-
1
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy, J.A. & Higgins, G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185 (1992).
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
2
-
-
84870796993
-
Genetic insights in Alzheimer's disease
-
Bettens, K., Sleegers, K. & Van Broeckhoven, C. Genetic insights in Alzheimer's disease. Lancet Neurol. 12, 92-104 (2013).
-
(2013)
Lancet Neurol.
, vol.12
, pp. 92-104
-
-
Bettens, K.1
Sleegers, K.2
Van Broeckhoven, C.3
-
3
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy, E. et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248, 1124-1126 (1990).
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
-
4
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706 (1991).
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
-
5
-
-
0038204547
-
Dutch flemish italian and arctic mutations of app and resistance of abeta to physiologically relevant proteolytic degradation
-
Tsubuki, S., Takaki, Y. & Saido, T.C. Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet 361, 1957-1958 (2003).
-
(2003)
Lancet
, vol.361
, pp. 1957-1958
-
-
Tsubuki, S.1
Takaki, Y.2
Saido, T.C.3
-
6
-
-
41749096713
-
A new amyloid beta variant favoring oligomerization in Alzheimer's-Type dementia
-
Tomiyama, T. et al. A new amyloid beta variant favoring oligomerization in Alzheimer's-Type dementia. Ann. Neurol. 63, 377-387 (2008).
-
(2008)
Ann. Neurol.
, vol.63
, pp. 377-387
-
-
Tomiyama, T.1
-
7
-
-
29444442794
-
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
-
Rovelet-Lecrux, A. et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38, 24-26 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
-
8
-
-
33750579333
-
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
-
Sleegers, K. et al. APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy. Brain 129, 2977-2983 (2006).
-
(2006)
Brain
, vol.129
, pp. 2977-2983
-
-
Sleegers, K.1
-
9
-
-
33749066060
-
Phenotype associated with APP duplication in five families
-
Cabrejo, L. et al. Phenotype associated with APP duplication in five families. Brain 129, 2966-2976 (2006).
-
(2006)
Brain
, vol.129
, pp. 2966-2976
-
-
Cabrejo, L.1
-
10
-
-
0031939059
-
Molecular mapping of Alzheimer-Type dementia in Down's syndrome
-
Prasher, V.P. et al. Molecular mapping of Alzheimer-Type dementia in Down's syndrome. Ann. Neurol. 43, 380-383 (1998).
-
(1998)
Ann. Neurol.
, vol.43
, pp. 380-383
-
-
Prasher, V.P.1
-
11
-
-
0026745610
-
Mutation of the beta-Amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
Citron, M. et al. Mutation of the beta-Amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360, 672-674 (1992).
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
-
12
-
-
9844261165
-
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)
-
Eckman, C.B. et al. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). Hum. Mol. Genet. 6, 2087-2089 (1997).
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2087-2089
-
-
Eckman, C.B.1
-
13
-
-
84861194622
-
The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease
-
Chavez-Gutierrez, L. et al. The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease. EMBO J. 31, 2261-2274 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 2261-2274
-
-
Chavez-Gutierrez, L.1
-
14
-
-
67349158815
-
Variations in the neuropathology of familial Alzheimer's disease
-
Shepherd, C., McCann, H. & Halliday, G.M. Variations in the neuropathology of familial Alzheimer's disease. Acta Neuropathol. 118, 37-52 (2009).
-
(2009)
Acta Neuropathol.
, vol.118
, pp. 37-52
-
-
Shepherd, C.1
McCann, H.2
Halliday, G.M.3
-
15
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
Bateman, R.J. et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795-804 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
-
16
-
-
84905868699
-
Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-Analysis
-
Ryman, D.C. et al. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-Analysis. Neurology 83, 253-260 (2014).
-
(2014)
Neurology
, vol.83
, pp. 253-260
-
-
Ryman, D.C.1
-
17
-
-
0027194791
-
Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E.H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923 (1993).
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
-
18
-
-
78649989467
-
Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects
-
Chiang, G.C. et al. Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology 75, 1976-1981 (2010).
-
(2010)
Neurology
, vol.75
, pp. 1976-1981
-
-
Chiang, G.C.1
-
19
-
-
79951713725
-
Apolipoprotein e in Alzheimer's disease and other neurological disorders
-
Verghese, P.B., Castellano, J.M. & Holtzman, D.M. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol. 10, 241-252 (2011).
-
(2011)
Lancet Neurol.
