Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4

Age

Volumn 34, Issue 5, 2012, Pages 1211-1224

  Chen, Song ^a   Liu, Ai Ran ^b   An, Feng Mao ^a   Yao, Wen Bing ^a   Gao, Xiang Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Diabetes mellitus; Exendin 4; Glycogen synthase kinase 3 ; Streptozotocin; Tau protein

Indexed keywords

EXENDIN 4; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; SODIUM CHLORIDE; STREPTOZOCIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE MODEL; DOWN REGULATION; DRUG MECHANISM; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN RESPONSE; LEARNING; MALE; MAZE TEST; MEMORY; NERVE CELL LESION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TASK PERFORMANCE;

ALZHEIMER DISEASE; ANIMALS; BLOOD GLUCOSE; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; GLUCAGON-LIKE PEPTIDE 1; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; NERVE DEGENERATION; OXIDATIVE STRESS; PEPTIDES; RATS; RATS, WISTAR; VENOMS;

EID: 84867577041     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9303-8     Document Type: Article

References (37)

1. Brant AM, Jess TJ, Milligan G, Brown CM, Gould GW (1993) Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. Biochem Biophys Res Commun 192(3):1297-1302
2. 2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Acta Biochim Biophys Sin 40(9):796-802
3. Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF (2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc Natl Acad Sci U S A 106(10):3907-3912
4. Clodfelder-Miller BJ, Zmijewska AA, Johnson GV, Jope RS (2006) Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes 55(12):3320-3325
5. Dhar A, Kaundal RK, Sharma SS (2006) Neuroprotective effects of FeTMPyP: a peroxynitrite decomposition catalyst in global cerebral ischemia model in gerbils. Pharmacol Res 54(4):311-316
6. Frisardi V, Solfrizzi V, Seripa D, Capurso C, Santamato A, Sancarlo D, Vendemiale G, Pilotto A, Panza F (2010) Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease. Ageing Res Rev 9(4):399-417
7. Gao M, Tian H, Ma C, Gao X, Guo W, Yao W (2010) Expression, purification, and C-terminal site-specific PEGylation of cysteine-mutated glucagon-like peptide-1. Appl Biochem Biotechnol 162(1):155-165
8. Gispen WH, Biessels GJ (2000) Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 23(11):542-549
9. Hamilton A, Hölscher C (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport 20(13):1161-1166
10. Hoyer S (2004) Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 490:115-125
11. Hur EM, Zhou FQ (2010) GSK3 signalling in neural development. Nat Rev Neurosci 11(8):539-551
12. Isik AT, Celik T, Ulusoy G, Ongoru O, Elibol B, Doruk H, Bozoglu E, Kayir H, Mas MR, Akman S (2009) Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model. Age 31(1):39-49
13. Kastin AJ, Akerstrom V (2003) Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 27(3):313-318
14. Kroner Z (2009) The relationship between Alzheimer's disease and diabetes: type 3 diabetes? Altern Med Rev 14(4):373-379
15. Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, De La Monte SM (2006) Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis 9(1):13-33
16. Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A 106(4):1285-1290
17. Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM (2009) Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes 58(2):318-328
18. Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47-60
19. Mousavi SH, Tayarani-Najaran Z, Asghari M, Sadeghnia HR (2010a) Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol 30(4):591-598
20. Mousavi SH, Tayarani NZ, Parsaee H (2010b) Protective effect of saffron extract and crocin on reactive oxygen speciesmediated high glucose-induced toxicity in PC12 cells. Cell Mol Neurobiol 30(2):185-191
21. Mussmann R, Geese M, Harder F, Kegel S, Andag U, Lomow A, Burk U, Onichtchouk D, Dohrmann C, Austen M (2007) Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. J Biol Chem 282(16):12030-12037
22. Ott A et al (1999) Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology 53:1937-1942
23. Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH (2002) A novel neurotrophic property of glucagonlike peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther 300(3):958-966
24. Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH (2003) Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res 72(5):603-612
25. Plastino M et al (2010) Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and diabetes mellitus type-2. J Neurol Sci 288(1-2):112-116
26. Profenno LA, Porsteinsson AP, Faraone SV (2010) Metaanalysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 67(6):505-512
27. Qian YF, Wang H, Yao WB, Gao XD (2008) Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell Biol Int 32(2):304-311
28. Querfurth HW, La Ferla FM (2010) Alzheimer's disease. N Eng J Med 362(4):329-344
29. Risner ME, Saunders AM, Altman JF, Ormandy GC, Craft S, Foley IM, Zvartau-Hind ME, Hosford DA, Roses AD (2006) Rosiglitazone in Alzheimer's Disease Study Group. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J 6(4):246-254
30. Sato T, Hanyu H, Hirao K, Kanetaka H, Sakurai H, Iwamoto T (2009) Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease. Neurobiol Aging. doi:10.1016/j. neurobiolaging.2009.10.009
31. Schnedl WJ, Ferber S, Johnson JH, Newgard CB (1994) STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 43(11):1326-1333
32. Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM (2010) Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 75(22):1982-1987
33. Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R (2010) Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A 107(15):7036-7041
34. Wang Z, Gleichmann H (1998) GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes 47(1):50-56
35. Wang H, Zhou G, Gao X, Wang Y, Yao W (2007) Acetylcholinesterase inhibitory-active components of Rhodiola rosea L. Food Chem 105:24-27
36. Wang H, Gao X, Zhou G, Cai L, Yao W (2008) In vitro and invivo antioxidant activity of aqueous extract from Choerospondias axillaris fruit. Food Chem 106:888-895
37. Yoon SY, Park JS, Choi JE, Choi JM, Lee WJ, Kim SW, Kim DH (2010) Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiol Dis 40(2):449-455