메뉴 건너뛰기




Volumn 16, Issue 1, 2016, Pages 38-58

Targeting cancer stem cells: Promises and challenges

Author keywords

Cancer stem cells (CSCs); Circulating tumor cells (CTCs); Clonal evolution; CSC plasticity; CSC targeted therapy; Tumor heterogeneity

Indexed keywords

PLERIXAFOR;

EID: 84947932908     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150716104152     Document Type: Article
Times cited : (34)

References (276)
  • 2
    • 0024958212 scopus 로고
    • The clonal nature of neoplasia
    • Nowell, P.C. The clonal nature of neoplasia. Cancer Cells, 1989, 1, 29-30.
    • (1989) Cancer Cells , vol.1 , pp. 29-30
    • Nowell, P.C.1
  • 3
  • 4
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P.C. The clonal evolution of tumor cell populations. Science, 1976, 194, 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 5
    • 84891434380 scopus 로고    scopus 로고
    • The evolution of the unstable cancer genome
    • Burrell, R.A.; Swanton, C. The evolution of the unstable cancer genome. Curr. Opin. Genet. Dev., 2014, 24, 61-67.
    • (2014) Curr. Opin. Genet. Dev , vol.24 , pp. 61-67
    • Burrell, R.A.1    Swanton, C.2
  • 6
    • 84914112343 scopus 로고    scopus 로고
    • Tumour heterogeneity and the evolution of polyclonal drug resistance
    • Burrell, R.A.; Swanton, C. Tumour heterogeneity and the evolution of polyclonal drug resistance. Mol. Oncol., 2014, 8, 1095-1111.
    • (2014) Mol. Oncol , vol.8 , pp. 1095-1111
    • Burrell, R.A.1    Swanton, C.2
  • 9
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: The challenges ahead
    • Medema, J.P. Cancer stem cells: The challenges ahead. Nat. Cell. Biol., 2013, 15, 338-344.
    • (2013) Nat. Cell. Biol , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 13
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton, M.; Quintana, E.; Fearon, E.R.; Morrison, S.J. Heterogeneity in cancer: Cancer stem cells versus clonal evolution. Cell, 2009, 138, 822-829.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 14
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D.; Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med., 1997, 3, 730-737.
    • (1997) Nat. Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 16
    • 84906963524 scopus 로고    scopus 로고
    • Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets
    • Ahmed, N.; Abubaker, K.; Findlay, J.K. Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets. Mol. Aspects Med., 2014, 39, 110-125.
    • (2014) Mol. Aspects Med , vol.39 , pp. 110-125
    • Ahmed, N.1    Abubaker, K.2    Findlay, J.K.3
  • 17
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham, C.E.; Morrison, S.J. Tumour heterogeneity and cancer cell plasticity. Nature, 2013, 501, 328-337.
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 19
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso, A.; Dick, J.E. Evolution of the cancer stem cell model. Cell Stem Cell, 2014, 14, 275-291.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 20
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana, E.; Shackleton, M.; Foster, H.R.; Fullen, D.R.; Sabel, M.S.; Johnson, T.M.; Morrison, S.J. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell, 2010, 18, 510-523.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4    Sabel, M.S.5    Johnson, T.M.6    Morrison, S.J.7
  • 22
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri, R.; Neilson, E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest., 2003, 112, 1776-1784.
    • (2003) J. Clin. Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 23
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R.; Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest., 2009, 119, 1420-1428.
    • (2009) J. Clin. Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 24
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2002, 2, 442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 26
    • 84924962104 scopus 로고    scopus 로고
    • The biological and clinical importance of epithelial-mesenchymal transition in circulating tumor cells
    • Liu, H.; Zhang, X.; Li, J.; Sun, B.; Qian, H.; Yin, Z. The biological and clinical importance of epithelial-mesenchymal transition in circulating tumor cells. J. Cancer Res. Clin. Oncol., 2015, 141(2), 189-201.
    • (2015) J. Cancer Res. Clin. Oncol , vol.141 , Issue.2 , pp. 189-201
    • Liu, H.1    Zhang, X.2    Li, J.3    Sun, B.4    Qian, H.5    Yin, Z.6
  • 28
    • 65249101685 scopus 로고    scopus 로고
    • ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells
    • Drake, J.M.; Strohbehn, G.; Bair, T.B.; Moreland, J.G.; Henry, M.D. ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells. Mol. Biol. Cell, 2009, 20, 2207-2217.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2207-2217
    • Drake, J.M.1    Strohbehn, G.2    Bair, T.B.3    Moreland, J.G.4    Henry, M.D.5
  • 29
    • 67650045932 scopus 로고    scopus 로고
    • A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis
    • Smit, M.A.; Geiger, T.R.; Song, J.Y.; Gitelman, I.; Peeper, D.S.A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis. Mol. Cell Biol., 2009, 29, 3722-3737.
    • (2009) Mol. Cell Biol , vol.29 , pp. 3722-3737
    • Smit, M.A.1    Geiger, T.R.2    Song, J.Y.3    Gitelman, I.4    Peeper, D.S.5
  • 33
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelialmesenchymal transition
    • Morel, A.P.; Lievre, M.; Thomas, C.; Hinkal, G.; Ansieau, S.; Puisieux, A. Generation of breast cancer stem cells through epithelialmesenchymal transition. PLoSOne, 2008, 3, e2888.
    • (2008) PLoSOne , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 34
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P.B.; Fillmore, C.M.; Jiang, G.; Shapira, S.D.; Tao, K.; Kuperwasser, C.; Lander, E.S. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell, 2011, 146, 633-644.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 38
    • 33644791800 scopus 로고    scopus 로고
    • Postmodern biology: [adult] [stem] cells are plastic, stochastic, complex, and uncertain
    • Theise, N.D.; Harris, R. Postmodern biology: [adult] [stem] cells are plastic, stochastic, complex, and uncertain. Handb. Exp. Pharmacol., 2006, 389-408.
    • (2006) Handb. Exp. Pharmacol , pp. 389-408
    • Theise, N.D.1    Harris, R.2
  • 39
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelialmesenchymal transitions in cancer and normal stem cells?
    • Scheel, C.; Weinberg, R.A. Phenotypic plasticity and epithelialmesenchymal transitions in cancer and normal stem cells? Int. J. Cancer., 2011, 129, 2310-2314.
    • (2011) Int. J. Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 40
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner, G.H. Tumor heterogeneity. Cancer Res., 1984, 44, 2259-2265.
    • (1984) Cancer Res , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 46
    • 77949448846 scopus 로고    scopus 로고
    • Darwin and evolutionary tales in leukemia. The Ham-Wasserman Lecture
    • Greaves, M. Darwin and evolutionary tales in leukemia. The Ham-Wasserman Lecture. Hematol. Am. Soc. Hematol. Educ. Prog., 2009, 3-12.
    • (2009) Hematol. Am. Soc. Hematol. Educ. Prog , pp. 3-12
    • Greaves, M.1
  • 47
    • 77953811725 scopus 로고    scopus 로고
    • Cancer stem cells: Back to Darwin?
    • Greaves, M. Cancer stem cells: Back to Darwin? Semin. Cancer Biol., 2010, 20, 65-70.
    • (2010) Semin. Cancer Biol , vol.20 , pp. 65-70
    • Greaves, M.1
  • 48
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird, A. Perceptions of epigenetics. Nature, 2007, 447, 396-398.
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 52
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja, N.; Li, Q.; Mohan, A.L.; Baylin, S.B.; Issa, J.P. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res., 1998, 58, 5489-5494.
