-
1
-
-
34249851328
-
IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways
-
DOI 10.1074/jbc.M611183200
-
Adlerz L, Holback S, Multhaup G, Iverfeldt K (2007) IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways. J Biol Chem 282:10203-10209 (Pubitemid 47093446)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.14
, pp. 10203-10209
-
-
Adlerz, L.1
Holback, S.2
Multhaup, G.3
Iverfeldt, K.4
-
2
-
-
33750151420
-
The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins
-
DOI 10.1159/000095262
-
Anliker B, Muller U (2006) The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins. Neurodegener Dis 3:239-246 (Pubitemid 44600310)
-
(2006)
Neurodegenerative Diseases
, vol.3
, Issue.4-5
, pp. 239-246
-
-
Anliker, B.1
Muller, U.2
-
3
-
-
0026318496
-
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture
-
Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J (1991) Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochem Biophys Res Commun 181:265-271
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 265-271
-
-
Araki, W.1
Kitaguchi, N.2
Tokushima, Y.3
Ishii, K.4
Aratake, H.5
Shimohama, S.6
Nakamura, S.7
Kimura, J.8
-
4
-
-
0037423289
-
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
-
DOI 10.1074/jbc.M211598200
-
Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (2003) Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 278:3897-3902 (Pubitemid 36801120)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.6
, pp. 3897-3902
-
-
Barthwal, M.K.1
Sathyanarayana, P.2
Kundu, C.N.3
Rana, B.4
Pradeep, A.5
Sharma, C.6
Woodgett, J.R.7
Rana, A.8
-
5
-
-
79959939343
-
BAG3 and friends: Co-chaperones in selective autophagy during aging and disease
-
Behl C (2011) BAG3 and friends: co-chaperones in selective autophagy during aging and disease. Autophagy 7:795-798
-
(2011)
Autophagy
, vol.7
, pp. 795-798
-
-
Behl, C.1
-
6
-
-
78650669822
-
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase dependent pathway
-
Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ (2010) The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase dependent pathway. J Biol Chem 285:41443-41454
-
(2010)
J Biol Chem
, vol.285
, pp. 41443-41454
-
-
Belyaev, N.D.1
Kellett, K.A.2
Beckett, C.3
Makova, N.Z.4
Revett, T.J.5
Nalivaeva, N.N.6
Hooper, N.M.7
Turner, A.J.8
-
7
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in alzheimer's disease
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28:6926-6937
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
8
-
-
4944259359
-
2+ entry in cortical neurons
-
DOI 10.1111/j.1460-9568.2004.03680.x
-
Bouron A, Mbebi C, Loeffler JP, De Waard M (2004) The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons. Eur J Neurosci 20:2071-2078 (Pubitemid 39331127)
-
(2004)
European Journal of Neuroscience
, vol.20
, Issue.8
, pp. 2071-2078
-
-
Bouron, A.1
Mbebi, C.2
Loeffler, J.-P.3
De Waard, M.4
-
9
-
-
0028114869
-
Reduction of neurological damage bye peptide segment of the amyloid β/A4 protein precursor in a rabbit spinal cord ischemia model
-
DOI 10.1006/exnr.1994.1152
-
Bowes MP, Masliah E, Otero DA, Zivin JA, Saitoh T (1994) Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model. Exp Neurol 129:112-119 (Pubitemid 24344162)
-
(1994)
Experimental Neurology
, vol.129
, Issue.1
, pp. 112-119
-
-
Bowes, M.P.1
Masliah, E.2
Otero, D.A.C.3
Zivin, J.A.4
Saitoh, T.5
-
11
-
-
1842843366
-
Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway
-
DOI 10.1016/S0169-328X(02)00519-3, PII S0169328X02005193
-
Burton TR, Dibrov A, Kashour T, Amara FM (2002) Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway. Brain Res Mol Brain Res 108:102-120 (Pubitemid 35447968)
-
(2002)
Molecular Brain Research
, vol.108
, Issue.1-2
, pp. 102-120
-
-
Burton, T.R.1
Dibrov, A.2
Kashour, T.3
Amara, F.M.4
-
12
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid β deposition in sporadic alzheimer's disease and down syndrome: Differential effects of APOE genotype and presenilin mutations
-
Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157:277-286 (Pubitemid 30641743)
-
(2000)
American Journal of Pathology
, vol.157
, Issue.1
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
13
-
-
0036285116
-
Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein
-
DOI 10.1006/exnr.2002.7920
-
Cheng G, Yu Z, Zhou D, Mattson MP (2002) Phosphatidylinositol-3-kinase- Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp Neurol 175:407-414 (Pubitemid 34634294)
-
(2002)
Experimental Neurology
, vol.175
, Issue.2
, pp. 407-414
-
-
Cheng, G.1
Yu, Z.2
Zhou, D.3
Mattson, M.P.4
-
14
-
-
77953958809
-
SAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress
-
