메뉴 건너뛰기




Volumn 105, Issue 11, 2005, Pages 4163-4169

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE; PROTEIN P53; SESQUITERPENE LACTONE;

EID: 16844363378     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-10-4135     Document Type: Article
Times cited : (613)

References (42)
  • 1
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 2
    • 0032402173 scopus 로고    scopus 로고
    • Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR
    • Blair A, Hogge DE, Sutherland HJ. Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR. Blood. 1998;92:4325-4335.
    • (1998) Blood , vol.92 , pp. 4325-4335
    • Blair, A.1    Hogge, D.E.2    Sutherland, H.J.3
  • 3
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645-648.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 4
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A, Hogge DE, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 1997; 89:3104-3112.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 5
    • 0034097928 scopus 로고    scopus 로고
    • Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)
    • Blair A, Sutherland HJ. Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117). Exp Hematol. 2000;28:660-671.
    • (2000) Exp Hematol , vol.28 , pp. 660-671
    • Blair, A.1    Sutherland, H.J.2
  • 6
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000;14:1777-1784.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3
  • 7
    • 0037606054 scopus 로고    scopus 로고
    • Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)
    • Guan Y, Gerhard B, Hogge DE. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood. 2003;101:3142-3149.
    • (2003) Blood , vol.101 , pp. 3142-3149
    • Guan, Y.1    Gerhard, B.2    Hogge, D.E.3
  • 8
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98:2301-2307.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3
  • 9
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 2004;5:738-743.
    • (2004) Nat Immunol , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 10
    • 0035313467 scopus 로고    scopus 로고
    • Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells
    • Guzman ML, Upchurch D, Grimes B, et al. Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. Blood. 2001;97:2177-2179.
    • (2001) Blood , vol.97 , pp. 2177-2179
    • Guzman, M.L.1    Upchurch, D.2    Grimes, B.3
  • 11
    • 0037059012 scopus 로고    scopus 로고
    • Preferential induction of apoptosis for primary human leukemic stem cells
    • Guzman ML, Swiderski CF, Howard DS, et al. Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci U S A. 2002;99:16220-16225.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16220-16225
    • Guzman, M.L.1    Swiderski, C.F.2    Howard, D.S.3
  • 12
    • 0029311312 scopus 로고
    • Feverfew: Chemistry and biological activity
    • Knight DW. Feverfew: chemistry and biological activity. Nat Prod Rep. 1995;12:271-276.
    • (1995) Nat Prod Rep , vol.12 , pp. 271-276
    • Knight, D.W.1
  • 13
    • 2442538125 scopus 로고    scopus 로고
    • Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells
    • Zhang S, Ong CN, Shen HM. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett. 2004;208:143-153.
    • (2004) Cancer Lett , vol.208 , pp. 143-153
    • Zhang, S.1    Ong, C.N.2    Shen, H.M.3
  • 14
    • 0032990502 scopus 로고    scopus 로고
    • Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion
    • Ross JJ, Arnason JT, Birnboim HC. Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion. Planta Med. 1999;65:126-129.
    • (1999) Planta Med , vol.65 , pp. 126-129
    • Ross, J.J.1    Arnason, J.T.2    Birnboim, H.C.3
  • 15
    • 0019491333 scopus 로고
    • Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactones
    • Woynarowski JM, Konopa J. Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactones. Mol Pharmacol. 1981;19:97-102.
    • (1981) Mol Pharmacol , vol.19 , pp. 97-102
    • Woynarowski, J.M.1    Konopa, J.2
  • 16
    • 0015582319 scopus 로고
    • Tumor inhibitory agent from Magnolia grandiflora (Magnoliaceae), I: Parthenolide
    • Wiedhopf RM, Young M, Bianchi E, Cole JR. Tumor inhibitory agent from Magnolia grandiflora (Magnoliaceae), I: parthenolide. J Pharm Sci. 1973;62:345.
    • (1973) J Pharm Sci , vol.62 , pp. 345
    • Wiedhopf, R.M.1    Young, M.2    Bianchi, E.3    Cole, J.R.4
  • 17
    • 7044275192 scopus 로고    scopus 로고
    • Suppressed NF-{kappa}B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-{alpha}-induced apoptosis in human cancer cells
    • Zhang S, Lin ZN, Yang CF, Shi X, Ong CN, Shen HM. Suppressed NF-{kappa}B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-{alpha}-induced apoptosis in human cancer cells. Carcinogenesis. 2004;25:2191-2199.
    • (2004) Carcinogenesis , vol.25 , pp. 2191-2199
    • Zhang, S.1    Lin, Z.N.2    Yang, C.F.3    Shi, X.4    Ong, C.N.5    Shen, H.M.6
  • 18
    • 6044240634 scopus 로고    scopus 로고
    • Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    • Nakshatri H, Rice SE, Bhat-Nakshatri P. Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Oncogene. 2004;23:7330-7344.
