-
1
-
-
33645116252
-
Genetics of Parkinson disease: Paradigm shifts and future prospects
-
Farrer MJ. Genetics of Parkinson disease: paradigm shifts and future prospects. Nat. Rev. Genet. 7(4), 306-318 (2006).
-
(2006)
Nat. Rev. Genet.
, vol.7
, Issue.4
, pp. 306-318
-
-
Farrer, M.J.1
-
2
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39(6), 889-909 (2003).
-
(2003)
Neuron
, vol.39
, Issue.6
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
3
-
-
0035409575
-
A-synuclein and neurodegenerative diseases
-
Goedert M. a-synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2(7), 492-501 (2001).
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, Issue.7
, pp. 492-501
-
-
Goedert, M.1
-
4
-
-
0035960120
-
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease
-
Deep-Brain Stimulation for Parkinson's Disease Study Group
-
Deep-Brain Stimulation for Parkinson's Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N. Engl. J. Med. 345(13), 956-963 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, Issue.13
, pp. 956-963
-
-
-
5
-
-
0036581222
-
The GDNF family: Signalling, biological functions and therapeutic value
-
Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci. 3(5), 383-394 (2002).
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, Issue.5
, pp. 383-394
-
-
Airaksinen, M.S.1
Saarma, M.2
-
6
-
-
1642499508
-
Localized striatal delivery of GDNF as a treatment for Parkinson disease
-
Kirik D, Georgievska B, Bjorklund A. Localized striatal delivery of GDNF as a treatment for Parkinson disease. Nat. Neurosci. 7(2), 105-110 (2004).
-
(2004)
Nat. Neurosci.
, vol.7
, Issue.2
, pp. 105-110
-
-
Kirik, D.1
Georgievska, B.2
Bjorklund, A.3
-
7
-
-
0027285510
-
GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
-
Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260(5111), 1130-1132 (1993).
-
(1993)
Science
, vol.260
, Issue.5111
, pp. 1130-1132
-
-
Lin, L.F.1
Doherty, D.H.2
Lile, J.D.3
Bektesh, S.4
Collins, F.5
-
8
-
-
0028220834
-
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
-
Sauer H, Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59(2), 401-415 (1994).
-
(1994)
Neuroscience
, vol.59
, Issue.2
, pp. 401-415
-
-
Sauer, H.1
Oertel, W.H.2
-
9
-
-
0030884756
-
Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
-
Rosenblad C, Martinez-Serrano A, Bjorklund A. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience 82(1), 129-137 (1998).
-
(1998)
Neuroscience
, vol.82
, Issue.1
, pp. 129-137
-
-
Rosenblad, C.1
Martinez-Serrano, A.2
Bjorklund, A.3
-
10
-
-
0034097605
-
Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
-
Rosenblad C, Kirik D, Bjorklund A. Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp. Neurol. 161(2), 503-516 (2000).
-
(2000)
Exp. Neurol.
, vol.161
, Issue.2
, pp. 503-516
-
-
Rosenblad, C.1
Kirik, D.2
Bjorklund, A.3
-
11
-
-
0032939002
-
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
-
Rosenblad C, Kirik D, Devaux B, Moffat B, Phillips HS, Bjorklund A. Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. Eur. J. Neurosci. 11(5), 1554-1566 (1999).
-
(1999)
Eur. J. Neurosci.
, vol.11
, Issue.5
, pp. 1554-1566
-
-
Rosenblad, C.1
Kirik, D.2
Devaux, B.3
Moffat, B.4
Phillips, H.S.5
Bjorklund, A.6
-
12
-
-
0032125462
-
Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
-
Horger BA, Nishimura MC, Armanini MP et al. Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci. 18(13), 4929-4937 (1998).
-
(1998)
J. Neurosci.
, vol.18
, Issue.13
, pp. 4929-4937
-
-
Horger, B.A.1
Nishimura, M.C.2
Armanini, M.P.3
-
13
-
-
0030438456
-
Functional effects of GDNF in normal rat striatum: Presynaptic studies using in vivo electrochemistry and microdialysis
-
Hebert MA, Van Horne CG, Hoffer BJ, Gerhardt GA. Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. J. Pharmacol. Exp. Ther. 279(3), 1181-1190 (1996).
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, Issue.3
, pp. 1181-1190
-
-
Hebert, M.A.1
Van Horne, C.G.2
Hoffer, B.J.3
Gerhardt, G.A.4
-
14
-
-
0030593912
-
Intranigral or intrastriatal injections of GDNF: Effects on monoamine levels and behavior in rats
-
Martin D, Miller G, Cullen T, Fischer N, Dix D, Russell D. Intranigral or intrastriatal injections of GDNF: effects on monoamine levels and behavior in rats. Eur. J. Pharmacol. 317(2-3), 247-256 (1996).
-
(1996)
Eur. J. Pharmacol.
, vol.317
, Issue.2-3
, pp. 247-256
-
-
Martin, D.1
Miller, G.2
Cullen, T.3
Fischer, N.4
Dix, D.5
Russell, D.6
-
15
-
-
0030854870
-
Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats
-
Hebert MA, Gerhardt GA. Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats. J. Pharmacol. Exp. Ther. 282(2), 760-768 (1997).