Copanaki E, Chang S, Vlachos A, Tschape JA, Muller UC, Kogel D, Deller T (2010) sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci 44:386-393
-
(2010)
Mol Cell Neurosci
, vol.44
, pp. 386-393
-
-
Copanaki, E.1
Chang, S.2
Vlachos, A.3
Tschape, J.A.4
Muller, U.C.5
Kogel, D.6
Deller, T.7
-
15
-
-
79951946382
-
The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains
-
Corrigan F, Pham CL, Vink R, Blumbergs PC, Masters CL, van den Heuvel C, Cappai R (2011) The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. Brain Res 1378:137-143
-
(2011)
Brain Res
, vol.1378
, pp. 137-143
-
-
Corrigan, F.1
Pham, C.L.2
Vink, R.3
Blumbergs, P.C.4
Masters, C.L.5
Van Den Heuvel, C.6
Cappai, R.7
-
16
-
-
78649777075
-
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing
-
Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Muller WE, Kogel D (2011) Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. Biochim Biophys Acta 1808:236-243
-
(2011)
Biochim Biophys Acta
, vol.1808
, pp. 236-243
-
-
Eckert, G.P.1
Chang, S.2
Eckmann, J.3
Copanaki, E.4
Hagl, S.5
Hener, U.6
Muller, W.E.7
Kogel, D.8
-
17
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
-
DOI 10.1083/jcb.200207113
-
Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160:113-123 (Pubitemid 36091721)
-
(2003)
Journal of Cell Biology
, vol.160
, Issue.1
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
18
-
-
79960930836
-
The role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins
-
[Epub ahead of print]
-
Endres K, Fahrenholz F (2011) The role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins. Curr Alzheimer Res [Epub ahead of print]
-
(2011)
Curr Alzheimer Res
-
-
Endres, K.1
Fahrenholz, F.2
-
19
-
-
10644290831
-
Intracellularly generated amyloid-β peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells
-
DOI 10.1111/j.1471-4159.2004.02816.x
-
Esposito L, Gan L, Yu GQ, Essrich C, Mucke L (2004) Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J Neurochem 91:1260-1274 (Pubitemid 39658553)
-
(2004)
Journal of Neurochemistry
, vol.91
, Issue.6
, pp. 1260-1274
-
-
Esposito, L.1
Gan, L.2
Yu, G.-Q.3
Essrich, C.4
Mucke, L.5
-
20
-
-
34548688657
-
Alpha-secretase as a therapeutic target
-
DOI 10.2174/156720507781788837
-
Fahrenholz F (2007) Alpha-secretase as a therapeutic target. Curr Alzheimer Res 4:412-417 (Pubitemid 47416634)
-
(2007)
Current Alzheimer Research
, vol.4
, Issue.4
, pp. 412-417
-
-
Fahrenholz, F.1
-
21
-
-
65249105453
-
Selective vulnerability in alzheimer's disease: Amyloid precursor protein and p75(NTR) interaction
-
Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE (2009) Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol 65:294-303
-
(2009)
Ann Neurol
, vol.65
, pp. 294-303
-
-
Fombonne, J.1
Rabizadeh, S.2
Banwait, S.3
Mehlen, P.4
Bredesen, D.E.5
-
22
-
-
0031905682
-
Secreted amyloid precursor protein a selectively suppresses N-methyl-D- aspartate currents in hippocampal neurons: Involvement of cyclic GMP
-
DOI 10.1016/S0306-4522(97)00398-9, PII S0306452297003989
-
Furukawa K, Mattson MP (1998) Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. Neurosci-ence 83:429-438 (Pubitemid 28062633)
-
(1998)
Neuroscience
, vol.83
, Issue.2
, pp. 429-438
-
-
Furukawa, K.1
Mattson, M.P.2
-
23
-
-
0030068094
-
+ channels and suppression of neuronal activity by secreted β-amyloid-precursor protein
-
DOI 10.1038/379074a0
-
Furukawa K, Barger SW, Blalock EM, Mattson MP (1996) Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379:74-78 (Pubitemid 26008138)
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 74-78
-
-
Furukawa, K.1
Barger, S.W.2
Blalock, E.M.3
Mattson, M.P.4
-
24
-
-
65449117176
-
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
-
Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009) Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J 28:889-901
-
(2009)
EMBO J
, vol.28
, pp. 889-901
-
-
Gamerdinger, M.1
Hajieva, P.2
Kaya, A.M.3
Wolfrum, U.4
Hartl, F.U.5
Behl, C.6
-
25
-
-
70350370474
-
Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
-
Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U (2009) Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J Cell Sci 122:3703-3714
-
(2009)
J Cell Sci
, vol.122
, pp. 3703-3714
-
-
Goodger, Z.V.1
Rajendran, L.2
Trutzel, A.3
Kohli, B.M.4
Nitsch, R.M.5
Konietzko, U.6
-
26
-
-
0028169905
-
Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
-
Goodman Y, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128:1-12
-
(1994)
Exp Neurol
, vol.128
, pp. 1-12
-
-
Goodman, Y.1
Mattson, M.P.2
-
27
-
-
67649366042
-
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers
-
Gralle M, Botelho MG, Wouters FS (2009) Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem 284:15016-15025
-
