Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Nature

Volumn 497, Issue 7448, 2013, Pages 211-216

  Zhang, Guo ^a   Li, Juxue ^a   Purkayastha, Sudarshana ^a   Tang, Yizhe ^a   Zhang, Hai ^a   Yin, Ye ^a   Li, Bo ^a   Liu, Gang ^a   Cai, Dongsheng ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GREEN FLUORESCENT PROTEIN; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

AGING; BRAIN; HORMONE; IMMUNITY; NEUROLOGY; PUBLIC HEALTH;

AGING; ARTICLE; ENZYME ACTIVATION; GROWTH RETARDATION; HYPOTHALAMUS; IMMUNITY; LIFE EXTENSION; LONGEVITY; MEDIOBASAL HYPOTHALAMUS; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

MUS;

EID: 84877734347     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12143     Document Type: Article

References (44)

1. Miller, R. A. Genes against aging. J. Gerontol. A Biol. Sci. Med. Sci. 67A, 495-502 (2012).
2. Mattson, M. P. Pathways towards and away fromAlzheimer's disease. Nature 430, 631-639 (2004).
3. Masoro, E. J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922 (2005).
4. Finch, C. E. Neurons, glia, and plasticity in normal brain aging. Adv. Gerontol. 10, 35-39 (2002).
5. Zitnik, G. & Martin, G. M. Age-related decline in neurogenesis: old cells or old environment? J. Neurosci. Res. 70, 258-263 (2002).
6. Martin, G. M. Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging. Aging Cell 8, 761-764 (2009).
7. Bishop, N. A. & Guarente, L. Two neurons mediate diet-restriction- induced longevity in C. elegans. Nature 447, 545-549 (2007).
8. Fridell, Y. W., Sanchez-Blanco, A., Silvia, B.A. & Helfand, S. L. Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab. 1, 145-152 (2005).
9. Alcedo, J. & Kenyon, C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41, 45-55 (2004).
10. Wolkow, C. A., Kimura, K. D., Lee, M. S. & Ruvkun, G. Regulation of C. elegans lifespan by insulinlike signaling in the nervous system. Science290,147-150(2000).
11. Taguchi, A., Wartschow, L. M. & White, M. F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372 (2007).
12. Li, J., Tang, Y. & Cai, D. IKKb/NF-kB disrupts adult hypothalamic neural stemcells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nature Cell Biol. 14, 999-1012 (2012).
13. Zhang, X. et al. Hypothalamic IKKb/NF-kB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
14. Purkayastha, S. et al. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc. Natl Acad. Sci. USA 108, 2939-2944 (2011).
15. Purkayastha, S., Zhang, G. & Cai, D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-b and NF-kB. Nature Med. 17, 883-887 (2011).
16. Okun, E., Griffioen, K. J. & Mattson, M. P. Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci. 34, 269-281 (2011).
17. Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. & Gage, F. H. Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934 (2010).
18. Saijo, K. et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47-59 (2009).
19. Saijo, K., Collier, J. G., Li, A. C., Katzenellenbogen, J. A. & Glass, C. K. An ADIOL-ERb-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145, 584-595 (2011).
20. Saijo, K. & Glass, C. K. Microglial cell origin and phenotypes in health and disease. Nature Rev. Immunol. 11, 775-787 (2011).
21. Lucin, K. M. & Wyss-Coray, T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64, 110-122 (2009).
22. Villeda, S. & Wyss-Coray, T. Microglia-a wrench in the running wheel? Neuron 59, 527-529 (2008).
23. Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90-94 (2011).
24. Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351 (2007).
25. Adler, A. S. et al. Motif module map reveals enforcement of aging by continual NF-kB activity. Genes Dev. 21, 3244-3257 (2007).
26. Peng, B. et al. Defective feedback regulation of NF-kB underlies Sjogren's syndrome in mice with mutated kB enhancers of the IkBa promoter. Proc. Natl Acad. Sci. USA 107, 15193-15198 (2010).
27. Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
28. Barger, S. W. et al. Tumor necrosis factors a and b protect neurons against amyloid b-peptide toxicity: evidence for involvement of a k B-binding factor and attenuation of peroxide and Ca21 accumulation. Proc. Natl Acad. Sci. USA 92, 9328-9332 (1995).
29. Bruce, A. J. et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med. 2, 788-794 (1996).
30. Taoufik, E. et al. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kB. Brain 134, 2722-2735 (2011).
31. Kaltschmidt, B. et al. NF-kB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol. Cell. Biol. 26, 2936-2946 (2006).
32. Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S. & Baltimore, D. NF-kB functions in synaptic signaling and behavior. Nature Neurosci. 6, 1072-1078 (2003).
33. O'Mahony, A. et al.NF-kB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol. Cell. Biol. 26, 7283-7298 (2006).
34. Huang, W., Ghisletti, S., Perissi, V., Rosenfeld, M. G. & Glass, C. K. Transcriptional integration of TLR2and TLR4signaling at theNCoR derepression checkpoint.Mol. Cell 35, 48-57 (2009).
35. Kawahara, T. L. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kBdependent gene expression and organismal life span. Cell 136, 62-74 (2009).
36. Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496 (2008).
37. Meng, Q. & Cai, D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkBkinase b (IKKb)/NF-kBpathway. J. Biol. Chem. 286, 32324-32332 (2011).
38. Banks, W. A. et al. Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice. Proc. Natl Acad. Sci. USA 107, 22272-22277 (2010).
39. Tillerson, J. L. & Miller, G. W. Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism. J. Neurosci. Methods 123, 189-200 (2003).
40. Mueller, J. M. & Pahl, H. L. Assaying NF-kB and AP-1 DNA-binding and transcriptional activity. Methods Mol. Biol. 99, 205-216 (2000).
41. Flurkey, K., Papaconstantinou, J., Miller, R. A. & Harrison, D. E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA 98, 6736-6741 (2001).
42. Ramanadham, S. et al. Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2b)-null mice. Am. J. Pathol. 172, 868-881 (2008).
43. Meylan, E. et al. Requirement for NF-kB signalling in a mouse model of lung adenocarcinoma. Nature 462, 104-107 (2009).
44. Wang, C., Li, Q., Redden, D. T.,Weindruch, R. & Allison, D. B.Statistical methods for testing effectson "maximumlifespan".Mech. AgeingDev.125,629-632(2004).