    • (1998) Cancer Res , vol.58 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.P.5
  • 54
    • 47949123984 scopus 로고    scopus 로고
    • Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
    • Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Herman, J.G. Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin. Cancer. Res., 2008, 14, 2570-2578.
    • (2008) Clin. Cancer. Res , vol.14 , pp. 2570-2578
    • Licchesi, J.D.1    Westra, W.H.2    Hooker, C.M.3    Herman, J.G.4
  • 55
    • 84901853867 scopus 로고    scopus 로고
    • Cancer epigenetics: Tumor heterogeneity, plasticity of stem-like states, and drug resistance
    • Easwaran, H.; Tsai, H.C.; Baylin, S.B. Cancer epigenetics: Tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol. Cell, 2014, 54, 716-727.
    • (2014) Mol. Cell , vol.54 , pp. 716-727
    • Easwaran, H.1    Tsai, H.C.2    Baylin, S.B.3
  • 56
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen, H.; Laird, P.W. Interplay between the cancer genome and epigenome. Cell, 2013, 153, 38-55.
    • (2013) Cell , vol.153 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 57
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: two sides of the same coin?
    • You, J.S.; Jones, P.A. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell, 2012, 22, 9-20.
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 58
    • 79953182741 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Shah, M.Y.; Licht, J.D. DNMT3A mutations in acute myeloid leukemia. Nat. Genet., 2011, 43, 289-290.
    • (2011) Nat. Genet , vol.43 , pp. 289-290
    • Shah, M.Y.1    Licht, J.D.2
  • 60
    • 0024254165 scopus 로고
    • Genomic instability, tumor heterogeneity and progression
    • Kendal, W.S.; Frost, P. Genomic instability, tumor heterogeneity and progression. Adv. Exp. Med. Biol., 1988, 233, 1-4.
    • (1988) Adv. Exp. Med. Biol , vol.233 , pp. 1-4
    • Kendal, W.S.1    Frost, P.2
  • 61
    • 0035845482 scopus 로고    scopus 로고
    • Investigating stem cells in human colon by using methylation patterns
    • Yatabe, Y.; Tavare, S.; Shibata, D. Investigating stem cells in human colon by using methylation patterns. Proc. Natl. Acad. Sci. USA, 2001, 98, 10839-10844.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10839-10844
    • Yatabe, Y.1    Tavare, S.2    Shibata, D.3
  • 66
    • 84883647494 scopus 로고    scopus 로고
    • Poised with purpose: Cell plasticity enhances tumorigenicity
    • Marjanovic, N.D.; Weinberg, R.A.; Chaffer, C.L. Poised with purpose: Cell plasticity enhances tumorigenicity. Cell Cycle, 2013, 12, 2713-2714.
    • (2013) Cell Cycle , vol.12 , pp. 2713-2714
    • Marjanovic, N.D.1    Weinberg, R.A.2    Chaffer, C.L.3
  • 67
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves, M.; Maley, C.C. Clonal evolution in cancer. Nature, 2012, 481, 306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 68
    • 0025313294 scopus 로고
    • Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
    • Cotsarelis, G.; Sun, T.T.; Lavker, R.M. Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell, 1990, 61, 1329-1337.
    • (1990) Cell , vol.61 , pp. 1329-1337
    • Cotsarelis, G.1    Sun, T.T.2    Lavker, R.M.3
  • 69
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai, F.; Hirao, A.; Ohmura, M.; Sato, H.; Matsuoka, S.; Takubo, K.; Ito, K.; Koh, G.Y.; Suda, T. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell, 2004, 118, 149-161.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3    Sato, H.4    Matsuoka, S.5    Takubo, K.6    Ito, K.7    Koh, G.Y.8    Suda, T.9
  • 73
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann, P.C.; Huber, S.L.; Herrler, T.; Aicher, A.; Ellwart, J. W.; Guba, M.; Bruns, C. J.; Heeschen, C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell, 2007, 1, 313-323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 74
    • 84875320058 scopus 로고    scopus 로고
    • Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden
    • Abubaker, K.; Latifi, A.; Luwor, R.; Nazaretian, S.; Zhu, H.; Quinn, M.A.; Thompson, E. W.; Findlay, J.K.; Ahmed, N. Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden. Mol. Cancer., 2013, 12, 24.
    • (2013) Mol. Cancer , vol.12 , pp. 24
    • Abubaker, K.1    Latifi, A.2    Luwor, R.3    Nazaretian, S.4    Zhu, H.5    Quinn, M.A.6    Thompson, E.W.7    Findlay, J.K.8    Ahmed, N.9
  • 77
    • 60949110035 scopus 로고    scopus 로고
    • Therapeutic implications of the cancer stem cell hypothesis
    • Diehn, M.; Cho, R.W.; Clarke, M.F. Therapeutic implications of the cancer stem cell hypothesis. Semin. Radiat. Oncol., 2009, 19, 78-86.
    • (2009) Semin. Radiat. Oncol , vol.19 , pp. 78-86
    • Diehn, M.1    Cho, R.W.2    Clarke, M.F.3
  • 78
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh, A.; Settleman, J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene, 2010, 29, 4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 79
    • 84915749487 scopus 로고    scopus 로고
    • Cancer stem cells-important players in tumor therapy resistance
    • Colak, S.; Medema, J.P. Cancer stem cells-important players in tumor therapy resistance. FEBS J, 2014, 281(21), 4779-4777.
    • (2014) FEBS J , vol.281 , Issue.21 , pp. 4777-4779
    • Colak, S.1    Medema, J.P.2
  • 80
    • 77952240931 scopus 로고    scopus 로고
    • CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
    • Gao, M.Q.; Choi, Y P.; Kang, S.; Youn, J.H.; Cho, N.H. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene, 2010, 29, 2672-2680.
    • (2010) Oncogene , vol.29 , pp. 2672-2680
    • Gao, M.Q.1    Choi, Y.P.2    Kang, S.3    Youn, J.H.4    Cho, N.H.5
  • 84
    • 45949101159 scopus 로고    scopus 로고
    • Expression of multidrug resistance genes in normal and cancer stem cells
    • Shervington, A.; Lu, C. Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Invest., 2008, 26, 535-542.
    • (2008) Cancer Invest , vol.26 , pp. 535-542
    • Shervington, A.1    Lu, C.2
  • 85
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer., 2002, 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 86
    • 84923248130 scopus 로고    scopus 로고
    • A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
    • Cojoc, M.; Mabert, K.; Muders, M.H.; Dubrovska, A. A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms. Semin. Cancer. Biol., 2015, 31, 16-27.
    • (2015) Semin. Cancer. Biol , vol.31 , pp. 16-27
    • Cojoc, M.1    Mabert, K.2    Muders, M.H.3    Dubrovska, A.4
  • 90
    • 84864887658 scopus 로고    scopus 로고
    • How to manage acute promyelocytic leukemia
    • Mi, J.Q.; Li, J.M.; Shen, Z.X.; Chen, S.J.; Chen, Z. How to manage acute promyelocytic leukemia. Leukemia, 2012, 26, 1743-1751.
    • (2012) Leukemia , vol.26 , pp. 1743-1751
    • Mi, J.Q.1    Li, J.M.2    Shen, Z.X.3    Chen, S.J.4    Chen, Z.5
  • 93
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe, N.; Harris, P.J.; Warren, R.Q.; Ivy, S.P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat. Rev. Clin. Oncol., 2011, 8, 97-106.