(2009)
J Biol Chem
, vol.284
, pp. 15016-15025
-
-
Gralle, M.1
Botelho, M.G.2
Wouters, F.S.3
-
28
-
-
0042733013
-
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production
-
DOI 10.1074/jbc.M304122200
-
Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM (2003) Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem 278:31261-31268 (Pubitemid 36994643)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 31261-31268
-
-
Grbovic, O.M.1
Mathews, P.M.2
Jiang, Y.3
Schmidt, S.D.4
Dinakar, R.5
Summers-Terio, N.B.6
Ceresa, B.P.7
Nixon, R.A.8
Cataldo, A.M.9
-
29
-
-
0028980795
-
Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase
-
Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS (1995) Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett 198:52-56
-
(1995)
Neurosci Lett
, vol.198
, pp. 52-56
-
-
Greenberg, S.M.1
Qiu, W.Q.2
Selkoe, D.J.3
Ben-Itzhak, A.4
Kosik, K.S.5
-
30
-
-
0032524319
-
Secreted β-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-κB and stabilization of calcium homeostasis
-
DOI 10.1074/jbc.273.20.12341
-
Guo Q, Robinson N, Mattson MP (1998) Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J Biol Chem 273:12341-12351 (Pubitemid 28240603)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.20
, pp. 12341-12351
-
-
Guo, Q.1
Robinson, N.2
Mattson, M.P.3
-
32
-
-
30744472172
-
Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: A novel excitoprotective mechanism involving modulation of tau phosphorylation
-
DOI 10.1523/JNEUROSCI.3831-05.2005
-
Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF (2005) Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci 25:11542-11552 (Pubitemid 43098447)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.50
, pp. 11542-11552
-
-
Han, P.1
Dou, F.2
Li, F.3
Zhang, X.4
Zhang, Y.-W.5
Zheng, H.6
Lipton, S.A.7
Xu, H.8
Liao, F.-F.9
-
33
-
-
0034329291
-
Mice with combined gene knockouts reveal essential and partially redundant functions of amyloid precursor protein family members
-
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U (2000) Mice with combined gene knockouts reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci 20:7951-7963
-
(2000)
J Neurosci
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
Herms, J.2
Gajic, V.3
Hainfellner, J.4
Aguzzi, A.5
Rulicke, T.6
Von Kretzschmar, H.7
Von Koch, C.8
Sisodia, S.9
Tremml, P.10
Lipp, H.P.11
Wolfer, D.P.12
Muller, U.13
-
34
-
-
8144230876
-
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
-
DOI 10.1038/sj.emboj.7600390
-
Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Muller U (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J 23:4106-4115 (Pubitemid 39472431)
-
(2004)
EMBO Journal
, vol.23
, Issue.20
, pp. 4106-4115
-
-
Herms, J.1
Anliker, B.2
Heber, S.3
Ring, S.4
Fuhrmann, M.5
Kretzschmar, H.6
Sisodia, S.7
Muller, U.8
-
35
-
-
79959196089
-
Determination of the proteolytic cleavage sites of the amyloid precursorlike protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
-
Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF (2011) Determination of the proteolytic cleavage sites of the amyloid precursorlike protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS One 6:e21337
-
(2011)
PLoS One
, vol.6
-
-
Hogl, S.1
Kuhn, P.H.2
Colombo, A.3
Lichtenthaler, S.F.4
-
36
-
-
34247349579
-
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching
-
DOI 10.1016/j.mcn.2007.02.003, PII S1044743107000280
-
Ikin AF, Sabo SL, Lanier LM, Buxbaum JD (2007) A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching. Mol Cell Neurosci 35:57-63 (Pubitemid 46636301)
-
(2007)
Molecular and Cellular Neuroscience
, vol.35
, Issue.1
, pp. 57-63
-
-
Ikin, A.F.1
Sabo, S.L.2
Lanier, L.M.3
Buxbaum, J.D.4
-
37
-
-
0038603918
-
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1
-
DOI 10.1074/jbc.M212160200
-
Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N (2003) A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278:22946-22955 (Pubitemid 36830359)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.25
, pp. 22946-22955
-
-
Inomata, H.1
Nakamura, Y.2
Hayakawa, A.3
Takata, H.4
Suzuki, T.5
Miyazawa, K.6
Kitamura, N.7
-
38
-
-
67650383731
-
Amyloid precursor protein and its homologues: A family of proteolysis-dependent receptors
-
Jacobsen KT, Iverfeldt K (2009) Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors. Cell Mol Life Sci 66:2299-2318
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2299-2318
-
-
Jacobsen, K.T.1
Iverfeldt, K.2
-
39
-
-
79956320988
-
Age-dependent accumulation of soluble amyloid beta (A{beta}) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-{alpha} (sAPP{alpha}) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3{beta} pathway in alzheimer mouse model