, vol.10
, pp. 241-252
-
-
Verghese, P.B.1
Castellano, J.M.2
Holtzman, D.M.3
-
20
-
-
79959772357
-
Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance
-
Castellano, J.M. et al. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci. Transl. Med. 3, 89ra57 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
, pp. 89ra57
-
-
Castellano, J.M.1
-
21
-
-
0036233168
-
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease
-
Fagan, A.M. et al. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol. Dis. 9, 305-318 (2002).
-
(2002)
Neurobiol. Dis.
, vol.9
, pp. 305-318
-
-
Fagan, A.M.1
-
22
-
-
84890365334
-
Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain
-
212ra161
-
Hudry, E. et al. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci. Transl. Med. 5, 212ra161 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
-
-
Hudry, E.1
-
23
-
-
77649314191
-
APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
-
Morris, J.C. et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann. Neurol. 67, 122-131 (2010).
-
(2010)
Ann. Neurol.
, vol.67
, pp. 122-131
-
-
Morris, J.C.1
-
24
-
-
77950545456
-
Effect of apolipoprotein e on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
-
Vemuri, P. et al. Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease. Ann. Neurol. 67, 308-316 (2010).
-
(2010)
Ann. Neurol.
, vol.67
, pp. 308-316
-
-
Vemuri, P.1
-
25
-
-
84877326649
-
ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions
-
Verghese, P.B. et al. ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions. Proc. Natl. Acad. Sci. USA 110, E1807-E1816 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E1807-E1816
-
-
Verghese, P.B.1
-
26
-
-
0031278270
-
Lack of apolipoprotein e dramatically reduces amyloid beta-peptide deposition
-
Bales, K.R. et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17, 263-264 (1997).
-
(1997)
Nat. Genet.
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
-
27
-
-
84858423000
-
Reducing human apolipoprotein e levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice
-
Bien-Ly, N., Gillespie, A.K., Walker, D., Yoon, S.Y. & Huang, Y. Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J. Neurosci. 32, 4803-4811 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 4803-4811
-
-
Bien-Ly, N.1
Gillespie, A.K.2
Walker, D.3
Yoon, S.Y.4
Huang, Y.5
-
28
-
-
83055160869
-
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis
-
Kim, J. et al. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. J. Neurosci. 31, 18007-18012 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 18007-18012
-
-
Kim, J.1
-
29
-
-
84871887566
-
Anti-ApoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis
-
Kim, J. et al. Anti-ApoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis. J. Exp. Med. 209, 2149-2156 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2149-2156
-
-
Kim, J.1
-
30
-
-
7444271086
-
Cerebrospinal fluid beta-Amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: The effect of APOE epsilon4 allele
-
Sunderland, T. et al. Cerebrospinal fluid beta-Amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biol. Psychiatry 56, 670-676 (2004).
-
(2004)
Biol. Psychiatry
, vol.56
, pp. 670-676
-
-
Sunderland, T.1
-
31
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson, T. et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99 (2012).
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
-
32
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239-259 (1991).
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
33
-
-
84858046578
-
Neuropathological alterations in Alzheimer disease
-
Serrano-Pozo, A., Frosch, M.P., Masliah, E. & Hyman, B.T. Neuropathological alterations in Alzheimer disease. Cold Spring Harb. Perspect. Med. 1, a006189 (2011).
-
(2011)
Cold Spring Harb. Perspect. Med.
, vol.1
, pp. a006189
-
-
Serrano-Pozo, A.1
Frosch, M.P.2
Masliah, E.3
Hyman, B.T.4
-
34
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
-
Gomez-Isla, T. et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann. Neurol. 41, 17-24 (1997).
-
(1997)
Ann. Neurol.
, vol.41
, pp. 17-24
-
-
Gomez-Isla, T.1
-
35
-
-
0026743110
-
Distribution of Alzheimer-Type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
-
Arriagada, P.V., Marzloff, K. & Hyman, B.T. Distribution of Alzheimer-Type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology 42, 1681-1688 (1992).
-
(1992)
Neurology
, vol.42
, pp. 1681-1688
-
-
Arriagada, P.V.1
Marzloff, K.2
Hyman, B.T.3
-
36
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada, P.V., Growdon, J.H., Hedley-Whyte, E.T. & Hyman, B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639 (1992).
-
(1992)
Neurology
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
37
-
-
0025770134
-
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
-
Price, J.L., Davis, P.B., Morris, J.C. & White, D.L. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol. Aging 12, 295-312 (1991).
-
(1991)
Neurobiol. Aging
, vol.12
, pp. 295-312
-
-
Price, J.L.1
Davis, P.B.2
Morris, J.C.3
White, D.L.4
-
38
-
-
79451471618
-
The pathological process underlying Alzheimer's disease in individuals under thirty
-
Braak, H. & Del Tredici, K. The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol. 121, 171-181 (2011).
