Presenilin-1 knockin mice reveal loss-of-function mechanism for familial alzheimer's disease

Neuron

Volumn 85, Issue 5, 2015, Pages 967-981

  Xia, Dan ^a   Watanabe, Hirotaka ^a   Wu, Bei ^a   Lee, Sang Hun ^a   Li, Yan ^a   Tsvetkov, Evgeny ^a   Bolshakov, Vadim Y ^a   Shen, Jie ^a   Kelleher, Raymond J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; AMYLOID BETA PROTEIN; PRESENILIN 1, MOUSE;

ADULT; ALLELE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; CONTROLLED STUDY; GENETIC VARIABILITY; HETEROZYGOSITY; HIPPOCAMPUS; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MALE; MEMORY; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PSEN 1 GENE; SIGNAL TRANSDUCTION; 129 MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; GENE TARGETING; GENETICS; HUMAN; METABOLISM; MUTATION; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CEREBRAL CORTEX; GENE KNOCK-IN TECHNIQUES; HIPPOCAMPUS; HUMANS; MALE; MEMORY DISORDERS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROGENESIS; ORGAN CULTURE TECHNIQUES; PRESENILIN-1;

EID: 84924262484     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.02.010     Document Type: Article

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