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Volumn 467, Issue 7319, 2010, Pages 1109-1113

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CELL ORGANELLE; CLONAL ORGANISM; FUNCTIONAL MORPHOLOGY; GENETIC ANALYSIS; GENETIC VARIATION; GENOMICS; HETEROGENEITY; MORTALITY; MUTATION; PHYLOGENETICS; SELECTION; TUMOR;

EID: 78049380554     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09460     Document Type: Article
Times cited : (1130)

References (30)
  • 1
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 2
    • 41149156431 scopus 로고    scopus 로고
    • Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays
    • Harada, T. et al. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene 27, 1951-1960 (2008).
    • (2008) Oncogene , vol.27 , pp. 1951-1960
    • Harada, T.1
  • 3
    • 54349103007 scopus 로고    scopus 로고
    • Frequent genomic copy number gain and overexpressionofGATA-6inpancreatic carcinoma
    • Fu, B., Luo, M., Lakkur, S., Lucito, R. & Iacobuzio-Donahue, C. A. Frequent genomic copy number gain and overexpressionofGATA-6inpancreatic carcinoma. Cancer Biol. Ther. 7, 1593-1601 (2008).
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 1593-1601
    • Fu, B.1    Luo, M.2    Lakkur, S.3    Lucito, R.4    Iacobuzio-Donahue, C.A.5
  • 4
    • 58049221106 scopus 로고    scopus 로고
    • Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
    • Kimmelman, A. C. et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc. Natl Acad. Sci. USA 105, 19372-19377 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19372-19377
    • Kimmelman, A.C.1
  • 5
    • 0035940501 scopus 로고    scopus 로고
    • Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
    • Gisselsson, D. et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl Acad. Sci. USA 98, 12683-12688 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 12683-12688
    • Gisselsson, D.1
  • 6
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein, C. A. Parallel progression of primary tumours and metastases. Nature Rev. Cancer 9, 302-312 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 7
    • 0342887306 scopus 로고    scopus 로고
    • Genetic heterogeneity and clonal evolution underlying development ofasynchronous metastasis in human breast cancer
    • Kuukasjarvi, T. et al. Genetic heterogeneity and clonal evolution underlying development ofasynchronous metastasis in human breast cancer. Cancer Res.57, 1597-1604 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 1597-1604
    • Kuukasjarvi, T.1
  • 8
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding, L. et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464, 999-1005 (2010).
    • (2010) Nature , vol.464 , pp. 999-1005
    • Ding, L.1
  • 9
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis, E. R. et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361, 1058-1066 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 10
    • 74449093973 scopus 로고    scopus 로고
    • A comprehensive catalogue of somatic mutations from a human cancer genome
    • Pleasance, E. D. et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463, 191-196 (2010).
    • (2010) Nature , vol.463 , pp. 191-196
    • Pleasance, E.D.1
  • 11
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance, E. D. et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463, 184-190 (2010).
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1
  • 12
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah, S. P. et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461, 809-813 (2009).
    • (2009) Nature , vol.461 , pp. 809-813
    • Shah, S.P.1
  • 13
    • 44349191457 scopus 로고    scopus 로고
    • Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
    • Campbell, P. J. et al. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nature Genet. 40, 722-729 (2008).
    • (2008) Nature Genet. , vol.40 , pp. 722-729
    • Campbell, P.J.1
  • 14
    • 72949119310 scopus 로고    scopus 로고
    • Complex landscapes of somatic rearrangement in human breast cancer genomes
    • Stephens, P. J. et al. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462, 1005-1010 (2009).
    • (2009) Nature , vol.462 , pp. 1005-1010
    • Stephens, P.J.1
  • 15
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in Zea mays
    • McLintock, B. The stability of broken ends of chromosomes in Zea mays. Genetics 26, 234-282 (1941).
    • (1941) Genetics , vol.26 , pp. 234-282
    • McLintock, B.1
  • 16
    • 34548441098 scopus 로고    scopus 로고