-
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J (2011) Age-dependent accumulation of soluble amyloid beta (A{beta}) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-{alpha} (sAPP{alpha}) by modulating phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3{beta} pathway in Alzheimer mouse model. J Biol Chem 286:18414-18425
-
(2011)
J Biol Chem
, vol.286
, pp. 18414-18425
-
-
Jimenez, S.1
Torres, M.2
Vizuete, M.3
Sanchez-Varo, R.4
Sanchez-Mejias, E.5
Trujillo-Estrada, L.6
Carmona-Cuenca, I.7
Caballero, C.8
Ruano, D.9
Gutierrez, A.10
Vitorica, J.11
-
40
-
-
83755199395
-
The amyloid precursor protein and its homologues: Structural and functional aspects of native and pathogenic oligomerization
-
[Epub ahead of print]
-
Kaden D, Munter LM, Reif B, Multhaup G (2011) The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization. Eur J Cell Biol [Epub ahead of print]
-
(2011)
Eur J Cell Biol
-
-
Kaden, D.1
Munter, L.M.2
Reif, B.3
Multhaup, G.4
-
41
-
-
69949107465
-
The unsolved relationship of brain aging and lateonset alzheimer disease
-
Kern A, Behl C (2009) The unsolved relationship of brain aging and lateonset Alzheimer disease. Biochim Biophys Acta 1790:1124-1132
-
(2009)
Biochim Biophys Acta
, vol.1790
, pp. 1124-1132
-
-
Kern, A.1
Behl, C.2
-
42
-
-
33646383889
-
Down-regulation of endogenous amyloid precursor protein processing due to cellular aging
-
DOI 10.1074/jbc.M505625200
-
Kern A, Roempp B, Prager K, Walter J, Behl C (2006) Downregulation of endogenous amyloid precursor protein processing due to cellular aging. J Biol Chem 281:2405-2413 (Pubitemid 43845700)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.5
, pp. 2405-2413
-
-
Kern, A.1
Roempp, B.2
Prager, K.3
Walter, J.4
Behl, C.5
-
43
-
-
66549104205
-
Bridging physiology and pathology in AD
-
Kim D, Tsai LH (2009) Bridging physiology and pathology in AD. Cell 137:997-1000
-
(2009)
Cell
, vol.137
, pp. 997-1000
-
-
Kim, D.1
Tsai, L.H.2
-
44
-
-
33845324145
-
C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression
-
Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, Suh YH (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. Faseb J 17: 1951-1953
-
(2003)
Faseb J
, vol.17
, pp. 1951-1953
-
-
Kim, H.S.1
Kim, E.M.2
Lee, J.P.3
Park, C.H.4
Kim, S.5
Seo, J.H.6
Chang, K.A.7
Yu, E.8
Jeong, S.J.9
Chong, Y.H.10
Suh, Y.H.11
-
45
-
-
0037047434
-
The γ secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells
-
DOI 10.1074/jbc.M203372200
-
Kinoshita A, Whelan CM, Berezovska O, Hyman BT (2002) The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem 277:28530-28536 (Pubitemid 41079279)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.32
, pp. 28530-28536
-
-
Kinoshita, A.1
Whelan, C.M.2
Berezovska, O.3
Hyman, B.T.4
-
46
-
-
0141531088
-
The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis
-
DOI 10.1046/j.1471-4159.2003.02000.x
-
Kögel D, Schomburg R, Schürmann T, Reimertz C, König HG, Poppe M, Eckert A, Müller WE, Prehn JH (2003) The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis. J Neurochem 87:248-256 (Pubitemid 37210658)
-
(2003)
Journal of Neurochemistry
, vol.87
, Issue.1
, pp. 248-256
-
-
Kogel, D.1
Schomburg, R.2
Schurmann, T.3
Reimertz, C.4
Konig, H.-G.5
Poppe, M.6
Eckert, A.7
Muller, W.E.8
Prehn, J.H.M.9
-
47
-
-
11844251260
-
Regulation of gene expression by the amyloid precursor protein: Inhibition of the JNK/c-Jun pathway
-
DOI 10.1038/sj.cdd.4401495
-
Kögel D, Schomburg R, Copanaki E, Prehn JH (2005) Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death Differ 12:1-9 (Pubitemid 40090023)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.1
, pp. 1-9
-
-
Kogel, D.1
Schomburg, R.2
Copanaki, E.3
Prehn, J.H.M.4
-
48
-
-
84655176843
-
The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis
-
[Epub ahead of print]
-
Kögel D, Concannon CG, Müller T, König H, Bonner C, Poeschel S, Chang S, Egensperger R, Prehn JH (2011) The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis. Neurobiol Aging [Epub ahead of print]
-
(2011)
Neurobiol Aging
-
-
Kögel, D.1
Concannon, C.G.2
Müller, T.3
König, H.4
Bonner, C.5
Poeschel, S.6
Chang, S.7
Egensperger, R.8
Prehn, J.H.9
-
49
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
DOI 10.1038/nrn960
-
LaFerla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 3:862-872 (Pubitemid 135706704)
-
(2002)
Nature Reviews Neuroscience
, vol.3
, Issue.11
, pp. 862-872
-
-
LaFerla, F.M.1
-
50
-
-
28644449284
-
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
-
DOI 10.1038/sj.emboj.7600757, PII 7600757
-
Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA (2005) Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24:2944-2955 (Pubitemid 43079897)
