Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse

Journal of Neuroscience

Volumn 17, Issue 18, 1997, Pages 7053-7059

  Irizarry, Michael C ^a   Soriano, Ferdie ^b   McNamara, Megan ^a   Page, Keith J ^a   Schenk, Dale ^b   Games, Dora ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Athena Neurosciences Inc   (United States)

Author keywords

Alzheimer's disease; Amyloid; Amyloid precursor protein; Cingulate cortex; Entorhinal cortex; Glial fibrillary acidic protein; Hippocampus; Microtubule associated protein 2; Neuritic dystrophy; Synaptophysin; Sytochrome oxidase; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYTOCHROME C OXIDASE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; SYNAPTOPHYSIN; PLATELET DERIVED GROWTH FACTOR;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CINGULATE GYRUS; CONTROLLED STUDY; ENTORHINAL CORTEX; GENE OVEREXPRESSION; GLIOSIS; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NEURITE; NEUROPATHY; NEUROPIL; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; STEREOLOGY; TRANSGENIC MOUSE; AGING; ANIMAL; APOPTOSIS; ASTROCYTE; BRAIN; C57BL MOUSE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; PROMOTER REGION; TRANSGENE; UPREGULATION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PLATELET-DERIVED GROWTH FACTOR; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANSGENES; UP-REGULATION;

EID: 0030611097     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-18-07053.1997     Document Type: Article

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