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Volumn 29, Issue 4, 2014, Pages 518-526

Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease

Author keywords

Ceramide; Ceramide synthase genes; Parkinson's disease; Postmortem tissue analysis; Sphingolipidomics; Sphingomyelin

Indexed keywords

MESSENGER RNA; SPHINGOMYELIN; CERAMIDE; DIHYDROCERAMIDE DESATURASE; OXIDOREDUCTASE;

EID: 84898057274     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25729     Document Type: Article
Times cited : (107)

References (51)
  • 1
    • 0038727936 scopus 로고    scopus 로고
    • Description of Parkinson's disease as a clinical syndrome
    • Fahn S. Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci 2003;991:1-14.
    • (2003) Ann N Y Acad Sci , vol.991 , pp. 1-14
    • Fahn, S.1
  • 2
    • 77953229747 scopus 로고    scopus 로고
    • Missing pieces in the Parkinson's disease puzzle
    • Obeso JA, Rodriguez-Oroz MC, Goetz CG, et al. Missing pieces in the Parkinson's disease puzzle. Nat Med 2010;16:653-661.
    • (2010) Nat Med , vol.16 , pp. 653-661
    • Obeso, J.A.1    Rodriguez-Oroz, M.C.2    Goetz, C.G.3
  • 3
    • 71849092190 scopus 로고    scopus 로고
    • Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria
    • Dickson DW, Braak H, Duda JE, et al. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol 2009;8:1150-1157.
    • (2009) Lancet Neurol , vol.8 , pp. 1150-1157
    • Dickson, D.W.1    Braak, H.2    Duda, J.E.3
  • 4
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai WP, Yuan HX, Li XQ, Power JT, Blumbergs PC, Jensen PH. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp Neurol 2000;166:324-333.
    • (2000) Exp Neurol , vol.166 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 5
    • 27644548054 scopus 로고    scopus 로고
    • Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
    • Halliday GM, Ophof A, Broe M, et al. Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease. Brain 2005;128:2654-2664.
    • (2005) Brain , vol.128 , pp. 2654-2664
    • Halliday, G.M.1    Ophof, A.2    Broe, M.3
  • 7
    • 71849089219 scopus 로고    scopus 로고
    • Neuropathology of non-motor features of Parkinson disease
    • Dickson DW, Fujishiro H, Orr C, et al. Neuropathology of non-motor features of Parkinson disease. Parkinsonism Relat Disord 2009;15(Suppl 3):S1-S5.
    • (2009) Parkinsonism Relat Disord , vol.15 , Issue.SUPPL 3
    • Dickson, D.W.1    Fujishiro, H.2    Orr, C.3
  • 8
    • 77949897463 scopus 로고    scopus 로고
    • The progression of pathology in Parkinson's disease
    • Halliday GM, McCann H. The progression of pathology in Parkinson's disease. Ann N Y Acad Sci 2010;1184:188-195.
    • (2010) Ann N Y Acad Sci , vol.1184 , pp. 188-195
    • Halliday, G.M.1    McCann, H.2
  • 10
    • 55949119836 scopus 로고    scopus 로고
    • Emerging pathways in genetic Parkinson's disease: potential role of ceramide metabolism in Lewy body disease
    • Bras J, Singleton A, Cookson MR, Hardy J. Emerging pathways in genetic Parkinson's disease: potential role of ceramide metabolism in Lewy body disease. FEBS J 2008;275:5767-5773.
    • (2008) FEBS J , vol.275 , pp. 5767-5773
    • Bras, J.1    Singleton, A.2    Cookson, M.R.3    Hardy, J.4
  • 11
    • 78649790233 scopus 로고    scopus 로고
    • Sphingolipids in neurodegeneration
    • Haughey NJ. Sphingolipids in neurodegeneration. Neuromolecular Med 2010;12:301-305.
    • (2010) Neuromolecular Med , vol.12 , pp. 301-305
    • Haughey, N.J.1
  • 12
    • 77953268102 scopus 로고    scopus 로고
    • Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
    • Haughey NJ, Bandaru VV, Bae M, Mattson MP. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta 2010;1801:878-886.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 878-886
    • Haughey, N.J.1    Bandaru, V.V.2    Bae, M.3    Mattson, M.P.4
  • 13
    • 84855973361 scopus 로고    scopus 로고
    • Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease
    • Fabelo N, Martin V, Santpere G, et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Mol Med 2011;17:1107-1118.
    • (2011) Mol Med , vol.17 , pp. 1107-1118
    • Fabelo, N.1    Martin, V.2    Santpere, G.3
  • 14
    • 79957979887 scopus 로고    scopus 로고
    • A deficiency of ceramide biosynthesis causes cerebellar Purkinje cell neurodegeneration and lipofuscin accumulation
    • Zhao L, Spassieva SD, Jucius TJ, et al. A deficiency of ceramide biosynthesis causes cerebellar Purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet 2011;7:e1002063.
    • (2011) PLoS Genet , vol.7
    • Zhao, L.1    Spassieva, S.D.2    Jucius, T.J.3
  • 16
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • Kolesnick RN, Kronke M. Regulation of ceramide production and apoptosis. Annu Rev Physiol 1998;60:643-665.
    • (1998) Annu Rev Physiol , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 17
    • 84857762476 scopus 로고    scopus 로고
    • Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes
    • Silva LC, Ben David O, Pewzner-Jung Y, et al. Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes. J Lipid Res 2012;53:430-436.
    • (2012) J Lipid Res , vol.53 , pp. 430-436
    • Silva, L.C.1    Ben David, O.2    Pewzner-Jung, Y.3
  • 20
    • 27844517355 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
    • Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 2005;118:4605-4612.
    • (2005) J Cell Sci , vol.118 , pp. 4605-4612
    • Chalfant, C.E.1    Spiegel, S.2
  • 21
    • 84872284081 scopus 로고    scopus 로고
    • Ceramide function in the brain: when a slight tilt is enough
    • Mencarelli C, Martinez-Martinez P. Ceramide function in the brain: when a slight tilt is enough. Cell Mol Life Sci 2013;70:181-203.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 181-203
    • Mencarelli, C.1    Martinez-Martinez, P.2
  • 22
    • 42249105215 scopus 로고    scopus 로고
    • The sphingolipid salvage pathway in ceramide metabolism and signaling
    • Kitatani K, Idkowiak-Baldys J, Hannun YA. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 2008;20:1010-1018.
    • (2008) Cell Signal , vol.20 , pp. 1010-1018
    • Kitatani, K.1    Idkowiak-Baldys, J.2    Hannun, Y.A.3
  • 23
    • 0031661695 scopus 로고    scopus 로고
    • Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways
    • Gillard BK, Clement RG, Marcus DM. Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways. Glycobiology 1998;8:885-890.
    • (1998) Glycobiology , vol.8 , pp. 885-890
    • Gillard, B.K.1    Clement, R.G.2    Marcus, D.M.3
  • 24
    • 0037518448 scopus 로고    scopus 로고
    • Salvage pathways in glycosphingolipid metabolism
    • Tettamanti G, Bassi R, Viani P, Riboni L. Salvage pathways in glycosphingolipid metabolism. Biochimie 2003;85:423-437.
    • (2003) Biochimie , vol.85 , pp. 423-437
    • Tettamanti, G.1    Bassi, R.2    Viani, P.3    Riboni, L.4
  • 25
    • 0345714776 scopus 로고    scopus 로고
    • Aberrant sphingomyelin/ceramide metabolic-induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration
    • Soreghan B, Thomas SN, Yang AJ. Aberrant sphingomyelin/ceramide metabolic-induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration. Adv Drug Deliv Rev 2003;55:1515-1524.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 1515-1524
    • Soreghan, B.1    Thomas, S.N.2    Yang, A.J.3
  • 26
    • 69949134511 scopus 로고    scopus 로고
    • The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism
    • DePaolo J, Goker-Alpan O, Samaddar T, Lopez G, Sidransky E. The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism. Mov Disord 2009;24:1571-1578.
    • (2009) Mov Disord , vol.24 , pp. 1571-1578
    • DePaolo, J.1    Goker-Alpan, O.2    Samaddar, T.3    Lopez, G.4    Sidransky, E.5
  • 27
    • 66249109910 scopus 로고    scopus 로고
    • Mutations for Gaucher disease confer high susceptibility to Parkinson disease