-
(2005)
EMBO Journal
, vol.24
, Issue.16
, pp. 2944-2955
-
-
Leyssen, M.1
Ayaz, D.2
Hebert, S.S.3
Reeve, S.4
De Strooper, B.5
Hassan, B.A.6
-
51
-
-
0029954239
-
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells
-
DOI 10.1073/pnas.93.12.6158
-
Li ZW, Stark G, Gotz J, Rulicke T, Gschwind M, Huber G, Muller U, Weissmann C (1996) Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proc Natl Acad Sci USA 93:6158-6162 (Pubitemid 26190820)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.12
, pp. 6158-6162
-
-
Li, Z.-W.1
Stark, G.2
Gotz, J.3
Rulicke, T.4
Muller, U.5
Weissmann, C.6
-
52
-
-
0035282739
-
Characterization of the neurotrophic interaction between nerve growth factor and secreted α-amyloid precursor protein
-
DOI 10.1002/1097-4547(20010 301)63:5<410::AID-J NR1036>3.0.CO;2-B
-
Luo JJ, Wallace MS, Hawver DB, Kusiak JW, Wallace WC (2001) Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein. J Neurosci Res 63:410-420 (Pubitemid 32183790)
-
(2001)
Journal of Neuroscience Research
, vol.63
, Issue.5
, pp. 410-420
-
-
Luo, J.-J.1
Wallace, M.S.2
Hawver, D.B.3
Kusiak, J.W.4
Wallace, W.C.5
-
53
-
-
0030969297
-
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo
-
DOI 10.1016/S0306-4522(96)00553-2, PII S0306452296005532
-
Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L (1997) Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78:135-146 (Pubitemid 27132591)
-
(1997)
Neuroscience
, vol.78
, Issue.1
, pp. 135-146
-
-
Masliah, E.1
Westland, C.E.2
Rockenstein, E.M.3
Abraham, C.R.4
Mallory, M.5
Veinberg, I.6
Sheldon, E.7
Mucke, L.8
-
54
-
-
0035449943
-
C-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK
-
Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21:6597-6607 (Pubitemid 32781104)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.17
, pp. 6597-6607
-
-
Matsuda, S.1
Yasukawa, T.2
Homma, Y.3
Ito, Y.4
Niikura, T.5
Hiraki, T.6
Hirai, S.7
Ohno, S.8
Kita, Y.9
Kawasumi, M.10
Kouyama, K.11
Yamamoto, T.12
Kyriakis, J.M.13
Nishimoto, I.14
-
55
-
-
0030779677
-
Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
-
Mattson MP (1997) Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77: 1081-1132 (Pubitemid 27459580)
-
(1997)
Physiological Reviews
, vol.77
, Issue.4
, pp. 1081-1132
-
-
Mattson, M.P.1
-
56
-
-
0032424264
-
Signaling events regulating the neurodevelopmental triad glutamate and secreted forms of β-amyloid precursor protein as examples
-
Mattson MP, Furukawa K (1998) Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples. Persp Dev Neurobiol 5:337-352 (Pubitemid 29156518)
-
(1998)
Perspectives on Developmental Neurobiology
, vol.5
, Issue.4
, pp. 337-352
-
-
Mattson, M.P.1
Furukawa, K.2
-
57
-
-
0027478347
-
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
-
DOI 10.1016/0896-6273(93)90315-I
-
Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10:243-254 (Pubitemid 23079546)
-
(1993)
Neuron
, vol.10
, Issue.2
, pp. 243-254
-
-
Mattson, M.P.1
Cheng, B.2
Culwell, A.R.3
Esch, F.S.4
Lieberburg, I.5
Rydel, R.E.6
-
58
-
-
0030612106
-
Distruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom
-
DOI 10.1021/tx9601317
-
Mattson MP, Mark RJ, Furukawa K, Bruce AJ (1997) Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom. Chem Res Toxicol 10:507-517 (Pubitemid 27217206)
-
(1997)
Chemical Research in Toxicology
, vol.10
, Issue.5
, pp. 507-517
-
-
Mattson, M.P.1
Mark, R.J.2
Furukawa, K.3
Bruce, A.J.4
-
59
-
-
0037036463
-
Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway
-
DOI 10.1074/jbc.M107948200
-
Mbebi C, See V, Mercken L, Pradier L, Muller U, Loeffler JP (2002) Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmod-ulin protein kinase IV-dependent signaling pathway. J Biol Chem 277:20979-20990 (Pubitemid 34967409)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.23
, pp. 20979-20990
-
-
Mbebi, C.1
See, V.2
Mercken, L.3
Pradier, L.4
Muller, U.5
Loeffler, J.-P.6
-
60
-
-
0028329090
-
The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis
-
DOI 10.1006/dbio.1994.1055
-
Moya KL, Benowitz LI, Schneider GE, Allinquant B (1994) The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. Dev Biol 161:597-603 (Pubitemid 24077425)
-
(1994)
Developmental Biology
, vol.161
, Issue.2
, pp. 597-603
-
-
Moya, K.L.1
Benowitz, L.I.2
Schneider, G.E.3
Allinquant, B.4
-
62
-
-
0028018919
-
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
-
Müller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C (1994) Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79:755-765
-
(1994)
Cell
, vol.79
, pp. 755-765
-
-
Müller, U.1
Cristina, N.2
Li, Z.W.3
Wolfer, D.P.4
Lipp, H.P.5
Rulicke, T.6
Brandner, S.7
Aguzzi, A.8
Weissmann, C.9
-
63
-
-