    • (2011) Nat. Rev. Clin. Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 94
    • 84863955787 scopus 로고    scopus 로고
    • Shared signaling pathways in normal and breast cancer stem cells
    • Malhotra, G.K.; Zhao, X.; Band, H.; Band, V. Shared signaling pathways in normal and breast cancer stem cells. J. Carcinog., 2011, 10, 38.
    • (2011) J. Carcinog , vol.10 , pp. 38
    • Malhotra, G.K.1    Zhao, X.2    Band, H.3    Band, V.4
  • 95
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • Van Amerongen, R.; Nusse, R. Towards an integrated view of Wnt signaling in development. Development, 2009, 136, 3205-3214.
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 96
    • 84878148574 scopus 로고    scopus 로고
    • beta-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: A meta-analysis
    • Chen, Z.; He, X.; Jia, M.; Liu, Y.; Qu, D.; Wu, D.; Wu, P.; Ni, C.; Zhang, Z.; Ye, J.; Xu, J.; Huang, J. beta-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: A meta-analysis. PLoSOne, 2013, 8, e63854.
    • (2013) PLoSOne , vol.8
    • Chen, Z.1    He, X.2    Jia, M.3    Liu, Y.4    Qu, D.5    Wu, D.6    Wu, P.7    Ni, C.8    Zhang, Z.9    Ye, J.10    Xu, J.11    Huang, J.12
  • 97
    • 84906242449 scopus 로고    scopus 로고
    • Nuclear localizaiton of beta-catenin is associated with poor survival and chemo-/radioresistance in human cervical squamous cell cancer
    • Zhang, Y.; Liu, B.; Zhao, Q.; Hou, T.; Huang, X. Nuclear localizaiton of beta-catenin is associated with poor survival and chemo-/radioresistance in human cervical squamous cell cancer. Int. J. Clin. Exp. Pathol., 2014, 7, 3908-3917.
    • (2014) Int. J. Clin. Exp. Pathol , vol.7 , pp. 3908-3917
    • Zhang, Y.1    Liu, B.2    Zhao, Q.3    Hou, T.4    Huang, X.5
  • 100
    • 79960857043 scopus 로고    scopus 로고
    • Key signaling nodes in mammary gland development and cancer: Betacatenin
    • Incassati, A.; Chandramouli, A.; Eelkema, R.; Cowin, P. Key signaling nodes in mammary gland development and cancer: Betacatenin. Breast Cancer Res., 2010, 12, 213.
    • (2010) Breast Cancer Res , vol.12 , pp. 213
    • Incassati, A.1    Chandramouli, A.2    Eelkema, R.3    Cowin, P.4
  • 101
    • 79955496473 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
    • Pacheco-Pinedo, E.C.; Durham, A.C.; Stewart, K.M.; Goss, A.M.; Lu, M.M.; Demayo, F.J.; Morrisey, E.E. Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J. Clin. Invest., 2011, 121, 1935-1945.
    • (2011) J. Clin. Invest , vol.121 , pp. 1935-1945
    • Pacheco-Pinedo, E.C.1    Durham, A.C.2    Stewart, K.M.3    Goss, A.M.4    Lu, M.M.5    Demayo, F.J.6    Morrisey, E.E.7
  • 105
    • 85027928015 scopus 로고    scopus 로고
    • Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line
    • Vangipuram, S.D.; Buck, S.A.; Lyman, W.D. Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line. Tumour. Biol., 2012, 33, 2173-2183.
    • (2012) Tumour. Biol , vol.33 , pp. 2173-2183
    • Vangipuram, S.D.1    Buck, S.A.2    Lyman, W.D.3
  • 106
    • 84927001056 scopus 로고    scopus 로고
    • Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition
    • Warrier, S.; Bhuvanalakshmi, G.; Arfuso, F.; Rajan, G.; Millward, M.; Dharmarajan, A. Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition. Cancer Gen. Ther., 2014, 21, 381-388.
    • (2014) Cancer Gen. Ther , vol.21 , pp. 381-388
    • Warrier, S.1    Bhuvanalakshmi, G.2    Arfuso, F.3    Rajan, G.4    Millward, M.5    Dharmarajan, A.6
  • 108
    • 0034678357 scopus 로고    scopus 로고
    • The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
    • Takemaru, K.I.; Moon, R.T. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J. Cell. Biol., 2000, 149, 249-254.
    • (2000) J. Cell. Biol , vol.149 , pp. 249-254
    • Takemaru, K.I.1    Moon, R.T.2
  • 109
    • 84908185262 scopus 로고    scopus 로고
    • Safely targeting cancer stem cells via selective catenin coactivator antagonism
    • Lenz, H.J.; Kahn, M. Safely targeting cancer stem cells via selective catenin coactivator antagonism. Cancer Sci., 2014, 105, 1087-1092.
    • (2014) Cancer Sci , vol.105 , pp. 1087-1092
    • Lenz, H.J.1    Kahn, M.2
  • 111
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: Can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga, F.; Kahn, M. Targeting Wnt signaling: Can we safely eradicate cancer stem cells? Clin. Cancer Res., 2010, 16, 3153-3162.
    • (2010) Clin. Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 112
    • 84885350053 scopus 로고    scopus 로고
    • Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Horwich, A.; Parker, C.; De Reijke, T.; Kataja, V.; Group, E.G.W. Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 2013, 24 Suppl 6, vi106-14.
    • (2013) Ann. Oncol , vol.24
    • Horwich, A.1    Parker, C.2    De Reijke, T.3    Kataja, V.4    Group, E.G.W.5
  • 114
    • 84910098336 scopus 로고    scopus 로고
    • Molecular biology of liver cancer stem cells
    • Oishi, N.; Yamashita, T.; Kaneko, S. Molecular biology of liver cancer stem cells. Liver Cancer, 2014, 3, 71-84.
    • (2014) Liver Cancer , vol.3 , pp. 71-84
    • Oishi, N.1    Yamashita, T.2    Kaneko, S.3
  • 117
    • 68049128117 scopus 로고    scopus 로고
    • Paracrine Hedgehog signaling in cancer
    • Theunissen, JW.; de Sauvage, F.J. Paracrine Hedgehog signaling in cancer. Cancer Res, 2009, 69, 6007-6010.
    • (2009) Cancer Res , vol.69 , pp. 6007-6010
    • Theunissen, J.W.1    de Sauvage, F.J.2
  • 118
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement, V.; Sanchez, P.; De Tribolet, N.; Radovanovic, I.; Ruiz i Altaba, A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol., 2007, 17, 165-172.
    • (2007) Curr. Biol , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    De Tribolet, N.3    Radovanovic, I.4    Ruiz i Altaba, A.5
  • 119
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells
    • Liu, S.; Dontu, G.; Mantle, I.D.; Patel, S.; Ahn, N.S.; Jackson, K.W.; Suri, P.; Wicha, M.S. Hedgehog signaling and Bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells. Cancer. Res., 2006, 66, 6063-6071.
    • (2006) Cancer. Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 121
    • 0032486433 scopus 로고    scopus 로고
    • Teratogenmediated inhibition of target tissue response to Shh signaling
    • Cooper, M.K.; Porter, J.A.; Young, K.E.; Beachy, P.A. Teratogenmediated inhibition of target tissue response to Shh signaling. Science, 1998, 280, 1603-1607.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 123
    • 72949103044 scopus 로고    scopus 로고
    • Small-molecule modulators of the Sonic Hedgehog signaling pathway
    • Stanton, B.Z.; Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst., 2010, 6, 44-54.
