메뉴 건너뛰기




Volumn 112, Issue 12, 2003, Pages 1776-1784

Epithelial-mesenchymal transition and its implications for fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BETA INTEGRIN; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOKERATIN 18; CYTOKINE; DESMOPLAKIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 8; FIBRONECTIN; GELATINASE A; GELATINASE B; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOGENIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN B; SYNDECAN 1; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 0346724511     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200320530     Document Type: Review
Times cited : (2267)

References (154)
  • 2
    • 0034712075 scopus 로고    scopus 로고
    • Stem cells in epithelial tissues
    • Slack, J.M.W. 2000. Stem cells in epithelial tissues. Science. 287:1431-1433.
    • (2000) Science , vol.287 , pp. 1431-1433
    • Slack, J.M.W.1
  • 3
    • 0034712109 scopus 로고    scopus 로고
    • Out of Eden: Stem cells and their niches
    • Watt, F.M., and Hogan, B.L. 2000. Out of Eden: stem cells and their niches. Science. 287:1427-1430.
    • (2000) Science , vol.287 , pp. 1427-1430
    • Watt, F.M.1    Hogan, B.L.2
  • 4
    • 0035967892 scopus 로고    scopus 로고
    • The evolving concept of a stem cell: Entity or function?
    • Blau, H.M., Brazelton, T.R., and Weimainn, J.M. 2001. The evolving concept of a stem cell: entity or function? Cell. 105:829-841.
    • (2001) Cell , vol.105 , pp. 829-841
    • Blau, H.M.1    Brazelton, T.R.2    Weimainn, J.M.3
  • 5
    • 0035178997 scopus 로고    scopus 로고
    • Boundaries in development: Formation and Function
    • Irvine, K.D., and Rauskolb, C. 2001. Boundaries in development: formation and Function. Annu. Rev. Cell Dev. Biol. 17:189-214.
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 189-214
    • Irvine, K.D.1    Rauskolb, C.2
  • 6
    • 0025287890 scopus 로고
    • Pattern Formation in skin development
    • Sengel, P. 1990. Pattern Formation in skin development. Int. J. Dev. Biol. 34:33-50
    • (1990) Int. J. Dev. Biol. , vol.34 , pp. 33-50
    • Sengel, P.1
  • 7
    • 0031603510 scopus 로고    scopus 로고
    • Neural crest development: The interplay between morphogenesis and cell differentiation
    • Erickson, C.A., and Reedy, M.V. 1998. Neural crest development: the interplay between morphogenesis and cell differentiation. Curr. Top. Dev. Biol. 40:177-209.
    • (1998) Curr. Top. Dev. Biol. , vol.40 , pp. 177-209
    • Erickson, C.A.1    Reedy, M.V.2
  • 8
    • 0036633647 scopus 로고    scopus 로고
    • Organogenesis: Molecular mechanisms of tubulogenesis
    • Hogan, B.L., and Kolodziej, P.A. 2002. Organogenesis: molecular mechanisms of tubulogenesis. Nat. Rev. Genet. 3:513-523.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 513-523
    • Hogan, B.L.1    Kolodziej, P.A.2
  • 10
    • 0037428084 scopus 로고    scopus 로고
    • Tube morphogenesis: Making and shaping biological tubes
    • Lubarsky, B., and Krasnow, M.A. 2003. Tube morphogenesis: making and shaping biological tubes. Cell. 112:19-28.
    • (2003) Cell , vol.112 , pp. 19-28
    • Lubarsky, B.1    Krasnow, M.A.2
  • 11
    • 0026723902 scopus 로고
    • Epithelial morphogenesis
    • Gumbiner, B.M. 1992. Epithelial morphogenesis. Cell. 69:385-387.
    • (1992) Cell , vol.69 , pp. 385-387
    • Gumbiner, B.M.1
  • 13
    • 0141605376 scopus 로고    scopus 로고
    • Terminal differentiation of epithelia
    • Al-Awqati, Q., Vijayakumar, S., and Takito, J. 2003. Terminal differentiation of epithelia. Biol. Chem. 384:1255-1258.
    • (2003) Biol. Chem. , vol.384 , pp. 1255-1258
    • Al-Awqati, Q.1    Vijayakumar, S.2    Takito, J.3
  • 14
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer, B., Valles, A.M., and Edme, N. 2000. Induction and regulation of epithelial-mesenchymal transitions. Biochem. Pharmacol. 60:1091-1099.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 15
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors Nat
    • Nieto, M.A. 2002. The snail superfamily of zinc-finger transcription factors Nat. Rev. Mol. Cell Biol. 3:155-166.
    • (2002) Rev. Mol. Cell Biol. , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 16
    • 0036083433 scopus 로고    scopus 로고
    • Plasticity, niches, and the use of stem cells
    • Tsai, R. Y., Kittappa, R., and McKay, R.D. 2002. Plasticity, niches, and the use of stem cells. Dev. Cell. 2:707-712.
    • (2002) Dev. Cell , vol.2 , pp. 707-712
    • Tsai, R.Y.1    Kittappa, R.2    McKay, R.D.3
  • 17
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformations
    • Hay, E.D. 1995. An overview of epithelio-mesenchymal transformations. Acta Anat. 154:8-20.
    • (1995) Acta Anat. , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 18
    • 0029091682 scopus 로고
    • Identification and characterization of a Fibroblast marker: FSPI
    • Strutz, F., et al. 1995. Identification and characterization of a Fibroblast marker: FSPI. J. Cell Biol. 130:393-405.
    • (1995) J. Cell Biol. , vol.130 , pp. 393-405
    • Strutz, F.1
  • 19
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that Fibroblasts derive from epithelium during tissue fibrosis
    • doi:10.1172/JC1200215518
    • Iwano, M., et al. 2002. Evidence that Fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110:341-350.doi:10.1172/JC1200215518.
    • (2002) J. Clin. Invest. , vol.110 , pp. 341-350
    • Iwano, M.1
  • 20
    • 0035845845 scopus 로고    scopus 로고
    • Identification of genes involved in epithelial-mesenchymal transition and tumor progression
    • Kiemer, A.K., Takeuchi, K., and Quinlan, M.P. 2001. Identification of genes involved in epithelial-mesenchymal transition and tumor progression. Oncogene. 20:6679-6688.