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, Issue.2
, pp. 760-768
-
-
Hebert, M.A.1
Gerhardt, G.A.2
-
16
-
-
0035887595
-
Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
-
Akerud P, Canals JM, Snyder EY, Arenas E. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. J. Neurosci. 21(20), 8108-8118 (2001).
-
(2001)
J. Neurosci.
, vol.21
, Issue.20
, pp. 8108-8118
-
-
Akerud, P.1
Canals, J.M.2
Snyder, E.Y.3
Arenas, E.4
-
17
-
-
0037106156
-
Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease
-
Shingo T, Date I, Yoshida H, Ohmoto T. Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease. J. Neurosci. Res. 69(6), 946-954 (2002).
-
(2002)
J. Neurosci. Res.
, vol.69
, Issue.6
, pp. 946-954
-
-
Shingo, T.1
Date, I.2
Yoshida, H.3
Ohmoto, T.4
-
18
-
-
0036458044
-
Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF
-
McBride JL, Kordower JH. Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF. Prog. Brain Res. 138, 421-432 (2002).
-
(2002)
Prog. Brain Res.
, vol.138
, pp. 421-432
-
-
McBride, J.L.1
Kordower, J.H.2
-
19
-
-
0034659835
-
Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
-
Kirik D, Rosenblad C, Bjorklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J. Neurosci. 20(12), 4686-4700 (2000).
-
(2000)
J. Neurosci.
, vol.20
, Issue.12
, pp. 4686-4700
-
-
Kirik, D.1
Rosenblad, C.2
Bjorklund, A.3
Mandel, R.J.4
-
20
-
-
0034672304
-
Towards a neuroprotective gene therapy for Parkinson's disease: Use of adenovirus AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
-
Bjorklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Res. 886(1-2), 82-98 (2000).
-
(2000)
Brain Res.
, vol.886
, Issue.1-2
, pp. 82-98
-
-
Bjorklund, A.1
Kirik, D.2
Rosenblad, C.3
Georgievska, B.4
Lundberg, C.5
Mandel, R.J.6
-
21
-
-
34250336916
-
AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson's disease
-
Gasmi M, Brandon EP, Herzog CD et al. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiol. Dis. 27(1), 67-76 (2007).
-
(2007)
Neurobiol. Dis.
, vol.27
, Issue.1
, pp. 67-76
-
-
Gasmi, M.1
Brandon, E.P.2
Herzog, C.D.3
-
22
-
-
38049112581
-
RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals
-
Kowsky S, Poppelmeyer C, Kramer ER et al. RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proc. Natl Acad. Sci. USA 104(50), 20049-20054 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.50
, pp. 20049-20054
-
-
Kowsky, S.1
Poppelmeyer, C.2
Kramer, E.R.3
-
23
-
-
46049095244
-
Absolute requirement of GDNF for adult catecholaminergic neuron survival
-
Pascual A, Hidalgo-Figueroa M, Piruat JI, Pintado CO, Gomez-Diaz R, Lopez-Barneo J. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat. Neurosci. 11(7), 755-761 (2008).
-
(2008)
Nat. Neurosci.
, vol.11
, Issue.7
, pp. 755-761
-
-
Pascual, A.1
Hidalgo-Figueroa, M.2
Piruat, J.I.3
Pintado, C.O.4
Gomez-Diaz, R.5
Lopez-Barneo, J.6
-
24
-
-
0037336930
-
Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys
-
Grondin R, Cass WA, Zhang Z, Stanford JA, Gash DM, Gerhardt GA. Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys. J. Neurosci. 23(5), 1974-1980 (2003).
-
(2003)
J. Neurosci.
, vol.23
, Issue.5
, pp. 1974-1980
-
-
Grondin, R.1
Cass, W.A.2
Zhang, Z.3
Stanford, J.A.4
Gash, D.M.5
Gerhardt, G.A.6
-
25
-
-
13344277993
-
Functional recovery in parkinsonian monkeys treated with GDNF
-
Gash DM, Zhang Z, Ovadia A et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380(6571), 252-255 (1996).
-
(1996)
Nature
, vol.380
, Issue.6571
, pp. 252-255
-
-
Gash, D.M.1
Zhang, Z.2
Ovadia, A.3
-
26
-
-
0036787532
-
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
-
Grondin R, Zhang Z, Yi A et al. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain 125(Pt 10), 2191-2201 (2002).
-
(2002)
Brain
, vol.125
, Issue.PART 10
, pp. 2191-2201
-
-
Grondin, R.1
Zhang, Z.2
Yi, A.3
-
27
-
-
0035131350
-
GDNF reverses priming for dyskinesia in MPTP-treated, l-DOPA-primed common marmosets
-
Iravani MM, Costa S, Jackson MJ et al. GDNF reverses priming for dyskinesia in MPTP-treated, l-DOPA-primed common marmosets. Eur. J. Neurosci. 13(3), 597-608 (2001).
-
(2001)
Eur. J. Neurosci.