    • (2010) Mol. Biosyst , vol.6 , pp. 44-54
    • Stanton, B.Z.1    Peng, L.F.2
  • 125
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth, M.; Bergstrom, A.; Shimokawa, T.; Toftgard, R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA, 2007, 104, 8455-8460.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3    Toftgard, R.4
  • 130
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 [Vismodegib] inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
    • Singh, B.N.; Fu, J.; Srivastava, R.K.; Shankar, S. Hedgehog signaling antagonist GDC-0449 [Vismodegib] inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms. PLoS. One, 2011, 6, e27306.
    • (2011) PLoS. One , vol.6
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 132
    • 47749118343 scopus 로고    scopus 로고
    • Kuz and TACE can activate Notch independent of ligand
    • Delwig, A.; Rand, M.D. Kuz and TACE can activate Notch independent of ligand. Cell Mol. Life Sci., 2008, 65, 2232-2243.
    • (2008) Cell Mol. Life Sci , vol.65 , pp. 2232-2243
    • Delwig, A.1    Rand, M.D.2
  • 133
    • 84867415859 scopus 로고    scopus 로고
    • Characterization of CSL [CBF-1, Su[H], Lag-1] mutants reveals differences in signaling mediated by Notch1 and Notch2
    • Yuan, Z.; Friedmann, D.R.; VanderWielen, B.D.; Collins, K.J.; Kovall, R.A. Characterization of CSL [CBF-1, Su[H], Lag-1] mutants reveals differences in signaling mediated by Notch1 and Notch2. J. Biol. Chem., 2012, 287, 34904-34916.
    • (2012) J. Biol. Chem , vol.287 , pp. 34904-34916
    • Yuan, Z.1    Friedmann, D.R.2    VanderWielen, B.D.3    Collins, K.J.4    Kovall, R.A.5
  • 135
    • 0037071412 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell fate
    • Krause, D.S. Regulation of hematopoietic stem cell fate. Oncogene, 2002, 21, 3262-3269.
    • (2002) Oncogene , vol.21 , pp. 3262-3269
    • Krause, D.S.1
  • 136
    • 84896732141 scopus 로고    scopus 로고
    • New approaches to target cancer stem cells: Current scenario
    • Insan, M.B.; Jaitak, V. New approaches to target cancer stem cells: Current scenario. Mini. Rev. Med. Chem., 2014, 14, 20-34.
    • (2014) Mini. Rev. Med. Chem , vol.14 , pp. 20-34
    • Insan, M.B.1    Jaitak, V.2
  • 137
    • 84891840587 scopus 로고    scopus 로고
    • Targeting notch signaling pathway in cancer: Clinical development advances and challenges
    • Takebe, N.; Nguyen, D.; Yang, S.X. Targeting notch signaling pathway in cancer: Clinical development advances and challenges. Pharmacol. Ther., 2014, 141, 140-149.
    • (2014) Pharmacol. Ther , vol.141 , pp. 140-149
    • Takebe, N.1    Nguyen, D.2    Yang, S.X.3
  • 141
    • 79952240423 scopus 로고    scopus 로고
    • Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations
    • Fischer, M.; Yen, W.C.; Kapoun, A.M.; Wang, M.; O'Young, G.; Lewicki, J.; Gurney, A.; Hoey, T. Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res., 2011, 71, 1520-1525.
    • (2011) Cancer Res , vol.71 , pp. 1520-1525
    • Fischer, M.1    Yen, W.C.2    Kapoun, A.M.3    Wang, M.4    O'Young, G.5    Lewicki, J.6    Gurney, A.7    Hoey, T.8
  • 142
    • 0022771586 scopus 로고
    • The resources of the Chinese traditional medicine mabo in Guizhou Province
    • He, S.Z. The resources of the Chinese traditional medicine mabo in Guizhou Province. Zhong Yao Tong Bao, 1986, 11, 14-6.
    • (1986) Zhong Yao Tong Bao , vol.11 , pp. 14-16
    • He, S.Z.1
  • 143
    • 84877093512 scopus 로고    scopus 로고
    • Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
    • Hassan, K.A.; Wang, L.; Korkaya, H.; Chen, G.; Maillard, I.; Beer, D.G.; Kalemkerian, G.P.; Wicha, M.S. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin. Cancer Res., 2013, 19, 1972-1980.
    • (2013) Clin. Cancer Res , vol.19 , pp. 1972-1980
    • Hassan, K.A.1    Wang, L.2    Korkaya, H.3    Chen, G.4    Maillard, I.5    Beer, D.G.6    Kalemkerian, G.P.7    Wicha, M.S.8
  • 144
    • 80051710743 scopus 로고    scopus 로고
    • FAK and WNT signaling: The meeting of two pathways in cancer and development
    • Fonar, Y.; Frank, D. FAK and WNT signaling: The meeting of two pathways in cancer and development. Anticancer Agents Med. Chem., 2011, 11, 600-606.
    • (2011) Anticancer Agents Med. Chem , vol.11 , pp. 600-606
    • Fonar, Y.1    Frank, D.2
  • 145
    • 77956471611 scopus 로고    scopus 로고
    • Convergence between Wnt-beta-catenin and EGFR signaling in cancer
    • Hu, T.; Li, C. Convergence between Wnt-beta-catenin and EGFR signaling in cancer. Mol. Cancer, 2010, 9, 236.
    • (2010) Mol. Cancer , vol.9 , pp. 236
    • Hu, T.1    Li, C.2
  • 146
    • 84887242051 scopus 로고    scopus 로고
    • New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of gamma-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
    • Hales, E.C.; Taub, J.W.; Matherly, L.H. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of gamma-secretase inhibitor resistant T-cell acute lymphoblastic leukemia. Cell Signal., 2014, 26, 149-161.
    • (2014) Cell Signal , vol.26 , pp. 149-161
    • Hales, E.C.1    Taub, J.W.2    Matherly, L.H.3
  • 147
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein, C.A. Parallel progression of primary tumours and metastases. Nat. Rev. Cancer, 2009, 9, 302-312.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 148
    • 0030852491 scopus 로고    scopus 로고
    • Foulds' dangerous idea revisited: The multistep development of tumors 40 years later
    • Klein, G. Foulds' dangerous idea revisited: The multistep development of tumors 40 years later. Adv. Cancer Res., 1998, 72, 1-23.
    • (1998) Adv. Cancer Res , vol.72 , pp. 1-23
    • Klein, G.1
  • 150
    • 80052190496 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Detection systems, molecular characterization, and future challenges
    • Lianidou, E.S.; Markou, A. Circulating tumor cells in breast cancer: Detection systems, molecular characterization, and future challenges. Clin. Chem., 2011, 57, 1242-1255.
    • (2011) Clin. Chem , vol.57 , pp. 1242-1255
    • Lianidou, E.S.1    Markou, A.2
  • 155
    • 84857613654 scopus 로고    scopus 로고
    • High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients
    • Pierga, J.Y.; Hajage, D.; Bachelot, T.; Delaloge, S.; Brain, E.; Campone, M.; Dieras, V.; Rolland, E.; Mignot, L.; Mathiot, C.; Bidard, F.C. High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients. Ann. Oncol., 2012, 23, 618-624.