    • Mitsui J, Mizuta I, Toyoda A, et al. Mutations for Gaucher disease confer high susceptibility to Parkinson disease. Arch Neurol 2009;66:571-576.
    • (2009) Arch Neurol , vol.66 , pp. 571-576
    • Mitsui, J.1    Mizuta, I.2    Toyoda, A.3
  • 28
    • 70350319531 scopus 로고    scopus 로고
    • Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
    • Sidransky E, Nalls MA, Aasly JO, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 2009;361:1651-1661.
    • (2009) N Engl J Med , vol.361 , pp. 1651-1661
    • Sidransky, E.1    Nalls, M.A.2    Aasly, J.O.3
  • 29
    • 84867036900 scopus 로고    scopus 로고
    • Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
    • Gegg ME, Burke D, Heales SJ, et al. Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol 2012;72:455-463.
    • (2012) Ann Neurol , vol.72 , pp. 455-463
    • Gegg, M.E.1    Burke, D.2    Heales, S.J.3
  • 30
    • 79960009804 scopus 로고    scopus 로고
    • Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies
    • Mazzulli JR, Xu YH, Sun Y, et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011;146:37-52.
    • (2011) Cell , vol.146 , pp. 37-52
    • Mazzulli, J.R.1    Xu, Y.H.2    Sun, Y.3
  • 31
    • 78649790713 scopus 로고    scopus 로고
    • The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases
    • Ben-David O, Futerman AH. The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Med 2010;12:341-350.
    • (2010) Neuromolecular Med , vol.12 , pp. 341-350
    • Ben-David, O.1    Futerman, A.H.2
  • 32
    • 77953561361 scopus 로고    scopus 로고
    • Mammalian ceramide synthases
    • Levy M, Futerman AH. Mammalian ceramide synthases. IUBMB Life 2010;62:347-356.
    • (2010) IUBMB Life , vol.62 , pp. 347-356
    • Levy, M.1    Futerman, A.H.2
  • 33
    • 84867581207 scopus 로고    scopus 로고
    • Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies
    • Lue LF, Walker DG, Adler CH, et al. Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies. Brain Pathol 2012;22:745-756.
    • (2012) Brain Pathol , vol.22 , pp. 745-756
    • Lue, L.F.1    Walker, D.G.2    Adler, C.H.3
  • 34
    • 79958169700 scopus 로고    scopus 로고
    • Changes in the solubility and phosphorylation of alpha-synuclein over the course of Parkinson's disease
    • Zhou J, Broe M, Huang Y, et al. Changes in the solubility and phosphorylation of alpha-synuclein over the course of Parkinson's disease. Acta Neuropathol 2011;121:695-704.
    • (2011) Acta Neuropathol , vol.121 , pp. 695-704
    • Zhou, J.1    Broe, M.2    Huang, Y.3
  • 35
    • 0036942832 scopus 로고    scopus 로고
    • Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria
    • Halliday G, Ng T, Rodriguez M, et al. Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria. Acta Neuropathol 2002;104:72-78.
    • (2002) Acta Neuropathol , vol.104 , pp. 72-78
    • Halliday, G.1    Ng, T.2    Rodriguez, M.3
  • 36
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184.
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 37
    • 84878352619 scopus 로고    scopus 로고
    • An improved high-throughput lipid extraction method for the analysis of human brain lipids
    • Abbott SK, Jenner AM, Mitchell TW, Brown SH, Halliday GM, Garner B. An improved high-throughput lipid extraction method for the analysis of human brain lipids. Lipids 2013;48:307-318.
    • (2013) Lipids , vol.48 , pp. 307-318
    • Abbott, S.K.1    Jenner, A.M.2    Mitchell, T.W.3    Brown, S.H.4    Halliday, G.M.5    Garner, B.6
  • 38
    • 33748514364 scopus 로고    scopus 로고
    • Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning
    • Ejsing CS, Duchoslav E, Sampaio J, et al. Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning. Anal Chem 2006;78:6202-6214.
    • (2006) Anal Chem , vol.78 , pp. 6202-6214
    • Ejsing, C.S.1    Duchoslav, E.2    Sampaio, J.3
  • 39
    • 79952237910 scopus 로고    scopus 로고