, vol.13
, Issue.3
, pp. 597-608
-
-
Iravani, M.M.1
Costa, S.2
Jackson, M.J.3
-
29
-
-
0034721690
-
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
-
Kordower JH, Emborg ME, Bloch J et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290(5492), 767-773 (2000).
-
(2000)
Science
, vol.290
, Issue.5492
, pp. 767-773
-
-
Kordower, J.H.1
Emborg, M.E.2
Bloch, J.3
-
30
-
-
12844287442
-
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
-
Eslamboli A, Georgievska B, Ridley RM et al. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. J. Neurosci. 25(4), 769-777 (2005).
-
(2005)
J. Neurosci.
, vol.25
, Issue.4
, pp. 769-777
-
-
Eslamboli, A.1
Georgievska, B.2
Ridley, R.M.3
-
31
-
-
34447572589
-
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys
-
Herzog CD, Dass B, Holden JE et al. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov. Disord. 22(8), 1124-1132 (2007).
-
(2007)
Mov. Disord.
, vol.22
, Issue.8
, pp. 1124-1132
-
-
Herzog, C.D.1
Dass, B.2
Holden, J.E.3
-
32
-
-
33845993229
-
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
-
Kordower JH, Herzog CD, Dass B et al. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann. Neurol. 60(6), 706-715 (2006).
-
(2006)
Ann. Neurol.
, vol.60
, Issue.6
, pp. 706-715
-
-
Kordower, J.H.1
Herzog, C.D.2
Dass, B.3
-
33
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273(5271), 59-63 (1996).
-
(1996)
Science
, vol.273
, Issue.5271
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
34
-
-
0033391395
-
Caloric intake and aging: Mechanisms in rodents and a study in nonhuman primates
-
Wanagat J, Allison DB, Weindruch R. Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol. Sci. 52(2 Suppl.), 35-40 (1999).
-
(1999)
Toxicol. Sci.
, vol.52
, Issue.2 SUPPL.
, pp. 35-40
-
-
Wanagat, J.1
Allison, D.B.2
Weindruch, R.3
-
35
-
-
72949117234
-
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
-
Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462(7276), 1061-1064 (2009).
-
(2009)
Nature
, vol.462
, Issue.7276
, pp. 1061-1064
-
-
Grandison, R.C.1
Piper, M.D.2
Partridge, L.3
-
37
-
-
19944427435
-
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
-
Maswood N, Young J, Tilmont E et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc. Natl Acad. Sci. USA 101(52), 18171-18176 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.52
, pp. 18171-18176
-
-
Maswood, N.1
Young, J.2
Tilmont, E.3
-
38
-
-
0032850453
-
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
-
Kordower JH, Palfi S, Chen EY et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann. Neurol. 46(3), 419-424 (1999).
-
(1999)
Ann. Neurol.
, vol.46
, Issue.3
, pp. 419-424
-
-
Kordower, J.H.1
Palfi, S.2
Chen, E.Y.3
-
39
-
-
0037435511
-
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
-
Nutt JG, Burchiel KJ, Comella CL et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60(1), 69-73 (2003).
-
(2003)
Neurology
, vol.60
, Issue.1
, pp. 69-73
-
-
Nutt, J.G.1
Burchiel, K.J.2
Comella, C.L.3
-
40
-
-
0038249170
-
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
-
Gill SS, Patel NK, Hotton GR et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat. Med. 9(5), 589-595 (2003).
-
(2003)
Nat. Med.
, vol.9
, Issue.5
, pp. 589-595
-
-
Gill, S.S.1
Patel, N.K.2
Hotton, G.R.3
-
41
-
-
13144282676
-
Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
-
Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann. Neurol. 57(2), 298-302 (2005).
-
(2005)
Ann. Neurol.
, vol.57
, Issue.2
, pp. 298-302
-
-
Patel, N.K.1
Bunnage, M.2
Plaha, P.3
Svendsen, C.N.4
Heywood, P.5
Gill, S.S.6
-
42
-
-
22544461907
-
Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
-
Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, Gill SS. Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat. Med. 11(7), 703-704 (2005).
-
(2005)
Nat. Med.
, vol.11
, Issue.7
, pp. 703-704
-
-
Love, S.1
Plaha, P.2
Patel, N.K.3
Hotton, G.R.4
Brooks, D.J.5
Gill, S.S.6
-
43
-
-
33644833272
-
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
-
Lang AE, Gill S, Patel NK et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol. 59(3), 459-466 (2006).
-
(2006)
Ann. Neurol.
, vol.59
, Issue.3
, pp. 459-466
-
-
Lang, A.E.1
Gill, S.2
Patel, N.K.3
-
44
-
-
41949110690
-
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: An open-label Phase i trial
-
Marks WJ Jr, Ostrem JL, Verhagen L et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, Phase I trial. Lancet Neurol. 7(5), 400-408 (2008).
-
(2008)
Lancet Neurol.
, vol.7
, Issue.5
, pp. 400-408
-
-
Marks Jr., W.J.1
Ostrem, J.L.2
Verhagen, L.3
-
45
-
-
0034927081
-
Neurotrophins: Roles in neuronal development and function
-
Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24, 677-736 (2001).
