Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

European Journal of Neuroscience

Volumn 37, Issue 12, 2013, Pages 1962-1969

  Deng, Yu ^a   Wang, Zhe ^a   Wang, Ruitao ^a   Zhang, Xiaozhu ^a   Zhang, Shuting ^a   Wu, Yili ^a   Staufenbiel, Matthias ^b   Cai, Fang ^a   Song, Weihong ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

A ; APP; BACE1; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; GAMMA SECRETASE; PROTEIN ASP1; PROTEIN GLU11; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; ETHNIC GROUP; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTATIONAL ANALYSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SENILE PLAQUE; SIGNAL TRANSDUCTION; SWEDISH; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELLS, CULTURED; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC;

EID: 84879218180     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12235     Document Type: Article

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