Bicarbonate increases tumor pH and inhibits spontaneous metastases

Cancer Research

Volumn 69, Issue 6, 2009, Pages 2260-2268

  Robey, Ian F ^a   Baggett, Brenda K ^a   Kirkpatrick, Nathaniel D ^a   Roe, Denise J ^a   Dosescu, Julie ^b   Sloane, Bonnie F ^b   Hashini, Arig Ibrahim ^c   Morse, David L ^c   Raghunand, Natarajan ^a   Gatenby, Robert A ^c   Gillies, Robert J ^c  

^a UNIVERSITY OF ARIZONA   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; BICARBONATE; CATHEPSIN B; PHOSPHORUS 31; PROTEINASE;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CANCER MODEL; CELL PH; CONTROLLED STUDY; EXTRACELLULAR MATRIX; EXTRAVASATION; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER METASTASIS; LYMPH NODE METASTASIS; MALE; MELANOMA B16; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR CELL; TUMOR GROWTH; ANIMAL; BREAST TUMOR; DRUG ANTAGONISM; EXPERIMENTAL MELANOMA; LIVER TUMOR; LUNG TUMOR; METABOLISM; METASTASIS; MOUSE MUTANT; NUDE MOUSE; PATHOLOGY; PH; PROSTATE TUMOR; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CATHEPSIN B; CELL LINE, TUMOR; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, NUDE; MICE, SCID; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; SODIUM BICARBONATE;

EID: 65549166946     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5575     Document Type: Article

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