메뉴 건너뛰기




Volumn 89, Issue , 2015, Pages 7-16

Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease

Author keywords

Alzheimers disease (AD); b amyloid (Ab); Diabetes; Geniposide; Insulin signaling; Secretase

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; GENIPOSIDE; INSULIN; INSULINASE; LIRAGLUTIDE; PRESENILIN 1; STREPTOZOCIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); IRIDOID; PEPTIDE FRAGMENT;

EID: 84942296710     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.04.002     Document Type: Article
Times cited : (45)

References (46)
  • 1
    • 84872491129 scopus 로고    scopus 로고
    • Overlapped metabolic and therapeutic links between Alzheimer and diabetes
    • Ahmad W. Overlapped metabolic and therapeutic links between Alzheimer and diabetes Mol. Neurobiol 47 2013 399 424
    • (2013) Mol. Neurobiol , vol.47 , pp. 399-424
    • Ahmad, W.1
  • 2
    • 54049136095 scopus 로고    scopus 로고
    • Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    • Beeri M.S., Schmeidler J., Silverman J.M., Gandy S., Wysocki M., Hannigan C.M., and et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology Neurology 71 2008 750 757
    • (2008) Neurology , vol.71 , pp. 750-757
    • Beeri, M.S.1    Schmeidler, J.2    Silverman, J.M.3    Gandy, S.4    Wysocki, M.5    Hannigan, C.M.6
  • 3
    • 3242777669 scopus 로고    scopus 로고
    • Insulin-degrading enzyme and Alzheimer disease: A genetic association study in the Han Chinese
    • Bian L., Yang J.D., Guo T.W., Sun Y., Duan S.W., Chen W.Y., and et al. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese Neurology 63 2004 241 245
    • (2004) Neurology , vol.63 , pp. 241-245
    • Bian, L.1    Yang, J.D.2    Guo, T.W.3    Sun, Y.4    Duan, S.W.5    Chen, W.Y.6
  • 4
    • 1842684436 scopus 로고    scopus 로고
    • Glucose, insulin and the brain: Modulation of cognition and synaptic plasticity in health and disease: A preface
    • Biessels G.J., Bravenboer B., and Gispen W.H. Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface Eur. J. Pharmacol 490 2004 1 4
    • (2004) Eur. J. Pharmacol , vol.490 , pp. 1-4
    • Biessels, G.J.1    Bravenboer, B.2    Gispen, W.H.3
  • 5
    • 27844472159 scopus 로고    scopus 로고
    • Increased risk of Alzheimer's disease in Type II diabetes: Insulin resistance of the brain or insulin-induced amyloid pathology?
    • Biessels G.J., Kappelle L.J. Utrecht Diabetic Encephalopathy Study Group Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochem. Soc. Trans 33 2005 1041 1044
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 1041-1044
    • Biessels, G.J.1    Kappelle, L.J.2
  • 7
    • 84655167543 scopus 로고    scopus 로고
    • Journal of Neurochemistry special issue on Alzheimer's disease: 'Amyloid cascade hypothesis-20 years on'
    • Checler F., and Turner A.J. Journal of Neurochemistry special issue on Alzheimer's disease: 'amyloid cascade hypothesis-20 years on' J. Neurochem 120 Suppl. 1 2012 iii iv
    • (2012) J. Neurochem , vol.120 , pp. iii-iv
    • Checler, F.1    Turner, A.J.2
  • 8
    • 33845577779 scopus 로고    scopus 로고
    • The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease
    • Cole G.M., and Frautschy S.A. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease Exp. Gerontol 42 2007 10 21
    • (2007) Exp. Gerontol , vol.42 , pp. 10-21
    • Cole, G.M.1    Frautschy, S.A.2
  • 9
    • 84857788978 scopus 로고    scopus 로고
    • Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
    • Correia S.C., Santos R.X., Carvalho C., Cardoso S., Candeias E., Santos M.S., and et al. Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation Brain Res 1441 2012 64 78
    • (2012) Brain Res , vol.1441 , pp. 64-78
    • Correia, S.C.1    Santos, R.X.2    Carvalho, C.3    Cardoso, S.4    Candeias, E.5    Santos, M.S.6
  • 10
    • 84857714157 scopus 로고    scopus 로고
    • Mechanisms underlying insulin deficiency-induced acceleration of beta-amyloidosis in a mouse model of Alzheimer's disease
    • Devi L., Alldred M.J., Ginsberg S.D., and Ohno M. Mechanisms underlying insulin deficiency-induced acceleration of beta-amyloidosis in a mouse model of Alzheimer's disease PLoS ONE 7 2012 e32792
    • (2012) PLoS ONE , vol.7 , pp. e32792
    • Devi, L.1    Alldred, M.J.2    Ginsberg, S.D.3    Ohno, M.4