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 677-736
-
-
Huang, E.J.1
Reichardt, L.F.2
-
46
-
-
23044488902
-
The yin and yang of neurotrophin action
-
Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat. Rev. Neurosci. 6(8), 603-614 (2005).
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, Issue.8
, pp. 603-614
-
-
Lu, B.1
Pang, P.T.2
Woo, N.H.3
-
47
-
-
0028215334
-
Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs
-
Seroogy KB, Lundgren KH, Tran TM, Guthrie KM, Isackson PJ, Gall CM. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J. Comp. Neurol. 342(3), 321-334 (1994).
-
(1994)
J. Comp. Neurol.
, vol.342
, Issue.3
, pp. 321-334
-
-
Seroogy, K.B.1
Lundgren, K.H.2
Tran, T.M.3
Guthrie, K.M.4
Isackson, P.J.5
Gall, C.M.6
-
48
-
-
0033597983
-
Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
-
Mogi M, Togari A, Kondo T et al. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci. Lett. 270(1), 45-48 (1999).
-
(1999)
Neurosci. Lett.
, vol.270
, Issue.1
, pp. 45-48
-
-
Mogi, M.1
Togari, A.2
Kondo, T.3
-
49
-
-
0033602009
-
Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra
-
Parain K, Murer MG, Yan Q et al. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 10(3), 557-561 (1999).
-
(1999)
Neuroreport
, vol.10
, Issue.3
, pp. 557-561
-
-
Parain, K.1
Murer, M.G.2
Yan, Q.3
-
50
-
-
0033762265
-
Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra
-
Howells DW, Porritt MJ, Wong JY et al. Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp. Neurol. 166(1), 127-135 (2000).
-
(2000)
Exp. Neurol.
, vol.166
, Issue.1
, pp. 127-135
-
-
Howells, D.W.1
Porritt, M.J.2
Wong, J.Y.3
-
51
-
-
0029035602
-
BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine
-
Shults CW, Kimber T, Altar CA. BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine. Neuroreport 6(8), 1109-1112 (1995).
-
(1995)
Neuroreport
, vol.6
, Issue.8
, pp. 1109-1112
-
-
Shults, C.W.1
Kimber, T.2
Altar, C.A.3
-
52
-
-
0029610630
-
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
-
Levivier M, Przedborski S, Bencsics C, Kang UJ. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 15(12), 7810-7820 (1995).
-
(1995)
J. Neurosci.
, vol.15
, Issue.12
, pp. 7810-7820
-
-
Levivier, M.1
Przedborski, S.2
Bencsics, C.3
Kang, U.J.4
-
53
-
-
0032704605
-
Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
-
Klein RL, Lewis MH, Muzyczka N, Meyer EM. Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain Res. 847(2), 314-320 (1999).
-
(1999)
Brain Res.
, vol.847
, Issue.2
, pp. 314-320
-
-
Klein, R.L.1
Lewis, M.H.2
Muzyczka, N.3
Meyer, E.M.4
-
54
-
-
0029103262
-
Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1, 2,3,6- tetrahydropyridine-induced parkinsonism in monkeys
-
Tsukahara T, Takeda M, Shimohama S, Ohara O, Hashimoto N. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery 37(4), 733-741 (1995).
-
(1995)
Neurosurgery
, vol.37
, Issue.4
, pp. 733-741
-
-
Tsukahara, T.1
Takeda, M.2
Shimohama, S.3
Ohara, O.4
Hashimoto, N.5
-
55
-
-
13444273332
-
Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons
-
Porritt MJ, Batchelor PE, Howells DW. Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Exp. Neurol. 192(1), 226-234 (2005).
-
(2005)
Exp. Neurol.
, vol.192
, Issue.1
, pp. 226-234
-
-
Porritt, M.J.1
Batchelor, P.E.2
Howells, D.W.3
-
56
-
-
21544446985
-
Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta
-
Baquet ZC, Bickford PC, Jones KR. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J. Neurosci. 25(26), 6251-6259 (2005).
-
(2005)
J. Neurosci.
, vol.25
, Issue.26
, pp. 6251-6259
-
-
Baquet, Z.C.1
Bickford, P.C.2
Jones, K.R.3
-
57
-
-
26444562924
-
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of a-synuclein in the substantia nigra
-
von Bohlen und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of a-synuclein in the substantia nigra. FASEB J. 19(12), 1740-1742 (2005).
-
(2005)
FASEB J.
, vol.19
, Issue.12
, pp. 1740-1742
-
-
Von Bohlen1
Halbach, O.2
Minichiello, L.3
Unsicker, K.4
-
58
-
-
0032765275
-
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
-
Croll SD, Suri C, Compton DL et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93(4), 1491-1506 (1999).
-
(1999)
Neuroscience
, vol.93
, Issue.4
, pp. 1491-1506
-
-
Croll, S.D.1
Suri, C.2
Compton, D.L.3
-
59
-
-
18744409324
-
Decreased BDNF signalling in transgenic mice reduces epileptogenesis
-
Lahteinen S, Pitkanen A, Saarelainen T, Nissinen J, Koponen E, Castren E. Decreased BDNF signalling in transgenic mice reduces epileptogenesis. Eur. J. Neurosci. 15(4), 721-734 (2002).
