-
1
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin-1 and amyloid precursor proteins
-
D.R. Borchelt, T. Ratovitski, J. van Lare, M.K. Lee, V. Gonzales, and N.A. Jenkins Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin-1 and amyloid precursor proteins Neuron 19 1997 939 945
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
-
2
-
-
0027194791
-
Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
-
E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, and G.W. Small Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
-
3
-
-
0038721956
-
The over-expression of the wild-type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line
-
M.J. Farquhar, C.W. Gray, and K.C. Breen The over-expression of the wild-type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line Neurosci Lett 346 2003 53 56
-
(2003)
Neurosci Lett
, vol.346
, pp. 53-56
-
-
Farquhar, M.J.1
Gray, C.W.2
Breen, K.C.3
-
4
-
-
0038037751
-
Gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta
-
H.S. Grimm, D. Beher, S.F. Lichtenthaler, M.S. Shearman, K. Beyreuther, and T. Hartmann Gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta J Biol Chem 278 2003 13077 13085
-
(2003)
J Biol Chem
, vol.278
, pp. 13077-13085
-
-
Grimm, H.S.1
Beher, D.2
Lichtenthaler, S.F.3
Shearman, M.S.4
Beyreuther, K.5
Hartmann, T.6
-
5
-
-
0033016172
-
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
-
Q. Guo, W. Fu, B.L. Sopher, M.W. Miller, C.B. Ware, and G.M. Martin Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice Nat Med 5 1999 101 106
-
(1999)
Nat Med
, vol.5
, pp. 101-106
-
-
Guo, Q.1
Fu, W.2
Sopher, B.L.3
Miller, M.W.4
Ware, C.B.5
Martin, G.M.6
-
6
-
-
0030891662
-
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
-
Q. Guo, K. Furukawa, B.L. Sopher, D.G. Pham, J. Xie, and N. Robinson Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide Neuroreport 8 1996 379 383
-
(1996)
Neuroreport
, vol.8
, pp. 379-383
-
-
Guo, Q.1
Furukawa, K.2
Sopher, B.L.3
Pham, D.G.4
Xie, J.5
Robinson, N.6
-
7
-
-
0035479289
-
Mortality with dementia: Results from a French prospective community-based cohort
-
C. Helmer, P. Joly, L. Letenneur, D. Commenges, and J.F. Dartigues Mortality with dementia: results from a French prospective community-based cohort Am J Epidemiol 154 2001 642 648
-
(2001)
Am J Epidemiol
, vol.154
, pp. 642-648
-
-
Helmer, C.1
Joly, P.2
Letenneur, L.3
Commenges, D.4
Dartigues, J.F.5
-
8
-
-
0037462753
-
Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein
-
J. Herms, I. Schneider, I. Dewachter, N. Caluwaerts, H. Kretzschmar, and F. Van Leuven Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein J Biol Chem 278 2003 2484 2489
-
(2003)
J Biol Chem
, vol.278
, pp. 2484-2489
-
-
Herms, J.1
Schneider, I.2
Dewachter, I.3
Caluwaerts, N.4
Kretzschmar, H.5
Van Leuven, F.6
-
9
-
-
0029661424
-
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
-
N. Ida, T. Hartmann, J. Pantel, J. Schroder, R. Zerfass, and H. Forstl Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay J Biol Chem 271 1996 22908 22914
-
(1996)
J Biol Chem
, vol.271
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
Schroder, J.4
Zerfass, R.5
Forstl, H.6
-
10
-
-
1642555780
-
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase
-
J.L. Jankowsky, D.J. Fadale, J. Anderson, G.M. Xu, V. Gonzales, and N.A. Jenkins Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase Hum Mol Genet 13 2004 159 170
-
(2004)
Hum Mol Genet
, vol.13
, pp. 159-170
-
-
Jankowsky, J.L.1
Fadale, D.J.2
Anderson, J.3
Xu, G.M.4
Gonzales, V.5
Jenkins, N.A.6
-
11
-
-
2442443209
-
Genotype-phenotype correlation in early-onset Alzheimer disease with presenilin-1 gene mutations
-
A.J. Larner Genotype-phenotype correlation in early-onset Alzheimer disease with presenilin-1 gene mutations Arch Neurol 61 2004 801
-
(2004)
Arch Neurol
, vol.61
, pp. 801
-
-
Larner, A.J.1
-
12
-
-
0242412140
-
Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: Relation to age, mortality, and risk
-
Mayeux R, Honig LS, Tang MX, Manly J, Stern Y, Schupf N, Mehta PD. Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology 2003; 611185-1190.
-
(2003)
Neurology
, pp. 611185-611190
-
-
Mayeux, R.1
Honig, L.S.2
Tang, M.X.3
Manly, J.4
Stern, Y.5
Schupf, N.6
Mehta, P.D.7
-
13
-
-
0031594142
-
Increased a beta 42(43) from cell lines expressing presenilin-1 mutations
-
N.D. Mehta, L.M. Refolo, C. Eckman, S. Sanders, D. Yager, and J. Perez-Tur Increased A beta 42(43) from cell lines expressing presenilin-1 mutations Annu Neurol 43 1998 256 258
-
(1998)
Annu Neurol
, vol.43
, pp. 256-258
-
-
Mehta, N.D.1
Refolo, L.M.2
Eckman, C.3
Sanders, S.4
Yager, D.5
Perez-Tur, J.6
-
14
-
-
0033537921
-
Enhancement of amyloid beta 42 secretion by 28 different presenilin-1 mutations of familial Alzheimer's disease
-
O. Murayama, T. Tomita, N. Nihonmatsu, M. Murayama, X. Sun, and T. Honda Enhancement of amyloid beta 42 secretion by 28 different presenilin-1 mutations of familial Alzheimer's disease Neurosci Lett 265 1999 61 63
-
(1999)
Neurosci Lett
, vol.265
, pp. 61-63
-
-
Murayama, O.1
Tomita, T.2
Nihonmatsu, N.3
Murayama, M.4
Sun, X.5
Honda, T.6
-
15
-
-
0038118207
-
Alzheimer's presenilin-1 mutations impair kinesin-based axonal transport
-
G. Pigino, G. Morfini, A. Pelsman, M.P. Mattson, S.T. Brady, and J. Busciglio Alzheimer's presenilin-1 mutations impair kinesin-based axonal transport J Neurosci 23 2003 4499 4508
-
(2003)
J Neurosci
, vol.23
, pp. 4499-4508
-
-
Pigino, G.1
Morfini, G.2
Pelsman, A.3
Mattson, M.P.4
Brady, S.T.5
Busciglio, J.6
-
16
-
-
0141540849
-
Secrets of a secretase: N-cadherin proteolysis regulates CBP function
-
V.R. Rao, and S. Finkbeiner Secrets of a secretase: N-cadherin proteolysis regulates CBP function Cell 114 2003 533 535
-
(2003)
Cell
, vol.114
, pp. 533-535
-
-
Rao, V.R.1
Finkbeiner, S.2
-
17
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin-1 and -2 and APP mutations linked to familial Alzheimer's disease
-
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, and N. Suzuki Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin-1 and -2 and APP mutations linked to familial Alzheimer's disease Nat Med 2 1996 864 870
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
-
18
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, and M.S. Wolfe Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535 539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
19
-
-
0028945660
-
Evidence that a beta 42 is the real culprit in Alzheimer's disease
-
S.G. Younkin Evidence that A beta 42 is the real culprit in Alzheimer's disease Ann Neurol 37 1995 287 288
-
(1995)
Ann Neurol
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
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