    • (2001) Oncogene , vol.20 , pp. 6679-6688
    • Kiemer, A.K.1    Takeuchi, K.2    Quinlan, M.P.3
  • 21
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • Janda, E., et al. 2002. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J. Cell Biol. 156:299-313.
    • (2002) J. Cell Biol. , vol.156 , pp. 299-313
    • Janda, E.1
  • 22
    • 0038700554 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: Epithelial-mesenchymal transition in breast cancer development
    • Vincent-Salomon, A., and Thiery, J.P. 2003. Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res. 5:101-106.
    • (2003) Breast Cancer Res. , vol.5 , pp. 101-106
    • Vincent-Salomon, A.1    Thiery, J.P.2
  • 23
    • 0038745381 scopus 로고    scopus 로고
    • The gate-keeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastases
    • Xue, C., Plieth, D., Venkov, C., Xu, C., and Neilson, E.G. 2003. The gate-keeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastases. Cancer Res. 63:3386-3394.
    • (2003) Cancer Res. , vol.63 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 24
    • 0035479834 scopus 로고    scopus 로고
    • Transdifferentiation and metaplasia-switching cell types
    • Slack, J.M., and Tosh, D. 2001. Transdifferentiation and metaplasia-switching cell types. Curr. Opin. Genet. Dev. 11:581-586.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 581-586
    • Slack, J.M.1    Tosh, D.2
  • 26
    • 0037309926 scopus 로고    scopus 로고
    • Eye regeneration at the molecular age
    • Ric-Tsonis, K.D., and Tsonis, P.A. 2003. Eye regeneration at the molecular age. Dev. Dyn. 226:211-224.
    • (2003) Dev. Dyn. , vol.226 , pp. 211-224
    • Ric-Tsonis, K.D.1    Tsonis, P.A.2
  • 27
    • 0036862318 scopus 로고    scopus 로고
    • Adipocyte differentiation and transdifferentiation: Plasticity of the adipose organ
    • Cinti, S. 2002. Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ. J. Endocrinol. Invest. 25:823-835.
    • (2002) J. Endocrinol. Invest. , vol.25 , pp. 823-835
    • Cinti, S.1
  • 28
    • 0037076796 scopus 로고    scopus 로고
    • Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: In vitro analysis
    • Frid, M.G., Kale, VA., and Stenmark, K.R. 2002. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ. Res. 90:1189-1196.
    • (2002) Circ. Res. , vol.90 , pp. 1189-1196
    • Frid, M.G.1    Kale, V.A.2    Stenmark, K.R.3
  • 29
    • 0035141709 scopus 로고    scopus 로고
    • Reversible transdifferentiation: Interconversion of somatotrophs and lacrotrophs in pituitary hyperplasia
    • Vidal, S., Horvath, E., Kovacs, K., Lloyd, R.V., and Smyth, H.S. 2001. Reversible transdifferentiation: interconversion of somatotrophs and lacrotrophs in pituitary hyperplasia. Mod. Pathol. 14:20-28.
    • (2001) Mod. Pathol. , vol.14 , pp. 20-28
    • Vidal, S.1    Horvath, E.2    Kovacs, K.3    Lloyd, R.V.4    Smyth, H.S.5
  • 30
    • 0033911990 scopus 로고    scopus 로고
    • Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
    • Rooman, I., Heremans, Y., Heimberg, H., and Bouwens, L. 2000. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia. 43:907-914.
    • (2000) Diabetologia , vol.43 , pp. 907-914
    • Rooman, I.1    Heremans, Y.2    Heimberg, H.3    Bouwens, L.4
  • 31
    • 0026608889 scopus 로고
    • Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas
    • Hall, P.A., and Lemoine, N.R. 1992. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J. Pathol. 166:97-103.
    • (1992) J. Pathol. , vol.166 , pp. 97-103
    • Hall, P.A.1    Lemoine, N.R.2
  • 32
    • 0033672199 scopus 로고    scopus 로고
    • Molecular basis of transdifferentiation of pancreas to liver
    • Shen, C.N., Slack, J. M., and Tosh, D. 2000. Molecular basis of transdifferentiation of pancreas to liver. Nat. Cell Biol. 2:879-887.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 879-887
    • Shen, C.N.1    Slack, J.M.2    Tosh, D.3
  • 33
    • 0037213612 scopus 로고    scopus 로고
    • Transdifferentiation of pancreas to liver
    • Shen, C.N., Horb, M.E., Slack, J.M., and Tosh, D. 2003. Transdifferentiation of pancreas to liver. Mech. Dev. 120:107-116.
    • (2003) Mech. Dev. , vol.120 , pp. 107-116
    • Shen, C.N.1    Horb, M.E.2    Slack, J.M.3    Tosh, D.4
  • 34
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion of liver to pancreas
    • Horb, M.E., Shen, C.N., Tosh, D., and Slack, J.M. 2003. Experimental conversion of liver to pancreas. Curr. Biol. 13:105-115.
    • (2003) Curr. Biol. , vol.13 , pp. 105-115
    • Horb, M.E.1    Shen, C.N.2    Tosh, D.3    Slack, J.M.4
  • 35
    • 0031464087 scopus 로고    scopus 로고
    • Mouse gastrulation: The formation of a mammalian body plan
    • Tam, P.P., and Behringer, R.R. 1997. Mouse gastrulation: the formation of a mammalian body plan. Mech. Dev. 68:3-25.
    • (1997) Mech. Dev. , vol.68 , pp. 3-25
    • Tam, P.P.1    Behringer, R.R.2
  • 36
    • 0034194466 scopus 로고    scopus 로고
    • Cell movements during gastrulation: Come in and be induced
    • Narasimha, M., and Leptin, M. 2000. Cell movements during gastrulation: come in and be induced. Trends Cell Biol. 10:169-172.
    • (2000) Trends Cell Biol. , vol.10 , pp. 169-172
    • Narasimha, M.1    Leptin, M.2
  • 37
    • 0035167812 scopus 로고    scopus 로고
    • The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    • Carver, E.A., Jiang, R., Lan, Y., Oram, K.F., and Gridley, T. 2001. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell Biol. 21:8184-8188.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 8184-8188
    • Carver, E.A.1    Jiang, R.2    Lan, Y.3    Oram, K.F.4    Gridley, T.5
  • 38
    • 0033629338 scopus 로고    scopus 로고
    • Transcriptional regulation during somitogenesis
    • Summerbell, D., and Rigby, P.W. 2000. Transcriptional regulation during somitogenesis. Curr. Top. Dev. Biol. 48:301-318.