-
(2011)
Acta Neuropathol.
, vol.121
, pp. 171-181
-
-
Braak, H.1
Del Tredici, K.2
-
39
-
-
0032989712
-
Tangles and plaques in nondemented aging and preclinical Alzheimer's disease
-
Price, J.L. & Morris, J.C. Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease. Ann. Neurol. 45, 358-368 (1999).
-
(1999)
Ann. Neurol.
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
40
-
-
84857029808
-
Hyperphosphorylated tau in young and middle-Aged subjects
-
Elobeid, A., Soininen, H. & Alafuzoff, I. Hyperphosphorylated tau in young and middle-Aged subjects. Acta Neuropathol. 123, 97-104 (2012).
-
(2012)
Acta Neuropathol.
, vol.123
, pp. 97-104
-
-
Elobeid, A.1
Soininen, H.2
Alafuzoff, I.3
-
41
-
-
0242693294
-
Neuropathology of cognitively normal elderly
-
Knopman, D.S. et al. Neuropathology of cognitively normal elderly. J. Neuropathol. Exp. Neurol. 62, 1087-1095 (2003).
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 1087-1095
-
-
Knopman, D.S.1
-
42
-
-
33646392455
-
Neuropathologic features of amnestic mild cognitive impairment
-
Petersen, R.C. et al. Neuropathologic features of amnestic mild cognitive impairment. Arch. Neurol. 63, 665-672 (2006).
-
(2006)
Arch. Neurol.
, vol.63
, pp. 665-672
-
-
Petersen, R.C.1
-
43
-
-
0029979798
-
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
-
Gomez-Isla, T. et al. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16, 4491-4500 (1996).
-
(1996)
J. Neurosci.
, vol.16
, pp. 4491-4500
-
-
Gomez-Isla, T.1
-
44
-
-
0028122463
-
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
-
West, M.J., Coleman, P.D., Flood, D.G. & Troncoso, J.C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344, 769-772 (1994).
-
(1994)
Lancet
, vol.344
, pp. 769-772
-
-
West, M.J.1
Coleman, P.D.2
Flood, D.G.3
Troncoso, J.C.4
-
45
-
-
2942561028
-
The importance of neuritic plaques and tangles to the development and evolution of AD
-
Tiraboschi, P., Hansen, L.A., Thal, L.J. & Corey-Bloom, J. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 62, 1984-1989 (2004).
-
(2004)
Neurology
, vol.62
, pp. 1984-1989
-
-
Tiraboschi, P.1
Hansen, L.A.2
Thal, L.J.3
Corey-Bloom, J.4
-
46
-
-
0030826625
-
Autosomal dominant dementia with widespread neurofibrillary tangles
-
Reed, L.A. et al. Autosomal dominant dementia with widespread neurofibrillary tangles. Ann. Neurol. 42, 564-572 (1997).
-
(1997)
Ann. Neurol.
, vol.42
, pp. 564-572
-
-
Reed, L.A.1
-
47
-
-
41049106547
-
Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation
-
Lindquist, S.G. et al. Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation. Eur. J. Neurol. 15, 377-385 (2008).
-
(2008)
Eur. J. Neurol.
, vol.15
, pp. 377-385
-
-
Lindquist, S.G.1
-
48
-
-
45849122478
-
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition
-
Kauwe, J.S. et al. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proc. Natl. Acad. Sci. USA 105, 8050-8054 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 8050-8054
-
-
Kauwe, J.S.1
-
49
-
-
0030879686
-
Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta
-
Ferreira, A., Lu, Q., Orecchio, L. & Kosik, K.S. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Mol. Cell. Neurosci. 9, 220-234 (1997).
-
(1997)
Mol. Cell. Neurosci.
, vol.9
, pp. 220-234
-
-
Ferreira, A.1
Lu, Q.2
Orecchio, L.3
Kosik, K.S.4
-
50
-
-
77956587739
-
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
-
Zempel, H., Thies, E., Mandelkow, E. & Mandelkow, E.M. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J. Neurosci. 30, 11938-11950 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 11938-11950
-
-
Zempel, H.1
Thies, E.2
Mandelkow, E.3
Mandelkow, E.M.4
-
51
-
-
0037197836
-
Tau is essential to beta-Amyloid-induced neurotoxicity
-
Rapoport, M., Dawson, H.N., Binder, L.I., Vitek, M.P. & Ferreira, A. Tau is essential to beta-Amyloid-induced neurotoxicity. Proc. Natl. Acad. Sci. USA 99, 6364-6369 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
52
-
-
79955044494
-
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
-
Jin, M. et al. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc. Natl. Acad. Sci. USA 108, 5819-5824 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 5819-5824
-
-
Jin, M.1
-
53
-
-
84912064761
-
A three-dimensional human neural cell culture model of Alzheimer's disease
-
Choi, S.H. et al. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature 515, 274-278 (2014).