48349085043
-
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for alzheimer's disease
-
Müller T, Meyer HE, Egensperger R, Marcus K (2008) The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol 85:393-406
-
(2008)
Prog Neurobiol
, vol.85
, pp. 393-406
-
-
Müller, T.1
Meyer, H.E.2
Egensperger, R.3
Marcus, K.4
-
64
-
-
0031770501
-
Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus
-
Murakami N, Yamaki T, Iwamoto Y, Sakakibara T, Kobori N, Fushiki S, Ueda S (1998) Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. J Neurotrauma 15:993-1003 (Pubitemid 28530210)
-
(1998)
Journal of Neurotrauma
, vol.15
, Issue.11
, pp. 993-1003
-
-
Murakami, N.1
Yamaki, T.2
Iwamoto, Y.3
Sakakibara, T.4
Kobori, N.5
Fushiki, S.6
Ueda, S.7
-
65
-
-
51349120462
-
The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis
-
Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H (2008) The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis. Neurosci Lett 444:127-131
-
(2008)
Neurosci Lett
, vol.444
, pp. 127-131
-
-
Nakayama, K.1
Ohkawara, T.2
Hiratochi, M.3
Koh, C.S.4
Nagase, H.5
-
66
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.3
Tessier-Lavigne, M.4
-
67
-
-
0027209083
-
Release of amyloid β-protein precursor derivatives by electrical depolarization of rat hippocampal slices
-
Nitsch RM, Farber SA, Growdon JH, Wurtman RJ (1993) Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc Natl Acad Sci USA 90:5191-5193 (Pubitemid 23183003)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.11
, pp. 5191-5193
-
-
Nitsch, R.M.1
Farber, S.A.2
Growdon, J.H.3
Wurtman, R.J.4
-
68
-
-
34250304714
-
Amyloid precursor protein and presenilin1 interact with the adaptor GRB2 and modulate ERK1,2 signaling
-
DOI 10.1074/jbc.M610146200
-
Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani MC, Carlo P, Florio T, Schettini G, Tacchetti C, Russo T, Diaspro A, Russo C (2007) Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1, 2 signaling. J Biol Chem 282:13833-13844 (Pubitemid 47100564)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.18
, pp. 13833-13844
-
-
Nizzari, M.1
Venezia, V.2
Repetto, E.3
Caorsi, V.4
Magrassi, R.5
Gagliani, M.C.6
Carlo, P.7
Florio, T.8
Schettini, G.9
Tacchetti, C.10
Russo, T.11
Diaspro, A.12
Russo, C.13
-
69
-
-
33750357041
-
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis
-
DOI 10.1016/j.bbrc.2006.09.162, PII S0006291X06022170
-
Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A (2006) The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Commun 351:57-63 (Pubitemid 44635406)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.1
, pp. 57-63
-
-
Ozaki, T.1
Li, Y.2
Kikuchi, H.3
Tomita, T.4
Iwatsubo, T.5
Nakagawara, A.6
-
70
-
-
0025302430
-
Soluble derivatives of the β amyloid protein precursor in cerebrospinal fluid: Alterations in normal aging and in Alzheimer's disease
-
Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG (1990) Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology 40:1028-1034 (Pubitemid 20213966)
-
(1990)
Neurology
, vol.40
, Issue.7
, pp. 1028-1034
-
-
Palmert, M.R.1
Usiak, M.2
Mayeux, R.3
Raskind, M.4
Tourtellotte, W.W.5
Younkin, S.G.6
-
71
-
-
0031453752
-
The β-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
-
Perez RG, Zheng H, Van der Ploeg LH, Koo EH (1997) The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407-9414 (Pubitemid 28006385)
-
(1997)
Journal of Neuroscience
, vol.17
, Issue.24
, pp. 9407-9414
-
-
Perez, R.G.1
Zheng, H.2
Van Der Ploeg, L.H.T.3
Koo, E.H.4
-
72
-
-
78149488153
-
Amyloid-independent mechanisms in alzheimer's disease pathogenesis
-
Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH (2011) Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30:14946-14954
-
(2011)
J Neurosci
, vol.30
, pp. 14946-14954
-
-
Pimplikar, S.W.1
Nixon, R.A.2
Robakis, N.K.3
Shen, J.4
Tsai, L.H.5
-
73
-
-
0037860975
-
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
-
DOI 10.1016/S0896-6273(03)00355-6
-
Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM Jr (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38:899-914 (Pubitemid 36782382)
-
(2003)
Neuron
, vol.38
, Issue.6
, pp. 899-914
-
-
Putcha, G.V.1
Le, S.2
Frank, S.3
Besirli, C.G.4
Clark, K.5
Chu, B.6
Alix, S.7
Youle, R.J.8
LaMarche, A.9
Maroney, A.C.10
Johnson Jr., E.M.11
-
74
-
-
0035854567
-
Expression of Amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions
-
DOI 10.1016/S0006-8993(01)02580-X, PII S000689930102580X
-
Ramirez MJ, Heslop KE, Francis PT, Rattray M (2001) Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain Res 907:222-232 (Pubitemid 32595531)
-
(2001)
Brain Research
, vol.907
, Issue.1-2
, pp. 222-232
-
-
Ramirez, M.J.1
Heslop, K.E.2