  • 11
    • 37749032040 scopus 로고    scopus 로고
    • Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition
    • Dominguez R.O., Marschoff E.R., Guareschi E.M., Repetto M.G., Famulari A.L., Pagano M.A., and et al. Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition J. Neural Transm 115 2008 77 84
    • (2008) J. Neural Transm , vol.115 , pp. 77-84
    • Dominguez, R.O.1    Marschoff, E.R.2    Guareschi, E.M.3    Repetto, M.G.4    Famulari, A.L.5    Pagano, M.A.6
  • 12
    • 84880555817 scopus 로고    scopus 로고
    • Intranasal insulin as a treatment for Alzheimer's disease: A review of basic research and clinical evidence
    • Freiherr J., Hallschmid M., Frey W.H. 2nd, Brunner Y.F., Chapman C.D., Holscher C., and et al. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence CNS Drugs 27 2013 505 514
    • (2013) CNS Drugs , vol.27 , pp. 505-514
    • Freiherr, J.1    Hallschmid, M.2    Frey, W.H.3    Brunner, Y.F.4    Chapman, C.D.5    Holscher, C.6
  • 13
    • 84898542999 scopus 로고    scopus 로고
    • Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3beta pathway in streptozotocin-induced Alzheimer rat model
    • Gao C., Liu Y., Jiang Y., Ding J., and Li L. Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3beta pathway in streptozotocin-induced alzheimer rat model Brain Pathol 24 2014 261 269
    • (2014) Brain Pathol , vol.24 , pp. 261-269
    • Gao, C.1    Liu, Y.2    Jiang, Y.3    Ding, J.4    Li, L.5
  • 14
    • 79151475030 scopus 로고    scopus 로고
    • Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice
    • Gengler S., Hamilton A., and Holscher C. Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice PLoS ONE 5 2010 e9764
    • (2010) PLoS ONE , vol.5 , pp. e9764
    • Gengler, S.1    Hamilton, A.2    Holscher, C.3
  • 15
    • 33747399431 scopus 로고    scopus 로고
    • Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat
    • Grunblatt E., Koutsilieri E., Hoyer S., and Riederer P. Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat J. Alzheimers Dis 9 2006 261 271
    • (2006) J. Alzheimers Dis , vol.9 , pp. 261-271
    • Grunblatt, E.1    Koutsilieri, E.2    Hoyer, S.3    Riederer, P.4
  • 16
    • 74549180462 scopus 로고    scopus 로고
    • Geniposide inhibits CoCl2-induced PC12 cells death via the mitochondrial pathway
    • Guo L.X., Liu J.H., and Xia Z.N. Geniposide inhibits CoCl2-induced PC12 cells death via the mitochondrial pathway Chin. Med. J. (Engl.) 122 2009 2886 2892
    • (2009) Chin. Med. J. (Engl.) , vol.122 , pp. 2886-2892
    • Guo, L.X.1    Liu, J.H.2    Xia, Z.N.3
  • 17
    • 84863133805 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
    • Guo L.X., Xia Z.N., Gao X., Yin F., and Liu J.H. Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells Acta Pharmacol. Sin 33 2012 237 241
    • (2012) Acta Pharmacol. Sin , vol.33 , pp. 237-241
    • Guo, L.X.1    Xia, Z.N.2    Gao, X.3    Yin, F.4    Liu, J.H.5
  • 18
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 19
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis Science 256 1992 184 185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 20
    • 34548456959 scopus 로고    scopus 로고
    • Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: A novel therapeutic approach to Alzheimer disease
    • Hemming M.L., Patterson M., Reske-Nielsen C., Lin L., Isacson O., and Selkoe D.J. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease PLoS Med 4 2007 e262
    • (2007) PLoS Med , vol.4 , pp. e262
    • Hemming, M.L.1    Patterson, M.2    Reske-Nielsen, C.3    Lin, L.4    Isacson, O.5    Selkoe, D.J.6
  • 21
    • 79960881826 scopus 로고    scopus 로고
    • Diabetes as a risk factor for Alzheimer's disease: Insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    • Holscher C. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease Biochem. Soc. Trans 39 2011 891 897
    • (2011) Biochem. Soc. Trans , vol.39 , pp. 891-897
    • Holscher, C.1
  • 22
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease Eur. J. Pharmacol 490 2004 115 125
    • (2004) Eur. J. Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 23
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer disease and type 2 diabetes: A review
    • Li L., and Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review Brain Res. Rev 56 2007 384 402