-
(2014)
Nature
, vol.515
, pp. 274-278
-
-
Choi, S.H.1
-
54
-
-
77957345679
-
A{beta} Accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model
-
Hurtado, D.E. et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am. J. Pathol. 177, 1977-1988 (2010).
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 1977-1988
-
-
Hurtado, D.E.1
-
55
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis, J. et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293, 1487-1491 (2001).
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
-
56
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Götz, J., Chen, F., van Dorpe, J. & Nitsch, R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293, 1491-1495 (2001).
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
57
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson, E.D. et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754 (2007).
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
-
58
-
-
78651506630
-
Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
Roberson, E.D. et al. Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J. Neurosci. 31, 700-711 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
-
59
-
-
18344417178
-
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
-
Lippa, C.F. et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am. J. Pathol. 153, 1365-1370 (1998).
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 1365-1370
-
-
Lippa, C.F.1
-
60
-
-
0032888789
-
Alpha-synuclein in Lewy body disease and Alzheimer's disease
-
Hashimoto, M. & Masliah, E. Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol. 9, 707-720 (1999).
-
(1999)
Brain Pathol.
, vol.9
, pp. 707-720
-
-
Hashimoto, M.1
Masliah, E.2
-
61
-
-
0035834076
-
Beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
-
Masliah, E. et al. beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc. Natl. Acad. Sci. USA 98, 12245-12250 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12245-12250
-
-
Masliah, E.1
-
62
-
-
84864247708
-
Soluble alpha-synuclein is a novel modulator of Alzheimer's disease pathophysiology
-
Larson, M.E. et al. Soluble alpha-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J. Neurosci. 32, 10253-10266 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 10253-10266
-
-
Larson, M.E.1
-
63
-
-
84901680165
-
TDP-43 is a key player in the clinical features associated with Alzheimer's disease
-
Josephs, K.A. et al. TDP-43 is a key player in the clinical features associated with Alzheimer's disease. Acta Neuropathol. 127, 811-824 (2014).
-
(2014)
Acta Neuropathol.
, vol.127
, pp. 811-824
-
-
Josephs, K.A.1
-
64
-
-
84872379077
-
Tracking pathophysiological processes in Alzheimer's disease: An updated hypothetical model of dynamic biomarkers
-
Jack, C.R. Jr. et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 12, 207-216 (2013).
-
(2013)
Lancet Neurol.
, vol.12
, pp. 207-216
-
-
Jack, C.R.1
-
65
-
-
81755177047
-
Evidence for ordering of Alzheimer disease biomarkers
-
Jack, C.R. Jr. et al. Evidence for ordering of Alzheimer disease biomarkers. Arch. Neurol. 68, 1526-1535 (2011).
-
(2011)
Arch. Neurol.
, vol.68
, pp. 1526-1535
-
-
Jack, C.R.1
-
66
-
-
84879122146
-
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
-
Roe, C.M. et al. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology 80, 1784-1791 (2013).
-
(2013)
Neurology
, vol.80
, pp. 1784-1791
-
-
Roe, C.M.1
-
67
-
-
84884127276
-
Preclinical Alzheimer's disease and its outcome: A longitudinal cohort study
-
Vos, S.J. et al. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol. 12, 957-965 (2013).
-
(2013)
Lancet Neurol.
, vol.12
, pp. 957-965
-
-
Vos, S.J.1
-
68
-
-
84875250937
-
Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
-
Villemagne, V.L. et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol. 12, 357-367 (2013).
-
(2013)
Lancet Neurol.
, vol.12
, pp. 357-367
-
-
Villemagne, V.L.1
-
69
-
-
84904025715
-
Pittsburgh compound B retention and progression of cognitive status-A meta-Analysis
-
Chen, X. et al. Pittsburgh compound B retention and progression of cognitive status-A meta-Analysis. Eur. J. Neurol. 21, 1060-1067 (2014).
-
(2014)
Eur. J. Neurol.
, vol.21
, pp. 1060-1067
-
-
Chen, X.1
-
70
-
-
79551495391
-
Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease
-
Villemagne, V.L. et al. Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease. Ann. Neurol. 69, 181-192 (2011).
-
(2011)
Ann. Neurol.
