An atomic structure of human γ-secretase

Nature

Volumn 525, Issue 7568, 2015, Pages 212-217

  Bai, Xiao Chen ^a   Yan, Chuangye ^b   Yang, Guanghui ^b   Lu, Peilong ^b   Ma, Dan ^b   Sun, Linfeng ^b   Zhou, Rui ^b   Scheres, Sjors H W ^a   Shi, Yigong ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; NICASTRIN; PHOSPHOLIPID; PRESENILIN 1; MEMBRANE PROTEIN; NICASTRIN PROTEIN; PROTEIN SUBUNIT; SECRETASE;

ELECTRON MICROSCOPY; ENZYME ACTIVITY; LIPID; MENTAL HEALTH; MUTATION; PLASTIC; PROTEIN;

ALPHA HELIX; ALZHEIMER DISEASE; ARTICLE; ATOM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; EXTRACELLULAR SPACE; HUMAN; MUTATION; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN SUBUNIT; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; CRYOELECTRON MICROSCOPY; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTATION; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS;

EID: 84941254172     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14892     Document Type: Article

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