    • (2000) Curr. Top. Dev. Biol. , vol.48 , pp. 301-318
    • Summerbell, D.1    Rigby, P.W.2
  • 40
    • 0024315501 scopus 로고
    • Developmentally regulated conversion of mesenchyme to epithelium
    • Ekblom, P. 1989. Developmentally regulated conversion of mesenchyme to epithelium. FASEB J. 3:2141-2150.
    • (1989) FASEB J. , vol.3 , pp. 2141-2150
    • Ekblom, P.1
  • 41
    • 0028430186 scopus 로고
    • Mesenchymal-epithelial transitions
    • Birchmeier, W., and Birchmeier, C. 1994. Mesenchymal-epithelial transitions. Bioessays. 16:305-307.
    • (1994) Bioessays , vol.16 , pp. 305-307
    • Birchmeier, W.1    Birchmeier, C.2
  • 42
    • 0032708307 scopus 로고    scopus 로고
    • Mesenchymal to epithelial conversion in rat metanephros is induced by LIF
    • Barasch, J., et al. 1999. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell. 99:377-386.
    • (1999) Cell , vol.99 , pp. 377-386
    • Barasch, J.1
  • 43
    • 0029149053 scopus 로고
    • Factors influencing myofibroblast differentiation during wound healing and fibrosis
    • Desmouliere, A. 1995. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 19:471-476.
    • (1995) Cell Biol. Int. , vol.19 , pp. 471-476
    • Desmouliere, A.1
  • 44
    • 0032321972 scopus 로고    scopus 로고
    • Plasticity of mammary epithelia during normal development and neoplastic progression
    • Lochter, A. 1998. Plasticity of mammary epithelia during normal development and neoplastic progression. Biochem. Cell Biol. 76:997-1008.
    • (1998) Biochem. Cell Biol. , vol.76 , pp. 997-1008
    • Lochter, A.1
  • 45
    • 0033055046 scopus 로고    scopus 로고
    • Pathological relevance of epithelial and mesenchymal phenotype plasticity
    • Guarino, M., Micheli, P., Pallotti, F., and Giordano, F. 1999. Pathological relevance of epithelial and mesenchymal phenotype plasticity. Pathol. Res. Pract. 195:379-389.
    • (1999) Pathol. Res. Pract. , vol.195 , pp. 379-389
    • Guarino, M.1    Micheli, P.2    Pallotti, F.3    Giordano, F.4
  • 46
    • 0034785496 scopus 로고    scopus 로고
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial Fibrosis
    • Yang, J., and Liu, Y. 2001. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial Fibrosis. Am. J. Pathol. 159:1465-1475.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1465-1475
    • Yang, J.1    Liu, Y.2
  • 47
    • 0036088906 scopus 로고    scopus 로고
    • Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelia] cells
    • Zeisberg, M., Maeshima, Y., Mosterman, B., and Kalluri, R. 2002. Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelia] cells. Am. J. Pathol. 160:2001-2008.
    • (2002) Am. J. Pathol. , vol.160 , pp. 2001-2008
    • Zeisberg, M.1    Maeshima, Y.2    Mosterman, B.3    Kalluri, R.4
  • 48
    • 0034799176 scopus 로고    scopus 로고
    • Renal fibrosis: Collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation
    • Zeisberg, M., et al. 2001. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am. J. Pathol. 159:1313-1321.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1313-1321
    • Zeisberg, M.1
  • 49
    • 0032842887 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
    • Fan, J.M., et al. 1999. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int. 56:1455-1467.
    • (1999) Kidney Int. , vol.56 , pp. 1455-1467
    • Fan, J.M.1
  • 50
    • 0030670132 scopus 로고    scopus 로고
    • The early role of FSP1 in epithelial-mesenchymal transformation
    • Okada, H., Danoff, T.M., Kalluri, R., and Neilson, E.G. 1997. The early role of FSP1 in epithelial-mesenchymal transformation. Am. J. Physiol. 273:563-574.
    • (1997) Am. J. Physiol. , vol.273 , pp. 563-574
    • Okada, H.1    Danoff, T.M.2    Kalluri, R.3    Neilson, E.G.4
  • 51
    • 0035899466 scopus 로고    scopus 로고
    • IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition
    • Morali, O.G., et al. 2001. IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene. 20:4942-4950.
    • (2001) Oncogene , vol.20 , pp. 4942-4950
    • Morali, O.G.1
  • 52
    • 0036233040 scopus 로고    scopus 로고
    • Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    • Scrutz, F., et al. 2002. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int. 61:1714-1728.
    • (2002) Kidney Int. , vol.61 , pp. 1714-1728
    • Scrutz, F.1
  • 53
    • 0035861541 scopus 로고    scopus 로고
    • Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
    • Bhowmick, N. A., Zent, R., Ghiassi, M., McDonnell, M., and Moses, H.L. 2001. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J. Biol. Chem. 276:46707-46713.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46707-46713
    • Bhowmick, N.A.1    Zent, R.2    Ghiassi, M.3    McDonnell, M.4    Moses, H.L.5
  • 54
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg, M., et al. 2003. BMP-7 counteracts TGF-beta 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Mat. Med. 9:964-968.
    • (2003) Mat. Med. , vol.9 , pp. 964-968
    • Zeisberg, M.1
  • 55
    • 0032953451 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFβ signal transduction mechanisms
    • Boyer, A.S., Erickson, C.P., and Runyan, R.B. 1999. Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFβ signal transduction mechanisms. Dev. Dyn. 214:81-91,
    • (1999) Dev. Dyn. , vol.214 , pp. 81-91
    • Boyer, A.S.1    Erickson, C.P.2    Runyan, R.B.3
  • 56
    • 0037099745 scopus 로고    scopus 로고
    • TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
    • Yu, L., Hebert, M.C., and Zhang, Y.E. 2002. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J. 21:3749-3759.
    • (2002) EMBO J. , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 57
    • 0033560169 scopus 로고    scopus 로고
    • TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart
    • Boyer, A.S., et al. 1999. TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Biol. 208:530-545.
    • (1999) Dev. Biol. , vol.208 , pp. 530-545
    • Boyer, A.S.1
  • 58
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick, N.A., et al. 2001. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell. 12:27-36.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1
  • 59
    • 0035984434 scopus 로고    scopus 로고
    • Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis
    • Camenisch, T.D., et al. 2002. Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev. Biol. 248:170-181.
