The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease

Pharmacological Reports

Volumn 66, Issue 4, 2014, Pages 660-669

  Joniec Maciejak, Ilona ^a   Ciesielska, Agnieszka ^c   Wawer, Adriana ^a   Sznejder Pachołek, Anna ^a   Schwenkgrub, Joanna ^a   Cudna, Agnieszka ^b   Hadaczek, Piotr ^c   Bankiewicz, Kristof S ^c   Członkowska, Anna ^b   Członkowski, Andrzej ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adeno associated virus; Inflammation; MPTP; Neuroprotection; Parkinson's disease

Indexed keywords

ALANINE; ASPARTIC ACID; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; INTERLEUKIN 10; MESSENGER RNA; TAURINE; TRANSFORMING GROWTH FACTOR BETA; TYROSINE 3 MONOOXYGENASE; DOPAMINE; IL10 PROTEIN, HUMAN;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GFAP GENE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IFN GAMMA GENE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; TGF BETA GENE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; C57BL MOUSE; CORPUS STRIATUM; DEPENDOPARVOVIRUS; DISEASE MODEL; DOPAMINERGIC NERVE CELL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PARKINSONIAN DISORDERS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CORPUS STRIATUM; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINERGIC NEURONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; MALE; MICE, INBRED C57BL; PARKINSONIAN DISORDERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TYROSINE 3-MONOOXYGENASE;

EID: 84902476451     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2014.03.008     Document Type: Article

References (43)