-
(2002)
Eur. J. Neurosci.
, vol.15
, Issue.4
, pp. 721-734
-
-
Lahteinen, S.1
Pitkanen, A.2
Saarelainen, T.3
Nissinen, J.4
Koponen, E.5
Castren, E.6
-
60
-
-
0344441260
-
Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling
-
Lahteinen S, Pitkanen A, Koponen E, Saarelainen T, Castren E. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling. Neuroscience 122(4), 1081-1092 (2003).
-
(2003)
Neuroscience
, vol.122
, Issue.4
, pp. 1081-1092
-
-
Lahteinen, S.1
Pitkanen, A.2
Koponen, E.3
Saarelainen, T.4
Castren, E.5
-
61
-
-
0034208461
-
A Phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis
-
Ochs G, Penn RD, York M et al. A Phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1(3), 201-206 (2000).
-
(2000)
Amyotroph. Lateral Scler. Other Motor Neuron Disord.
, vol.1
, Issue.3
, pp. 201-206
-
-
Ochs, G.1
Penn, R.D.2
York, M.3
-
62
-
-
77249168715
-
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
-
Jang SW, Liu X, Yepes M et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc. Natl Acad. Sci. USA 107(6), 2687-2692 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA 107
, vol.6
, pp. 2687-2692
-
-
Jang, S.W.1
Liu, X.2
Yepes, M.3
-
63
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9(6), 669-676 (2003).
-
(2003)
Nat. Med.
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
64
-
-
0033586471
-
Blood vessels change in the mesencephalon of patients with Parkinson's disease
-
Faucheux BA, Bonnet AM, Agid Y, Hirsch EC. Blood vessels change in the mesencephalon of patients with Parkinson's disease. Lancet 353(9157), 981-982 (1999).
-
(1999)
Lancet
, vol.353
, Issue.9157
, pp. 981-982
-
-
Faucheux, B.A.1
Bonnet, A.M.2
Agid, Y.3
Hirsch, E.C.4
-
65
-
-
2342667384
-
New roles for VEGF in nervous tissue - Beyond blood vessels
-
Rosenstein JM, Krum JM. New roles for VEGF in nervous tissue - beyond blood vessels. Exp. Neurol. 187(2), 246-253 (2004).
-
(2004)
Exp. Neurol.
, vol.187
, Issue.2
, pp. 246-253
-
-
Rosenstein, J.M.1
Krum, J.M.2
-
66
-
-
33745457691
-
Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease
-
Wada K, Arai H, Takanashi M et al. Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease. Neuroreport 17(7), 705-709 (2006).
-
(2006)
Neuroreport
, vol.17
, Issue.7
, pp. 705-709
-
-
Wada, K.1
Arai, H.2
Takanashi, M.3
-
67
-
-
0032903416
-
Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures
-
Silverman WF, Krum JM, Mani N, Rosenstein JM. Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience 90(4), 1529-1541 (1999).
-
(1999)
Neuroscience
, vol.90
, Issue.4
, pp. 1529-1541
-
-
Silverman, W.F.1
Krum, J.M.2
Mani, N.3
Rosenstein, J.M.4
-
68
-
-
0042665632
-
Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): Studies of grafted and cultured embryonic ventral mesencephalic cells
-
Pitzer MR, Sortwell CE, Daley BF et al. Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells. Exp. Neurol. 182(2), 435-445 (2003).
-
(2003)
Exp. Neurol.
, vol.182
, Issue.2
, pp. 435-445
-
-
Pitzer, M.R.1
Sortwell, C.E.2
Daley, B.F.3
-
69
-
-
12144291581
-
Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease
-
Yasuhara T, Shingo T, Kobayashi K et al. Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease. Eur. J. Neurosci. 19(6), 1494-1504 (2004).
-
(2004)
Eur. J. Neurosci.
, vol.19
, Issue.6
, pp. 1494-1504
-
-
Yasuhara, T.1
Shingo, T.2
Kobayashi, K.3
-
70
-
-
20044390031
-
The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model
-
Yasuhara T, Shingo T, Muraoka K et al. The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model. Brain Res. 1038(1), 1-10 (2005).
-
(2005)
Brain Res.
, vol.1038
, Issue.1
, pp. 1-10
-
-
Yasuhara, T.1
Shingo, T.2
Muraoka, K.3
-
71
-
-
23644431519
-
Neurorescue effects of VEGF on a rat model of Parkinson's disease
-
Yasuhara T, Shingo T, Muraoka K et al. Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Res. 1053(1-2), 10-18 (2005).
-
(2005)
Brain Res.
, vol.1053
, Issue.1-2
, pp. 10-18
-
-
Yasuhara, T.1
Shingo, T.2
Muraoka, K.3
-
72
-
-
34250624892
-
Favorable effects of VEGF gene transfer on a rat model of Parkinson disease using adeno-associated viral vectors
-
Tian YY, Tang CJ, Wang JN et al. Favorable effects of VEGF gene transfer on a rat model of Parkinson disease using adeno-associated viral vectors. Neurosci. Lett. 421(3), 239-244 (2007).