    • (2002) Dev. Biol. , vol.248 , pp. 170-181
    • Camenisch, T.D.1
  • 60
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen, P.J., Ebner, R., Lopez, A.R., and Derynck, R. 1994. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 127:2021-2036.
    • (1994) J. Cell Biol. , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 61
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R., and Zhang, Y.E. 2003. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 62
    • 0028061954 scopus 로고
    • Expression of transforming growth factor alpha (TGF alpha), epidermal growth factor receptor (EGF-R) and cell proliferation during human palatogenesis: An immunohistochemical study
    • Citterio, H.L., and Gaillard, D.A. 1994. Expression of transforming growth factor alpha (TGF alpha), epidermal growth factor receptor (EGF-R) and cell proliferation during human palatogenesis: an immunohistochemical study. Int. J. Dev. Biol. 38:499-505.
    • (1994) Int. J. Dev. Biol. , vol.38 , pp. 499-505
    • Citterio, H.L.1    Gaillard, D.A.2
  • 63
    • 0035370474 scopus 로고    scopus 로고
    • Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development
    • Morabito, C.J., Dettman, R.W., Katran, J., Collier, J.M., and Bristow J. 2001. Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development. Dev. Biol 234:204-215.
    • (2001) Dev. Biol. , vol.234 , pp. 204-215
    • Morabito, C.J.1    Dettman, R.W.2    Katran, J.3    Collier, J.M.4    Bristow, J.5
  • 64
    • 0030450542 scopus 로고    scopus 로고
    • Roles of kringle domain-containing serine proteases in epithelial-mesenchymal transitions during embryonic development
    • Thery, C., and Stern, C.D. 1996. Roles of kringle domain-containing serine proteases in epithelial-mesenchymal transitions during embryonic development. Acta Anat. (Basel). 156:162-172.
    • (1996) Acta Anat. (Basel) , vol.156 , pp. 162-172
    • Thery, C.1    Stern, C.D.2
  • 65
    • 0036000104 scopus 로고    scopus 로고
    • Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
    • Lamorte, L., Royal, I., Naujokas, M., and Park, M. 2002. Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol. Biol. Cell. 13:1449-1461.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1449-1461
    • Lamorte, L.1    Royal, I.2    Naujokas, M.3    Park, M.4
  • 66
    • 0032959159 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in the developing myocardium: Evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression
    • Song, W., Majka, S.M., and McGuire, P.G. 1999. Hepatocyte growth factor expression in the developing myocardium: evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression. Dev. Dyn. 214:92-100.
    • (1999) Dev. Dyn. , vol.214 , pp. 92-100
    • Song, W.1    Majka, S.M.2    McGuire, P.G.3
  • 67
    • 0029083311 scopus 로고
    • Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development
    • Thery, C., Sharpe, M.J., Batley, SJ., Stern, C.D., and Gherardi, E. 1995. Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development. Dev. Genet. 17:90-101.
    • (1995) Dev. Genet. , vol.17 , pp. 90-101
    • Thery, C.1    Sharpe, M.J.2    Batley, S.J.3    Stern, C.D.4    Gherardi, E.5
  • 68
    • 0028349254 scopus 로고
    • Hepacocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium
    • Nusrat, A., et al. 1994. Hepacocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J. Clin. Invest. 93:2056-2065.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2056-2065
    • Nusrat, A.1
  • 69
    • 0032080835 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
    • Mizuno, S., et al. 1998. Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J. Clin. Invest. 101:1827-1834.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1827-1834
    • Mizuno, S.1
  • 70
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and Hall, A. 2002. Rho GTPases in cell biology. Nature. 420:629-635,
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 71
    • 0034644537 scopus 로고    scopus 로고
    • Ras and Rho GTPases: A family reunion
    • Bar-Sagi, D., and Hall, A. 2000. Ras and Rho GTPases: a family reunion. Cell. 103:227-238.
    • (2000) Cell , vol.103 , pp. 227-238
    • Bar-Sagi, D.1    Hall, A.2
  • 72
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
    • Savagner, P. 2001. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays. 23:912-923.
    • (2001) Bioessays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 73
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • Kim, K., Lu, Z., and Hay, E.D. 2002. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol. Int. 26:463-476.
    • (2002) Cell Biol. Int. , vol.26 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 74
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science. 279:509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 75
    • 0141720342 scopus 로고    scopus 로고
    • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
    • doi:10.1172/JC1200317913
    • Li, Y., Yang, J, Dai, C., Wu, C., and Liu, Y. 2003. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J. Clin. Invest. 112:503-516. doi:10.1172/JC1200317913.
    • (2003) J. Clin. Invest. , vol.112 , pp. 503-516
    • Li, Y.1    Yang, J.2    Dai, C.3    Wu, C.4    Liu, Y.5
  • 76
    • 0032516094 scopus 로고    scopus 로고
    • Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
    • Novak, A., et al. 1998. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc. Natl. Acad. Sci. U. S. A. 95:4374-4379.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 4374-4379
    • Novak, A.1
  • 77
    • 0032847443 scopus 로고    scopus 로고
    • H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
    • Espada, J., Perez-Moreno, M., Braga, V.M., Rodriguez-Viciana, R. and Cano, A. 1999. H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J. Cell Biol. 146:967-980.
    • (1999) J. Cell Biol. , vol.146 , pp. 967-980
    • Espada, J.1    Perez-Moreno, M.2    Braga, V.M.3    Rodriguez-Viciana, R.4    Cano, A.5
  • 78
    • 0027507028 scopus 로고
    • Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
    • Behrens, J., et al. 1993. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol. 120:757-766.
    • (1993) J. Cell Biol. , vol.120 , pp. 757-766
    • Behrens, J.1
  • 79
    • 0027087075 scopus 로고
    • Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: Its expression pattern suggests multiple roles during postimplantation development
    • Smith, D.E., Franco del Amo, F., and Gridley, T. 1992. Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development. Development. 116:1033-1039.
    • (1992) Development. , vol.116 , pp. 1033-1039
    • Smith, D.E.1    Franco Del Amo, F.2    Gridley, T.3
  • 80
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-beta superfamily
    • Attisano, L., and Wrana, J.L. 2002. Signal transduction by the TGF-beta superfamily. Science. 296:1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 81
    • 0037604557 scopus 로고    scopus 로고
    • A wnt-wnt situation
    • He, X. 2003. A wnt-wnt situation. Dev. Cell. 4:791-797.