Francis, P.T.3
Rattray, M.4
-
75
-
-
34447640166
-
The secreted β-amyloid precursor protein ectodomain APPsα is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
DOI 10.1523/JNEUROSCI.1026-07.2007
-
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC (2007) The secreted beta-amyloid precursor protein ectodo-main APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817-7826 (Pubitemid 47093823)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.29
, pp. 7817-7826
-
-
Ring, S.1
Weyer, S.W.2
Kilian, S.B.3
Waldron, E.4
Pietrzik, C.U.5
Filippov, M.A.6
Herms, J.7
Buchholz, C.8
Eckman, C.B.9
Korte, M.10
Wolfer, D.P.11
Muller, U.C.12
-
76
-
-
0028071334
-
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor
-
DOI 10.1073/pnas.91.16.7450
-
Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci USA 91:7450-7454 (Pubitemid 24238201)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.16
, pp. 7450-7454
-
-
Roch, J.-M.1
Masliah, E.2
Roch-Levecq, A.-C.3
Sundsmo, M.P.4
Otero, D.A.C.5
Veinbergs, I.6
Saitoh, T.7
-
77
-
-
0036462590
-
2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's β-amyloid precursor protein (APP)
-
DOI 10.1074/jbc.M108357200
-
Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, D'Adamio L (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem 277:3767-3775 (Pubitemid 34953251)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.5
, pp. 3767-3775
-
-
Scheinfeld, M.H.1
Roncarati, R.2
Vito, P.3
Lopez, P.A.4
Abdallah, M.5
D'Adamio, L.6
-
78
-
-
0027421474
-
The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
-
DOI 10.1016/0006-8993(93)91331-L
-
Schubert D, Behl C (1993) The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Res 629:275-282 (Pubitemid 23337802)
-
(1993)
Brain Research
, vol.629
, Issue.2
, pp. 275-282
-
-
Schubert, D.1
Behl, C.2
-
79
-
-
7944233158
-
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
-
DOI 10.1038/ncb1104-1054
-
Selkoe DJ (2004) Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol 6:1054-1061 (Pubitemid 39468006)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.11
, pp. 1054-1061
-
-
Selkoe, D.J.1
-
80
-
-
33748426487
-
Unraveling in vivo functions of amyloid precursor protein: Insights from knockout and knockdown studies
-
DOI 10.1159/000094772
-
Senechal Y, Larmet Y, Dev KK (2006) Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies. Neurodegener Dis 3:134-147 (Pubitemid 44343885)
-
(2006)
Neurodegenerative Diseases
, vol.3
, Issue.3
, pp. 134-147
-
-
Senechal, Y.1
Larmet, Y.2
Dev, K.K.3
-
81
-
-
0028168596
-
Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury
-
Smith-Swintosky VL, Pettigrew LC, Craddock SD, Culwell AR, Rydel RE, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury. J Neurochem 63:781-784
-
(1994)
J Neurochem
, vol.63
, pp. 781-784
-
-
Smith-Swintosky, V.L.1
Pettigrew, L.C.2
Craddock, S.D.3
Culwell, A.R.4
Rydel, R.E.5
Mattson, M.P.6
-
82
-
-
27144547977
-
Homo- and heterodimerization of APP family members promotes intercellular adhesion
-
DOI 10.1038/sj.emboj.7600824, PII 7600824
-
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Lower A, Langer A, Merdes G, Paro R, Masters CL, Muller U, Kins S, Beyreuther K (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J 24:3624-3634 (Pubitemid 41509369)
-
(2005)
EMBO Journal
, vol.24
, Issue.20
, pp. 3624-3634
-
-
Soba, P.1
Eggert, S.2
Wagner, K.3
Zentgraf, H.4
Siehl, K.5
Kreger, S.6
Lower, A.7
Langer, A.8
Merdes, G.9
Paro, R.10
Masters, C.L.11
Muller, U.12
Kins, S.13
Beyreuther, K.14
-
83
-
-
4444255624
-
Sw mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis
-
DOI 10.1523/JNEUROSCI.2211-04.2004
-
Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA (2004) Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 24:7707-7717 (Pubitemid 39186826)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.35
, pp. 7707-7717
-
-
Stein, T.D.1
Anders, N.J.2
DeCarli, C.3
Chan, S.L.4
Mattson, M.P.5
Johnson, J.A.6
-
84
-
-
0031731261
-
Hypersensitivity to seizures in β-amyloid precursor protein deficient mice
-
Steinbach JP, Muller U, Leist M, Li ZW, Nicotera P, Aguzzi A (1998) Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. Cell Death Differ 5:858-866 (Pubitemid 28484396)
-
(1998)
Cell Death and Differentiation
, vol.5
, Issue.10
, pp. 858-866
-
-
Steinbach, J.P.1
Muller, U.2
Leist, M.3
Li, Z.-W.4
Nicotera, P.5
Aguzzi, A.6
-
85
-
-
0037178872
-
Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism
-
DOI 10.1074/jbc.M203713200
-
Taru H, Kirino Y, Suzuki T (2002) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem 277:27567-27574 (Pubitemid 34951778)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.30
, pp. 27567-27574
-
-
Taru, H.1
Kirino, Y.2
