Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2355-2371

  Venkataraman, Sujatha ^a   Alimova, Irina ^a   Balakrishnan, Ilango ^a   Harris, Peter ^a   Birks, Diane K ^a   Griesinger, Andrea ^a   Amani, Vladimir ^a   Cristiano, Brian ^a   Remke, Marc ^b   Taylor, Michael D ^b   Handler, Michael ^a   Foreman, Nicholas K ^a   Vibhakar, Rajeev ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

BRD4; JQ1; Medulloblastoma; MYC; Senescence

Indexed keywords

BRD4 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, HUMAN; MESSENGER RNA; MYC PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE; TUMOR MARKER;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STEM CELL; CANCER SURGERY; CELL CYCLE ARREST; CELL GROWTH; CHILD; GENE EXPRESSION; HUMAN; IN VIVO STUDY; MEDULLOBLASTOMA; MICROARRAY ANALYSIS; ONCOGENE C MYC; TUMOR CELL; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; DNA MICROARRAY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MORTALITY; MOUSE; NUDE MOUSE; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AZEPINES; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; CHILD; GENE EXPRESSION PROFILING; HUMANS; MEDULLOBLASTOMA; MICE; MICE, NUDE; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TRANSCRIPTION FACTORS; TRIAZOLES; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901236445     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: None     Document Type: Article

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