Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 20, 1998, Pages 11891-11896

  Belinsky, Steven A ^a   Nikula, Kristen J ^a   Palmisano, William A ^a   Michels, Ruth ^c   Saccomanno, Geno ^c   Gabrielson, Edward ^b   Baylin, Stephen B ^b   Herman, James G ^b  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NONE

Author keywords

NNK; p16 methylation; Sputum; Squamous cell carcinoma

Indexed keywords

PROTEIN P16;

ANIMAL CELL; ARTICLE; EARLY DIAGNOSIS; GENE FREQUENCY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; METHYLATION; NONHUMAN; PATIENT MONITORING; PRIORITY JOURNAL; PROMOTER REGION; RAT; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOMA; ANIMALS; CARCINOGENS; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; DNA METHYLATION; DNA, NEOPLASM; GENES, P16; HUMANS; HYPERPLASIA; LUNG NEOPLASMS; METAPLASIA; NITROSAMINES; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; SPUTUM; TUMOR MARKERS, BIOLOGICAL;

EID: 0032578509     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.20.11891     Document Type: Article

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