Metabolic modulation of glioblastoma with dichloroacetate

Science Translational Medicine

Volumn 2, Issue 31, 2010, Pages

  Michelakis, E D ^a   Sutendra, G ^a   Dromparis, P ^a   Webster, L ^a   Haromy, A ^a   Niven, E ^a   Maguire, C ^a   Gammer, T L ^a   Mackey, J R ^a   Fulton, D ^a   Abdulkarim, B ^a   McMurtry, M S ^a   Petruk, K C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; DICHLOROACETIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P53; PYRUVATE DEHYDROGENASE KINASE 2; REACTIVE OXYGEN METABOLITE;

ADULT; APOPTOSIS; ARTICLE; BLOOD TOXICITY; CARDIOTOXICITY; CELL MEMBRANE DEPOLARIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MALE; METABOLIC REGULATION; NEPHROTOXICITY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; TREATMENT DURATION;

ADULT; APOPTOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DICHLOROACETATE; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; NEOPLASTIC STEM CELLS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES;

EID: 77952995998     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3000677     Document Type: Article

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