, vol.69
, pp. 181-192
-
-
Villemagne, V.L.1
-
71
-
-
84863185648
-
Short-Term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease
-
Knopman, D.S. et al. Short-Term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease. Neurology 78, 1576-1582 (2012).
-
(2012)
Neurology
, vol.78
, pp. 1576-1582
-
-
Knopman, D.S.1
-
72
-
-
80051481026
-
Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease
-
Tarawneh, R. et al. Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease. Ann. Neurol. 70, 274-285 (2011).
-
(2011)
Ann. Neurol.
, vol.70
, pp. 274-285
-
-
Tarawneh, R.1
-
73
-
-
84905969638
-
The preclinical Alzheimer cognitive composite: Measuring amyloid-related decline
-
Donohue, M.C. et al. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol. 71, 961-970 (2014).
-
(2014)
JAMA Neurol.
, vol.71
, pp. 961-970
-
-
Donohue, M.C.1
-
74
-
-
84858141828
-
Accelerated cortical atrophy in cognitively normal elderly with high beta-Amyloid deposition
-
Chetelat, G. et al. Accelerated cortical atrophy in cognitively normal elderly with high beta-Amyloid deposition. Neurology 78, 477-484 (2012).
-
(2012)
Neurology
, vol.78
, pp. 477-484
-
-
Chetelat, G.1
-
75
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar, G.M. et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 14, 837-842 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
-
76
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-Term potentiation in vivo
-
Walsh, D.M. et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-Term potentiation in vivo. Nature 416, 535-539 (2002).
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
77
-
-
84880759156
-
Neurotoxicity of amyloid beta-protein: Synaptic and network dysfunction
-
Mucke, L. & Selkoe, D.J. Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction. Cold Spring Harb. Perspect. Med. 2, a006338 (2012).
-
(2012)
Cold Spring Harb. Perspect. Med.
, vol.2
, pp. a006338
-
-
Mucke, L.1
Selkoe, D.J.2
-
78
-
-
84873328025
-
Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls
-
Esparza, T.J. et al. Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls. Ann. Neurol. 73, 104-119 (2013).
-
(2013)
Ann. Neurol.
, vol.73
, pp. 104-119
-
-
Esparza, T.J.1
-
79
-
-
68149162581
-
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
-
Tomic, J.L., Pensalfini, A., Head, E. & Glabe, C.G. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol. Dis. 35, 352-358 (2009).
-
(2009)
Neurobiol. Dis.
, vol.35
, pp. 352-358
-
-
Tomic, J.L.1
Pensalfini, A.2
Head, E.3
Glabe, C.G.4
-
80
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean, C.A. et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860-866 (1999).
-
(1999)
Ann. Neurol.
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
-
81
-
-
84877293577
-
Brain amyloid-beta oligomers in ageing and Alzheimer's disease
-
Lesne, S.E. et al. Brain amyloid-beta oligomers in ageing and Alzheimer's disease. Brain 136, 1383-1398 (2013).
-
(2013)
Brain
, vol.136
, pp. 1383-1398
-
-
Lesne, S.E.1
-
82
-
-
84877271133
-
Correlation of specific amyloid-beta oligomers with tau in cerebrospinal fluid from cognitively normal older adults
-
Handoko, M. et al. Correlation of specific amyloid-beta oligomers with tau in cerebrospinal fluid from cognitively normal older adults. JAMA Neurol. 70, 594-599 (2013).
-
(2013)
JAMA Neurol.
, vol.70
, pp. 594-599
-
-
Handoko, M.1
-
83
-
-
84908191419
-
A lifespan observation of a novel mouse model: In vivo evidence supports abeta oligomer hypothesis
-
Zhang, Y. et al. A lifespan observation of a novel mouse model: in vivo evidence supports abeta oligomer hypothesis. PLoS ONE 9, e85885 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e85885
-
-
Zhang, Y.1
-
84
-
-
77950617631
-
A mouse model of amyloid beta oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
-
Tomiyama, T. et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci. 30, 4845-4856 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
-
85
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne, S. et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440, 352-357 (2006).
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
-
86
-
-
67650729973
-
Beta-Amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-Terminal kinase signaling: Suppression by omega-3 fatty acids and curcumin
-
Ma, Q.L. et al. Beta-Amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-Terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J. Neurosci. 29, 9078-9089 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 9078-9089
-
-
Ma, Q.L.1
-
87
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner, L.M. et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142, 387-397 (2010).
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
-
88
-
-
77955328980
-
Fyn-Tau-Amyloid: A toxic triad
-
Haass, C. & Mandelkow, E. Fyn-Tau-Amyloid: a toxic triad. Cell 142, 356-358 (2010).