Suzuki, T.3
-
86
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283:29615-29619
-
(2008)
J Biol Chem
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
87
-
-
33745263255
-
Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
-
DOI 10.1016/j.brainres.2006.03.107, PII S0006899306008675
-
Thornton E, Vink R, Blumbergs PC, Van Den Heuvel C (2006) Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats. Brain Res 1094:38-46 (Pubitemid 43927608)
-
(2006)
Brain Research
, vol.1094
, Issue.1
, pp. 38-46
-
-
Thornton, E.1
Vink, R.2
Blumbergs, P.C.3
Van Den Heuvel, C.4
-
88
-
-
0042634362
-
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
-
DOI 10.1016/S0301-0082(03)00089-3
-
Turner PR, O'Connor K, Tate WP, Abraham WC (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1-32 (Pubitemid 36966639)
-
(2003)
Progress in Neurobiology
, vol.70
, Issue.1
, pp. 1-32
-
-
Turner, P.R.1
O'Connor, K.2
Tate, W.P.3
Abraham, W.C.4
-
89
-
-
0032843660
-
Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury: An ovine head impact model
-
DOI 10.1006/exnr.1999.7150
-
Van den Heuvel C, Blumbergs PC, Finnie JW, Manavis J, Jones NR, Reilly PL, Pereira RA (1999) Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury: an ovine head impact model. Exp Neurol 159:441-450 (Pubitemid 29485230)
-
(1999)
Experimental Neurology
, vol.159
, Issue.2
, pp. 441-450
-
-
Van Den Heuvel, C.1
Blumbergs, P.C.2
Finnie, J.W.3
Manavis, J.4
Jones, N.R.5
Reilly, P.L.6
Pereira, R.A.7
-
90
-
-
34247560711
-
Amyloid precursor protein modulates ERK-1 and -2 signaling
-
DOI 10.1196/annals.1378.048, Signal Transduction Pathways, Part A: Apoptotic and Extracellular Signalling
-
Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C (2006) Amyloid precursor protein modulates ERK-1 and -2 signaling. Ann NY Acad Sci 1090:455-465 (Pubitemid 47092150)
-
(2006)
Annals of the New York Academy of Sciences
, vol.1090
, pp. 455-465
-
-
Venezia, V.1
Nizzari, M.2
Repetto, E.3
Violani, E.4
Corsaro, A.5
Thellung, S.6
Villa, V.7
Carlo, P.8
Schettini, G.9
Florio, T.10
Russo, C.11
-
91
-
-
34247123160
-
The APP family of proteins: Similarities and differences
-
DOI 10.1042/BST0350416
-
Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ (2007) The APP family of proteins: similarities and differences. Biochem Soc Trans 35:416-420 (Pubitemid 46596519)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.2
, pp. 416-420
-
-
Walsh, D.M.1
Minogue, A.M.2
Sala Frigerio, C.3
Fadeeva, J.V.4
Wasco, W.5
Selkoe, D.J.6
-
92
-
-
69749115919
-
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
-
Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H (2009) Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29:10788-10801
-
(2009)
J Neurosci
, vol.29
, pp. 10788-10801
-
-
Wang, Z.1
Wang, B.2
Yang, L.3
Guo, Q.4
Aithmitti, N.5
Songyang, Z.6
Zheng, H.7
-
93
-
-
84862854037
-
Role of APP and abeta in synaptic physiology
-
[Epub ahead of print]
-
Wang Z, Yang L, Zheng H (2011) Role of APP and Abeta in synaptic physiology. Curr Alzheimer Res [Epub ahead of print]
-
(2011)
Curr Alzheimer Res
-
-
Wang, Z.1
Yang, L.2
Zheng, H.3
-
94
-
-
12344259342
-
Cytoprotective function of sAPPα in human keratinocytes
-
DOI 10.1078/0171-9335-00427
-
Wehner S, Siemes C, Kirfel G, Herzog V (2004) Cytoprotective function of sAppalpha in human keratinocytes. Eur J Cell Biol 83:701-708 (Pubitemid 40123834)
-
(2004)
European Journal of Cell Biology
, vol.83
, Issue.11-12
, pp. 701-708
-
-
Wehner, S.1
Siemes, C.2
Kirfel, G.3
Herzog, V.4
-
96
-
-
0033595020
-
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis
-
DOI 10.1073/pnas.96.13.7547
-
Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L (1999) Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc Natl Acad Sci USA 96:7547-7552 (Pubitemid 29299699)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.13
, pp. 7547-7552
-
-
Xu, X.1
Yang, D.2
Wyss-Coray, T.3
Yan, J.4
Gan, L.5
Sun, Y.6
Mucke, L.7
-
97
-
-
46149126877
-
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
-
Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ (2008) Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev 3:15
-
(2008)
Neural Dev
, vol.3
, pp. 15
-
-
Young-Pearse, T.L.1
Chen, A.C.2
Chang, R.3
Marquez, C.4
Selkoe, D.J.5
-
98
-
-
33847724188
-
The amyloid precursor protein: Beyond amyloid
-
Zheng H, Koo EH (2006) The amyloid precursor protein: beyond amyloid. Mol Neurodegener 1:5
-
(2006)
Mol Neurodegener
, vol.1
, pp. 5
-
-
Zheng, H.1
Koo, E.H.2
-
99
-
-
0028988801
-
Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
Smith, D.W.6
Heavens, R.P.7
Dawson, G.R.8
Boyce, S.9
Conner, M.W.10
Stevens, K.A.11
Slunt, H.H.12
Sisoda, S.S.13
Chen, H.Y.14
Van Der Ploeg, L.H.15
|