Circulating tumor cells, disease progression, and survival in metastatic breast cancer

New England Journal of Medicine

Volumn 351, Issue 8, 2004, Pages 781-791

  Cristofanilli, Massimo ^a   Budd, G Thomas ^b   Ellis, Matthew J ^c   Stopeck, Alison ^d   Matera, Jeri ^e   Miller, M Craig ^e   Reuben, James M ^a   Doyle, Gerald V ^e   Allard, W Jeffrey ^e   Terstappen, Leon W M M ^e   Hayes, Daniel F ^f  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c DUKE UNIVERSITY   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e Immunicon   (United States)

^f UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD; BREAST CANCER; BREAST METASTASIS; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CIRCULATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; STANDARD; TRAINING; TREATMENT OUTCOME; TUMOR CELL;

BREAST NEOPLASMS; CELL SEPARATION; DISEASE PROGRESSION; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM CIRCULATING CELLS; NEOPLASM METASTASIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 4143094988     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa040766     Document Type: Article

References (27)

1. Ellis M, Hayes DF, Lippman ME. Treatment of metastatic disease. In: Harris J, Lippman M, Morrow M, et al., eds. Diseases of the breast. 3rd ed. Philadelphia: Lippincott-Raven, 2004;1101-59.
2. Ashworth TR. A case of cancer in which cells similar to those in the tumors were seen in the blood after death. Australian Med J 1869;14:146.
3. Carey RW, Taft PD, Bennett JM, Kaufman S. Carcinocythemia (carcinoma cell leukemia): an acute leukemia-like picture due to metastatic carcinoma cells. Am J Med 1976;60:273-8.
4. Engell HC. Cancer cells in the circulating blood: a clinical study on the occurrence of cancer cells in the peripheral blood and in venous blood draining the tumour area at operation. Acta Chir Scand Suppl 1955;201:1-70.
5. Myerowitz RL, Edwards PA, Sartiano GP. Carcinocythemia (carcinoma cell leukemia) due to metastatic carcinoma of the breast: report of a case. Cancer 1977;40:3107-11.
6. Gallivan MV, Lokich JJ. Carcinocythemia (carcinoma cell leukemia): report of two cases with English literature review. Cancer 1984;53:1100-2.
7. Sile CC, Perry DJ, Nam L. Small cell carcinocythemia. Arch Pathol Lab Med 1999;123:426-8.
8. Rodriguez-Salas N, Jimenez-Gordo AM, Gonzalez E, et al. Circulating cancer cells in peripheral blood: a case report. Acta Cytol 2000;44:237-41.
9. Seronie-Vivien S, Mery E, Delord JP, et al. Carcinocythemia as the single extension of breast cancer: report of a case and review of the literature. Ann Oncol 2001;12:1019-22.
10. Yam LT, Janckila AJ. Immunocytodiagnosis of carcinocythemia in disseminated breast cancer. Acta Cytol 1987;31:68-72.
11. Racila E, Euhus D, Weiss AJ, et al. Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci U S A 1998;95:4589-94.
12. Gaforio JJ, Serrano MJ, Sanchez-Rovira P, et al. Detection of breast cancer cells in the peripheral blood is positively correlated with estrogen-receptor status and predicts poor prognosis. Int J Cancer 2003;107:984-90.
13. Moreno JG, Croce CM, Fischer R, et al. Detection of hematogenous micrometastasis in patients with prostate cancer. Cancer Res 1992;52:6110-2.
14. Gullet U, Zajac P, Schnider A, et al. Disseminated single tumor cells as detected by real-time quantitative polymerase chain reaction represent a prognostic factor in patients undergoing surgery for colorectal cancer. Ann Surg 2002;236:768-76.
15. Terstappen LW, Rao C, Gross S, Weiss AJ. Peripheral blood tumor cell load reflects the clinical activity of the disease in patients with carcinoma of the breast. Int J Oncol 2000;17:573-8.
16. Kagan M, Howard D, Bendele T, et al. A sample preparation and analysis system for identification of circulating tumor cells. J Clin Ligand Assay 2002;25:104-10.
17. Kagan M, Howard D, Bendele T, et al. Circulating tumor cells as cancer markers: a sample preparation and analysis system. In: Diamandis EP, Fritsche HA, Lilja H, Chan DW, Schwartz M, eds. Tumor markers: physiology, pathobiology, technology, and clinical applications. Washington, D.C.: AACC Press, 2002:495-8.
18. Miller AB, Hoogstraten G, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981;47:207-14.
19. Rao C, Rutner H, Hermann M, et al. Preservation of blood specimens to prevent breakdown of circulating tumor cells. In: Vol. 3 of Proceedings of the 93rd Annual Meeting of the American Association of Cancer Research, San Francisco, April 6-10, 2002:734. abstract.
20. Allard WJ, Hayes DF, Repollet MI, et al. A cellular preservative improves the specificity and yield of circulating tumor cells in carcinoma patients. In: Vol. 22 of Proceedings of the 39th Annual Meeting of the American Society of Clinical Oncology, Chicago, May 31-June 3, 2003:851. abstract.
21. Food and Drug Administration. 510(k) Premarket notification database: plate, fixation, bone. (Accessed July 26, 2004, at http://www.accessdata.fda. gov/scripts/cdrh/cfdocs/cfPMN/pmn.cfin?ID=11014.)
22. Idem. 510(k) Premarket notification database: prosthesis, hip, semi-constrained, metal/polymer, porous uncemented. (Accessed July 26, 2004, at http://www. accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMN/pmn.cfm?ID=8985.)
23. Idem. 510(k) Premarket notification database: resin, denture, relining, repairing, rebasing. (Accessed July 26, 2004, at http://www.accessdata.fda.gov/ scripts/cdrh/cfdocs/cfPMN/pmn.cfin?ID=13775.)
24. Allard WJ, Matera J, Miller MC, et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res (in press).
25. Swenerton KD, Legha SS, Smith L, et al. Prognostic factors in metastatic breast cancer treated with combination chemotherapy. Cancer Res 1979;39:1552-62.
26. Hortobagyi GN, Smith TL, Legha SS, et al. Multivariate analysis of prognostic factors in metastatic breast cancer. J Clin Oncol 1983;1:776-86.
27. Fehm T, Sagalowsky A, Clifford E, et al. Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clin Cancer Res 2002;8:2073-84.