    • (2003) Dev. Cell , vol.4 , pp. 791-797
    • He, X.1
  • 82
    • 0034808019 scopus 로고    scopus 로고
    • Down-regulation of beta-catenin by activated p53
    • Sadot, E., Geiger, B., Oren, M., and Ben-Ze'ev, A. 2001. Down-regulation of beta-catenin by activated p53. Mol. Cell. Biol. 21:6768-6781.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6768-6781
    • Sadot, E.1    Geiger, B.2    Oren, M.3    Ben-Ze'ev, A.4
  • 83
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. 1997. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16:3797-3804.
    • (1997) EMBO J. , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 84
    • 0033813426 scopus 로고    scopus 로고
    • Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
    • von Kries, J.P., et al. 2000. Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat. Struct. Biol. 7:800-807,
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 800-807
    • Von Kries, J.P.1
  • 85
    • 0035210416 scopus 로고    scopus 로고
    • New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent, while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities
    • Kim, K., and Hay, E.D. 2001. New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent, while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities. Cell Biol. Int. 25:1149-1161.
    • (2001) Cell Biol. Int. , vol.25 , pp. 1149-1161
    • Kim, K.1    Hay, E.D.2
  • 86
    • 0031006251 scopus 로고    scopus 로고
    • APC expression in normal human tissues
    • Midgley, C.A., et al. 1997. APC expression in normal human tissues. J. Pathol. 181:426-433.
    • (1997) J. Pathol. , vol.181 , pp. 426-433
    • Midgley, C.A.1
  • 87
    • 0036668281 scopus 로고    scopus 로고
    • Cell movements during gastrulation: Snail dependent and independent pathways
    • Ip, Y.T., and Gridley, T. 2002, Cell movements during gastrulation: snail dependent and independent pathways. Curr. Opin. Genet. Dev. 12:423-429.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 423-429
    • Ip, Y.T.1    Gridley, T.2
  • 88
    • 0035810944 scopus 로고    scopus 로고
    • Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta
    • Zavadil, J., et al. 2001. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc. Natl. Acad. Sci. U. S. A. 98:6686-6691.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 6686-6691
    • Zavadil, J.1
  • 89
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy, S., Ross, K.N., Lander, E.S., and Golub, T.R. 2003. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33:49-54.
    • (2003) Nat. Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 90
    • 0033141822 scopus 로고    scopus 로고
    • Plasticity of cell fate: Insights from heterokaryons
    • Blau, H.M., and Blakely, B.T. 1999. Plasticity of cell fate: insights from heterokaryons. Semin. Cell Dev. Biol. 10:267-272.
    • (1999) Semin. Cell Dev. Biol. , vol.10 , pp. 267-272
    • Blau, H.M.1    Blakely, B.T.2
  • 91
    • 0037013153 scopus 로고    scopus 로고
    • Specificity of gene regulation
    • Emerson, B.M. 2002. Specificity of gene regulation. Cell. 109:267-270.
    • (2002) Cell , vol.109 , pp. 267-270
    • Emerson, B.M.1
  • 92
    • 0035316574 scopus 로고    scopus 로고
    • Chromosome territories, nuclear architecture and gene regulation in mammalian cells
    • Cremer, T., and Cremer, C. 2001. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat. Rev. Genet. 2:292-301.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 292-301
    • Cremer, T.1    Cremer, C.2
  • 93
    • 0033597438 scopus 로고    scopus 로고
    • Transcriptional coregulators in development
    • Mannervik, M., Nibu, Y., Zhang, H., and Levine, M. 1999. Transcriptional coregulators in development. Science. 284:606-609,
    • (1999) Science , vol.284 , pp. 606-609
    • Mannervik, M.1    Nibu, Y.2    Zhang, H.3    Levine, M.4
  • 94
    • 0037123763 scopus 로고    scopus 로고
    • Views of transcription initiation
    • Young, B.A., Gruber, T.M., and Gross, C.A. 2002. Views of transcription initiation. Cell. 109:417-420.
    • (2002) Cell , vol.109 , pp. 417-420
    • Young, B.A.1    Gruber, T.M.2    Gross, C.A.3
  • 95
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 induces snail transcription factor in epithelial cell lines. Mechanisms for epithelial-mesenchymal transitions
    • Peinado, H., Quintanilla, M., and Cano, A. 2003. Transforming growth factor beta 1 induces snail transcription factor in epithelial cell lines. Mechanisms for epithelial-mesenchymal transitions. J. Biol. Chem. 278:21113-21123.
    • (2003) J. Biol. Chem. , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 96
    • 0344921402 scopus 로고    scopus 로고
    • Ets-1 and Ets-2 transcription factors are essential for normal coronary and myocardial development in chicken embryos
    • Lie-Venerna, H., et al. 2003. Ets-1 and Ets-2 transcription factors are essential for normal coronary and myocardial development in chicken embryos. Circ. Res. 92:749-756.
    • (2003) Circ. Res. , vol.92 , pp. 749-756
    • Lie-Venerna, H.1
  • 97
    • 0031755408 scopus 로고    scopus 로고
    • Immunoreactivity of the ets-1 transcription factor correlates with areas of epithelial-mesenchymal transition in the developing avian heart
    • Macias, D., Perez-Pomares, J.M., Garcia-Garrido, L., Carmona, R., and Munoz-Chapuli, R. 1998. Immunoreactivity of the ets-1 transcription factor correlates with areas of epithelial-mesenchymal transition in the developing avian heart. Anat. Embryol. (Berl.), 198:307-315.
    • (1998) Anat. Embryol. (Berl.) , vol.198 , pp. 307-315
    • Macias, D.1    Perez-Pomares, J.M.2    Garcia-Garrido, L.3    Carmona, R.4    Munoz-Chapuli, R.5
  • 98
    • 0032426874 scopus 로고    scopus 로고
    • Clustered organization of S100 genes in human and mouse
    • Ridinger, K., et al. 1998. Clustered organization of S100 genes in human and mouse. Biochim. Biopbys. Acta. 1448:254-263.
    • (1998) Biochim. Biopbys. Acta , vol.1448 , pp. 254-263
    • Ridinger, K.1
  • 99
    • 0034981126 scopus 로고    scopus 로고
    • Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts
    • Iwano, M., et al. 2001. Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts. Mol. Ther. 3:149-15b.
