Familial frontotemporal dementia-associated Presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice

Journal of Neuroscience

Volumn 32, Issue 15, 2012, Pages 5085-5096

  Watanabe, Hirotaka ^a   Xia, Dan ^a   Kanekiyo, Takahisa ^b   Kelleher, Raymond J ^a,c   Shen, Jie ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MESSENGER RNA; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTOLOGY; MAZE TEST; MEMORY DISORDER; MOUSE; NEOCORTEX; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; SPATIAL MEMORY; WESTERN BLOTTING;

ALLELES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; CYCLOHEXIMIDE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FRONTOTEMPORAL DEMENTIA; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MUTATION; PRESENILIN-1; PROTEIN SYNTHESIS INHIBITORS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TAU PROTEINS;

EID: 84859520482     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0317-12.2012     Document Type: Article

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