Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways

Diabetes Research and Clinical Practice

Volumn 97, Issue 3, 2012, Pages 453-460

  Han, Lina ^a   Yu, Yerong ^a   Sun, Xiaodong ^a   Wang, Ben ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Endothelial dysfunction; Exendin 4; Glucagon like peptide 1; Obesity

Indexed keywords

ADENYLATE CYCLASE INHIBITOR; CYCLIC AMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EXENDIN 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; ISOLATED ORGAN; LIPID DIET; MALE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION; WISTAR RAT;

ADENYLATE KINASE; ANIMALS; AORTA; CELLS, CULTURED; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; HYPOGLYCEMIC AGENTS; MALE; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; ORGAN CULTURE TECHNIQUES; PEPTIDES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; VENOMS;

EID: 84866546292     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.04.001     Document Type: Article

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