    • (2001) Mol. Ther. , vol.3 , pp. 149-15b
    • Iwano, M.1
  • 100
    • 0032438029 scopus 로고    scopus 로고
    • Calcium-binding protein S100A4 in health and disease
    • Barraclough, R. 1998. Calcium-binding protein S100A4 in health and disease. Biochim. Biophys. Acta. 1448:190-199.
    • (1998) Biochim. Biophys. Acta , vol.1448 , pp. 190-199
    • Barraclough, R.1
  • 101
    • 0035933723 scopus 로고    scopus 로고
    • Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: Functional consequences of their interaction
    • Grigorian, M., et al. 2001. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction. J. Biol. Chem. 276:22699-22708.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22699-22708
    • Grigorian, M.1
  • 102
    • 0034816514 scopus 로고    scopus 로고
    • Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka)
    • Chen H., et al. 2001. Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). Biochem. Biophys. Res. Commun. 286:1212-1217.
    • (2001) Biochem. Biophys. Res. Commun. , vol.286 , pp. 1212-1217
    • Chen, H.1
  • 103
    • 17944368283 scopus 로고    scopus 로고
    • The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
    • Ambartsumian, N., et al. 2001. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. Oncogene. 20:4685-4695.
    • (2001) Oncogene , vol.20 , pp. 4685-4695
    • Ambartsumian, N.1
  • 104
    • 0031816584 scopus 로고    scopus 로고
    • Novel cis-acting elements in the FSP1 gene regulate Fibroblast-specific transcription
    • Okada, H., et al. 1998. Novel cis-acting elements in the FSP1 gene regulate Fibroblast-specific transcription. Am. J. Physiol. 275:306-314.
    • (1998) Am. J. Physiol. , vol.275 , pp. 306-314
    • Okada, H.1
  • 105
    • 0037707630 scopus 로고    scopus 로고
    • TGF-{beta}1-mediated alterations of renal proximal tubular epithelial cell phenotype
    • Tian, Y.C., Fraser, D., Attisano, L., and Phillips, A.O. 2003. TGF-{beta}1-mediated alterations of renal proximal tubular epithelial cell phenotype. Am. J. Physiol. Renal Physiol. 285:F130-F142.
    • (2003) Am. J. Physiol. Renal Physiol. , vol.285
    • Tian, Y.C.1    Fraser, D.2    Attisano, L.3    Phillips, A.O.4
  • 106
    • 0032848957 scopus 로고    scopus 로고
    • Epithelial cell plasticity in development and tumor progression
    • Thiery, J.P., and Chopin, D. 1999. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev. 18:31-42.
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 31-42
    • Thiery, J.P.1    Chopin, D.2
  • 107
    • 0036364408 scopus 로고    scopus 로고
    • A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases
    • Quilliam, L.A., Rebhun, J.F., and Castro, A.F. 2002. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71:391-444.
    • (2002) Prog. Nucleic Acid Res. Mol. Biol. , vol.71 , pp. 391-444
    • Quilliam, L.A.1    Rebhun, J.F.2    Castro, A.F.3
  • 108
    • 0037451803 scopus 로고    scopus 로고
    • GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
    • Bernards, A. 2003. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta. 1603:47-82.
    • (2003) Biochim. Biophys. Acta , vol.1603 , pp. 47-82
    • Bernards, A.1
  • 109
    • 0037405501 scopus 로고    scopus 로고
    • Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
    • Masszi, A., et al. 2003. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am. J. Physiol. Renal Physiol. 284:F911-924.
    • (2003) Am. J. Physiol. Renal Physiol. , vol.284
    • Masszi, A.1
  • 110
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 111
    • 0029166671 scopus 로고
    • Rho, rac and cdc42 GTPases: Regulators of actin structures, cell adhesion and motility
    • Nobes, C.D., and Hall, A. 1995. Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem. Soc. Trans. 23:456-459.
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 456-459
    • Nobes, C.D.1    Hall, A.2
  • 112
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • Sander, E.E., ten Klooster, J.P., van Delft, S., van der Kammen, R.A., and Collard, J.G. 1999. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147:1009-1022.
    • (1999) J. Cell Biol. , vol.147 , pp. 1009-1022
    • Sander, E.E.1    Ten Klooster, J.P.2    Van Delft, S.3    Van Der Kammen, R.A.4    Collard, J.G.5
  • 113
    • 0034658674 scopus 로고    scopus 로고
    • Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
    • Zondag, G.C., et al. 2000. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J. Cell Biol. 149:775-782.
    • (2000) J. Cell Biol. , vol.149 , pp. 775-782
    • Zondag, G.C.1
  • 114
    • 84918732190 scopus 로고
    • Übet Entzündung und Eiterung
    • Cohnheim, J. 1867. Übet Entzündung und Eiterung. Virchows Arch. 40:1-79.
    • (1867) Virchows Arch. , vol.40 , pp. 1-79
    • Cohnheim, J.1
  • 115
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites
    • Abe, R., Donnelly, S.C., Peng, T., Bucala, R., and Metz, C.N. 2001. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J. Immunol. 166:7556-7562.
    • (2001) J. Immunol. , vol.166 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 116
    • 0033959639 scopus 로고    scopus 로고
    • Isolation of primary and immortalized CD34-hematopoietic and mesenchymal stem cells from various sources
    • Huss, R. 2000. Isolation of primary and immortalized CD34-hematopoietic and mesenchymal stem cells from various sources. Stem Cells. 18:1-9.
    • (2000) Stem Cells , vol.18 , pp. 1-9
    • Huss, R.1
  • 117
    • 0033917320 scopus 로고    scopus 로고
    • Marrow stromal cells
    • Bianco, P., and Robey, P.G. 2000. Marrow stromal cells. J. Clin. Invest, 105:1663-1668.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1663-1668
    • Bianco, P.1    Robey, P.G.2
  • 119
    • 0030093454 scopus 로고    scopus 로고
    • The in vivo role of bone marrow Fibroblast-like stromal cells
    • Simmons, D.J. 1996. The in vivo role of bone marrow Fibroblast-like stromal cells. Calcif. Tissue Int. 58:129-132.