-
(2010)
Cell
, vol.142
, pp. 356-358
-
-
Haass, C.1
Mandelkow, E.2
-
89
-
-
84910669129
-
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
-
Zhang, Z. et al. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nat. Med. 20, 1254-1262 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 1254-1262
-
-
Zhang, Z.1
-
90
-
-
84867608068
-
Tau protein kinases: Involvement in Alzheimer's disease
-
Martin, L. et al. Tau protein kinases: involvement in Alzheimer's disease. Ageing Res. Rev. 12, 289-309 (2013).
-
(2013)
Ageing Res. Rev.
, vol.12
, pp. 289-309
-
-
Martin, L.1
-
91
-
-
33749020837
-
Exogenous induction of cerebral beta-Amyloidogenesis is governed by agent and host
-
Meyer-Luehmann, M. et al. Exogenous induction of cerebral beta-Amyloidogenesis is governed by agent and host. Science 313, 1781-1784 (2006).
-
(2006)
Science
, vol.313
, pp. 1781-1784
-
-
Meyer-Luehmann, M.1
-
92
-
-
84902486430
-
Distinct tau prion strains propagate in cells and mice and define different tauopathies
-
Sanders, D.W. et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82, 1271-1288 (2014).
-
(2014)
Neuron
, vol.82
, pp. 1271-1288
-
-
Sanders, D.W.1
-
93
-
-
84857275902
-
Propagation of tau pathology in a model of early Alzheimer's disease
-
de Calignon, A. et al. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron 73, 685-697 (2012).
-
(2012)
Neuron
, vol.73
, pp. 685-697
-
-
De Calignon, A.1
-
94
-
-
84856454190
-
Trans-synaptic spread of tau pathology in vivo
-
Liu, L. et al. Trans-synaptic spread of tau pathology in vivo. PLoS ONE 7, e31302 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e31302
-
-
Liu, L.1
-
95
-
-
84879895467
-
Distinct alpha-synuclein strains differentially promote tau inclusions in neurons
-
Guo, J.L. et al. Distinct alpha-synuclein strains differentially promote tau inclusions in neurons. Cell 154, 103-117 (2013).
-
(2013)
Cell
, vol.154
, pp. 103-117
-
-
Guo, J.L.1
-
96
-
-
0037466656
-
Initiation and synergistic fibrillization of tau and alpha-synuclein
-
Giasson, B.I. et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 300, 636-640 (2003).
-
(2003)
Science
, vol.300
, pp. 636-640
-
-
Giasson, B.I.1
-
97
-
-
84884863139
-
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis
-
Dasuri, K., Zhang, L. & Keller, J.N. Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radic. Biol. Med. 62, 170-185 (2013).
-
(2013)
Free Radic. Biol. Med.
, vol.62
, pp. 170-185
-
-
Dasuri, K.1
Zhang, L.2
Keller, J.N.3
-
98
-
-
77951060145
-
Proteases and proteolysis in Alzheimer disease: A multifactorial view on the disease process
-
De Strooper, B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol. Rev. 90, 465-494 (2010).
-
(2010)
Physiol. Rev.
, vol.90
, pp. 465-494
-
-
De Strooper, B.1
-
99
-
-
79955969705
-
Autophagy failure in Alzheimer's disease-locating the primary defect
-
Nixon, R.A. & Yang, D.S. Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol. Dis. 43, 38-45 (2011).
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
101
-
-
84897386660
-
REST and stress resistance in ageing and Alzheimer's disease
-
Lu, T. et al. REST and stress resistance in ageing and Alzheimer's disease. Nature 507, 448-454 (2014).
-
(2014)
Nature
, vol.507
, pp. 448-454
-
-
Lu, T.1
-
102
-
-
0035875690
-
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
-
Praticò, D., Uryu, K., Leight, S., Trojanoswki, J.Q. & Lee, V.M. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21, 4183-4187 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 4183-4187
-
-
Praticò, D.1
Uryu, K.2
Leight, S.3
Trojanoswki, J.Q.4
Lee, V.M.5
-
103
-
-
0033370498
-
Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice
-
Benzing, W.C. et al. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiol. Aging 20, 581-589 (1999).
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 581-589
-
-
Benzing, W.C.1
-
104
-
-
81255190781
-
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
-
Calkins, M.J., Manczak, M., Mao, P., Shirendeb, U. & Reddy, P.H. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum. Mol. Genet. 20, 4515-4529 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4515-4529
-
-
Calkins, M.J.1
Manczak, M.2
Mao, P.3
Shirendeb, U.4
Reddy, P.H.5
-
105
-
-
84862307062
-
Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
-
Guix, F.X. et al. Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol. Med. 4, 660-673 (2012).
