Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31867-31875

  Perrinjaquet, Maurice ^a   Vilar, Marçal ^a,b   Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; EMPLOYMENT; LIGANDS; NEURONS; PHOSPHATASES; PHOSPHORYLATION; PROTEINS; SIGNALING;

AXONAL GROWTH; FORSKOLIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LIGAND BINDING; NEURITE OUTGROWTH; NEURONAL SURVIVAL; NEUROTROPHIC; NEUROTROPHIC ACTIVITIES; PHOSPHORYLATION SITES; PROTEIN KINASE A; PROTEIN-TYROSINE PHOSPHATASE; RECEPTOR TYROSINE KINASE; REGULATORY FUNCTIONS; SIGNALING COMPLEX; SIGNALING MECHANISMS; TYROSINE RESIDUES;

AMINO ACIDS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN RET; PROTEIN TYROSINE PHOSPHATASE SHP 2; SERINE; TYROSINE; PTPN11 PROTEIN, MOUSE; RET PROTEIN, MOUSE; RET PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME REGULATION; FIBROBLAST; GENE MUTATION; LIGAND BINDING; MOTONEURON; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; 3T3 CELL LINE; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; MUTATION; PC12 CELL LINE; PHYSIOLOGY;

ANIMALS; CERCOPITHECUS AETHIOPS; COLFORSIN; COS CELLS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MICE; MUTATION; NIH 3T3 CELLS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RET; RATS; SIGNAL TRANSDUCTION;

EID: 77957760057     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.144923     Document Type: Article

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