    • Architectures of somatic genomic rearrangementin human cancer amplicons at sequence-level resolution
    • Bignell, G.R. et al.Architectures of somatic genomic rearrangementin human cancer amplicons at sequence-level resolution. Genome Res. 17 1296-1303 2007).
    • (2007) Genome Res. , vol.17 , pp. 1296-1303
    • Bignell, G.R.1
  • 17
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • O'Hagan, R. C. et al. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2, 149-155 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 149-155
    • O'Hagan, R.C.1
  • 18
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy, N. & DePinho, R.A. Pancreatic cancer biology and genetics. Nature Rev. Cancer 2, 897-909 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    Depinho, R.A.2
  • 19
    • 34250863886 scopus 로고    scopus 로고
    • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
    • Maser, R. S. et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447, 966-971 (2007).
    • (2007) Nature , vol.447 , pp. 966-971
    • Maser, R.S.1
  • 20
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin, E. & Depinho, R. A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464, 520-528 (2010).
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 21
    • 52549115459 scopus 로고    scopus 로고
    • Replication licensing and cancer a fatal entanglement?
    • Blow, J. J.& Gillespie, P.J.Replication licensing and cancer a fatal entanglement? Nature Rev. Cancer 8, 799-806 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 799-806
    • Blow, J.J.1    Gillespie, P.J.2
  • 22
    • 38149109033 scopus 로고    scopus 로고
    • Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas
    • HashimotoY, Murakami Y, Uemura K, et al. Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. J. Gastrointest. Surg. 12, 17-29 (2008).
    • (2008) J. Gastrointest. Surg. , vol.12 , pp. 17-29
    • Hashimoto, Y.1    Murakami, Y.2    Uemura, K.3
  • 23
    • 51349126920 scopus 로고    scopus 로고
    • Subclonal phylogenetic structuresin cancer revealed by ultra-deep sequencing
    • Campbell, P. J. et al. Subclonal phylogenetic structuresin cancer revealed by ultra-deep sequencing. Proc. Natl Acad. Sci. USA 105, 13081-13086 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13081-13086
    • Campbell, P.J.1
  • 24
    • 67349257845 scopus 로고    scopus 로고
    • Copy number analysis indicates monoclonal originoflethal metastatic prostate cancer
    • Liu, W. et al. Copy number analysis indicates monoclonal originoflethal metastatic prostate cancer. Nature Med. 15, 559-565 (2009).
    • (2009) Nature Med. , vol.15 , pp. 559-565
    • Liu, W.1
  • 25
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen, D. X. & Massague, J. Genetic determinants of cancer metastasis. Nature Rev. Genet. 8, 341-352 (2007).
    • (2007) Nature Rev. Genet. , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 26
    • 0037206022 scopus 로고    scopus 로고
    • Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    • Klein, C. A. et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 360, 683-689 (2002).
    • (2002) Lancet , vol.360 , pp. 683-689
    • Klein, C.A.1
  • 27
    • 25144519682 scopus 로고    scopus 로고
    • Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
    • Embuscado, E. E. et al. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol. Ther. 4, 548-554 (2005).
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 548-554
    • Embuscado, E.E.1
  • 28
    • 57049122389 scopus 로고    scopus 로고
    • A large genome center's improvements to the Illumina sequencing system
    • Quail, M. A. et al. A large genome center's improvements to the Illumina sequencing system. Nature Methods 5, 1005-1010 (2008).
    • (2008) Nature Methods , vol.5 , pp. 1005-1010
    • Quail, M.A.1
  • 29
    • 55549097836 scopus 로고    scopus 로고
    • Mapping short DNA sequencing reads and calling variants using mapping quality scores
    • Li, H., Ruan, J. & Durbin, R. Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 18, 1851-1858 (2008).
    • (2008) Genome Res. , vol.18 , pp. 1851-1858
    • Li, H.1    Ruan, J.2    Durbin, R.3
  • 30
    • 42349085052 scopus 로고    scopus 로고
    • Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia
    • Flohr, T. et al. Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia. Leukemia 22, 771-782 (2008).
    • (2008) Leukemia , vol.22 , pp. 771-782
    • Flohr, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.