-
(2007)
Neurosci. Lett.
, vol.421
, Issue.3
, pp. 239-244
-
-
Tian, Y.Y.1
Tang, C.J.2
Wang, J.N.3
-
73
-
-
0025772716
-
PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity
-
Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp. Eye Res. 53(3), 411-414 (1991).
-
(1991)
Exp. Eye Res.
, vol.53
, Issue.3
, pp. 411-414
-
-
Tombran-Tink, J.1
Chader, G.G.2
Johnson, L.V.3
-
74
-
-
0027446940
-
Pigment epithelium-derived factor: Neurotrophic activity and identification as a member of the serine protease inhibitor gene family
-
Steele FR, Chader GJ, Johnson LV, Tombran-Tink J. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc. Natl Acad. Sci. USA 90(4), 1526-1530 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, Issue.4
, pp. 1526-1530
-
-
Steele, F.R.1
Chader, G.J.2
Johnson, L.V.3
Tombran-Tink, J.4
-
76
-
-
0033538517
-
Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
-
Dawson DW, Volpert OV, Gillis P et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285(5425), 245-248 (1999).
-
(1999)
Science
, vol.285
, Issue.5425
, pp. 245-248
-
-
Dawson, D.W.1
Volpert, O.V.2
Gillis, P.3
-
77
-
-
0035654217
-
Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease
-
Spranger J, Osterhoff M, Reimann M et al. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 50(12), 2641-2645 (2001).
-
(2001)
Diabetes
, vol.50
, Issue.12
, pp. 2641-2645
-
-
Spranger, J.1
Osterhoff, M.2
Reimann, M.3
-
78
-
-
0034880565
-
Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment
-
Ogata N, Tombran-Tink J, Nishikawa M et al. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am. J. Ophthalmol. 132(3), 378-382 (2001).
-
(2001)
Am. J. Ophthalmol.
, vol.132
, Issue.3
, pp. 378-382
-
-
Ogata, N.1
Tombran-Tink, J.2
Nishikawa, M.3
-
79
-
-
0036329579
-
Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration
-
Holekamp NM, Bouck N, Volpert O. Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am. J. Ophthalmol. 134(2), 220-227 (2002).
-
(2002)
Am. J. Ophthalmol.
, vol.134
, Issue.2
, pp. 220-227
-
-
Holekamp, N.M.1
Bouck, N.2
Volpert, O.3
-
80
-
-
0035173448
-
Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
-
Ohno-Matsui K, Morita I, Tombran-Tink J et al. Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J. Cell Physiol. 189(3), 323-333 (2001).
-
(2001)
J. Cell Physiol.
, vol.189
, Issue.3
, pp. 323-333
-
-
Ohno-Matsui, K.1
Morita, I.2
Tombran-Tink, J.3
-
81
-
-
0036742063
-
Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy
-
Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am. J. Ophthalmol. 134(3), 348-353 (2002).
-
(2002)
Am. J. Ophthalmol.
, vol.134
, Issue.3
, pp. 348-353
-
-
Ogata, N.1
Nishikawa, M.2
Nishimura, T.3
Mitsuma, Y.4
Matsumura, M.5
-
82
-
-
0037173042
-
Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization
-
Raisler BJ, Berns KI, Grant MB, Beliaev D, Hauswirth WW. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc. Natl Acad. Sci. USA 99(13), 8909-8914 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, Issue.13
, pp. 8909-8914
-
-
Raisler, B.J.1
Berns, K.I.2
Grant, M.B.3
Beliaev, D.4
Hauswirth, W.W.5
-
83
-
-
33747355985
-
Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: Results from an in vitro model system
-
McKay BS, Goodman B, Falk T, Sherman SJ. Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system. Exp. Neurol. 201(1), 234-243 (2006).
-
(2006)
Exp. Neurol.
, vol.201
, Issue.1
, pp. 234-243
-
-
McKay, B.S.1
Goodman, B.2
Falk, T.3
Sherman, S.J.4
-
84
-
-
65149101576
-
Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease
-
Falk T, Zhang S, Sherman SJ. Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease. Neurosci. Lett. 458(2), 49-52 (2009).
-
(2009)
Neurosci. Lett.
, vol.458
, Issue.2
, pp. 49-52
-
-
Falk, T.1
Zhang, S.2
Sherman, S.J.3
-
85
-
-
0141940594
-
Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: A potential new cell therapy for Parkinson's disease
-
Watts RL, Raiser CD, Stover NP et al. Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson's disease. J. Neural Transm. Suppl. 65, 215-227 (2003).
-
(2003)
J. Neural Transm. Suppl.
, vol.65
, pp. 215-227
-
-
Watts, R.L.1
Raiser, C.D.2
Stover, N.P.3
-
86
-
-
41349115535
-
Spheramine for treatment of Parkinson's disease
-
Stover NP, Watts RL. Spheramine for treatment of Parkinson's disease. Neurotherapeutics 5(2), 252-259 (2008).