    • (2007) Brain Res. Rev , vol.56 , pp. 384-402
    • Li, L.1    Holscher, C.2
  • 24
    • 33750066662 scopus 로고    scopus 로고
    • Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells
    • Liu J., Zheng X., Yin F., Hu Y., Guo L., Deng X., and et al. Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells Int. J. Dev. Neurosci 24 2006 419 424
    • (2006) Int. J. Dev. Neurosci , vol.24 , pp. 419-424
    • Liu, J.1    Zheng, X.2    Yin, F.3    Hu, Y.4    Guo, L.5    Deng, X.6
  • 25
    • 34848901678 scopus 로고    scopus 로고
    • Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway
    • Liu J., Yin F., Zheng X., Jing J., and Hu Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway Neurochem. Int 51 2007 361 369
    • (2007) Neurochem. Int , vol.51 , pp. 361-369
    • Liu, J.1    Yin, F.2    Zheng, X.3    Jing, J.4    Hu, Y.5
  • 26
    • 84885977922 scopus 로고    scopus 로고
    • Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells
    • Liu J., Guo L., Yin F., Zhang Y., Liu Z., and Wang Y. Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells PLoS ONE 8 2013 e78315
    • (2013) PLoS ONE , vol.8 , pp. e78315
    • Liu, J.1    Guo, L.2    Yin, F.3    Zhang, Y.4    Liu, Z.5    Wang, Y.6
  • 27
    • 84883244791 scopus 로고    scopus 로고
    • Geniposide decreases the level of Abeta1-42 in the hippocampus of streptozotocin-induced diabetic rats
    • Liu J., Zhang Y., Deng X., and Yin F. Geniposide decreases the level of Abeta1-42 in the hippocampus of streptozotocin-induced diabetic rats Acta Biochim. Biophys. Sin. (Shanghai) 45 2013 787 791
    • (2013) Acta Biochim. Biophys. Sin. (Shanghai) , vol.45 , pp. 787-791
    • Liu, J.1    Zhang, Y.2    Deng, X.3    Yin, F.4
  • 28
    • 65349142455 scopus 로고    scopus 로고
    • Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: Involvement of PI3 kinase signal pathway
    • Liu J.H., Yin F., Guo L.X., Deng X.H., and Hu Y.H. Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway Acta Pharmacol. Sin 30 2009 159 165
    • (2009) Acta Pharmacol. Sin , vol.30 , pp. 159-165
    • Liu, J.H.1    Yin, F.2    Guo, L.X.3    Deng, X.H.4    Hu, Y.H.5
  • 29
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • Liu Y., Liu F., Grundke-Iqbal I., Iqbal K., and Gong C.X. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes J. Pathol 225 2011 54 62
    • (2011) J. Pathol , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 30
    • 84874722479 scopus 로고    scopus 로고
    • The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease
    • Long-Smith C.M., Manning S., McClean P.L., Coakley M.F., O'Halloran D.J., Holscher C., and et al. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease Neuromolecular Med 15 2013 102 114
    • (2013) Neuromolecular Med , vol.15 , pp. 102-114
    • Long-Smith, C.M.1    Manning, S.2    McClean, P.L.3    Coakley, M.F.4    O'Halloran, D.J.5    Holscher, C.6
  • 31
    • 77956373209 scopus 로고    scopus 로고
    • Insulin resistance, type 2 diabetes, and AD: Cerebrovascular disease or neurodegeneration?
    • Luchsinger J.A. Insulin resistance, type 2 diabetes, and AD: cerebrovascular disease or neurodegeneration? Neurology 75 2010 758 759
    • (2010) Neurology , vol.75 , pp. 758-759
    • Luchsinger, J.A.1
  • 32
    • 84904760940 scopus 로고    scopus 로고
    • Geniposide attenuates mitochondrial dysfunction and memory deficits in APP/PS1 transgenic mice
    • Lv C., Liu X., Liu H., Chen T., and Zhang W. Geniposide attenuates mitochondrial dysfunction and memory deficits in APP/PS1 transgenic mice Curr. Alzheimer Res 11 2014 580 587
    • (2014) Curr. Alzheimer Res , vol.11 , pp. 580-587
    • Lv, C.1    Liu, X.2    Liu, H.3    Chen, T.4    Zhang, W.5
  • 34
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney A.M., Griffin R.J., Timmons S., O'Connor R., Ravid R., and O'Neill C. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling Neurobiol. Aging 31 2010 224 243
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 35
    • 84863002103 scopus 로고    scopus 로고
    • Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin
    • Moreira P.I. Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin J. Alzheimers Dis 30 Suppl. 2 2012 S199 S215
    • (2012) J. Alzheimers Dis , vol.30 , pp. S199-S215
    • Moreira, P.I.1
