Targeting of CD44 eradicates human acute myeloid leukemic stem cells

Nature Medicine

Volumn 12, Issue 10, 2006, Pages 1167-1174

  Jin, Liqing ^a   Hope, Kristin J ^a   Zhai, Qiongli ^b   Smadja Joffe, Florence ^b   Dick, John E ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY H90; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL FATE; CELL MIGRATION; CONTROLLED STUDY; GENE TARGETING; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD34; ANTIGENS, CD38; ANTIGENS, CD44; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; IMMUNOTHERAPY; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; STEM CELLS;

EID: 33749515476     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1483     Document Type: Article

References (37)

1. Wang, J.C. & Dick, J.E. Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15, 494-501 (2005).
2. Hope, K., Jin, L. & Dick, J.E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 5, 738-743 (2004).
3. Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648 (1994).
4. Bonnet, D. & Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730-737 (1997).
5. Guan, Y. & Hogge, D.E. Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML). Leukemia 14, 2135-2141 (2000).
6. Guzman, M.L. et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98, 2301-2307 (2001).
7. Tallman, M.S. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents. Hematology Am. Soc. Hematol. Educ. Program 2005, 143-150 (2005).
8. Wilson, A. & Trumpp, A. Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6, 93-106 (2006).
9. Nilsson, S.K. et al. Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood 101, 856-862 (2003).
10. Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841 (2003).
11. Calvi, L.M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846 (2003).
12. Cancelas, J.A. & Williams, D.A. Stem cell mobilization by b2-agonists. Nat. Med. 12, 278-279 (2006).
13. Lapidot, T., Dar, A. & Kollet, O. How do stem cells find their way home? Blood 106, 1901-1910 (2005).
14. Kortlepel, K., Bendall, L.J. & Gottlieb, D.J. Human acute myeloid leukaemia cells express adhesion proteins and bind to bone marrow fibroblast monolayers and extracellular matrix proteins. Leukemia 7, 1174-1179 (1993).
15. + hematopoietic cells in normal human bone marrow and leukemia. Ann. Hematol. 65, 169-174 (1992).
16. + myeloid progenitors: role of marrow stromal, fibroblast, and cytomatrix components. Exp. Hematol. 19, 63-70 (1991).
17. Tavor, S. et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res. 64, 2817-2824 (2004).
18. Till, J.E. & McCulloch, E.A. Hemopoietic stem cell differentiation. Biochim. Biophys. Acta 605, 431-459 (1980).
19. Ponta, H., Sherman, L. & Herrlich, P.A. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell Biol. 4, 33-45 (2003).
20. + cells. Leukemia 14, 1239-1246 (2000).
21. Legras, S. et al. A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia. Blood 91, 3401-3413 (1998).
22. + stem/progenitor cells to bone marrow. Blood 103, 2981-2989 (2004).
23. Turley, E.A., Noble, P.W. & Bourguignon, L.Y. Signaling properties of hyaluronan receptors. J. Biol. Chem. 277, 4589-4592 (2002).
24. Charrad, R.S. et al. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nat. Med. 5, 669-676 (1999).
25. Charrad, R.S. et al. Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood 99, 290-299 (2002).
26. Gadhoum, Z. et al. CD44: a new means to inhibit acute myeloid leukemia cell proliferation via P27Kip1. Blood 103, 1059-1068 (2004).
27. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 91, 4523-4530 (1998).
28. Mazurier, F., Doedens, M., Gan, O.I. & Dick, J.E. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat. Med. 9, 959-963 (2003).
29. Mazurier, F., Gan, O., McKenzie, J., Doedens, M. & Dick, J. Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood 103, 545-552 (2004).
30. Madlambayan, G.J. et al. Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp. Hematol. 33, 1229-1239 (2005).
31. Peled, A. et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845-848 (1999).
32. Kim, C.F. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823-835 (2005).
33. Singh, S. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5281-5288 (2003).
34. Al-Hajj, M., Wicha, M., Morrison, S.J. & Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983-3988 (2003).
35. Liotta, L.A. & Kohn, E.C. The microenvironment of the tumour-host interface. Nature 411, 375-379 (2001).
36. Woerner, S.M. et al. Expression of CD44 splice variants in normal, dysplastic, and neoplastic cervical epithelium. Clin. Cancer Res. 1, 1125-1132 (1995).
37. Jo, D.Y., Rafii, S., Hamada, T. & Moore, M.A. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 105, 101-111 (2000).