    • Lipid pathway alterations in Parkinson's disease primary visual cortex
    • Cheng D, Jenner AM, Shui G, et al. Lipid pathway alterations in Parkinson's disease primary visual cortex. PLoS One 2011;6:e17299.
    • (2011) PLoS One , vol.6
    • Cheng, D.1    Jenner, A.M.2    Shui, G.3
  • 40
    • 84857765070 scopus 로고    scopus 로고
    • Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues
    • Li H, Evin G, Hill AF, Hung YH, Bush AI, Garner B. Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues. Clin Sci (Lond) 2012;122:409-419.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 409-419
    • Li, H.1    Evin, G.2    Hill, A.F.3    Hung, Y.H.4    Bush, A.I.5    Garner, B.6
  • 41
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 1995;57:289-300.
    • (1995) J R Stat Soc Series B Stat Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 42
    • 5344244656 scopus 로고    scopus 로고
    • R Development Core Team. Vienna, Austria: R Foundation for Statistical Computing; Available at:. Accessed October 17, 2013.
    • R Development Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2008. Available at: http://www.R-project.org. Accessed October 17, 2013.
    • (2008) R: A language and environment for statistical computing
  • 43
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • Laviad EL, Albee L, Pankova-Kholmyansky I, et al. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem 2008;283:5677-5684.
    • (2008) J Biol Chem , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3
  • 44
    • 71049138581 scopus 로고    scopus 로고
    • Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism
    • Manning-Bog AB, Schule B, Langston JW. Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. Neurotoxicology 2009;30:1127-1132.
    • (2009) Neurotoxicology , vol.30 , pp. 1127-1132
    • Manning-Bog, A.B.1    Schule, B.2    Langston, J.W.3
  • 45
    • 34548522699 scopus 로고    scopus 로고
    • The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
    • Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry 2007;46:10170-10185.
    • (2007) Biochemistry , vol.46 , pp. 10170-10185
    • Lei, X.1    Zhang, S.2    Bohrer, A.3    Bao, S.4    Song, H.5    Ramanadham, S.6
  • 46
    • 29444437871 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
    • Smith WW, Pei Z, Jiang H, et al. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A 2005;102:18676-18681.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18676-18681
    • Smith, W.W.1    Pei, Z.2    Jiang, H.3
  • 47
    • 0037338634 scopus 로고    scopus 로고
    • Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
    • Darios F, Corti O, Lucking CB, et al. Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet 2003;12:517-526.
    • (2003) Hum Mol Genet , vol.12 , pp. 517-526
    • Darios, F.1    Corti, O.2    Lucking, C.B.3
  • 48
    • 84861216157 scopus 로고    scopus 로고
    • A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells
    • Sassa T, Suto S, Okayasu Y, Kihara A. A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells. Biochim Biophys Acta 2012;1821:1031-1037.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 1031-1037
    • Sassa, T.1    Suto, S.2    Okayasu, Y.3    Kihara, A.4
  • 50
    • 58849160520 scopus 로고    scopus 로고
    • Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death
    • Jana A, Hogan EL, Pahan K. Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci 2009;278:5-15.
    • (2009) J Neurol Sci , vol.278 , pp. 5-15
    • Jana, A.1    Hogan, E.L.2    Pahan, K.3
  • 51
    • 84874086182 scopus 로고    scopus 로고
    • Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
    • Zigdon H, Kogot-Levin A, Park JW, et al. Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem 2013;288:4947-4956.
    • (2013) J Biol Chem , vol.288 , pp. 4947-4956
    • Zigdon, H.1    Kogot-Levin, A.2    Park, J.W.3


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