules on scoring apneic and hypopneic respiratory events in patients with heart failure with nocturnal Cheyne-Stokes respiration. Sleep Breath 19:489-494.
102. Hla KM, Skatrud JB, Finn L, Palta M, Young T. 2002. The effect of correction of sleep-disordered breathing on BP in untreated hypertension. Chest 122:1125-1132.
103. Hoffmann M, Bybee K, Accurso V, Somers VK. 2004. Sleep apnea and hypertension. Minerva Med 95:281-290.
104. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA. 2002. Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med 165:950-953.
105. Innes CR, Kelly PT, Hlavac M, Melzer TR, Jones RD. 2015. Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep 38:699-706.
106. Ives SJ, Harris RA, Witman MA, Fjeldstad AS, Garten RS, McDaniel J, Wray DW, Richardson RS. 2014. Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance. Hypertension 63:459-467.
107. Jackson ML, Howard ME, Barnes M. 2011. Cognition and daytime functioning in sleep-related breathing disorders. Prog Brain Res 190:53-68.
108. Jagielski AC, Jiang CQ, Xu L, Taheri S, Zhang WS, Cheng KK, Lam TH, Thomas GN. 2014. Glycaemia is associated with cognitive impairment in older adults: the Guangzhou Biobank Cohort Study. Age Ageing 44:65-71
109. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. 2008. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3×Tg-AD mice. Am J Pathol 173:1768-1782.
110. Janssens JP, Pautex S, Hilleret H, Michel JP. 2000. Sleep disordered breathing in the elderly. Aging 12:417-429.
111. Jaworski T, Lechat B, Demedts D, Gielis L, Devijver H, Borghgraef P, Duimel H, Verheyen F, Kügler S, Van Leuven F. 2011. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Am J Pathol 179:2001-2015.
112. Jendroska K, Poewe W, Daniel SE, Pluess J, Iwerssen-Schmidt H, Paulsen J, Barthel S, Schelosky L, Cervós-Navarro J, DeArmond SJ. 1995. Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain. Acta Neuropathol 90:461-466.
113. Joo EY, Tae WS, Lee MJ, Kang JW, Park HS, Lee JY, Suh M, Hong SB. 2010. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep 33:235-241.
114. Jun J, Polotsky VY. 2009. Metabolic consequences of sleep-disordered breathing. ILAR J 50:289-306.
115. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, Somers VK. 2000. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 102:2607-2610
116. Kelley BJ, Petersen RC. 2007. Alzheimer's disease and mild cognitive impairment. Neurol Clin 25:577-609.
117. Kiernan TE, Capampangan DJ, Hickey MG, Pearce LA, Aguilar MI. 2011. Sleep apnea and white matter disease in hypertensive patients: a case series. Neurologist 17:289-291.
118. Kim H, Yun CH, Thomas RJ, Lee SH, Seo HS, Cho ER, Lee SK, Yoon DW, Suh S, Shin C. 2013. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep 36:709B-715B.
119. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. 2005. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25:8843-8853.
120. Kljajevic V, Grothe MJ, Ewers M, Teipel S. 2014. Distinct pattern of hypometabolism and atrophy in preclinical and predementia Alzheimer's disease. Neurobiol Aging 35:1973-1981.
121. Kobayashi J, Ohtake K, Uchida H. 2015. NO-rich diet for lifestyle-related diseases. Nutrients 7:4911-4937.
122. Kokmen E, Whisnant JP, O'Fallon WM, Chu CP, Beard CM. 1996. Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984). Neurology 46:154-159.
123. Kumar R, Chavez AS, Macey PM, Woo MA, Yan-Go FL, Harper RM. 2012. Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea. J Neurosci Res 90:2043-2052.
124. Kumar R, Pham TT, Macey PM, Woo MA, Yan-Go FL, Harper RM. 2014. Abnormal myelin and axonal integrity in recently diagnosed patients with obstructive sleep apnea. Sleep 37:723-732.
125. Langbaum JB, Chen K, Launer LJ, Fleisher AS, Lee W, Liu X, Protas HD, Reeder SA, Bandy D, Yu M, Caselli RJ, Reiman EM. 2012. Blood pressure is associated with higher brain amyloid burden and lower glucose metabolism in healthy late middle-age persons. Neurobiol Aging 33:827.e11-e19.
126. Lattanzi S, Luzzi S, Provinciali L, Silvestrini M. 2015. Blood pressure variability in Alzheimer's disease and frontotemporal dementia: the effect on the rate of cognitive decline. J Alzheimers Dis 45:387-394.