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 660-673
-
-
Guix, F.X.1
-
106
-
-
84878847155
-
Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease
-
Wahlster, L. et al. Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol. 125, 187-199 (2013).
-
(2013)
Acta Neuropathol.
, vol.125
, pp. 187-199
-
-
Wahlster, L.1
-
107
-
-
84901294948
-
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease
-
Kukreja, L., Kujoth, G.C., Prolla, T.A., Van Leuven, F. & Vassar, R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol. Neurodegener. 9, 16 (2014).
-
(2014)
Mol. Neurodegener.
, vol.9
, Issue.16
-
-
Kukreja, L.1
Kujoth, G.C.2
Prolla, T.A.3
Van Leuven, F.4
Vassar, R.5
-
108
-
-
84907292984
-
IKKbeta deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology
-
Liu, Y. et al. IKKbeta deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J. Neurosci. 34, 12982-12999 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 12982-12999
-
-
Liu, Y.1
-
109
-
-
84902484347
-
Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
-
Durazzo, T.C., Mattsson, N. & Weiner, M.W. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement. 10, S122-S145 (2014).
-
(2014)
Alzheimers Dement.
, vol.10
, pp. S122-S145
-
-
Durazzo, T.C.1
Mattsson, N.2
Weiner, M.W.3
-
110
-
-
84874629047
-
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease
-
Moreno-Gonzalez, I., Estrada, L.D., Sanchez-Mejias, E. & Soto, C. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease. Nat. Commun. 4, 1495 (2013).
-
(2013)
Nat. Commun.
, vol.4
, Issue.1495
-
-
Moreno-Gonzalez, I.1
Estrada, L.D.2
Sanchez-Mejias, E.3
Soto, C.4
-
111
-
-
84902243410
-
Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2
-
Ulrich, J.D. et al. Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2. Mol. Neurodegener. 9, 20 (2014).
-
(2014)
Mol. Neurodegener.
, vol.9
, Issue.20
-
-
Ulrich, J.D.1
-
112
-
-
84897398469
-
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
-
Cady, J. et al. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol. 71, 449-453 (2014).
-
(2014)
JAMA Neurol.
, vol.71
, pp. 449-453
-
-
Cady, J.1
-
113
-
-
84879113935
-
TREM2 in neurodegeneration: Evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
-
Rayaprolu, S. et al. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol. Neurodegener. 8, 19 (2013).
-
(2013)
Mol. Neurodegener.
, vol.8
, Issue.19
-
-
Rayaprolu, S.1
-
114
-
-
84874605021
-
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-Amyloidosis
-
Melnikova, T. et al. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-Amyloidosis. J. Neurosci. 33, 3765-3779 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 3765-3779
-
-
Melnikova, T.1
-
115
-
-
84877259698
-
Normal cognition in transgenic BRI2-Abeta mice
-
Kim, J. et al. Normal cognition in transgenic BRI2-Abeta mice. Mol. Neurodegener. 8, 15 (2013).
-
(2013)
Mol. Neurodegener.
, vol.8
, Issue.15
-
-
Kim, J.1
-
116
-
-
0033586449
-
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-Terminus of the amyloid precursor protein
-
Berger-Sweeney, J. et al. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-Terminus of the amyloid precursor protein. Brain Res. Mol. Brain Res. 66, 150-162 (1999).
-
(1999)
Brain Res. Mol. Brain Res.
, vol.66
, pp. 150-162
-
-
Berger-Sweeney, J.1
-
117
-
-
0035909901
-
The gamma-secretase-cleaved C-Terminal fragment of amyloid precursor protein mediates signaling to the nucleus
-
Gao, Y. & Pimplikar, S.W. The gamma-secretase-cleaved C-Terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc. Natl. Acad. Sci. USA 98, 14979-14984 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14979-14984
-
-
Gao, Y.1
Pimplikar, S.W.2
-
118
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart, J.C. et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 5, 452-457 (2002).
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
-
119
-
-
79955128215
-
Biology and pathophysiology of the amyloid precursor protein
-
Zheng, H. & Koo, E.H. Biology and pathophysiology of the amyloid precursor protein. Mol. Neurodegener. 6, 27 (2011).
-
(2011)
Mol. Neurodegener.
, vol.6
, Issue.27
-
-
Zheng, H.1
Koo, E.H.2
-
120
-
-
79960809092
-
Neuronal activity regulates the regional vulnerability to amyloid-beta deposition
-
Bero, A.W. et al. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat. Neurosci. 14, 750-756 (2011).