    • (2012) Ann. Oncol , vol.23 , pp. 618-624
    • Pierga, J.Y.1    Hajage, D.2    Bachelot, T.3    Delaloge, S.4    Brain, E.5    Campone, M.6    Dieras, V.7    Rolland, E.8    Mignot, L.9    Mathiot, C.10    Bidard, F.C.11
  • 157
    • 80052795481 scopus 로고    scopus 로고
    • Molecular profiling and prognostic relevance of circulating tumor cells in the blood of ovarian cancer patients at primary diagnosis and after platinum-based chemotherapy
    • Aktas, B.; Kasimir-Bauer, S.; Heubner, M.; Kimmig, R.; Wimberger, P. Molecular profiling and prognostic relevance of circulating tumor cells in the blood of ovarian cancer patients at primary diagnosis and after platinum-based chemotherapy. Int. J. Gynecol. Cancer, 2011, 21, 822-830.
    • (2011) Int. J. Gynecol. Cancer , vol.21 , pp. 822-830
    • Aktas, B.1    Kasimir-Bauer, S.2    Heubner, M.3    Kimmig, R.4    Wimberger, P.5
  • 158
    • 84871926107 scopus 로고    scopus 로고
    • Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance--a study of the OVCAD consortium
    • Obermayr, E.; Castillo-Tong, D.C.; Pils, D.; Speiser, P.; Braicu, I.; Van Gorp, T.; Mahner, S.; Sehouli, J.; Vergote, I.; Zeillinger, R. Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance--a study of the OVCAD consortium. Gynecol. Oncol., 2013, 128, 15-21.
    • (2013) Gynecol. Oncol , vol.128 , pp. 15-21
    • Obermayr, E.1    Castillo-Tong, D.C.2    Pils, D.3    Speiser, P.4    Braicu, I.5    Van Gorp, T.6    Mahner, S.7    Sehouli, J.8    Vergote, I.9    Zeillinger, R.10
  • 161
    • 84856317859 scopus 로고    scopus 로고
    • Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect versus Veridex CellSearch system
    • Andreopoulou, E.; Yang, L.Y.; Rangel, K.M.; Reuben, J.M.; Hsu, L.; Krishnamurthy, S.; Valero, V.; Fritsche, H.A.; Cristofanilli, M. Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect versus Veridex CellSearch system. Int. J. Cancer, 2012, 130, 1590-1597.
    • (2012) Int. J. Cancer , vol.130 , pp. 1590-1597
    • Andreopoulou, E.1    Yang, L.Y.2    Rangel, K.M.3    Reuben, J.M.4    Hsu, L.5    Krishnamurthy, S.6    Valero, V.7    Fritsche, H.A.8    Cristofanilli, M.9
  • 163
    • 84908518413 scopus 로고    scopus 로고
    • Circulating tumor cells from a 4-dimensional lung cancer model are resistant to cisplatin
    • Vishnoi, M.; Mishra, D.K.; Thrall, M.J.; Kurie, J.M.; Kim, M.P. Circulating tumor cells from a 4-dimensional lung cancer model are resistant to cisplatin. J. Thorac. Cardiovasc. Surg., 2014, 148, 1056-1064.
    • (2014) J. Thorac. Cardiovasc. Surg , vol.148 , pp. 1056-1064
    • Vishnoi, M.1    Mishra, D.K.2    Thrall, M.J.3    Kurie, J.M.4    Kim, M.P.5
  • 164
    • 84906053458 scopus 로고    scopus 로고
    • Circulating tumor cells exhibit a biologically aggressive cancer phenotype accompanied by selective resistance to chemotherapy
    • Pavese, J.M.; Bergan, R.C. Circulating tumor cells exhibit a biologically aggressive cancer phenotype accompanied by selective resistance to chemotherapy. Cancer Lett., 2014, 352, 179-186.
    • (2014) Cancer Lett , vol.352 , pp. 179-186
    • Pavese, J.M.1    Bergan, R.C.2
  • 169
    • 84892938139 scopus 로고    scopus 로고
    • CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer
    • Swaminathan, S.K.; Roger, E.; Toti, U.; Niu, L.; Ohlfest, J.R.; Panyam, J. CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer. J. Cont. Rel., 2013, 171, 280-287.
    • (2013) J. Cont. Rel , vol.171 , pp. 280-287
    • Swaminathan, S.K.1    Roger, E.2    Toti, U.3    Niu, L.4    Ohlfest, J.R.5    Panyam, J.6
  • 170
    • 65349101638 scopus 로고    scopus 로고
    • Delivery of apoptotic signal to rolling cancer cells: A novel biomimetic technique using immobilized TRAIL and E-selectin
    • Rana, K.; Liesveld, J.L.; King, M.R. Delivery of apoptotic signal to rolling cancer cells: A novel biomimetic technique using immobilized TRAIL and E-selectin. Biotechnol. Bioeng., 2009, 102, 1692-1702.
    • (2009) Biotechnol. Bioeng , vol.102 , pp. 1692-1702
    • Rana, K.1    Liesveld, J.L.2    King, M.R.3
  • 171
    • 70350142394 scopus 로고    scopus 로고
    • An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation
    • Huang, Z.; King, M.R. An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation. Gene Ther., 2009, 16, 1271-1282.
    • (2009) Gene Ther , vol.16 , pp. 1271-1282
    • Huang, Z.1    King, M.R.2
  • 172
    • 84863792455 scopus 로고    scopus 로고
    • Nanobiotechnology for the capture and manipulation of circulating tumor cells
    • Hughes, A.D.; King, M.R. Nanobiotechnology for the capture and manipulation of circulating tumor cells. Wiley. Interdiscip. Rev. Nanomed. Nanobiotechnol., 2012, 4, 291-309.
    • (2012) Wiley. Interdiscip. Rev. Nanomed. Nanobiotechnol , vol.4 , pp. 291-309
    • Hughes, A.D.1    King, M.R.2
  • 174
    • 48749085964 scopus 로고    scopus 로고
    • Magnetic nanoparticle-peptide conjugates for in vitro and in vivo targeting and extraction of cancer cells
    • Scarberry, K.E.; Dickerson, E.B.; McDonald, J.F.; Zhang, Z.J. Magnetic nanoparticle-peptide conjugates for in vitro and in vivo targeting and extraction of cancer cells. J. Am. Chem. Soc., 2008, 130, 10258-10262.
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 10258-10262
    • Scarberry, K.E.1    Dickerson, E.B.2    McDonald, J.F.3    Zhang, Z.J.4
  • 175
    • 77952744087 scopus 로고    scopus 로고
    • Selective removal of ovarian cancer cells from human ascites fluid using magnetic nanoparticles
    • Scarberry, K.E.; Dickerson, E.B.; Zhang, Z.J.; Benigno, B.B.; McDonald, J.F. Selective removal of ovarian cancer cells from human ascites fluid using magnetic nanoparticles. Nanomedicine, 2010, 6, 399-408.
    • (2010) Nanomedicine , vol.6 , pp. 399-408
    • Scarberry, K.E.1    Dickerson, E.B.2    Zhang, Z.J.3    Benigno, B.B.4    McDonald, J.F.5
  • 176
    • 78650674462 scopus 로고    scopus 로고
    • Targeted removal of migratory tumor cells by functionalized magnetic nanoparticles impedes metastasis and tumor progression
    • Scarberry, K.E.; Mezencev, R.; McDonald, J.F. Targeted removal of migratory tumor cells by functionalized magnetic nanoparticles impedes metastasis and tumor progression. Nanomedicine [Lond], 2011, 6, 69-78.
    • (2011) Nanomedicine [Lond] , vol.6 , pp. 69-78
    • Scarberry, K.E.1    Mezencev, R.2    McDonald, J.F.3
  • 177
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield, R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells, 1978, 4, 7-25.
