APP intracellular domain derived from amyloidogenic β-and ?-secretase cleavage regulates neprilysin expression

Frontiers in Aging Neuroscience

Volumn 7, Issue APR, 2015, Pages

  Grimm, Marcus O W ^a,b   Mett, Janine ^a   Stahlmann, Christoph P ^a   Grösgen, Sven ^a   Haupenthal, Viola J ^a   Blümel, Tamara ^a   Hundsdörfer, Benjamin ^a   Zimmer, Valerie C ^a   Mylonas, Nadine T ^a   Tanila, Heikki ^c,d   Müller, Ulrike ^e   Grimm, Heike S ^a   Hartmann, Tobias ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b Deutsches Institut für DemenzPrävention DIDP Sarland University   (Germany)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

AICD; Alzheimer's disease; APP intracellular domain; A degradation; Gene regulation; Neprilysin

Indexed keywords

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; MEMBRANE METALLOENDOPEPTIDASE; PROTEIN FE65; PROTEIN PRECURSOR; RNA;

AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYST; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE CONTROL; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INVESTIGATIVE PROCEDURES; MOUSE; NONHUMAN; PLASMID; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

EID: 84928790134     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00077     Document Type: Article

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