Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Nature Genetics

Volumn 36, Issue 4, 2004, Pages 417-422

  Suzuki, Hiromu ^a,b   Watkins, D Neil ^a   Jair, Kam Wing ^a   Schuebel, Kornel E ^a   Markowitz, Sanford D ^c,d   Chen, Wei Dong ^d   Pretlow, Theresa P ^e   Yang, Bin ^a   Akiyama, Yoshimitsu ^a   Van Engeland, Manon ^f   Toyota, Minoru ^b,g   Tokino, Takashi ^b   Hinoda, Yuji ^h   Imai, Kohzoh ^b   Herman, James G ^a   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AXIN; AXIN 2; BETA CATENIN; CONDUCTIN; FRIZZLED PROTEIN; LIGAND; SECRETED FRIZZLED RELATED PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; AXIN2 GENE; CANCER GROWTH; CELL NUCLEUS; COLORECTAL CANCER; CONTROLLED STUDY; CTNNB1 GENE; DOWN REGULATION; EPIGENETICS; GENE; GENE INACTIVATION; GENE LOSS; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RECEPTOR BINDING; SFRP GENE; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; COLORECTAL NEOPLASMS; GENE SILENCING; GLYCOPROTEINS; HUMANS; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 12144291274     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1330     Document Type: Article

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