    • (2004) Oncogene , vol.23 , pp. 7330-7344
    • Nakshatri, H.1    Rice, S.E.2    Bhat-Nakshatri, P.3
  • 19
    • 3442901974 scopus 로고    scopus 로고
    • NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen
    • deGraffenried LA, Chandrasekar B, Friedrichs WE, et al. NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen. Ann Oncol. 2004;15:885-890.
    • (2004) Ann Oncol , vol.15 , pp. 885-890
    • Degraffenried, L.A.1    Chandrasekar, B.2    Friedrichs, W.E.3
  • 20
    • 0034710539 scopus 로고    scopus 로고
    • Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by Ikappa-Balpha super-repressor and parthenolide
    • Patel NM, Nozaki S, Shortle NH, et al. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by Ikappa-Balpha super-repressor and parthenolide. Oncogene. 2000;19:4159-4169.
    • (2000) Oncogene , vol.19 , pp. 4159-4169
    • Patel, N.M.1    Nozaki, S.2    Shortle, N.H.3
  • 21
    • 4344588130 scopus 로고    scopus 로고
    • Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms
    • Won YK, Ong CN, Shi X, Shen HM. Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis. 2004;25:1449-1458.
    • (2004) Carcinogenesis , vol.25 , pp. 1449-1458
    • Won, Y.K.1    Ong, C.N.2    Shi, X.3    Shen, H.M.4
  • 22
    • 0034879173 scopus 로고    scopus 로고
    • The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
    • Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001;8:759-766.
    • (2001) Chem Biol , vol.8 , pp. 759-766
    • Kwok, B.H.1    Koh, B.2    Ndubuisi, M.I.3    Elofsson, M.4    Crews, C.M.5
  • 23
    • 0033571108 scopus 로고    scopus 로고
    • The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex
    • Hehner SP, Hofmann TG, Droge W, Schmitz ML. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J Immunol. 1999;163:5617-5623.
    • (1999) J Immunol , vol.163 , pp. 5617-5623
    • Hehner, S.P.1    Hofmann, T.G.2    Droge, W.3    Schmitz, M.L.4
  • 24
    • 2942618506 scopus 로고    scopus 로고
    • Rote of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential
    • Garcia-Pineres AJ, Lindenmeyer MT, Merfort I. Rote of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential. Life Sci. 2004;75:841-856.
    • (2004) Life Sci , vol.75 , pp. 841-856
    • Garcia-Pineres, A.J.1    Lindenmeyer, M.T.2    Merfort, I.3
  • 25
    • 0035955729 scopus 로고    scopus 로고
    • Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    • Garcia-Pineres AJ, Castro V, Mora G, et al. Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J Biol Chem. 2001;276:39713-39720.
    • (2001) J Biol Chem , vol.276 , pp. 39713-39720
    • Garcia-Pineres, A.J.1    Castro, V.2    Mora, G.3
  • 26
    • 0034614643 scopus 로고    scopus 로고
    • Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family
    • Sobota R, Szwed M, Kasza A, Bugno M, Kordula T. Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family. Biochem Biophys Res Commun. 2000;267:329-333.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 329-333
    • Sobota, R.1    Szwed, M.2    Kasza, A.3    Bugno, M.4    Kordula, T.5
  • 27
    • 0037064130 scopus 로고    scopus 로고
    • Oxidative stress-mediated apoptosis: The anticancer effect of the sesquiterpene lactone parthenolide
    • Wen J, You KR, Lee SY, Song CH, Kim DG. Oxidative stress-mediated apoptosis: the anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem. 2002;277:38954-38964.
    • (2002) J Biol Chem , vol.277 , pp. 38954-38964
    • Wen, J.1    You, K.R.2    Lee, S.Y.3    Song, C.H.4    Kim, D.G.5
  • 28
    • 0026505736 scopus 로고
    • Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow
    • Lansdorp PM, Dragowska W. Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow. J Exp Med. 1992;175:1501-1509.
    • (1992) J Exp Med , vol.175 , pp. 1501-1509
    • Lansdorp, P.M.1    Dragowska, W.2
  • 29
    • 0142074899 scopus 로고    scopus 로고
    • 15-Deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma
    • Okano H, Shiraki K, Inoue H, et al. 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. Lab Invest. 2003;83:1529-1539.
    • (2003) Lab Invest , vol.83 , pp. 1529-1539
    • Okano, H.1    Shiraki, K.2    Inoue, H.3
  • 30
    • 0141738654 scopus 로고    scopus 로고
    • Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
    • Kim BE, Roh SR, Kim JW, Jeong SW, Kim IK. Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2. Exp Mol Med. 2003;35:290-300.