    • (1996) Calcif. Tissue Int. , vol.58 , pp. 129-132
    • Simmons, D.J.1
  • 120
    • 0025938439 scopus 로고
    • Barrier cells: Stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow
    • Weiss, L., and Geduldig, U. 1991. Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow. Blood. 78:975-990.
    • (1991) Blood , vol.78 , pp. 975-990
    • Weiss, L.1    Geduldig, U.2
  • 121
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang, J., et al. 2003. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 425:836-841.
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1
  • 122
    • 0035805055 scopus 로고    scopus 로고
    • Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    • Krause, D.S., et al. 2001. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 105:369-377
    • (2001) Cell , vol.105 , pp. 369-377
    • Krause, D.S.1
  • 123
    • 0028859099 scopus 로고
    • Differentiation of canine bone marrow cells with hemopoietic characteristics from an adherent stromal cell precursor
    • Huss, R., Hong, D.S., McSweeney, P.A., Hoy, C.A., and Deeg, HJ. 1995. Differentiation of canine bone marrow cells with hemopoietic characteristics from an adherent stromal cell precursor. Proc. Natl. Acad. Sci U. S. A. 92:748-752.
    • (1995) Proc. Natl. Acad. Sci U. S. A. , vol.92 , pp. 748-752
    • Huss, R.1    Hong, D.S.2    McSweeney, P.A.3    Hoy, C.A.4    Deeg, H.J.5
  • 124
    • 0034489771 scopus 로고    scopus 로고
    • Perspectives on the morphology and biology of CD34-negative stem cells
    • Huss, R. 2000. Perspectives on the morphology and biology of CD34-negative stem cells. J. Hematother. Stem Cell Res. 9:783-793.
    • (2000) J. Hematother. Stem Cell Res. , vol.9 , pp. 783-793
    • Huss, R.1
  • 125
    • 0018765620 scopus 로고
    • Fibroblast-like cells from embryonic chick cornea, heart, and skin are antigenically distinct
    • Garrett, D.M., and Conrad, G.W. 1979. Fibroblast-like cells from embryonic chick cornea, heart, and skin are antigenically distinct. Dev. Biol. 70:50-70.
    • (1979) Dev. Biol. , vol.70 , pp. 50-70
    • Garrett, D.M.1    Conrad, G.W.2
  • 126
    • 0023440740 scopus 로고
    • Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial-mesenchymal interactions
    • Schor, S.L., and Schor, A.M. 1987. Clonal heterogeneity in fibroblast phenotype: implications for the control of epithelial-mesenchymal interactions. Bioessays. 7:200-204.
    • (1987) Bioessays , vol.7 , pp. 200-204
    • Schor, S.L.1    Schor, A.M.2
  • 127
    • 0025733932 scopus 로고
    • Characterization of human renal fibroblasts in health and disease. I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis
    • Müller, G.A., and Rodemann, H.P. 1991. Characterization of human renal fibroblasts in health and disease. I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis. Am. J. Kidney Dis. 17:680-683.
    • (1991) Am. J. Kidney Dis. , vol.17 , pp. 680-683
    • Müller, G.A.1    Rodemann, H.P.2
  • 128
    • 0032004524 scopus 로고    scopus 로고
    • Rat fibroblasts cultured from various organs exhibit differences in alpha-smooth muscle actin expression, cytoskeletal pattern, and adhesive structure organization
    • Dugina, V., Alexandrova, A., Chaponnier, C., Vasiliev, J., and Gabbiani, G. 1998. Rat fibroblasts cultured from various organs exhibit differences in alpha-smooth muscle actin expression, cytoskeletal pattern, and adhesive structure organization. Exp. Cell. Res. 238:481-490.
    • (1998) Exp. Cell. Res. , vol.238 , pp. 481-490
    • Dugina, V.1    Alexandrova, A.2    Chaponnier, C.3    Vasiliev, J.4    Gabbiani, G.5
  • 129
    • 0026531659 scopus 로고
    • Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines
    • Alvarez, R.J., et al. 1992. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int. 41:14-23.
    • (1992) Kidney Int. , vol.41 , pp. 14-23
    • Alvarez, R.J.1
  • 130
    • 0036790977 scopus 로고    scopus 로고
    • Diversity, topographic differentiation, and positional memory in human fibroblasts
    • Chang, H.Y., et al. 2002. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 99:12877-12882.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 12877-12882
    • Chang, H.Y.1
  • 131
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • Chilosi, M., et al. 2003. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am. J. Pathol. 162:1495-1502.
    • (2003) Am. J. Pathol. , vol.162 , pp. 1495-1502
    • Chilosi, M.1
  • 132
    • 0030704301 scopus 로고    scopus 로고
    • Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice
    • Kalluri, R., Danoff, T.M., Okada, H., and Neilson, E.G. 1997. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J. Clin. Invest. 100:2263-2275.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2263-2275
    • Kalluri, R.1    Danoff, T.M.2    Okada, H.3    Neilson, E.G.4
  • 133
    • 0029829425 scopus 로고    scopus 로고
    • Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome
    • Cosgrove, D., et al. 1996. Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev. 10:2981-2992.
    • (1996) Genes Dev. , vol.10 , pp. 2981-2992
    • Cosgrove, D.1
  • 134
    • 0342955726 scopus 로고    scopus 로고
    • Murine models of renal disease: Possibilities and problems in studies using mutant mice
    • Anders, H., and Schlondorff, D. 2000. Murine models of renal disease: possibilities and problems in studies using mutant mice. Exp. Nephrol. 8:181-193.
    • (2000) Exp. Nephrol. , vol.8 , pp. 181-193
    • Anders, H.1    Schlondorff, D.2
  • 135
    • 0032777587 scopus 로고    scopus 로고
    • Rodent models of nephropathy associated with type II diabetes
    • Janssen, U., Phillips, A.O., and Floege, J. 1999. Rodent models of nephropathy associated with type II diabetes. J. Nephrol. 12:159-172.
    • (1999) J. Nephrol. , vol.12 , pp. 159-172
    • Janssen, U.1    Phillips, A.O.2    Floege, J.3
  • 136
    • 0031766270 scopus 로고    scopus 로고
    • Mechanisms of interstitial fibrosis in obstructive nephropathy
    • Diamond, J.R., Ricardo, S.D., and Klahr, S. 1998. Mechanisms of interstitial fibrosis in obstructive nephropathy. Semin. Nephrol. 18:594-602.