-
(2008)
Neurotherapeutics
, vol.5
, Issue.2
, pp. 252-259
-
-
Stover, N.P.1
Watts, R.L.2
-
87
-
-
67651043684
-
Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: Possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease
-
Ming M, Li X, Fan X et al. Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. J. Transl. Med. 7, 53 (2009).
-
(2009)
J. Transl. Med.
, vol.7
, pp. 53
-
-
Ming, M.1
Li, X.2
Fan, X.3
-
88
-
-
34447617722
-
Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease
-
Yasuda T, Fukuda-Tani M, Nihira T et al. Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease. Exp. Neurol. 206(2), 308-317 (2007).
-
(2007)
Exp. Neurol.
, vol.206
, Issue.2
, pp. 308-317
-
-
Yasuda, T.1
Fukuda-Tani, M.2
Nihira, T.3
-
89
-
-
0032432604
-
An immortalized, type-1 astrocyte of mesencephalic origin source of a dopaminergic neurotrophic factor
-
Panchision DM, Martin-DeLeon PA, Takeshima T et al. An immortalized, type-1 astrocyte of mesencephalic origin source of a dopaminergic neurotrophic factor. J. Mol. Neurosci. 11(3), 209-221 (1998).
-
(1998)
J. Mol. Neurosci.
, vol.11
, Issue.3
, pp. 209-221
-
-
Panchision, D.M.1
Martin-Deleon, P.A.2
Takeshima, T.3
-
90
-
-
0037942718
-
MANF: A new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons
-
Petrova P, Raibekas A, Pevsner J et al. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J. Mol. Neurosci. 20(2), 173-188 (2003).
-
(2003)
J. Mol. Neurosci.
, vol.20
, Issue.2
, pp. 173-188
-
-
Petrova, P.1
Raibekas, A.2
Pevsner, J.3
-
91
-
-
68049127516
-
Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease
-
Voutilainen MH, Back S, Porsti E et al. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. J. Neurosci. 29(30), 9651-9659 (2009).
-
(2009)
J. Neurosci.
, vol.29
, Issue.30
, pp. 9651-9659
-
-
Voutilainen, M.H.1
Back, S.2
Porsti, E.3
-
92
-
-
34447132381
-
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
-
Lindholm P, Voutilainen MH, Lauren J et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 448(7149), 73-77 (2007).
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 73-77
-
-
Lindholm, P.1
Voutilainen, M.H.2
Lauren, J.3
-
93
-
-
0031876655
-
Anti-inflammatory effects of granulocyte colony-stimulating factor
-
Hartung T. Anti-inflammatory effects of granulocyte colony-stimulating factor. Curr. Opin. Hematol. 5(3), 221-225 (1998).
-
(1998)
Curr. Opin. Hematol.
, vol.5
, Issue.3
, pp. 221-225
-
-
Hartung, T.1
-
94
-
-
0032535052
-
Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor
-
Armitage JO. Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. Blood 92(12), 4491-4508 (1998).
-
(1998)
Blood
, vol.92
, Issue.12
, pp. 4491-4508
-
-
Armitage, J.O.1
-
95
-
-
0042259168
-
Safety and efficacy of pegfilgrastim in patients receiving myelosuppressive chemotherapy
-
Crawford J. Safety and efficacy of pegfilgrastim in patients receiving myelosuppressive chemotherapy. Pharmacotherapy 23(8 Pt 2), S15-S19 (2003).
-
(2003)
Pharmacotherapy
, vol.23
, Issue.8 PART 2
-
-
Crawford, J.1
-
96
-
-
34547915244
-
Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial
-
Yoon SH, Shim YS, Park YH et al. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells 25(8), 2066-2073 (2007).
-
(2007)
Stem Cells
, vol.25
, Issue.8
, pp. 2066-2073
-
-
Yoon, S.H.1
Shim, Y.S.2
Park, Y.H.3
-
97
-
-
0037083294
-
G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation
-
Zavala F, Abad S, Ezine S, Taupin V, Masson A, Bach JF. G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J. Immunol. 168(4), 2011-2019 (2002).
-
(2002)
J. Immunol.
, vol.168
, Issue.4
, pp. 2011-2019
-
-
Zavala, F.1
Abad, S.2
Ezine, S.3
Taupin, V.4
Masson, A.5
Bach, J.F.6
-
98
-
-
0037338416
-
Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia
-
Schabitz WR, Kollmar R, Schwaninger M et al. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34(3), 745-751 (2003).
-
(2003)
Stroke
, vol.34
, Issue.3
, pp. 745-751
-
-
Schabitz, W.R.1
Kollmar, R.2
Schwaninger, M.3
-
99
-
-
23644445498
-
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
-
Schneider A, Kruger C, Steigleder T et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115(8), 2083-2098 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.8
, pp. 2083-2098
-
-
Schneider, A.1
Kruger, C.2
Steigleder, T.3
-
100
-
-
33845667413
-
Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages
-
Bouhy D, Malgrange B, Multon S et al. Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous macrophages. FASEB J. 20(8), 1239-1241 (2006).
-
(2006)
FASEB J.