127. Lau EY, Eskes GA, Morrison DL, Rajda M, Spurr KF. 2010. Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure. J Int Neuropsychol Soc 16:1077-1088.
128. Lavie L. 2005. Sleep-disordered breathing and cerebrovascular disease: a mechanistic approach. Neurol Clin 23:1059-1075.
129. Lavie L, Vishnevsky A, Lavie P. 2004. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 27:123-128.
130. Lee CW, Shih YS, Wu SY, Yang T, Lin C, Kuo YM. 2013. Hypoglycemia induces tau hyperphosphorylation. Curr Alzheimer Res 10:298-308.
131. Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. 2010. LPS-induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflammation 7:56.
132. Lee M, McGeer E, McGeer PL. 2015. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiol Aging 36:42-52.
133. Lee VMY, Goedert M, Trojanowski JQ. 2001. Neurodegenerative tauopathies. Annu Rev Neurosci 24:1121-1159.
134. Leuenberger UA, Brubaker D, Quraishi S, Hogeman CS, Imadojemu VA, Gray KS. 2005. Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans. Auton Neurosci 121:87-93.
135. Li L, Zhang X, Yang D, Luo G, Chen S, Le W. 2009. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 30:1091-1098.
136. Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y. 2004. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A 101:3632-3637.
137. Liak C, Fitzpatrick M. 2011. Coagulability in obstructive sleep apnea. Can Respir J 18:338-348.
138. Lüdemann P, Dziewas R, Sörös P, Happe S, Frese A. 2001. Axonal polyneuropathy in obstructive sleep apnoea. J Neurol Neurosurg Psychiatry 70:685-687.
139. Lurie A. 2011a. Metabolic disorders associated with obstructive sleep apnea in adults. Adv Cardiol 46:67-138.
140. Lurie A. 2011b. Endothelial dysfunction in adults with obstructive sleep apnea. Adv Cardiol 46:139-170.
141. Macey KE, Macey PM, Woo MA, Henderson LA, Frysinger RC, Harper RK, Alger JR, Yan-Go F, Harper RM. 2006. Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea. Respir Physiol Neurobiol 151:44-60.
142. Macey PM, Kumar R, Woo MA, Henderson LA, Frysinger RC, Harper RK, Alger JR, Yan-Go F, Harper RM. 2008. Brain structural changes in obstructive sleep apnea. Sleep 31:967-977.
143. Maillet D, Rajah MN. 2013. Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: a review. Ageing Res Rev 12:479-489.
144. Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. 2006. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med 119:72 e9-e14.
145. Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP. 2013. Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. Nat Neurosci 16:357-364.
146. Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP. 2014. Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults. Cereb Cortex 24:3301-3309.
147. Maricić L, Vceva A, Visević R, Vcev A, Milić M, Serić V, Fijacko V. 2013. Assessment of endothelial dysfunction by measuring von Willebrand factor and exhaled nitric oxide in patients with chronic obstructive pulmonary disease. Coll Antropol 37:1153-1160.
148. Mattson MP, Engle MG, Rychlik B. 1991. Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons. Mol Chem Neuropathol 15:117-142.
149. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR Jr, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW. 2014. Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain 137:1550-1561.
150. McCurry SM, Ancoli-Israel S. 2003. Sleep dysfunction in Alzheimer's disease and other dementias. Curr Treat Options Neurol 5:261-272.
151. McDermott CM, LaHoste GJ, Chen C, Musto A, Bazan NG, Magee JC. 2003. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci 23:9687-9695.
152. McKay LC, Evans KC, Frackowiak RS, Corfield DR. 2003. Neural correlates of voluntary breathing in humans. J Appl Physiol 95:1170-1178.
153. McNicholas WT, Bonsigore MR. 2007. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms, and research priorities. Eur Respir J 29:156-178.
154. Medeiros CA, de Bruin VM, Andrade GM, Coutinho WM, de Castro-Silva C, de Bruin PF. 2012. Obstructive sleep apnea and biomarkers of inflammation in ischemic stroke. Acta Neurol Scand 126:17-22.
155. Mehra R, Stone KL, Blackwell T, Ancoli Israel S, Dam TT, Stefanick ML, Redline S. 2007. Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study. J Am Geriatr Soc 55:1356-1364.
156. Montesi SB, Edwards BA, Malhotra A, Bakker JP. 2012. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med 8:587-596.
157. Montezano AC, Touyz RM. 2012. Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: a basic science update for the clinician. Can J Cardiol 28:288-295.