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 178
  • 179
    • 84924249260 scopus 로고    scopus 로고
    • The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
    • Plaks, V.; Kong, N.; Werb, Z. The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells? Cell Stem Cell, 2015, 16, 225-238.
    • (2015) Cell Stem Cell , vol.16 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 180
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
    • Folkins, C.; Man, S.; Xu, P.; Shaked, Y.; Hicklin, D.J.; Kerbel, R.S. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res., 2007, 67, 3560-3564.
    • (2007) Cancer Res , vol.67 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3    Shaked, Y.4    Hicklin, D.J.5    Kerbel, R.S.6
  • 182
    • 84879422834 scopus 로고    scopus 로고
    • Notch inhibitors for cancer treatment
    • Espinoza, I.; Miele, L. Notch inhibitors for cancer treatment. Pharmacol. Ther., 2013, 139, 95-110.
    • (2013) Pharmacol. Ther , vol.139 , pp. 95-110
    • Espinoza, I.1    Miele, L.2
  • 183
    • 77953722864 scopus 로고    scopus 로고
    • The difficulty of targeting cancer stem cell niches
    • LaBarge, M.A. The difficulty of targeting cancer stem cell niches. Clin. Cancer Res., 2010, 16, 3121-3129.
    • (2010) Clin. Cancer Res , vol.16 , pp. 3121-3129
    • LaBarge, M.A.1
  • 185
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin, L.; Hope, K.J.; Zhai, Q.; Smadja-Joffe, F.; Dick, J.E. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med., 2006, 12, 1167-1174.
    • (2006) Nat. Med , vol.12 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 187
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor [CD184] antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger, M.; Hartmann, T.; Krome, M.; Rawluk, J.; Tamamura, H.; Fujii, N.; Kipps, T.J.; Burger, J.A. Small peptide inhibitors of the CXCR4 chemokine receptor [CD184] antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood, 2005, 106, 1824-1830.
    • (2005) Blood , vol.106 , pp. 1824-1830
    • Burger, M.1    Hartmann, T.2    Krome, M.3    Rawluk, J.4    Tamamura, H.5    Fujii, N.6    Kipps, T.J.7    Burger, J.A.8
  • 191
  • 195
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche, J.; Ilc, K.; Laferriere, J.; Trottier, E.; Dayan, F.; Mazure, N.M.; Brahimi-Horn, M.C.; Pouyssegur, J. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res., 2009, 69, 358-368.
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouyssegur, J.8
  • 196
    • 79961070760 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and activators for novel therapeutic applications
    • Supuran, C.T. Carbonic anhydrase inhibitors and activators for novel therapeutic applications. Future Med. Chem., 2011, 3, 1165-1180.
    • (2011) Future Med. Chem , vol.3 , pp. 1165-1180
    • Supuran, C.T.1
  • 197
    • 47349097049 scopus 로고    scopus 로고
    • Super pH-sensitive multifunctional polymeric micelle for tumor pH[e] specific TAT exposure and multidrug resistance
    • Lee, E.S.; Gao, Z.; Kim, D.; Park, K.; Kwon, I.C.; Bae, Y.H. Super pH-sensitive multifunctional polymeric micelle for tumor pH[e] specific TAT exposure and multidrug resistance. J. Cont. Rel., 2008, 129, 228-236.
    • (2008) J. Cont. Rel , vol.129 , pp. 228-236
    • Lee, E.S.1    Gao, Z.2    Kim, D.3    Park, K.4    Kwon, I.C.5    Bae, Y.H.6
  • 198
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol, W.H.; Bounds, P.L.; Dang, C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer, 2011, 11, 325-337.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 199
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. On respiratory impairment in cancer cells. Science, 1956, 124, 269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 200
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz, J.D.; White, E. Autophagy and metabolism. Science, 2010, 330, 1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 202
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen, N.; Karantza, V. Autophagy as a therapeutic target in cancer. Cancer Biol. Ther., 2011, 11, 157-168.
    • (2011) Cancer Biol. Ther , vol.11 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 203
    • 54949098894 scopus 로고    scopus 로고
    • Nucleoside analogs: Molecular mechanisms signaling cell death
    • Ewald, B.; Sampath, D.; Plunkett, W. Nucleoside analogs: Molecular mechanisms signaling cell death. Oncogene, 2008, 27, 6522-6537.
    • (2008) Oncogene , vol.27 , pp. 6522-6537
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 207
    • 23944498840 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 [LDH5] relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
    • Koukourakis, M.I.; Giatromanolaki, A.; Simopoulos, C.; Polychronidis, A.; Sivridis, E. Lactate dehydrogenase 5 [LDH5] relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin. Exp. Metastasis, 2005, 22, 25-30.
    • (2005) Clin. Exp. Metastasis , vol.22 , pp. 25-30
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Simopoulos, C.3    Polychronidis, A.4    Sivridis, E.5
  • 214
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch, H.A.; Iliopoulos, D.; Tsichlis, P.N.; Struhl, K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res., 2009, 69, 7507-7511.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 216
    • 84887025650 scopus 로고    scopus 로고
    • Clinical perspectives of cancer stem cell research in radiation oncology
    • Butof, R.; Dubrovska, A.; Baumann, M. Clinical perspectives of cancer stem cell research in radiation oncology. Radiother. Oncol., 2013, 108, 388-396.
    • (2013) Radiother. Oncol , vol.108 , pp. 388-396
    • Butof, R.1    Dubrovska, A.2    Baumann, M.3
  • 219
    • 84923257721 scopus 로고    scopus 로고
    • A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
    • Cojoc, M.; Mabert, K.; Muders, M.H.; Dubrovska, A. A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms. Semin. Cancer Biol., 2014.
    • (2014) Semin. Cancer Biol
    • Cojoc, M.1    Mabert, K.2    Muders, M.H.3    Dubrovska, A.4
  • 220
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli, I.; Trumpp, A. The evolving concept of cancer and metastasis stem cells. J. Cell Biol., 2012, 198, 281-293.
    • (2012) J. Cell Biol , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 222
    • 0035899332 scopus 로고    scopus 로고
    • Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
    • Gayet, J.; Zhou, X.P.; Duval, A.; Rolland, S.; Hoang, J.M.; Cottu, P.; Hamelin, R. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene, 2001, 20, 5025-5032.
    • (2001) Oncogene , vol.20 , pp. 5025-5032
    • Gayet, J.1    Zhou, X.P.2    Duval, A.3    Rolland, S.4    Hoang, J.M.5    Cottu, P.6    Hamelin, R.7
  • 224
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell
    • Reynolds, B.A.; Weiss, S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol., 1996, 175, 1-13.
    • (1996) Dev. Biol , vol.175 , pp. 1-13
    • Reynolds, B.A.1    Weiss, S.2
  • 225
    • 79955679188 scopus 로고    scopus 로고
    • Eyes wide open: A critical review of sphere-formation as an assay for stem cells
    • Pastrana, E.; Silva-Vargas, V.; Doetsch, F. Eyes wide open: A critical review of sphere-formation as an assay for stem cells. Cell Stem Cell, 2011, 8, 486-498.
    • (2011) Cell Stem Cell , vol.8 , pp. 486-498
    • Pastrana, E.1    Silva-Vargas, V.2    Doetsch, F.3
  • 228
    • 84856575716 scopus 로고    scopus 로고
    • Small interfering RNA library screen identified polo-like kinase-1 [PLK1] as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells
    • Hu K, L.J.; Fotovati, A.; Dunn, S.E. Small interfering RNA library screen identified polo-like kinase-1 [PLK1] as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res., 2012, 14, R22.