, vol.20
, Issue.8
, pp. 1239-1241
-
-
Bouhy, D.1
Malgrange, B.2
Multon, S.3
-
101
-
-
34247877666
-
GM-CSF inhibits apoptosis of neural cells via regulating the expression of apoptosis-related proteins
-
Huang X, Choi JK, Park SR et al. GM-CSF inhibits apoptosis of neural cells via regulating the expression of apoptosis-related proteins. Neurosci. Res. 58(1), 50-57 (2007).
-
(2007)
Neurosci. Res.
, vol.58
, Issue.1
, pp. 50-57
-
-
Huang, X.1
Choi, J.K.2
Park, S.R.3
-
102
-
-
37549052559
-
A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
-
Schabitz WR, Kruger C, Pitzer C et al. A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J. Cereb. Blood Flow Metab. 28(1), 29-43 (2008).
-
(2008)
J. Cereb. Blood Flow Metab.
, vol.28
, Issue.1
, pp. 29-43
-
-
Schabitz, W.R.1
Kruger, C.2
Pitzer, C.3
-
103
-
-
58149119552
-
Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis
-
Pitzer C, Kruger C, Plaas C et al. Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain 131(Pt 12), 3335-3347 (2008).
-
(2008)
Brain
, vol.131
, Issue.PART 12
, pp. 3335-3347
-
-
Pitzer, C.1
Kruger, C.2
Plaas, C.3
-
104
-
-
33750043456
-
Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels
-
Cao XQ, Arai H, Ren YR et al. Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels. J. Neurochem. 99(3), 861-867 (2006).
-
(2006)
J. Neurochem.
, vol.99
, Issue.3
, pp. 861-867
-
-
Cao, X.Q.1
Arai, H.2
Ren, Y.R.3
-
105
-
-
33645878579
-
Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease
-
Meuer K, Pitzer C, Teismann P et al. Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. J. Neurochem. 97(3), 675-686 (2006).
-
(2006)
J. Neurochem.
, vol.97
, Issue.3
, pp. 675-686
-
-
Meuer, K.1
Pitzer, C.2
Teismann, P.3
-
106
-
-
61449227467
-
Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine- induced murine Parkinson's disease model
-
Kim NK, Choi BH, Huang X et al. Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced murine Parkinson's disease model. Eur. J. Neurosci. 29(5), 891-900 (2009).
-
(2009)
Eur. J. Neurosci.
, vol.29
, Issue.5
, pp. 891-900
-
-
Kim, N.K.1
Choi, B.H.2
Huang, X.3
-
107
-
-
37549042851
-
Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease
-
Ebert AD, Beres AJ, Barber AE, Svendsen CN. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp. Neurol. 209(1), 213-223 (2008).
-
(2008)
Exp. Neurol.
, vol.209
, Issue.1
, pp. 213-223
-
-
Ebert, A.D.1
Beres, A.J.2
Barber, A.E.3
Svendsen, C.N.4
-
108
-
-
0027295944
-
Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging
-
Date I, Yoshimoto Y, Imaoka T et al. Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging. Brain Res. 621(1), 150-154 (1993).
-
(1993)
Brain Res.
, vol.621
, Issue.1
, pp. 150-154
-
-
Date, I.1
Yoshimoto, Y.2
Imaoka, T.3
-
109
-
-
34047190752
-
The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system
-
Grothe C, Timmer M. The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system. Brain Res. Rev. 54(1), 80-91 (2007).
-
(2007)
Brain Res. Rev.
, vol.54
, Issue.1
, pp. 80-91
-
-
Grothe, C.1
Timmer, M.2
-
110
-
-
0028953328
-
Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease
-
Takayama H, Ray J, Raymon HK et al. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat. Med. 1(1), 53-58 (1995).
-
(1995)
Nat. Med.
, vol.1
, Issue.1
, pp. 53-58
-
-
Takayama, H.1
Ray, J.2
Raymon, H.K.3
-
111
-
-
1842664149
-
Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms
-
Timmer M, Muller-Ostermeyer F, Kloth V, Winkler C, Grothe C, Nikkhah G. Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms. Exp. Neurol. 187(1), 118-136 (2004).
-
(2004)
Exp. Neurol.
, vol.187
, Issue.1
, pp. 118-136
-
-
Timmer, M.1
Muller-Ostermeyer, F.2
Kloth, V.3
Winkler, C.4
Grothe, C.5
Nikkhah, G.6
-
112
-
-
33846436077
-
Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion
-
Timmer M, Cesnulevicius K, Winkler C et al. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J. Neurosci. 27(3), 459-471 (2007).
-
(2007)
J. Neurosci.
, vol.27
, Issue.3
, pp. 459-471
-
-
Timmer, M.1
Cesnulevicius, K.2
Winkler, C.3
-
113
-
-
33751181265
-
Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: A model of gene therapy for Parkinson's disease
-
Koike H, Ishida A, Shimamura M et al. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease. Gene Ther. 13(23), 1639-1644 (2006).
-
(2006)
Gene Ther.
, vol.13
, Issue.23
, pp. 1639-1644
-
-
Koike, H.1
Ishida, A.2
Shimamura, M.3
|