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Volumn 26, Issue 6, 2005, Pages 785-788

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42

Author keywords

Age of onset; Alzheimer's disease; Beta amyloid protein; Pathogenesis; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; PRESENILIN 1;

EID: 13844275951     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2004.08.002     Document Type: Article
Times cited : (94)

References (19)
  • 1
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin-1 and amyloid precursor proteins
    • D.R. Borchelt, T. Ratovitski, J. van Lare, M.K. Lee, V. Gonzales, and N.A. Jenkins Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin-1 and amyloid precursor proteins Neuron 19 1997 939 945
    • (1997) Neuron , vol.19 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    Van Lare, J.3    Lee, M.K.4    Gonzales, V.5    Jenkins, N.A.6
  • 2
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, and G.W. Small Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 3
    • 0038721956 scopus 로고    scopus 로고
    • The over-expression of the wild-type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line
    • M.J. Farquhar, C.W. Gray, and K.C. Breen The over-expression of the wild-type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line Neurosci Lett 346 2003 53 56
    • (2003) Neurosci Lett , vol.346 , pp. 53-56
    • Farquhar, M.J.1    Gray, C.W.2    Breen, K.C.3
  • 4
    • 0038037751 scopus 로고    scopus 로고
    • Gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta
    • H.S. Grimm, D. Beher, S.F. Lichtenthaler, M.S. Shearman, K. Beyreuther, and T. Hartmann Gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta J Biol Chem 278 2003 13077 13085
    • (2003) J Biol Chem , vol.278 , pp. 13077-13085
    • Grimm, H.S.1    Beher, D.2    Lichtenthaler, S.F.3    Shearman, M.S.4    Beyreuther, K.5    Hartmann, T.6
  • 5
    • 0033016172 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
    • Q. Guo, W. Fu, B.L. Sopher, M.W. Miller, C.B. Ware, and G.M. Martin Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice Nat Med 5 1999 101 106
    • (1999) Nat Med , vol.5 , pp. 101-106
    • Guo, Q.1    Fu, W.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6
  • 6
    • 0030891662 scopus 로고    scopus 로고
    • Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
    • Q. Guo, K. Furukawa, B.L. Sopher, D.G. Pham, J. Xie, and N. Robinson Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide Neuroreport 8 1996 379 383
    • (1996) Neuroreport , vol.8 , pp. 379-383
    • Guo, Q.1    Furukawa, K.2    Sopher, B.L.3    Pham, D.G.4    Xie, J.5    Robinson, N.6
  • 7
    • 0035479289 scopus 로고    scopus 로고
    • Mortality with dementia: Results from a French prospective community-based cohort
    • C. Helmer, P. Joly, L. Letenneur, D. Commenges, and J.F. Dartigues Mortality with dementia: results from a French prospective community-based cohort Am J Epidemiol 154 2001 642 648
    • (2001) Am J Epidemiol , vol.154 , pp. 642-648
    • Helmer, C.1    Joly, P.2    Letenneur, L.3    Commenges, D.4    Dartigues, J.F.5
  • 8
    • 0037462753 scopus 로고    scopus 로고
    • Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein
    • J. Herms, I. Schneider, I. Dewachter, N. Caluwaerts, H. Kretzschmar, and F. Van Leuven Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein J Biol Chem 278 2003 2484 2489
    • (2003) J Biol Chem , vol.278 , pp. 2484-2489
    • Herms, J.1    Schneider, I.2    Dewachter, I.3    Caluwaerts, N.4    Kretzschmar, H.5    Van Leuven, F.6
  • 9
    • 0029661424 scopus 로고    scopus 로고
    • Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
    • N. Ida, T. Hartmann, J. Pantel, J. Schroder, R. Zerfass, and H. Forstl Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay J Biol Chem 271 1996 22908 22914
    • (1996) J Biol Chem , vol.271 , pp. 22908-22914
    • Ida, N.1    Hartmann, T.2    Pantel, J.3    Schroder, J.4    Zerfass, R.5    Forstl, H.6
  • 10
    • 1642555780 scopus 로고    scopus 로고
    • Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase
    • J.L. Jankowsky, D.J. Fadale, J. Anderson, G.M. Xu, V. Gonzales, and N.A. Jenkins Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase Hum Mol Genet 13 2004 159 170
    • (2004) Hum Mol Genet , vol.13 , pp. 159-170
    • Jankowsky, J.L.1    Fadale, D.J.2    Anderson, J.3    Xu, G.M.4    Gonzales, V.5    Jenkins, N.A.6
  • 11
    • 2442443209 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in early-onset Alzheimer disease with presenilin-1 gene mutations
    • A.J. Larner Genotype-phenotype correlation in early-onset Alzheimer disease with presenilin-1 gene mutations Arch Neurol 61 2004 801
    • (2004) Arch Neurol , vol.61 , pp. 801
    • Larner, A.J.1
  • 12
    • 0242412140 scopus 로고    scopus 로고
    • Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: Relation to age, mortality, and risk
    • Mayeux R, Honig LS, Tang MX, Manly J, Stern Y, Schupf N, Mehta PD. Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology 2003; 611185-1190.
    • (2003) Neurology , pp. 611185-611190
    • Mayeux, R.1    Honig, L.S.2    Tang, M.X.3    Manly, J.4    Stern, Y.5    Schupf, N.6    Mehta, P.D.7
  • 14
    • 0033537921 scopus 로고    scopus 로고
    • Enhancement of amyloid beta 42 secretion by 28 different presenilin-1 mutations of familial Alzheimer's disease
    • O. Murayama, T. Tomita, N. Nihonmatsu, M. Murayama, X. Sun, and T. Honda Enhancement of amyloid beta 42 secretion by 28 different presenilin-1 mutations of familial Alzheimer's disease Neurosci Lett 265 1999 61 63
    • (1999) Neurosci Lett , vol.265 , pp. 61-63
    • Murayama, O.1    Tomita, T.2    Nihonmatsu, N.3    Murayama, M.4    Sun, X.5    Honda, T.6
  • 16
    • 0141540849 scopus 로고    scopus 로고
    • Secrets of a secretase: N-cadherin proteolysis regulates CBP function
    • V.R. Rao, and S. Finkbeiner Secrets of a secretase: N-cadherin proteolysis regulates CBP function Cell 114 2003 533 535
    • (2003) Cell , vol.114 , pp. 533-535
    • Rao, V.R.1    Finkbeiner, S.2
  • 17
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin-1 and -2 and APP mutations linked to familial Alzheimer's disease
    • D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, and N. Suzuki Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin-1 and -2 and APP mutations linked to familial Alzheimer's disease Nat Med 2 1996 864 870
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6
  • 18
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, and M.S. Wolfe Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535 539
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6
  • 19
    • 0028945660 scopus 로고
    • Evidence that a beta 42 is the real culprit in Alzheimer's disease
    • S.G. Younkin Evidence that A beta 42 is the real culprit in Alzheimer's disease Ann Neurol 37 1995 287 288
    • (1995) Ann Neurol , vol.37 , pp. 287-288
    • Younkin, S.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.