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 750-756
-
-
Bero, A.W.1
-
121
-
-
72449161215
-
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
-
Kang, J.E. et al. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326, 1005-1007 (2009).
-
(2009)
Science
, vol.326
, pp. 1005-1007
-
-
Kang, J.E.1
-
122
-
-
84885775321
-
Sleep drives metabolite clearance from the adult brain
-
Xie, L. et al. Sleep drives metabolite clearance from the adult brain. Science 342, 373-377 (2013).
-
(2013)
Science
, vol.342
, pp. 373-377
-
-
Xie, L.1
-
123
-
-
33846949357
-
The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation
-
Siegel, S.J., Bieschke, J., Powers, E.T. & Kelly, J.W. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry 46, 1503-1510 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 1503-1510
-
-
Siegel, S.J.1
Bieschke, J.2
Powers, E.T.3
Kelly, J.W.4
-
124
-
-
0034746895
-
Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome
-
Head, E. et al. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol. Dis. 8, 792-806 (2001).
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 792-806
-
-
Head, E.1
-
125
-
-
84913582567
-
Impairment of paravascular clearance pathways in the aging brain
-
Kress, B.T. et al. Impairment of paravascular clearance pathways in the aging brain. Ann. Neurol. 76, 845-861 (2014).
-
(2014)
Ann. Neurol.
, vol.76
, pp. 845-861
-
-
Kress, B.T.1
-
126
-
-
84906214948
-
Aging reduces glial uptake and promotes extracellular accumulation of Abeta from a lentiviral vector
-
Zhao, W., Zhang, J., Davis, E.G. & Rebeck, G.W. Aging reduces glial uptake and promotes extracellular accumulation of Abeta from a lentiviral vector. Front. Aging Neurosci. 6, 210 (2014).
-
(2014)
Front. Aging Neurosci.
, vol.6
, Issue.210
-
-
Zhao, W.1
Zhang, J.2
Davis, E.G.3
Rebeck, G.W.4
-
127
-
-
78650678688
-
Decreased clearance of CNS beta-Amyloid in Alzheimer's disease
-
Mawuenyega, K.G. et al. Decreased clearance of CNS beta-Amyloid in Alzheimer's disease. Science 330, 1774 (2010).
-
(2010)
Science
, vol.330
, Issue.1774
-
-
Mawuenyega, K.G.1
-
128
-
-
84906794886
-
Proteostasis impairment in protein-misfolding and-Aggregation diseases
-
Hipp, M.S., Park, S.H. & Hartl, F.U. Proteostasis impairment in protein-misfolding and-Aggregation diseases. Trends Cell Biol. 24, 506-514 (2014).
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 506-514
-
-
Hipp, M.S.1
Park, S.H.2
Hartl, F.U.3
-
129
-
-
47149112621
-
Long-Term effects of Abeta42 immunization in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase i trial
-
Holmes, C. et al. Long-Term effects of Abeta42 immunization in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216-223 (2008).
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
-
130
-
-
77953872812
-
Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
-
Boche, D. et al. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta Neuropathol. 120, 13-20 (2010).
-
(2010)
Acta Neuropathol.
, vol.120
, pp. 13-20
-
-
Boche, D.1
-
131
-
-
77951893095
-
Beneficial effect of human anti-Amyloid-beta active immunization on neurite morphology and tau pathology
-
Serrano-Pozo, A. et al. Beneficial effect of human anti-Amyloid-beta active immunization on neurite morphology and tau pathology. Brain 133, 1312-1327 (2010).
-
(2010)
Brain
, vol.133
, pp. 1312-1327
-
-
Serrano-Pozo, A.1
-
132
-
-
64549152492
-
Long-Term follow-up of patients immunized with AN1792: Reduced functional decline in antibody responders
-
Vellas, B. et al. Long-Term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr. Alzheimer Res. 6, 144-151 (2009).
-
(2009)
Curr. Alzheimer Res.
, vol.6
, pp. 144-151
-
-
Vellas, B.1
-
133
-
-
84884979769
-
Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial
-
Mills, S.M. et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev. Neurol. (Paris) 169, 737-743 (2013).
-
(2013)
Rev. Neurol. (Paris)
, vol.169
, pp. 737-743
-
-
Mills, S.M.1
-
134
-
-
80055034288
-
Alzheimer's Prevention Initiative: A plan to accelerate the evaluation of presymptomatic treatments
-
Reiman, E.M. et al. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J. Alzheimers Dis. 26 (suppl. 3), 321-329 (2011).
-
(2011)
J. Alzheimers Dis.
, vol.26
, Issue.SUPPL3
, pp. 321-329
-
-
Reiman, E.M.1
|