1. K.A. Jellinger Post mortem studies in Parkinson's disease - is it possible to detect brain areas for specific symptoms? J Neural Transm Suppl 56 1999 1 29
2. U.K. Rinne, J.O. Rinne, J.K. Rinne, and K. Laakso Chemical neurotransmission in the parkinsonian brain Med Biol 65 1987 75 81
3. T. Nagatsu, M. Mogi, H. Ichinose, and A. Togari Changes in cytokines and neurotrophins in Parkinson's disease J Neural Transm Suppl 60 2000 277 290 (Pubitemid 32037200)
4. E.C. Hirsch, and S. Hunot Neuroinflammation in Parkinson's disease: a target for neuroprotection Lancet Neurol 8 2009 382 397
5. R.L. Mosley, E.J. Benner, I. Kadiu, M. Thomas, M.D. Boska, and K. Hasan et al. Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease Clin Neurosci Res 6 2006 261 281 (Pubitemid 44849177)
6. L. Qian, P.M. Flood, and J.S. Hong Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy J Neural Transm 117 2010 971 979
7. M.G. Tansey, and M.S. Goldberg Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention Neurobiol Dis 37 2010 510 518
8. M.G. Tansey, M.K. McCoy, and T.C. Frank-Cannon Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention Exp Neurol 208 2007 1 25 (Pubitemid 47603240)
9. K. Frei, H. Lins, and A. Fontana Production and function of IL-10 in the central nervous system Schweiz Arch Neurol Psychiatr 145 1994 30 31
10. H. Spits, and R. de Waal Malefyt Functional characterization of human IL-10 Int Arch Allergy Immunol 99 1992 8 15 (Pubitemid 23010347)
11. H. Fickenscher, S. Hör, H. Küpers, A. Knappe, S. Wittmann, and H. Sticht The interleukin-10 family of cytokines Trends Immunol 23 2002 89 96 (Pubitemid 34310150)
12. A.J. Kastin, V. Akerstrom, and W. Pan Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier Brain Res Mol Brain Res 114 2003 168 171 (Pubitemid 36773559)
13. L.C. Johnston, X. Su, K. Maguire-Zeiss, K. Horovitz, I. Ankoudinova, and D. Guschin et al. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease Mol Ther 16 2008 1392 1399
14. G. Paxinos, and K.B.J. Franklin The Mouse Brain in Stereotaxic Coordinates 2001
15. P. Maciejak, J. Szyndler, D. Turzyńska, A. Sobolewska, A. Bidziński, and K. Kołosowska et al. Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole- kindled rats Brain Res 1342 2010 150 159
16. H.L. Rowley, K.F. Martin, and C.A. Marsden Determination of in vivo amino acid neurotransmitters by high-performance liquid chromatography with o-phthalaldehyde-sulphite derivatisation J Neurosci Meth 57 1995 93 99
17. I. Joniec, A. Ciesielska, I. Kurkowska-Jastrzebska, A. Przybylkowski, A. Czlonkowska, and A. Czlonkowski Age- and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Brain Res 1261 2009 7 19
18. A. Ciesielska, I. Joniec, I. Kurkowska-Jastrzebska, A. Przybyłkowski, G. Gromadzka, and A. Członkowska et al. Influence of age and gender on cytokine expression in a murine model of Parkinson's disease Neuroimmunomodulation 14 2007 255 265 (Pubitemid 351339992)
19. T. Arimoto, D.Y. Choi, X. Lu, M. Liu, X.V. Nguyen, and N. Zheng et al. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra Neurobiol Aging 28 2007 894 906 (Pubitemid 46589742)
20. L. Qian, J.S. Hong, and P.M. Flood Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10 J Neural Transm Suppl 70 2006 367 371 (Pubitemid 44622225)
21. K.M. Dhandapani, and D.W. Brann Transforming growth factor-beta: a neuroprotective factor in cerebral ischemia Cell Biochem Biophys 39 2003 13 22 (Pubitemid 41270804)
22. K.C. Flanders, R.F. Ren, and C.F. Lippa Transforming growth factor-betas in neurodegenerative disease Prog Neurobiol 54 1998 71 85 (Pubitemid 28049820)
23. E. Roussa, O. von Bohlen und Halbach, and K. Krieglstein TGF-beta in dopamine neuron development, maintenance and neuroprotection Adv Exp Med Biol 651 2009 81 90
24. K. Krieglstein, C. Suter-Crazzolara, W.H. Fischer, and K. Unsicker TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity EMBO J 14 1995 736 742
25. K. Unsicker, C. Suter-Crazzalora, and K. Krieglstein Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-fl CIBA Found Symp 196 1996 70 80
26. A. Sánchez-Capelo, P. Colin, B. Guibert, N.F. Biguet, and J. Mallet Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice Mol Cell Neurosci 23 2003 614 625 (Pubitemid 36970222)
27. C.F. Lippa, K.C. Flanders, E.S. Kim, and S. Croul TGF-beta receptors-I and -II immunoexpression in Alzheimer's disease: a comparison with aging and progressive supranuclear palsy Neurobiol Aging 19 1998 527 533 (Pubitemid 29117119)
28. M. Schwartz, O. Butovsky, W. Brück, and U.K. Hanisch Microglial phenotype: is the commitment reversible Trends Neurosci 29 2006 68 74
29. T.C. de Sampaio e Spohr, R. Martinez, E.F. da Silva, V.M. Neto, and F.C. Gomes Neuro-glia interaction effects on GFAP gene: a novel role for transforming growth factor-beta1 Eur J Neurosci 16 2002 2059 2069 (Pubitemid 35454250)
30. J.P. O'Callaghan, and K. Sriram Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity Expert Opin Drug Saf 4 2005 433 442 (Pubitemid 40723718)
31. I. Allaman, M. Bélanger, and P.J. Magistretti Astrocyte-neuron metabolic relationships: for better and for worse Trends Neurosci 34 2011 76 87
32. A. Ciesielska, I. Joniec, I. Kurkowska-Jastrzebska, A. Cudna, A. Przybyłkowski, and A. Członkowska et al. The impact of age and gender on the striatal astrocytes activation in murine model of Parkinson's disease Inflamm Res 58 2009 747 753
33. L.F. Eng, R.S. Ghirnikar, and Y.L. Lee Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000) Neurochem Res 25 2000 1439 1451
34. M.M. Shull, I. Ormsby, A.B. Kier, S. Pawlowski, R.J. Diebold, and M. Yin et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease Nature 359 1992 693 699
35. K. Saud, R. Herrera-Molina, and R. Von Bernhardi Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells Neurotox Res 8 2005 277 287
36. J. Lin, Y. Zhi, L. Mays, and J.M. Wilson Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in mice Virol 81 2007 11840 11849 (Pubitemid 47623816)
37. A. Sznejder, I. Joniec-Maciejak, A. Ciesielska, J. Schwenkgrub, A. Wawer, and K. Bankiewicz et al. The influence of IL-10 on the inflammatory reaction changes in the mice after 1-methyl-4-phenyl-1,2,3,6-tertahydropyridine (MPTP) treatment Acta Neurobiol Exp (Wars) 71 S 2011 71 72
38. I. Höidén, and G. Möller CD8+ cells are the main producers of IL10 and IFN gamma after superantigen stimulation Scand J Immunol 44 1996 501 505 (Pubitemid 26382333)
39. M. Maesa, G. Kenisa, and E. Bosmansa The negative immunoregulatory effects of serotonin (5-ht) moduline, an endogenous 5-ht1b receptor antagonist with anti-anxiety properties Cytokine 19 2002 308 311
40. N. del Olmo, J. Bustamante, R.M. del Río, and J.M. Solis Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area Brain Res 864 2000 298 307 (Pubitemid 30235111)
41. P.R. Louzada, A.C. Paula Lima, D.L. Mendonca-Silva, F. Noël, F.G. De Mello, and S.T. Ferreira Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders FASEB J 18 2004 511 518 (Pubitemid 38326307)
42. A.K. Navneet, T.A. Appukuttan, M. Pandey, and K.P. Mohanakumar Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice Amino Acids 35 2008 457 461
43. M. Tanabe, A. Nitta, and H. Ono Neuroprotection via strychnine-sensitive glycine receptors during post-ischemic recovery of excitatory synaptic transmission in the hippocampus J Pharmacol Sci 113 2010 378 386