    • (2012) Breast Cancer Res , vol.14
    • Hu, K.L.J.1    Fotovati, A.2    Dunn, S.E.3
  • 230
    • 84896068181 scopus 로고    scopus 로고
    • The culture of cancer cell lines as tumorspheres does not systematically result in cancer stem cell enrichment
    • Calvet, C.Y.; Andre, F.M.; Mir, L.M. The culture of cancer cell lines as tumorspheres does not systematically result in cancer stem cell enrichment. PLoSOne, 2014, 9, e89644.
    • (2014) PLoSOne , vol.9
    • Calvet, C.Y.1    Andre, F.M.2    Mir, L.M.3
  • 231
    • 84887273608 scopus 로고    scopus 로고
    • Epithelial plasticity: a common theme in embryonic and cancer cells
    • Nieto, M.A. Epithelial plasticity: a common theme in embryonic and cancer cells. Science, 2013, 342, 1234850.
    • (2013) Science , vol.342 , pp. 1234850
    • Nieto, M.A.1
  • 233
    • 84901787644 scopus 로고    scopus 로고
    • Oncogenic roles of EMTinducing transcription factors
    • Puisieux, A.; Brabletz, T.; Caramel, J. Oncogenic roles of EMTinducing transcription factors. Nat. Cell Biol., 2014, 16, 488-494.
    • (2014) Nat. Cell Biol , vol.16 , pp. 488-494
    • Puisieux, A.1    Brabletz, T.2    Caramel, J.3
  • 234
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P.B.; Onder, T.T.; Jiang, G.; Tao, K.; Kuperwasser, C.; Weinberg, R.A.; Lander, E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell, 2009, 138, 645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 235
    • 84871395763 scopus 로고    scopus 로고
    • Salinomycin as a drug for targeting human cancer stem cells
    • Naujokat, C.; Steinhart, R. Salinomycin as a drug for targeting human cancer stem cells. J. Biomed. Biotechnol., 2012, 2012, 950658.
    • (2012) J. Biomed. Biotechnol , vol.2012 , pp. 950658
    • Naujokat, C.1    Steinhart, R.2
  • 236
    • 84907999055 scopus 로고    scopus 로고
    • Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
    • Nishi, M.; Akutsu, H.; Kudoh, A.; Kimura, H.; Yamamoto, N.; Umezawa, A.; Lee, S.W.; Ryo, A. Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell. Oncotarget, 2014, 5, 8665-8680.
    • (2014) Oncotarget , vol.5 , pp. 8665-8680
    • Nishi, M.1    Akutsu, H.2    Kudoh, A.3    Kimura, H.4    Yamamoto, N.5    Umezawa, A.6    Lee, S.W.7    Ryo, A.8
  • 239
    • 84856596426 scopus 로고    scopus 로고
    • A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside
    • McDermott, S.P.; Eppert, K.; Notta, F.; Isaac, M.; Datti, A.; Al-Awar, R.; Wrana, J.; Minden, M.D.; Dick, J.E. A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood, 2012, 119, 1200-1207.
    • (2012) Blood , vol.119 , pp. 1200-1207
    • McDermott, S.P.1    Eppert, K.2    Notta, F.3    Isaac, M.4    Datti, A.5    Al-Awar, R.6    Wrana, J.7    Minden, M.D.8    Dick, J.E.9
  • 242
    • 84887626984 scopus 로고    scopus 로고
    • Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells
    • Ke, X.Y.; Lin Ng, V.W.; Gao, S.J.; Tong, Y.W.; Hedrick, J.L.; Yang, Y.Y. Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells. Biomaterials, 2014, 35, 1096-1108.
    • (2014) Biomaterials , vol.35 , pp. 1096-1108
    • Ke, X.Y.1    Lin Ng, V.W.2    Gao, S.J.3    Tong, Y.W.4    Hedrick, J.L.5    Yang, Y.Y.6
  • 246
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • Kim, J.; Woo, A.J.; Chu, J.; Snow, J.W.; Fujiwara, Y.; Kim, C.G.; Cantor, A.B.; Orkin, S.H. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell, 2010, 143, 313-324.
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1    Woo, A.J.2    Chu, J.3    Snow, J.W.4    Fujiwara, Y.5    Kim, C.G.6    Cantor, A.B.7    Orkin, S.H.8
  • 249
    • 47049105891 scopus 로고    scopus 로고
    • Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data
    • Hassane, D.C.; Guzman, M.L.; Corbett, C.; Li, X.; Abboud, R.; Young, F.; Liesveld, J.L.; Carroll, M.; Jordan, C.T. Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood, 2008, 111, 5654-5662.
    • (2008) Blood , vol.111 , pp. 5654-5662
    • Hassane, D.C.1    Guzman, M.L.2    Corbett, C.3    Li, X.4    Abboud, R.5    Young, F.6    Liesveld, J.L.7    Carroll, M.8    Jordan, C.T.9
  • 251
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman, M.L.; Rossi, R.M.; Karnischky, L.; Li, X.; Peterson, D.R.; Howard, D.S.; Jordan, C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood, 2005, 105, 4163-4169.
    • (2005) Blood , vol.105 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3    Li, X.4    Peterson, D.R.5    Howard, D.S.6    Jordan, C.T.7
  • 253
    • 84898619055 scopus 로고    scopus 로고
    • Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation
    • Zhang, B.; Shimada, Y.; Kuroyanagi, J.; Umemoto, N.; Nishimura, Y.; Tanaka, T. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS. One, 2014, 9, e85439.
    • (2014) PLoS. One , vol.9
    • Zhang, B.1    Shimada, Y.2    Kuroyanagi, J.3    Umemoto, N.4    Nishimura, Y.5    Tanaka, T.6
  • 254
    • 84925283504 scopus 로고    scopus 로고
    • Zebrafish xenotransplantation model for cancer stem-like cell study and highthroughput screening of inhibitors
    • Zhang, B.; Shimada, Y.; Kuroyanagi, J.; Nishimura, Y.; Umemoto, N.; Nomoto, T.; Shintou, T.; Miyazaki, T.; Tanaka, T. Zebrafish xenotransplantation model for cancer stem-like cell study and highthroughput screening of inhibitors. Tumour Biol., 2014, 35(12), 11861-11869.
    • (2014) Tumour Biol , vol.35 , Issue.12 , pp. 11861-11869
    • Zhang, B.1    Shimada, Y.2    Kuroyanagi, J.3    Nishimura, Y.4    Umemoto, N.5    Nomoto, T.6    Shintou, T.7    Miyazaki, T.8    Tanaka, T.9
  • 255
    • 84904003575 scopus 로고    scopus 로고
    • Hooking the big one: The potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era
    • Veinotte, C.J.; Dellaire, G.; Berman, J.N. Hooking the big one: The potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era. Dis. Model Mech., 2014, 7, 745-754.
    • (2014) Dis. Model Mech , vol.7 , pp. 745-754
    • Veinotte, C.J.1    Dellaire, G.2    Berman, J.N.3
  • 256
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee, J.A.; Piskounova, E.; Morrison, S.J. Cancer stem cells: Impact, heterogeneity, and uncertainty. Cancer Cell, 2012, 21, 283-296.
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 258
    • 0030461577 scopus 로고    scopus 로고
    • The role of the immune response in MULV-induced lymphomagenesis
    • Marshall, D.J.; Gaulton, G.N. The role of the immune response in MULV-induced lymphomagenesis. Leukemia, 1996, 10, 1860-1866.
