Nuclear translocation uncovers the amyloid peptide aβ42 as a regulator of gene transcription

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20182-20191

  Barucker, Christian ^a,b   Harmeier, Anja ^a,f   Weiske, Joerg ^c,g   Fauler, Beatrix ^d   Albring, Kai Frederik ^c,e   Prokop, Stefan ^c   Hildebrand, Peter ^c   Lurz, Rudi ^d   Heppner, Frank L ^c   Huber, Otmar ^c,e   Multhaup, Gerhard ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^e JENA UNIVERSITY HOSPITAL   (Germany)

^f F HOFFMANN LA ROCHE LTD   (Switzerland)

^g BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; MAMMALS; NEURODEGENERATIVE DISEASES; PEPTIDES; SCANNING ELECTRON MICROSCOPY;

AMYLOID PRECURSOR PROTEINS; AMYLOID-BETA PEPTIDES; BIOCHEMICAL ANALYSIS; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL LASER SCANNING MICROSCOPY; INTRACELLULAR DOMAIN; NEUROBLASTOMA CELLS; NUCLEAR TRANSLOCATIONS;

TRANSCRIPTION;

AMINO ACID; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BIOTIN; MESSENGER RNA; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL CULTURE; CELL NUCLEUS; CHEMICAL ANALYSIS; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL LASER MICROSCOPY; GENE CONTROL; GENETIC TRANSCRIPTION; IMMUNODETECTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; REGULATOR GENE; REPRESSOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID Β42 TOXICITY; AMYLOID Β42-CHROMATIN INTERACTION; CHROMATIN IMMUNOPRECIPITATION (CHIP); GENE REGULATION; NUCLEAR AMYLOID Β PEPTIDES; RNA;

ACTIVE TRANSPORT, CELL NUCLEUS; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEURONS; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; RNA, MESSENGER; STATIC ELECTRICITY;

EID: 84904497399     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.564690     Document Type: Article

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