Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B

Journal of Neurochemistry

Volumn 110, Issue 1, 2009, Pages 23-33

  Ries, Vincent ^b   Cheng, Hsiao Chun ^c   Baohan, Amy ^c   Kareva, Tatyana ^c   Oo, Tinmarla F ^c   Rzhetskaya, Margarita ^c   Bland, Ross J ^d   During, Matthew J ^e   Kholodilov, Nikolai ^c   Burke, Robert E ^a,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY HOSPITAL MARBURG   (Germany)

^c Columbia University ^*  (United States)

^d Neurologix Inc   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; MTor; Neurotrophic; Parkinson's disease; Sprouting

Indexed keywords

PARVOVIRUS VECTOR; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL SIZE; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENZYME ANALYSIS; ENZYME REGULATION; FEMALE; IN VIVO STUDY; INNERVATION; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SIZE; DOPAMINE; GENETIC VECTORS; GROWTH CONES; IMMUNOHISTOCHEMISTRY; MALE; NEURAL PATHWAYS; NEUROGENESIS; NEURONS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TRANSDUCTION, GENETIC;

EID: 67449161796     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06101.x     Document Type: Article

References (49)

1. Ahmed N. N., Grimes H. L., Bellacosa A., Chan T. O. Tsichlis P. N. (1997) Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl Acad. Sci. USA 94, 3627 3632. (Pubitemid 27180423)
2. Alonso-Vanegas M. A., Fawcett J. P., Causing C. G., Miller F. D. Sadikot A. F. (1999) Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse. J. Comp. Neurol. 413, 449 462. (Pubitemid 29445030)
3. Backman S. A., Stambolic V., Suzuki A. et al. (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396 403. (Pubitemid 34326689)
4. Besset V., Scott R. P. Ibanez C. F. (2000) Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J. Biol. Chem. 275, 39159 39166. (Pubitemid 32058932)
5. Bogush A., Pedrini S., Pelta-Heller J., Chan T., Yang Q., Mao Z., Sluzas E., Gieringer T. Ehrlich M. E. (2007) AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. J. Biol. Chem. 282, 7352 7359. (Pubitemid 47093688)
6. Brunet A., Datta S. R. Greenberg M. E. (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 11, 297 305. (Pubitemid 32524094)
7. Burke R. E. (2003) Postnatal Developmental Programmed Cell Death in Dopamine Neurons. Ann. NY Acad. Sci. 991, 69 79. (Pubitemid 36793802)
8. Burke R. E. (2004) Ontogenic cell death in the nigrostriatal system. Cell Tissue Res. 318, 63 72. (Pubitemid 39362627)
9. Campbell D. S. Holt C. E. (2001) Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32, 1013 1026. (Pubitemid 34075393)
10. Downward J. (2004) PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177 182. (Pubitemid 38251646)
11. Dudek H., Datta S. R., Franke T. F., Birnbaum M. J., Yao R., Cooper G. M., Segal R. A., Kaplan D. R. Greenberg M. E. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661 665. (Pubitemid 27061332)
12. El-Khodor B. F. Burke R. E. (2002) Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons. J. Comp. Neurol. 452, 65 79. (Pubitemid 34977539)
13. Encinas M., Tansey M. G., Tsui-Pierchala B. A., Comella J. X., Milbrandt J. Johnson Jr. E. M. (2001) c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway. J. Neurosci. 21, 1464 1472. (Pubitemid 32182188)
14. Franke T. F., Yang S. I., Chan T. O., Datta K., Kazlauskas A., Morrison D. K., Kaplan D. R. Tsichlis P. N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727 736.
15. Ganguly A., Oo T. F., Rzhetskaya M., Pratt R., Yarygina O., Momoi T., Kholodilov N. Burke R. E. (2004) CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine. J. Neurochem. 88, 469 480. (Pubitemid 38084563)
16. Gerfen C. R., Herkenham M. Thibault J. (1987) The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. J. Neurosci. 7, 3915 3934. (Pubitemid 18012405)
17. Hanada M., Feng J. Hemmings B. A. (2004) Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim. Biophys. Acta 1697, 3 16. (Pubitemid 38326757)
18. Jackson-Lewis V., Vila M., Djaldetti R., Guegan C., Liberatore G., Liu J., O'Malley K. L., Burke R. E. Przedborski S. (2000) Developmental cell death in dopaminergic neurons of the substantia nigra of mice. J. Comp. Neurol. 424, 476 488. (Pubitemid 30670445)
19. Janec E. Burke R. E. (1993) Naturally occurring cell death during postnatal development of the substantia nigra of the rat. Mol. Cell. Neurosci. 4, 30 35.
20. Jarskog L. F., Miyamoto S. Lieberman J. A. (2007) Schizophrenia: new pathological insights and therapies. Annu. Rev. Med. 58, 49 61. (Pubitemid 46706500)
21. Jeon B. S., Kholodilov N. G., Oo T. F., Kim S., Tomaselli K. J., Srinivasan A., Stefanis L. Burke R. E. (1999) Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra. J. Neurochem. 73, 322 333. (Pubitemid 29289141)