158. Montplaisir J, Bedard MA, Richer F, Rouleau I. 1992. Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure. Sleep 15:S17-S19.
159. Morgenthaler T, Kagramanov V, Hanak V, Decker PA. 2006. Complex sleep apnea syndrome: is it a unique clinical syndrome? Sleep 29:1203-1209.
160. Moro L, Pedone C, Scarlata S, Malafarina V, Fimognari F, Antonelli-Incalzi R. 2008. Endothelial dysfunction in chronic obstructive pulmonary disease. Angiology 59:357-364.
161. Moroney JT, Bagiella E, Desmond DW, Paik MC, Stern Y, Tatemichi TK. 1996. Risk factors for incident dementia after stroke. Role of hypoxic and ischemic disorders. Stroke 27:1283-1289.
162. Morrell MJ, Twigg G. 2006. Neural consequences of sleep disordered breathing: the role of intermittent hypoxia. Adv Exp Med Biol 588:75-88.
163. Morrell MJ, Finn L, Kim H, Peppard PE, Badr MS, Young T. 2000. Sleep fragmentation, awake blood pressure, and sleep-disordered breathing in a population-based study. Am J Respir Crit Care Med 162:2091-2096.
164. Mugnai G. 2010. [Pathophysiological links between obstructive sleep apnea syndrome and metabolic syndrome]. G Ital Cardiol 1:453-459.
165. Muller M, van der Graaf Y, Visseren FL, Mali WP, Geerlings MI. 2012. Hypertension and longitudinal changes in cerebral blood flow: the SMART-MR study. Ann Neurol 71:825-833.
166. Nadeem R, Molnar J, Madbouly EM, Nida M, Aggarwal S, Sajid H, Naseem J, Loomba R. 2013. Serum inflammatory markers in obstructive sleep apnea: a meta-analysis. J Clin Sleep Med 9:1003-1012.
167. Nägga K, Wattmo C, Zhang Y, Wahlund LO, Palmqvist S. 2014. Cerebral inflammation is an underlying mechanism of early death in Alzheimer's disease: a 13-year cause-specific multivariate mortality study. Alzheimers Res Ther 6:41.
168. Narkiewicz K, Somers VK. 1997. The sympathetic nervous system and obstructive sleep apnea: implications for hypertension. J Hypertens 15:1613-1619.
169. Narkiewicz K, Somers VK. 2003. Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand 177:385-390.
170. Neumann KF, Rojo L, Navarrete LP, Farías G, Reyes P, Maccioni RB. 2008. Insulin resistance and Alzheimer's disease: molecular links and clinical implications. Curr Alzheimer Res 5:438-447.
171. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG. 2000. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283:1829-1836.
172. Nilsson JP, Söderström M, Karlsson AU, Lekander M, Akerstedt T, Lindroth NE, Axelsson J. 2005. Less effective executive functioning after one night's sleep deprivation. J Sleep Res 14:1-6.
173. Nixon GM, Hyde M, Biggs SN, Walter LM, Horne RS, Davey MJ. 2014. The impact of recent changes to the respiratory scoring rules in pediatrics. J Clin Sleep Med 10:1217-1221.
174. Ogunshola OO, Antoniou X. 2009. Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? Cell Mol Life Sci 66:3555-3563.
175. Osorio RS, Gumb T, Pirraglia E, Varga AW, Lu SE, Lim J, Wohlleber ME, Ducca EL, Koushyk V, Glodzik L, Mosconi L, Ayappa I, Rapoport DM, de Leon MJ. 2015. Sleep-disordered breathing advances cognitive decline in the elderly. Neurology 84:1964-1971.
176. Pace-Schott EF, Spencer RM. 2015. Sleep-dependent memory consolidation in healthy aging and mild cognitive impairment. Curr Top Behav Neurosci 25:307-330.
177. Pack AI, Pien GW. 2011. Update on sleep and its disorders. Annu Rev Med 62:447-460.
178. Pallayova M, Steele KE, Magnuson TH, Schweitzer MA, Hill NR, Bevans-Fonti S, Schwartz AR. 2010. Sleep apnea predicts distinct alterations in glucose homeostasis and biomarkers in obese adults with normal and impaired glucose metabolism. Cardiovasc Diabetol 9:83.
