Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40

Human Mutation

Volumn 27, Issue 7, 2006, Pages 686-695

  Kumar Singh, Samir ^a,b,d   Theuns, Jessie ^a,b   Van Broeck, Bianca ^a,b   Pirici, Daniel ^a,b   Vennekens, Krist'l ^a,b   Corsmit, Ellen ^a,b   Cruts, Marc ^a,b   Dermaut, Bart ^a,b   Wang, Rong ^c   Van Broeckhoven, Christine ^a,b,d  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

A 1 40; A 1 42; Age of onset; Alzheimer disease; APP; ELISA; Immunohistochemistry; MALDI TOF MS; PSEN1; PSEN2

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CLINICAL ARTICLE; CORRELATION ANALYSIS; DENSITOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NEUROPROTECTION; ONSET AGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ADULT; AGE OF ONSET; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BIOLOGICAL MARKERS; BRAIN; CELL LINE; DENSITOMETRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MUS MUSCULUS;

EID: 33745700370     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.20336     Document Type: Article

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