    • (2003) Exp Mol Med , vol.35 , pp. 290-300
    • Kim, B.E.1    Roh, S.R.2    Kim, J.W.3    Jeong, S.W.4    Kim, I.K.5
  • 31
    • 0035929351 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis
    • Eibl G, Wente MN, Reber HA, Hines OJ. Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis. Biochem Biophys Res Commun. 2001;287:522-529.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 522-529
    • Eibl, G.1    Wente, M.N.2    Reber, H.A.3    Hines, O.J.4
  • 32
    • 0012954726 scopus 로고    scopus 로고
    • 15-Deoxy-Delta(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis
    • Kondo M, Shibata T, Kumagai T, et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Proc Natl Acad Sci U S A. 2002;99:7367-7372.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7367-7372
    • Kondo, M.1    Shibata, T.2    Kumagai, T.3
  • 33
    • 0343765810 scopus 로고    scopus 로고
    • Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB
    • Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. FEBS Lett. 1997;402:85-90.
    • (1997) FEBS Lett , vol.402 , pp. 85-90
    • Bork, P.M.1    Schmitz, M.L.2    Kuhnt, M.3    Escher, C.4    Heinrich, M.5
  • 34
    • 0033929398 scopus 로고    scopus 로고
    • Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel-specific decoy oligodeoxynucleotides
    • Romano MF, Lamberti A, Bisogni R, et al. Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel-specific decoy oligodeoxynucleotides. Gene Ther. 2000;7:1234-1237.
    • (2000) Gene Ther , vol.7 , pp. 1234-1237
    • Romano, M.F.1    Lamberti, A.2    Bisogni, R.3
  • 35
    • 3142745263 scopus 로고    scopus 로고
    • Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: Implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma
    • Amiri KI, Horton LW, LaFleur BJ, Sosman JA, Richmond A. Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma. Cancer Res. 2004;64:4912-4918.
    • (2004) Cancer Res , vol.64 , pp. 4912-4918
    • Amiri, K.I.1    Horton, L.W.2    LaFleur, B.J.3    Sosman, J.A.4    Richmond, A.5
  • 36
    • 6344265692 scopus 로고    scopus 로고
    • Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas
    • An J, Sun Y, Fisher M, Rettig MB. Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas. Leukemia. 2004;18:1699-1704.
    • (2004) Leukemia , vol.18 , pp. 1699-1704
    • An, J.1    Sun, Y.2    Fisher, M.3    Rettig, M.B.4
  • 37
    • 0242367469 scopus 로고    scopus 로고
    • Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone
    • Fukuchi K, Date M, Azuma Y, Shinohara M, Takahashi H, Ohura K. Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. J Dent Res. 2003;82:802-806.
    • (2003) J Dent Res , vol.82 , pp. 802-806
    • Fukuchi, K.1    Date, M.2    Azuma, Y.3    Shinohara, M.4    Takahashi, H.5    Ohura, K.6
  • 38
    • 0036847134 scopus 로고    scopus 로고
    • 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells
    • Clay CE, Monjazeb A, Thorburn J, Chilton FH, High KP. 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res. 2002;43:1818-1828.
    • (2002) J Lipid Res , vol.43 , pp. 1818-1828
    • Clay, C.E.1    Monjazeb, A.2    Thorburn, J.3    Chilton, F.H.4    High, K.P.5
  • 39
    • 0034712933 scopus 로고    scopus 로고
    • 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway
    • Straus DS, Pascual G, Li M, et al. 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A. 2000;97:4844-4849.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4844-4849
    • Straus, D.S.1    Pascual, G.2    Li, M.3
  • 40
    • 0035853707 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress
    • Kondo M, Oya-Ito T, Kumagai T, Osawa T, Uchida K. Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J Biol Chem. 2001;276:12076-12083.
    • (2001) J Biol Chem , vol.276 , pp. 12076-12083
    • Kondo, M.1    Oya-Ito, T.2    Kumagai, T.3    Osawa, T.4    Uchida, K.5
  • 41
    • 2342622545 scopus 로고    scopus 로고
    • Considerations for targeting malignant stem cells in leukemia
    • Guzman ML, Jordan CT. Considerations for targeting malignant stem cells in leukemia. Cancer Control. 2004;11:97-104.
    • (2004) Cancer Control , vol.11 , pp. 97-104
    • Guzman, M.L.1    Jordan, C.T.2
  • 42
    • 3543018495 scopus 로고    scopus 로고
    • Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
    • Curry EA 3rd, Murry DJ, Yoder C, et al. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs. 2004;22:299-305.
    • (2004) Invest New Drugs , vol.22 , pp. 299-305
    • Curry III, E.A.1    Murry, D.J.2    Yoder, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.