    • (1996) Leukemia , vol.10 , pp. 1860-1866
    • Marshall, D.J.1    Gaulton, G.N.2
  • 259
    • 27744466162 scopus 로고    scopus 로고
    • Strategies of antigen-specific Tcell-based immunotherapy for cancer
    • Liu, S.H.; Zhang, M.; Zhang, W.G. Strategies of antigen-specific Tcell-based immunotherapy for cancer. Cancer Biother. Radiopharm., 2005, 20, 491-501.
    • (2005) Cancer Biother. Radiopharm , vol.20 , pp. 491-501
    • Liu, S.H.1    Zhang, M.2    Zhang, W.G.3
  • 260
    • 84908058440 scopus 로고    scopus 로고
    • Animal models and therapeutic molecular targets of cancer: utility and limitations
    • Cekanova, M.; Rathore, K. Animal models and therapeutic molecular targets of cancer: utility and limitations. Drug Des. Devel. Ther., 2014, 8, 1911-1922.
    • (2014) Drug Des. Devel. Ther , vol.8 , pp. 1911-1922
    • Cekanova, M.1    Rathore, K.2
  • 262
    • 1542436704 scopus 로고    scopus 로고
    • Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived-but they can be improved
    • Kerbel, R.S. Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived-but they can be improved. Cancer Biol. Ther., 2003, 2, S134-S139.
    • (2003) Cancer Biol. Ther , vol.2 , pp. 134-139
    • Kerbel, R.S.1
  • 263
    • 64249106832 scopus 로고    scopus 로고
    • Mouse xenograft models vs GEM models for human cancer therapeutics
    • Richmond, A.; Su, Y. Mouse xenograft models vs GEM models for human cancer therapeutics. Dis. Model Mech., 2008, 1, 78-82.
    • (2008) Dis. Model Mech , vol.1 , pp. 78-82
    • Richmond, A.1    Su, Y.2
  • 264
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J.; Li, Y.; Yu, T.S.; McKay, R.M.; Burns, D.K.; Kernie, S.G.; Parada, L.F.A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 2012, 488, 522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 265
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • Driessens, G.; Beck, B.; Caauwe, A.; Simons, B.D.; Blanpain, C. Defining the mode of tumour growth by clonal analysis. Nature, 2012, 488, 527-530.
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3    Simons, B.D.4    Blanpain, C.5
  • 266
    • 84877836210 scopus 로고    scopus 로고
    • In vivo RNAi screen for BMI1 targets identifies TGF-beta/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis
    • Gargiulo, G.; Cesaroni, M.; Serresi, M.; De Vries, N.; Hulsman, D.; Bruggeman, S.W.; Lancini, C.; Van Lohuizen, M. In vivo RNAi screen for BMI1 targets identifies TGF-beta/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis. Cancer Cell, 2013, 23, 660-676.
    • (2013) Cancer Cell , vol.23 , pp. 660-676
    • Gargiulo, G.1    Cesaroni, M.2    Serresi, M.3    De Vries, N.4    Hulsman, D.5    Bruggeman, S.W.6    Lancini, C.7    Van Lohuizen, M.8
  • 267
    • 14844319300 scopus 로고    scopus 로고
    • Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin
    • Yan, C.; Jamaluddin, M.S.; Aggarwal, B.; Myers, J.; Boyd, D.D. Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol. Cancer Ther., 2005, 4, 233-241.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 233-241
    • Yan, C.1    Jamaluddin, M.S.2    Aggarwal, B.3    Myers, J.4    Boyd, D.D.5
  • 268
    • 36148962372 scopus 로고    scopus 로고
    • Berberine, A natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells
    • Piyanuch, R.; Sukhthankar, M.; Wandee, G.; Baek, S.J. Berberine, A natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Lett., 2007, 258, 230-240.
    • (2007) Cancer Lett , vol.258 , pp. 230-240
    • Piyanuch, R.1    Sukhthankar, M.2    Wandee, G.3    Baek, S.J.4
  • 269
    • 35448953654 scopus 로고    scopus 로고
    • Green tea catechin [-]-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation
    • Cho, K.N.; Sukhthankar, M.; Lee, S.H.; Yoon, J.H.; Baek, S.J. Green tea catechin [-]-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation. Eur. J. Cancer, 2007, 43, 2404-2412.
    • (2007) Eur. J. Cancer , vol.43 , pp. 2404-2412
    • Cho, K.N.1    Sukhthankar, M.2    Lee, S.H.3    Yoon, J.H.4    Baek, S.J.5
  • 270
    • 63949087469 scopus 로고    scopus 로고
    • Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells
    • Tian, Z.; An, N.; Zhou, B.; Xiao, P.; Kohane, I.S.; Wu, E. Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells. Cancer Chemother. Pharmacol., 2009, 63, 1131-1139.
    • (2009) Cancer Chemother. Pharmacol , vol.63 , pp. 1131-1139
    • Tian, Z.1    An, N.2    Zhou, B.3    Xiao, P.4    Kohane, I.S.5    Wu, E.6
  • 271
    • 84921055072 scopus 로고    scopus 로고
    • EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of Pglycoprotein inhibition
    • Zhang, Y.; Wang, S.X.; Ma, J.W.; Li, H.Y.; Ye, J.C.; Xie, S.M.; Du, B.; Zhong, X.Y. EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of Pglycoprotein inhibition. J. Neurooncol., 2015. 121(1), 41-52.
    • (2015) J. Neurooncol , vol.121 , Issue.1 , pp. 41-52
    • Zhang, Y.1    Wang, S.X.2    Ma, J.W.3    Li, H.Y.4    Ye, J.C.5    Xie, S.M.6    Du, B.7    Zhong, X.Y.8
  • 272
    • 54049094704 scopus 로고    scopus 로고
    • Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells
    • Li, H.; Guo, L.; Jie, S.; Liu, W.; Zhu, J.; Du, W.; Fan, L.; Wang, X.; Fu, B.; Huang, S. Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. Biomed. Pharmacother., 2008, 62, 573-578.
    • (2008) Biomed. Pharmacother , vol.62 , pp. 573-578
    • Li, H.1    Guo, L.2    Jie, S.3    Liu, W.4    Zhu, J.5    Du, W.6    Fan, L.7    Wang, X.8    Fu, B.9    Huang, S.10
  • 273
    • 84904117834 scopus 로고    scopus 로고
    • Curcumin: A promising agent targeting cancer stem cells
    • Zang, S.; Liu, T.; Shi, J.; Qiao, L. Curcumin: A promising agent targeting cancer stem cells. Anticanc. Agen. Med. Chem., 2014, 14, 787-792.
    • (2014) Anticanc. Agen. Med. Chem , vol.14 , pp. 787-792
    • Zang, S.1    Liu, T.2    Shi, J.3    Qiao, L.4
  • 274
    • 84866467182 scopus 로고    scopus 로고
    • Drug screening study using glioma stem-like cells
    • Feng, X.; Zhou, Q.; Liu, C.; Tao, M.L. Drug screening study using glioma stem-like cells. Mol. Med. Rep., 2012, 6, 1117-1120.
    • (2012) Mol. Med. Rep , vol.6 , pp. 1117-1120
    • Feng, X.1    Zhou, Q.2    Liu, C.3    Tao, M.L.4
  • 276
    • 67650444760 scopus 로고    scopus 로고
    • ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
    • Hu, Y.; Smyth, G.K. ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods, 2009, 347, 70-78.
    • (2009) J. Immunol. Methods , vol.347 , pp. 70-78
    • Hu, Y.1    Smyth, G.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.