    • (1998) Semin. Nephrol. , vol.18 , pp. 594-602
    • Diamond, J.R.1    Ricardo, S.D.2    Klahr, S.3
  • 137
    • 0033865917 scopus 로고    scopus 로고
    • Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation
    • Okada, H., et al. 2000. Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int. 58:587-597.
    • (2000) Kidney Int. , vol.58 , pp. 587-597
    • Okada, H.1
  • 139
    • 0025233985 scopus 로고
    • Subpopulations of rat lung fibroblasts with different amounts of type I and type III collagen mRNAs
    • Breen, E., Falco, V.M., Absher, M., and Cutroneo, K.R. 1990. Subpopulations of rat lung fibroblasts with different amounts of type I and type III collagen mRNAs. J. Biol. Chem. 265:6286-6290.
    • (1990) J. Biol. Chem. , vol.265 , pp. 6286-6290
    • Breen, E.1    Falco, V.M.2    Absher, M.3    Cutroneo, K.R.4
  • 140
    • 0025248716 scopus 로고
    • Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts
    • Goldring, S.R., Stephenson, M.L., Downie, E., Krane, S.M., and Korn, J.H, 1990. Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts. J. Clin. Invest. 85:798-803.
    • (1990) J. Clin. Invest. , vol.85 , pp. 798-803
    • Goldring, S.R.1    Stephenson, M.L.2    Downie, E.3    Krane, S.M.4    Korn, J.H.5
  • 141
    • 0033361118 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in physiological conditions and fibrotic disease
    • Jelaska, A., Strehlow, D., and Korn, J.H. 1999. Fibroblast heterogeneity in physiological conditions and fibrotic disease. Springer Semin. Immunopathol. 21:385-395.
    • (1999) Springer Semin. Immunopathol. , vol.21 , pp. 385-395
    • Jelaska, A.1    Strehlow, D.2    Korn, J.H.3
  • 142
    • 0030065712 scopus 로고    scopus 로고
    • Identification of a minimal sequence of the mouse pro-a1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts
    • Rossert, R.A., Chen, S.S., Eberspaecher, H., Smith, C.N., and De Crombrugghe, B. 1996. Identification of a minimal sequence of the mouse pro-a1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc. Natl. Acad. Set. U. S. A. 93:1027-1031.
    • (1996) Proc. Natl. Acad. Set. U. S. A. , vol.93 , pp. 1027-1031
    • Rossert, R.A.1    Chen, S.S.2    Eberspaecher, H.3    Smith, C.N.4    De Crombrugghe, B.5
  • 143
    • 0034323610 scopus 로고    scopus 로고
    • Role of Fibroblast activation in inducing interstitial fibrosis
    • Zeisberg, M., Strutz, F., and Muller, G.A. 2000. Role of Fibroblast activation in inducing interstitial fibrosis. J. Nephrol. 13(Suppl. 3):S111-S120.
    • (2000) J. Nephrol. , vol.13 , Issue.SUPPL. 3
    • Zeisberg, M.1    Strutz, F.2    Muller, G.A.3
  • 144
    • 0033178473 scopus 로고    scopus 로고
    • Mechanisms of myofibroblast activity and phenotypic modulation
    • Serini, G., and Gabbiani, G. 1999. Mechanisms of myofibroblast activity and phenotypic modulation. Exp. Cell Res. 250:273-283.
    • (1999) Exp. Cell Res. , vol.250 , pp. 273-283
    • Serini, G.1    Gabbiani, G.2
  • 145
    • 0029869237 scopus 로고    scopus 로고
    • Platelet-derived growth Factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis
    • Tang, W.W., et al. 1996. Platelet-derived growth Factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am. J. Pathol. 148:1169-1180.
    • (1996) Am. J. Pathol. , vol.148 , pp. 1169-1180
    • Tang, W.W.1
  • 146
    • 0031682715 scopus 로고    scopus 로고
    • Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats
    • Ng, Y.Y., et al. 1998. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int. 54:864-876.
    • (1998) Kidney Int. , vol.54 , pp. 864-876
    • Ng, Y.Y.1
  • 147
    • 0035115666 scopus 로고    scopus 로고
    • The myofibroblast: An assessment of controversial issues and a definition useful in diagnosis and research
    • Eyden, B. 2001. The myofibroblast: an assessment of controversial issues and a definition useful in diagnosis and research. Ultrastruct. Pathol. 25:39-50.
    • (2001) Ultrastruct. Pathol. , vol.25 , pp. 39-50
    • Eyden, B.1
  • 148
    • 0036854980 scopus 로고    scopus 로고
    • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    • doi:10.1172/JC1200216219
    • Yang, J., et al. 2002. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J. Clin. Invest. 110:1525-1538. doi:10.1172/JC1200216219.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1525-1538
    • Yang, J.1
  • 149
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Yang, J., and Liu, Y. 2002. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J. Am. Sec. Nephrol. 13:96-107.
    • (2002) J. Am. Sec. Nephrol. , vol.13 , pp. 96-107
    • Yang, J.1    Liu, Y.2
  • 150
    • 0242582117 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two generic mouse models
    • Zeisberg, M., et al. 2003. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two generic mouse models. Am. J. Physiol. Renal Physiol. 285:F1060-F1067.
    • (2003) Am. J. Physiol. Renal Physiol. , vol.285
    • Zeisberg, M.1
  • 151
    • 0037214941 scopus 로고    scopus 로고
    • Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7
    • Kalluri, R., and Zeisberg, M. 2003. Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7. Histol. Histopathol. 18:217-224.
    • (2003) Histol. Histopathol. , vol.18 , pp. 217-224
    • Kalluri, R.1    Zeisberg, M.2
  • 152
    • 0035651361 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function
    • Morrissey, J., et al. 2002. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J. Am. Soc. Nephrol. 13(Suppl. 1):S14-S21.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , Issue.SUPPL. 1
    • Morrissey, J.1
  • 153
    • 0037648482 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy
    • Wang, S., et al. 2003. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 63:2037-2049.
    • (2003) Kidney Int. , vol.63 , pp. 2037-2049
    • Wang, S.1
  • 154
    • 0020402387 scopus 로고
    • Exaptation - A missing term in the science of form
    • Gould, S.J., and Vrba, E.S. 1982. Exaptation - a missing term in the science of form. Paleobiology. 8:4-15.
    • (1982) Paleobiology , vol.8 , pp. 4-15
    • Gould, S.J.1    Vrba, E.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.