22. Kauer J. A. Malenka R. C. (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8, 844 858. (Pubitemid 350006216)
23. Kwon C. H., Zhu X., Zhang J., Knoop L. L., Tharp R., Smeyne R. J., Eberhart C. G., Burger P. C. Baker S. J. (2001) Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404 411. (Pubitemid 34326690)
24. Kwon C. H., Luikart B. W., Powell C. M., Zhou J., Matheny S. A., Zhang W., Li Y., Baker S. J. Parada L. F. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron 50, 377 388.
25. Lee V. M., Goedert M. Trojanowski J. Q. (2001) Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24, 1121 1159. (Pubitemid 32695256)
26. Li Y. H., Werner H. Puschel A. W. (2008) Rheb and mTOR regulate neuronal polarity through Rap1B. J. Biol. Chem. 283, 33784 33792.
27. Macaya A., Munell F., Gubits R. M. Burke R. E. (1994) Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc. Natl Acad. Sci. USA 91, 8117 8121. (Pubitemid 24253897)
28. Manning B. D. Cantley L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261 1274.
29. Markus A., Zhong J. Snider W. D. (2002) Raf and akt mediate distinct aspects of sensory axon growth. Neuron 35, 65 76. (Pubitemid 34804323)
30. Mograbi B., Bocciardi R., Bourget I., Busca R., Rochet N., Farahi-Far D., Juhel T. Rossi B. (2001) Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells. J. Biol. Chem. 276, 45307 45319.
31. Morton G. J., Cummings D. E., Baskin D. G., Barsh G. S. Schwartz M. W. (2006) Central nervous system control of food intake and body weight. Nature 443, 289 295. (Pubitemid 44435142)
32. Olson V. G., Heusner C. L., Bland R. J., During M. J., Weinshenker D. Palmiter R. D. (2006) Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward. Science 311, 1017 1020. (Pubitemid 43271731)
33. Oo T. F. Burke R. E. (1997) The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra. Dev Brain Res 98, 191 196. (Pubitemid 27075274)
34. Oo T. F., Kholodilov N. Burke R. E. (2003) Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal GDNF in vivo. J. Neurosci. 23, 5141 5148.
35. Oppenheim R. W. (1991) Cell death during development of the nervous system. Ann Rev Neurosci 14, 453 501.
36. Pascual A., Hidalgo-Figueroa M., Piruat J. I., Pintado C. O., Gomez-Diaz R. Lopez-Barneo J. (2008) Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat. Neurosci. 11, 755 761. (Pubitemid 351896676)
37. Paxinos G. Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego, CA.
38. Pong K., Xu R. Y., Baron W. F., Louis J. C. Beck K. D. (1998) Inhibition of phosphatidylinositol 3-kinase activity blocks cellular differentiation mediated by glial cell line-derived neurotrophic factor in dopaminergic neurons. J. Neurochem. 71, 1912 1919. (Pubitemid 28491546)
39. Prakash N. Wurst W. (2006) Genetic networks controlling the development of midbrain dopaminergic neurons. J. Physiol. 575, 403 410. (Pubitemid 44270171)
40. Ries V., Henchcliffe C., Kareva T., Rzhetskaya M., Bland R. J., During M. J., Kholodilov N. Burke R. E. (2006) Oncoprotein Akt/PKB: Trophic effects in murine models of Parkinson's Disease. Proc. Natl Acad. Sci. USA 103, 18757 18762. (Pubitemid 44913483)
41. Shioi T., McMullen J. R., Kang P. M., Douglas P. S., Obata T., Franke T. F., Cantley L. C. Izumo S. (2002) Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22, 2799 2809. (Pubitemid 34263000)
42. Smidt M. P. Burbach J. P. (2007) How to make a mesodiencephalic dopaminergic neuron. Nat Rev Neurosci 8, 21 32. (Pubitemid 46011996)
43. Soler R. M., Dolcet X., Encinas M., Egea J., Bayascas J. R. Comella J. X. (1999) Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J. Neurosci. 19, 9160 9169. (Pubitemid 30228068)
44. Songyang Z., Baltimore D., Cantley L. C., Kaplan D. R. Franke T. F. (1997) Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl Acad. Sci. USA 94, 11345 11350. (Pubitemid 27451001)
45. Swiech L., Perycz M., Malik A. Jaworski J. (2008) Role of mTOR in physiology and pathology of the nervous system. Biochim. Biophys. Acta 1784, 116 132.
46. Ugarte S. D., Lin E., Klann E., Zigmond M. J. Perez R. G. (2003) Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK. J. Neurosci. Res. 73, 105 112. (Pubitemid 36791375)
47. Wang Q., Liu L., Pei L., Ju W., Ahmadian G., Lu J., Wang Y., Liu F. Wang Y. T. (2003) Control of synaptic strength, a novel function of Akt. Neuron 38, 915 928. (Pubitemid 36782383)
48. Wullschleger S., Loewith R. Hall M. N. (2006) TOR signaling in growth and metabolism. Cell 124, 471 484. (Pubitemid 43199434)
49. Yao R. Cooper G. M. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003 2006.