  • 36
    • 34249821079 scopus 로고    scopus 로고
    • Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
    • Moreira P.I., Santos M.S., Seica R., and Oliveira C.R. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes J. Neurol. Sci 257 2007 206 214
    • (2007) J. Neurol. Sci , vol.257 , pp. 206-214
    • Moreira, P.I.1    Santos, M.S.2    Seica, R.3    Oliveira, C.R.4
  • 37
    • 0344665724 scopus 로고    scopus 로고
    • Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons
    • Negishi T., Ishii Y., Kyuwa S., Kuroda Y., and Yoshikawa Y. Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons Neurosci. Lett 353 2003 99 102
    • (2003) Neurosci. Lett , vol.353 , pp. 99-102
    • Negishi, T.1    Ishii, Y.2    Kyuwa, S.3    Kuroda, Y.4    Yoshikawa, Y.5
  • 38
    • 69249216440 scopus 로고    scopus 로고
    • Failures to reconsolidate memory in a mouse model of Alzheimer's disease
    • Ohno M. Failures to reconsolidate memory in a mouse model of Alzheimer's disease Neurobiol. Learn. Mem 92 2009 455 459
    • (2009) Neurobiol. Learn. Mem , vol.92 , pp. 455-459
    • Ohno, M.1
  • 39
    • 33644957833 scopus 로고    scopus 로고
    • Temporal memory deficits in Alzheimer's mouse models: Rescue by genetic deletion of BACE1
    • Ohno M., Chang L., Tseng W., Oakley H., Citron M., Klein W.L., and et al. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1 Eur. J. Neurosci 23 2006 251 260
    • (2006) Eur. J. Neurosci , vol.23 , pp. 251-260
    • Ohno, M.1    Chang, L.2    Tseng, W.3    Oakley, H.4    Citron, M.5    Klein, W.L.6
  • 40
    • 58149216847 scopus 로고    scopus 로고
    • Nonviral DNA vaccination augments microglial phagocytosis of beta-amyloid deposits as a major clearance pathway in an Alzheimer disease mouse model
    • Okura Y., Kohyama K., Park I.K., and Matsumoto Y. Nonviral DNA vaccination augments microglial phagocytosis of beta-amyloid deposits as a major clearance pathway in an Alzheimer disease mouse model J. Neuropathol. Exp. Neurol 67 2008 1063 1071
    • (2008) J. Neuropathol. Exp. Neurol , vol.67 , pp. 1063-1071
    • Okura, Y.1    Kohyama, K.2    Park, I.K.3    Matsumoto, Y.4
  • 41
    • 29844432266 scopus 로고    scopus 로고
    • Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: Review and hypothesis
    • Qiu W.Q., and Folstein M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis Neurobiol. Aging 27 2006 190 198
    • (2006) Neurobiol. Aging , vol.27 , pp. 190-198
    • Qiu, W.Q.1    Folstein, M.F.2
  • 42
    • 3543067962 scopus 로고    scopus 로고
    • Neurodegenerative disorders associated with diabetes mellitus
    • Ristow M. Neurodegenerative disorders associated with diabetes mellitus J. Mol. Med. (Berl.) 82 2004 510 529
    • (2004) J. Mol. Med. (Berl.) , vol.82 , pp. 510-529
    • Ristow, M.1
  • 43
  • 44
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • Stockhorst U., de Fries D., Steingrueber H.J., and Scherbaum W.A. Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans Physiol. Behav 83 2004 47 54
    • (2004) Physiol. Behav , vol.83 , pp. 47-54
    • Stockhorst, U.1    De Fries, D.2    Steingrueber, H.J.3    Scherbaum, W.A.4
  • 45
    • 84872603163 scopus 로고    scopus 로고
    • Insulin receptor signaling mediates APP processing and beta-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
    • Stohr O., Schilbach K., Moll L., Hettich M.M., Freude S., Wunderlich F.T., and et al. Insulin receptor signaling mediates APP processing and beta-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease Age (Dordr.) 35 2013 83 101
    • (2013) Age (Dordr.) , vol.35 , pp. 83-101
    • Stohr, O.1    Schilbach, K.2    Moll, L.3    Hettich, M.M.4    Freude, S.5    Wunderlich, F.T.6
  • 46
    • 84874582683 scopus 로고    scopus 로고
    • Geniposide regulates insulin-degrading enzyme expression to inhibit the cytotoxicity of Abeta(1)(-)(4)(2) in cortical neurons
    • Yin F., Zhang Y., Guo L., Kong S., and Liu J. Geniposide regulates insulin-degrading enzyme expression to inhibit the cytotoxicity of Abeta(1)(-)(4)(2) in cortical neurons CNS Neurol. Disord. Drug Targets 11 2012 1045 1051
    • (2012) CNS Neurol. Disord. Drug Targets , vol.11 , pp. 1045-1051
    • Yin, F.1    Zhang, Y.2    Guo, L.3    Kong, S.4    Liu, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.