Trans-dominant negative effects of pathogenic PSEN1 mutations on-secretase activity and Aβ production

Journal of Neuroscience

Volumn 33, Issue 28, 2013, Pages 11606-11617

  Heilig, Elizabeth A ^a   Gutti, Usha ^a   Tai, Tara ^a   Shen, Jie ^b   Kelleher III, Raymond J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; PRESENILIN 1;

ALLELE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DOMINANT GENE; EMBRYO; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE MUTATION; GENETIC HETEROGENEITY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PSEN1 GENE; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; GENES, DOMINANT; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1;

EID: 84880442012     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0954-13.2013     Document Type: Article

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