179. Pan W, Kastin AJ. 2014. Can sleep apnea cause Alzheimer's disease? Neurosci Biobehav Rev 47:656-69.
180. Parenti A, Macchi V, Snenghi R, Porzionato A, Scaravilli T, Ferrara SD, De Caro R. 2005. Selective stroke of the solitary tract nuclei in two cases of central sleep apnoea. Clin Neuropathol 24:239-246.
181. Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, Rood JC, Burk DH, Smith SR. 2009. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58:718-725.
182. Passaro A, Dalla Nora E, Morieri ML, Soavi C, Sanz JM, Zurlo A, Fellin R, Zuliani G. 2015. Brain-derived neurotrophic factor plasma levels: relationship with dementia and diabetes in the elderly population. J Gerontol A Biol Sci Med Sci 70:294-302.
183. Patel AR, Kowlessar BS, Donaldson GC, Mackay AJ, Singh R, George SN, Garcha DS, Wedzicha JA, Hurst JR. 2013. Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 188:1091-1099.
184. Peppard PE, Young T, Palta M, Skatrud J. 2000. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378-1384.
185. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. 2013. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177:1006-1014.
186. Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. 2010. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30:14946-14954.
187. Placidi F, Diomedi M, Cupini LM, Bernardi G, Silvestrini M. 1998. Impairment of daytime cerebrovascular reactivity in patients with obstructive sleep apnoea syndrome. J Sleep Res 7:288-292.
188. Posner HB, Tang MX, Luchsinger J, Lantigua R, Stern Y, Mayeux R. 2002. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 58:1175-81.
189. Pulsinelli WA, Brierley JB, Plum F. 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498.
190. Qi JP, Wu H, Yang Y, Wang DD, Chen YX, Gu YH, Liu T. 2007. Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus. J Alzheimers Dis 12:335-341.
191. Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. 2008. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes 32:451-463.
192. Redline S, Strauss ME, Adams N, Winters M, Roebuck T, Spry K, Rosenberg C, Adams K. 1997. Neuropsychological function in mild sleep-disordered breathing. Sleep 20:160-167.
193. Redman LM, Scroop GC, Norman RJ. 2003. Impact of menstrual cycle phase on the exercise status of young, sedentary women. Eur J Appl Physiol 90:505-513.
194. Resta O, Bonfitto P, Sabato R, De Pergola G, Barbaro MP. 2004. Prevalence of obstructive sleep apnoea in a sample of obese women: effect of menopause. Diabetes Nutr Metab 17:296-303.
195. Reutrakul S, Van Cauter E. 2014. Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes. Ann N Y Acad Sci 1311:151-173.
196. Revesz T, Geddes JF. 1988. Symmetrical columnar necrosis of the basal ganglia and brain stem in an adult following cardiac arrest. Clin Neuropathol 6:294-298.
197. Row BW. 2007. Intermittent hypoxia and cognitive function: implications from chronic animal models. Adv Exp Med Biol 618:51-67.
198. Row BW, Liu R, Xu W, Kheirandish L, Gozal D. 2003. Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am J Respir Crit Care Med 167:1548-1553.
199. Row BW, Kheirandish L, Cheng Y, Rowell PP, Gozal D. 2007. Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep. Behav Brain Res 177:308-314.
200. Ryan CM, Bradley TD. 2005. Pathogenesis of obstructive sleep apnea. J Appl Physiol 99:2440-2450.
201. Ryan S, Nolan GM, Hannigan E, Cunningham S, Taylor C, McNicholas WT. 2007. Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity. Thorax 62:509-514.
202. Ryan S, Taylor CT, McNicholas WT. 2009. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 64:631-636.
203. Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T. 2004. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res 29:1257-1266.
204. Sassani A, Findley L, Kryger M, Goldlust E, George C, Davidson TM. 2004. Reducing motor-vehicle collisions, costs, and fatalities by treating obstructive sleep apnea syndrome. Sleep 27:453-458.
205. 2+. FEBS J 272:3593-3601.
206. Schröder C, O'Hara R. 2004. Depression and obstructive sleep apnea (OSA). Ann Gen Psychiatry 4:13.
207. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lücke C, Mayer K, Olschewski H, Seeger W, Grimminger F. 2000. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea-response to CPAP therapy. Thorax 55:1046-1051.
208. Seetho IW, Wilding JP. 2014. Sleep-disordered breathing, type 2 diabetes, and the metabolic syndrome. Chron Respir Dis 11:257-275.
209. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476-483.
210. Sforza E, Roche F. 2012. Sleep apnea syndrome and cognition. Front Neurol 3:87.
211. Shahar E. 2014. Apnea-hypopnea index: time to wake up. Nat Sci Sleep 6:51-56.
212. Sims NR, Anderson MF. 2002. Mitochondrial contributions to tissue damage in stroke. Neurochem Int 40:511-512.
213. Sivanandam TM, Thakur MK. 2012. Traumatic brain injury: a risk factor for Alzheimer's disease. Neurosci Biobehav Rev 36:1376-1381.
214. Smith SM, Friedle SA, Watters JJ. 2013. Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression. PLoS One 8:e81584.
215. Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL. 2015. High prevalence of obstructive sleep apnea in patients with moderate to severe COPD. Ann Am Thorac Soc (E-pub ahead of print).
216. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. 2008. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118:1080-1111.
217. Sparks DL. 1997. Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann N Y Acad Sci 826:128-146.
218. Sparks DL, Scheff SW, Liu H, Landers TM, Coyne CM, Hunsaker JC 3rd. 1995. Increased incidence of neurofibrillary tangles (NFT) in nondemented individuals with hypertension. J Neurol Sci 131:162-169.
219. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. 2005. Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol 99:2008-2019.
220. Sroriz-Filho J, Sá-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves ML, Moriguti JC, Roriz-Cruz M. 2009. (Pre) diabetes, brain aging, and cognition. Biochim Biophys Acta 1792:432-443.
221. Steiropoulos P, Papanas N, Nena E, Tsara V, Fitili C, Tzouvelekis A, Christaki P, Maltezos E, Bouros D. 2009. Markers of glycemic control and insulin resistance in nondiabetic patients with obstructive sleep apnea hypopnea syndrome: does adherence to CPAP treatment improve glycemic control? Sleep Med 10:887-891.
222. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. 1997. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 94:13287-13292.
223. Su JH, Cummings BJ, Cotman CW. 1996. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 739:79-87.
224. Sun MK, Xu H, Alkon DL. 2002. Pharmacological protection of synaptic function, spatial learning, and memory from transient hypoxia in rats. J Pharmacol Exp Ther 300:408D-416D.
225. Sun X, Tong Y, Qing H, Chen CH, Song W. 2006a. Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J 20:1361-1368.
226. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, Song W. 2006b. Hypoxia facilitates Alzheimer's disease pathogenesis by upregulating BACE1 gene expression. Proc Natl Acad Sci U S A 103:18727-18732.
227. 18F]-FEPPA. Mol Psychiatry (E-pub ahead of print).
228. Swerdlow RH. 2007. Pathogenesis of Alzheimer's disease. Clin Interv Aging 2:347-359.
229. Swomley AM, Butterfield DA. 2015. Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics. Arch Toxicol (E-pub ahead of print).
230. Tadavarty R, Kaan TK, Sastry BR. 2009. Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep deprivation. Exp Neurol 216:239-242.
231. Taddei S, Bruno RM. 2015. Endothelial dysfunction in hypertension: implications for treatment. J Hypertens 33:1137-1138.
232. Tamagno E, Guglielmotto M, Monteleone D, Tabaton M. 2012. Amyloid-β production: major link between oxidative stress and BACE1. Neurotox Res 22:208-219.
233. Tang EH, Vanhoutte PM. 2010. Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch 459:995-1004.
234. Thornton AT, Singh P, Ruehland WR, Rochford PD. 2012. AASM criteria for scoring respiratory events: interaction between apnea sensor and hypopnea definition. Sleep 35:425-432.
235. Tian M, Zhu D, Xie W, Shi J. 2012. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett 586:3737-3745.
236. Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR. 2011. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage 54:787-793.
237. Torres AG, Fabani MM, Vigorito E, Gait MJ. 2011. MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection. RNA 17:933-943.
238. Urbano F, Roux F, Schindler J, Mohsenin V. 2008. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol 105:1852-1857.
239. van den Borst B, Gosker HR, Wesseling G, de Jager W, Hellwig VA, Snepvangers FJ, Schols AM. 2011. Low-grade adipose tissue inflammation in patients with mild-to-moderate chronic obstructive pulmonary disease. Am J Clin Nutr 94:1504-1512.
240. Vecchierini MF. 2010. [Sleep disturbances in Alzheimer's disease and other dementias]. Psychol Neuropsychiatr Vieil 8:15-23.
241. Ward NR, Roldao V, Cowie MR, Rosen SD, McDonagh TA, Simonds AK, Morrell MJ. 2013. The effect of respiratory scoring on the diagnosis and classification of sleep disordered breathing in chronic heart failure. Sleep 36:1341-1348.
242. Wellman A, Eckert DJ, Jordan AS, Edwards BA, Passaglia CL, Jackson AC, Gautam S, Owens RL, Malhotra A, White DP. 2011. A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol 110:1627-1637.
243. Wes PD, Easton A, Corradi J, Barten DM, Devidze N, DeCarr LB, Truong A, He A, Barrezueta NX, Polson C, Bourin C, Flynn ME, Keenan S, Lidge R, Meredith J, Natale J, Sankaranarayanan S, Cadelina GW, Albright CF, Cacace AM. 2014. Tau overexpression impacts neuroinflammation gene expression network perturbed in Alzheimer's disease. PLoS One 9:e106050.
244. Wessendorf TE, Thilmann AF, Wang YM, Schreiber A, Konietzko N, Teschler H. 2000. Fibrinogen levels and obstructive sleep apnea in ischemic stroke. Am J Respir Crit Care Med 162:2039-2042.
245. White DP. 2005. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med 172:1363-1370.
246. Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. 2011. Intraneuronal APP, not free Aβ peptides in 3×Tg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. J Neurosci 31:7691-7699.
247. Wirths O, Breyhan H, Marcello A, Cotel MC, Brück W, Bayer TA. 2010. Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol Aging 31:747-757.
248. Wong S, Flanagan E, Savage G, Hodges JR, Hornberger M. 2014. Contrasting prefrontal cortex contributions to episodic memory dysfunction in behavioural variant frontotemporal dementia and Alzheimer's disease. PLoS One 9:e87778.
249. Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. 2011. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306:613-619.
250. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. 2005. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353:2034-2041.
251. Yang Q, Underwood MJ, Hsin MK, Liu XC, He GW. 2008. Dysfunction of pulmonary vascular endothelium in chronic obstructive pulmonary disease: basic considerations for future drug development. Curr Drug Metab 9:661-667.
252. Yao L, Kan EM, Lu J, Hao A, Dheen ST, Kaur C, Ling EA. 2013. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation 10:23.
253. Yaouhi K, Bertran F, Clochon P, Mézenge F, Denise P, Foret J, Eustache F, Desgranges B. 2009. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res 18:36-48.
254. Yardim-Akaydin S, Caliskan-Can E, Firat H, Ardic S, Simsek B. 2014. Influence of gender on C-reactive protein, fibrinogen, and erythrocyte sedimentation rate in obstructive sleep apnea. Antiinflamm Antiallergy Agents Med Chem 13:56-63.
255. Yokoe T, Alonso LC, Romano LC, Rosa TC, O-Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP. 2008. Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol 586:899-911.
256. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. 1993. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230-1235.
257. Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, Walsleben JA, Finn L, Enright P, Samet JM. 2002. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 162:893-900.
258. Yuan X, Guo X, Deng Y, Zhu D, Shang J, Liu H. 2015. Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses. Brain Res 1596:48-57.
259. Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, Klann E, Veasey SC. 2005. NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med 172:921-929.
260. Zhang F, Yin W, Chen J. 2004. Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms. Neurol Res 26:835-845.
261. Zhang J, Veasey S. 2012. Making sense of oxidative stress in obstructive sleep apnea: mediator or distracter? Front Neurol 3:179.
262. Zhang JH, Fung SJ, Xi M, Sampogna S, Chase MH. 2010. Apnea produces neuronal degeneration in the pons and medulla of guinea pigs. Neurobiol Dis 40:251-264.
263. Zhang X, Le W. 2010. Pathological role of hypoxia in Alzheimer's disease. Exp Neurol 223:299-303.
264. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW. 2007. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem 282:10873-10880.
265. Zhao K, Ippolito G, Wang L, Price V, Kim MH, Cornwell G, Fulenchek S, Breen GA, Goux WJ, D'Mello SR. 2010. Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. J Neurosci Res 88:3399-3413.
266. Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G, Veasey SC. 2007. Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. J Neurosci 27:10060-10071.
267. Zizi F, Jean-Louis G, Brown CD, Ogedegbe G, Boutin-Foster C, McFarlane SI. 2010. Sleep duration and the risk of diabetes mellitus: epidemiologic evidence and pathophysiologic insights. Curr Diab Rep 10:43-47.
268. Zlokovic BV. 2011. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12:723-738.
269. Zoccal DB, Bonagamba LG, Oliveira FR, Antunes-Rodrigues J, Machado BH. 2007. Increased sympathetic activity in rats submitted to chronic intermittent hypoxia. Exp Physiol 92:79-85.